OLAH (oleoyl-ACP hydrolase)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55301
• Gene name: Oleoyl-ACP hydrolase
• Gene symbol: OLAH
• Synonyms (NCBI Gene): AURA1, SAST, TE2, THEDC1
• Chromosome: 10
• Chromosome location: 10p13

miRNA Show/Hide all (131)

miRTarBase ID	miRNA	Experiments	Reference
MIRT528064	hsa-miR-4699-3p	PAR-CLIP	22012620
MIRT528063	hsa-miR-4729	PAR-CLIP	22012620
MIRT528062	hsa-miR-6801-3p	PAR-CLIP	22012620
MIRT528061	hsa-miR-6810-3p	PAR-CLIP	22012620
MIRT528060	hsa-miR-331-3p	PAR-CLIP	22012620
MIRT528059	hsa-miR-569	PAR-CLIP	22012620
MIRT528058	hsa-miR-3682-5p	PAR-CLIP	22012620
MIRT528057	hsa-miR-5696	PAR-CLIP	22012620
MIRT528056	hsa-miR-6826-3p	PAR-CLIP	22012620
MIRT528055	hsa-miR-2053	PAR-CLIP	22012620
MIRT528054	hsa-miR-498	PAR-CLIP	22012620
MIRT528053	hsa-miR-3679-3p	PAR-CLIP	22012620
MIRT528064	hsa-miR-4699-3p	PAR-CLIP	22012620
MIRT528063	hsa-miR-4729	PAR-CLIP	22012620
MIRT528062	hsa-miR-6801-3p	PAR-CLIP	22012620
MIRT528061	hsa-miR-6810-3p	PAR-CLIP	22012620
MIRT528060	hsa-miR-331-3p	PAR-CLIP	22012620
MIRT528059	hsa-miR-569	PAR-CLIP	22012620
MIRT528058	hsa-miR-3682-5p	PAR-CLIP	22012620
MIRT528057	hsa-miR-5696	PAR-CLIP	22012620
MIRT528056	hsa-miR-6826-3p	PAR-CLIP	22012620
MIRT528055	hsa-miR-2053	PAR-CLIP	22012620
MIRT528054	hsa-miR-498	PAR-CLIP	22012620
MIRT528053	hsa-miR-3679-3p	PAR-CLIP	22012620
MIRT1202990	hsa-miR-122	CLIP-seq
MIRT1202991	hsa-miR-1228	CLIP-seq
MIRT1202992	hsa-miR-1915	CLIP-seq
MIRT1202993	hsa-miR-1976	CLIP-seq
MIRT1202994	hsa-miR-2113	CLIP-seq
MIRT1202995	hsa-miR-2276	CLIP-seq
MIRT1202996	hsa-miR-3135b	CLIP-seq
MIRT1202997	hsa-miR-3152-3p	CLIP-seq
MIRT1202998	hsa-miR-3170	CLIP-seq
MIRT1202999	hsa-miR-3199	CLIP-seq
MIRT1203000	hsa-miR-3652	CLIP-seq
MIRT1203001	hsa-miR-377	CLIP-seq
MIRT1203002	hsa-miR-4279	CLIP-seq
MIRT1203003	hsa-miR-4420	CLIP-seq
MIRT1203004	hsa-miR-4430	CLIP-seq
MIRT1203005	hsa-miR-4454	CLIP-seq
MIRT1203006	hsa-miR-4662a-5p	CLIP-seq
MIRT1203007	hsa-miR-4676-5p	CLIP-seq
MIRT1203008	hsa-miR-4694-5p	CLIP-seq
MIRT1203009	hsa-miR-4707-3p	CLIP-seq
MIRT1203010	hsa-miR-4722-3p	CLIP-seq
MIRT1203011	hsa-miR-4726-3p	CLIP-seq
MIRT1203012	hsa-miR-4735-5p	CLIP-seq
MIRT1203013	hsa-miR-4740-3p	CLIP-seq
MIRT1203014	hsa-miR-4775	CLIP-seq
MIRT1203015	hsa-miR-552	CLIP-seq
MIRT1203016	hsa-miR-575	CLIP-seq
MIRT1203017	hsa-miR-590-3p	CLIP-seq
MIRT1203018	hsa-miR-599	CLIP-seq
MIRT1203019	hsa-miR-764	CLIP-seq
MIRT1202991	hsa-miR-1228	CLIP-seq
MIRT1202992	hsa-miR-1915	CLIP-seq
MIRT1202993	hsa-miR-1976	CLIP-seq
MIRT1202995	hsa-miR-2276	CLIP-seq
MIRT1202999	hsa-miR-3199	CLIP-seq
MIRT1203001	hsa-miR-377	CLIP-seq
MIRT1203002	hsa-miR-4279	CLIP-seq
MIRT1203003	hsa-miR-4420	CLIP-seq
MIRT1203005	hsa-miR-4454	CLIP-seq
MIRT1203006	hsa-miR-4662a-5p	CLIP-seq
MIRT1203007	hsa-miR-4676-5p	CLIP-seq
MIRT1203010	hsa-miR-4722-3p	CLIP-seq
MIRT1203011	hsa-miR-4726-3p	CLIP-seq
MIRT1203013	hsa-miR-4740-3p	CLIP-seq
MIRT1203015	hsa-miR-552	CLIP-seq
MIRT1203016	hsa-miR-575	CLIP-seq
MIRT1203019	hsa-miR-764	CLIP-seq
MIRT1202990	hsa-miR-122	CLIP-seq
MIRT1202991	hsa-miR-1228	CLIP-seq
MIRT2286832	hsa-miR-150	CLIP-seq
MIRT1202992	hsa-miR-1915	CLIP-seq
MIRT1202993	hsa-miR-1976	CLIP-seq
MIRT1202995	hsa-miR-2276	CLIP-seq
MIRT1202996	hsa-miR-3135b	CLIP-seq
MIRT1202999	hsa-miR-3199	CLIP-seq
MIRT1203000	hsa-miR-3652	CLIP-seq
MIRT1203001	hsa-miR-377	CLIP-seq
MIRT1203002	hsa-miR-4279	CLIP-seq
MIRT1203003	hsa-miR-4420	CLIP-seq
MIRT1203004	hsa-miR-4430	CLIP-seq
MIRT1203010	hsa-miR-4722-3p	CLIP-seq
MIRT1203011	hsa-miR-4726-3p	CLIP-seq
MIRT1203012	hsa-miR-4735-5p	CLIP-seq
MIRT1203013	hsa-miR-4740-3p	CLIP-seq
MIRT1203014	hsa-miR-4775	CLIP-seq
MIRT1203015	hsa-miR-552	CLIP-seq
MIRT1203017	hsa-miR-590-3p	CLIP-seq
MIRT1203019	hsa-miR-764	CLIP-seq
MIRT1202990	hsa-miR-122	CLIP-seq
MIRT1202991	hsa-miR-1228	CLIP-seq
MIRT1202993	hsa-miR-1976	CLIP-seq
MIRT1202994	hsa-miR-2113	CLIP-seq
MIRT1202996	hsa-miR-3135b	CLIP-seq
MIRT1202999	hsa-miR-3199	CLIP-seq
MIRT1203000	hsa-miR-3652	CLIP-seq
MIRT1203002	hsa-miR-4279	CLIP-seq
MIRT1203004	hsa-miR-4430	CLIP-seq
MIRT1203010	hsa-miR-4722-3p	CLIP-seq
MIRT1203012	hsa-miR-4735-5p	CLIP-seq
MIRT1203013	hsa-miR-4740-3p	CLIP-seq
MIRT1203014	hsa-miR-4775	CLIP-seq
MIRT1203015	hsa-miR-552	CLIP-seq
MIRT1203017	hsa-miR-590-3p	CLIP-seq
MIRT1203018	hsa-miR-599	CLIP-seq
MIRT1203019	hsa-miR-764	CLIP-seq
MIRT2585168	hsa-miR-936	CLIP-seq
MIRT1202990	hsa-miR-122	CLIP-seq
MIRT1202991	hsa-miR-1228	CLIP-seq
MIRT1202993	hsa-miR-1976	CLIP-seq
MIRT1202994	hsa-miR-2113	CLIP-seq
MIRT1202996	hsa-miR-3135b	CLIP-seq
MIRT1202999	hsa-miR-3199	CLIP-seq
MIRT1203000	hsa-miR-3652	CLIP-seq
MIRT1203002	hsa-miR-4279	CLIP-seq
MIRT2686824	hsa-miR-4427	CLIP-seq
MIRT1203004	hsa-miR-4430	CLIP-seq
MIRT2686825	hsa-miR-4645-3p	CLIP-seq
MIRT2686826	hsa-miR-4680-3p	CLIP-seq
MIRT1203010	hsa-miR-4722-3p	CLIP-seq
MIRT1203012	hsa-miR-4735-5p	CLIP-seq
MIRT1203013	hsa-miR-4740-3p	CLIP-seq
MIRT1203014	hsa-miR-4775	CLIP-seq
MIRT1203015	hsa-miR-552	CLIP-seq
MIRT1203017	hsa-miR-590-3p	CLIP-seq
MIRT1203018	hsa-miR-599	CLIP-seq
MIRT1203019	hsa-miR-764	CLIP-seq
MIRT2585168	hsa-miR-936	CLIP-seq

Gene ontology (GO) Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	ISS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006633	Process	Fatty acid biosynthetic process	IEA
GO:0008610	Process	Lipid biosynthetic process	IBA
GO:0016297	Function	Fatty acyl-[ACP] hydrolase activity	IDA	26663084
GO:0016297	Function	Fatty acyl-[ACP] hydrolase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0051792	Process	Medium-chain fatty acid biosynthetic process	IDA	26663084
GO:0051792	Process	Medium-chain fatty acid biosynthetic process	IEA

Other IDs

• MIM: 621227
• HGNC: 25625
• e!Ensembl: ENSG00000152463

Protein

• UniProt ID: Q9NV23
• Protein name: S-acyl fatty acid synthase thioesterase, medium chain (EC 3.1.2.14) (Augmented in rheumatoid arthritis 1) (AURA1) (Oleoyl-ACP hydrolase) (Thioesterase 2) (TE2) (Thioesterase II) (Thioesterase domain-containing protein 1)
• Protein function: Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16). {ECO:0000269|PubMed:266630
• PDB: 4XJV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00975	Thioesterase	27 → 256	Thioesterase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected both in lactating and non-lactating breast epithelium (at protein level) (PubMed:6589427). Isoform 2 is up-regulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients (PubMed:17082220). {ECO:0000269|Pub
• Sequence:

  MERGDQPKRTRNENIFNCLYKNPEATFKLICFPWMGGGSTHFAKWGQDTHDLLEVHSLRL
  PGRESRVEEPLENDISQLVDEVVCALQPVIQDKPFAFFGHSMGSYIAFRTALGLKENNQP
  EPLHLFLSSATPVHSKAWHRIPKDDELSEEQISHYLMEFGGTPKHFAEAKEFVKQCSPII
  RADLNIVRSCTSNVPSKAVLSCDLTCFVGSEDIAKDMEAWKDVTSGNAKIYQLPGGHFYL
  LDPANEKLIKNYIIKCLEVSSISNF

• Sequence length: 265

Pathways

KEGG Pathway

Fatty acid biosynthesis

Metabolic pathways

Related Genes

No strongly related genes found yet for OLAH.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to OLAH.