OIP5 (Opa interacting protein 5)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 11339
• Gene name: Opa interacting protein 5
• Gene symbol: OIP5
• Synonyms (NCBI Gene): 5730547N13Rik, CT86, LINT-25, MIS18B, MIS18beta, hMIS18beta
• Chromosome: 15
• Chromosome location: 15q15.1
• Summary: The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeu

miRNA Show/Hide all (214)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016268	hsa-miR-193b-3p	Microarray	20304954
MIRT020369	hsa-miR-29c-3p	Sequencing	20371350
MIRT026997	hsa-miR-103a-3p	Sequencing	20371350
MIRT031576	hsa-miR-16-5p	Sequencing	20371350
MIRT540937	hsa-miR-371b-3p	HITS-CLIP	21572407
MIRT540936	hsa-miR-371a-3p	HITS-CLIP	21572407
MIRT540935	hsa-miR-33b-3p	HITS-CLIP	21572407
MIRT540934	hsa-miR-515-3p	HITS-CLIP	21572407
MIRT540933	hsa-miR-519e-3p	HITS-CLIP	21572407
MIRT540932	hsa-miR-6080	HITS-CLIP	21572407
MIRT540931	hsa-miR-508-3p	HITS-CLIP	21572407
MIRT540930	hsa-miR-219a-5p	HITS-CLIP	21572407
MIRT540928	hsa-miR-4782-3p	HITS-CLIP	21572407
MIRT540929	hsa-miR-6766-3p	HITS-CLIP	21572407
MIRT540927	hsa-miR-4445-5p	HITS-CLIP	21572407
MIRT540926	hsa-miR-8086	HITS-CLIP	21572407
MIRT540925	hsa-miR-526b-5p	HITS-CLIP	21572407
MIRT540924	hsa-miR-449c-3p	HITS-CLIP	21572407
MIRT540923	hsa-miR-218-5p	HITS-CLIP	21572407
MIRT540922	hsa-miR-578	HITS-CLIP	21572407
MIRT655646	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT655645	hsa-miR-5580-3p	HITS-CLIP	23824327
MIRT655644	hsa-miR-4775	HITS-CLIP	23824327
MIRT574298	hsa-miR-501-3p	PAR-CLIP	20371350
MIRT574297	hsa-miR-502-3p	PAR-CLIP	20371350
MIRT574296	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT574295	hsa-miR-6865-3p	PAR-CLIP	20371350
MIRT574294	hsa-miR-5690	PAR-CLIP	20371350
MIRT574292	hsa-miR-6787-3p	PAR-CLIP	20371350
MIRT574293	hsa-miR-767-5p	PAR-CLIP	20371350
MIRT540937	hsa-miR-371b-3p	PAR-CLIP	21572407
MIRT540936	hsa-miR-371a-3p	PAR-CLIP	21572407
MIRT540935	hsa-miR-33b-3p	PAR-CLIP	21572407
MIRT540934	hsa-miR-515-3p	PAR-CLIP	21572407
MIRT540933	hsa-miR-519e-3p	PAR-CLIP	21572407
MIRT540932	hsa-miR-6080	PAR-CLIP	21572407
MIRT540931	hsa-miR-508-3p	PAR-CLIP	21572407
MIRT540930	hsa-miR-219a-5p	PAR-CLIP	21572407
MIRT540928	hsa-miR-4782-3p	PAR-CLIP	21572407
MIRT540929	hsa-miR-6766-3p	PAR-CLIP	21572407
MIRT540927	hsa-miR-4445-5p	PAR-CLIP	21572407
MIRT540926	hsa-miR-8086	PAR-CLIP	21572407
MIRT540925	hsa-miR-526b-5p	PAR-CLIP	21572407
MIRT540924	hsa-miR-449c-3p	PAR-CLIP	21572407
MIRT540923	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT540922	hsa-miR-578	PAR-CLIP	21572407
MIRT540937	hsa-miR-371b-3p	PAR-CLIP	21572407
MIRT540936	hsa-miR-371a-3p	PAR-CLIP	21572407
MIRT540935	hsa-miR-33b-3p	PAR-CLIP	21572407
MIRT540934	hsa-miR-515-3p	PAR-CLIP	21572407
MIRT540933	hsa-miR-519e-3p	PAR-CLIP	21572407
MIRT540932	hsa-miR-6080	PAR-CLIP	21572407
MIRT540931	hsa-miR-508-3p	PAR-CLIP	21572407
MIRT540930	hsa-miR-219a-5p	PAR-CLIP	21572407
MIRT540928	hsa-miR-4782-3p	PAR-CLIP	21572407
MIRT540929	hsa-miR-6766-3p	PAR-CLIP	21572407
MIRT540927	hsa-miR-4445-5p	PAR-CLIP	21572407
MIRT540926	hsa-miR-8086	PAR-CLIP	21572407
MIRT540925	hsa-miR-526b-5p	PAR-CLIP	21572407
MIRT540924	hsa-miR-449c-3p	PAR-CLIP	21572407
MIRT540923	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT540922	hsa-miR-578	PAR-CLIP	21572407
MIRT532527	hsa-miR-1296-3p	PAR-CLIP	22012620
MIRT532526	hsa-miR-3199	PAR-CLIP	22012620
MIRT532525	hsa-miR-8052	PAR-CLIP	22012620
MIRT532524	hsa-miR-365a-5p	PAR-CLIP	22012620
MIRT532523	hsa-miR-365b-5p	PAR-CLIP	22012620
MIRT532521	hsa-miR-4648	PAR-CLIP	22012620
MIRT532522	hsa-miR-4727-3p	PAR-CLIP	22012620
MIRT442658	hsa-miR-4480	PAR-CLIP	22291592
MIRT442657	hsa-miR-221-3p	PAR-CLIP	22291592
MIRT442656	hsa-miR-222-3p	PAR-CLIP	22291592
MIRT442655	hsa-miR-621	PAR-CLIP	22291592
MIRT442654	hsa-miR-7977	PAR-CLIP	22291592
MIRT442658	hsa-miR-4480	PAR-CLIP	23708386
MIRT442657	hsa-miR-221-3p	PAR-CLIP	23708386
MIRT442656	hsa-miR-222-3p	PAR-CLIP	23708386
MIRT442655	hsa-miR-621	PAR-CLIP	23708386
MIRT442654	hsa-miR-7977	PAR-CLIP	23708386
MIRT442658	hsa-miR-4480	PAR-CLIP	22100165
MIRT442657	hsa-miR-221-3p	PAR-CLIP	22100165
MIRT442656	hsa-miR-222-3p	PAR-CLIP	22100165
MIRT442655	hsa-miR-621	PAR-CLIP	22100165
MIRT442654	hsa-miR-7977	PAR-CLIP	22100165
MIRT442658	hsa-miR-4480	PAR-CLIP	22100165
MIRT442657	hsa-miR-221-3p	PAR-CLIP	22100165
MIRT442656	hsa-miR-222-3p	PAR-CLIP	22100165
MIRT442655	hsa-miR-621	PAR-CLIP	22100165
MIRT442654	hsa-miR-7977	PAR-CLIP	22100165
MIRT731550	hsa-miR-139-5p	Luciferase reporter assay, qRT-PCR, Western blot	27916718
MIRT731550	hsa-miR-139-5p	Luciferase reporter assay, qRT-PCR, Western blot	27916718
MIRT540937	hsa-miR-371b-3p	HITS-CLIP	21572407
MIRT540936	hsa-miR-371a-3p	HITS-CLIP	21572407
MIRT540935	hsa-miR-33b-3p	HITS-CLIP	21572407
MIRT540934	hsa-miR-515-3p	HITS-CLIP	21572407
MIRT540933	hsa-miR-519e-3p	HITS-CLIP	21572407
MIRT540932	hsa-miR-6080	HITS-CLIP	21572407
MIRT540931	hsa-miR-508-3p	HITS-CLIP	21572407
MIRT540930	hsa-miR-219a-5p	HITS-CLIP	21572407
MIRT540928	hsa-miR-4782-3p	HITS-CLIP	21572407
MIRT540929	hsa-miR-6766-3p	HITS-CLIP	21572407
MIRT540927	hsa-miR-4445-5p	HITS-CLIP	21572407
MIRT540926	hsa-miR-8086	HITS-CLIP	21572407
MIRT540925	hsa-miR-526b-5p	HITS-CLIP	21572407
MIRT540924	hsa-miR-449c-3p	HITS-CLIP	21572407
MIRT540923	hsa-miR-218-5p	HITS-CLIP	21572407
MIRT540922	hsa-miR-578	HITS-CLIP	21572407
MIRT655646	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT655645	hsa-miR-5580-3p	HITS-CLIP	23824327
MIRT655644	hsa-miR-4775	HITS-CLIP	23824327
MIRT574298	hsa-miR-501-3p	PAR-CLIP	20371350
MIRT574297	hsa-miR-502-3p	PAR-CLIP	20371350
MIRT574296	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT574295	hsa-miR-6865-3p	PAR-CLIP	20371350
MIRT574294	hsa-miR-5690	PAR-CLIP	20371350
MIRT574292	hsa-miR-6787-3p	PAR-CLIP	20371350
MIRT574293	hsa-miR-767-5p	PAR-CLIP	20371350
MIRT540937	hsa-miR-371b-3p	PAR-CLIP	21572407
MIRT540936	hsa-miR-371a-3p	PAR-CLIP	21572407
MIRT540935	hsa-miR-33b-3p	PAR-CLIP	21572407
MIRT540934	hsa-miR-515-3p	PAR-CLIP	21572407
MIRT540933	hsa-miR-519e-3p	PAR-CLIP	21572407
MIRT540932	hsa-miR-6080	PAR-CLIP	21572407
MIRT540931	hsa-miR-508-3p	PAR-CLIP	21572407
MIRT540930	hsa-miR-219a-5p	PAR-CLIP	21572407
MIRT540928	hsa-miR-4782-3p	PAR-CLIP	21572407
MIRT540929	hsa-miR-6766-3p	PAR-CLIP	21572407
MIRT540927	hsa-miR-4445-5p	PAR-CLIP	21572407
MIRT540926	hsa-miR-8086	PAR-CLIP	21572407
MIRT540925	hsa-miR-526b-5p	PAR-CLIP	21572407
MIRT540924	hsa-miR-449c-3p	PAR-CLIP	21572407
MIRT540923	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT540922	hsa-miR-578	PAR-CLIP	21572407
MIRT540937	hsa-miR-371b-3p	PAR-CLIP	21572407
MIRT540936	hsa-miR-371a-3p	PAR-CLIP	21572407
MIRT540935	hsa-miR-33b-3p	PAR-CLIP	21572407
MIRT540934	hsa-miR-515-3p	PAR-CLIP	21572407
MIRT540933	hsa-miR-519e-3p	PAR-CLIP	21572407
MIRT540932	hsa-miR-6080	PAR-CLIP	21572407
MIRT540931	hsa-miR-508-3p	PAR-CLIP	21572407
MIRT540930	hsa-miR-219a-5p	PAR-CLIP	21572407
MIRT540928	hsa-miR-4782-3p	PAR-CLIP	21572407
MIRT540929	hsa-miR-6766-3p	PAR-CLIP	21572407
MIRT540927	hsa-miR-4445-5p	PAR-CLIP	21572407
MIRT540926	hsa-miR-8086	PAR-CLIP	21572407
MIRT540925	hsa-miR-526b-5p	PAR-CLIP	21572407
MIRT540924	hsa-miR-449c-3p	PAR-CLIP	21572407
MIRT540923	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT540922	hsa-miR-578	PAR-CLIP	21572407
MIRT532527	hsa-miR-1296-3p	PAR-CLIP	22012620
MIRT532526	hsa-miR-3199	PAR-CLIP	22012620
MIRT532525	hsa-miR-8052	PAR-CLIP	22012620
MIRT532524	hsa-miR-365a-5p	PAR-CLIP	22012620
MIRT532523	hsa-miR-365b-5p	PAR-CLIP	22012620
MIRT532521	hsa-miR-4648	PAR-CLIP	22012620
MIRT532522	hsa-miR-4727-3p	PAR-CLIP	22012620
MIRT442658	hsa-miR-4480	PAR-CLIP	22291592
MIRT442657	hsa-miR-221-3p	PAR-CLIP	22291592
MIRT442656	hsa-miR-222-3p	PAR-CLIP	22291592
MIRT442655	hsa-miR-621	PAR-CLIP	22291592
MIRT442654	hsa-miR-7977	PAR-CLIP	22291592
MIRT442658	hsa-miR-4480	PAR-CLIP	23708386
MIRT442657	hsa-miR-221-3p	PAR-CLIP	23708386
MIRT442656	hsa-miR-222-3p	PAR-CLIP	23708386
MIRT442655	hsa-miR-621	PAR-CLIP	23708386
MIRT442654	hsa-miR-7977	PAR-CLIP	23708386
MIRT442658	hsa-miR-4480	PAR-CLIP	22100165
MIRT442657	hsa-miR-221-3p	PAR-CLIP	22100165
MIRT442656	hsa-miR-222-3p	PAR-CLIP	22100165
MIRT442655	hsa-miR-621	PAR-CLIP	22100165
MIRT442654	hsa-miR-7977	PAR-CLIP	22100165
MIRT442658	hsa-miR-4480	PAR-CLIP	22100165
MIRT442657	hsa-miR-221-3p	PAR-CLIP	22100165
MIRT442656	hsa-miR-222-3p	PAR-CLIP	22100165
MIRT442655	hsa-miR-621	PAR-CLIP	22100165
MIRT442654	hsa-miR-7977	PAR-CLIP	22100165
MIRT1202897	hsa-miR-136	CLIP-seq
MIRT1202898	hsa-miR-15a	CLIP-seq
MIRT1202899	hsa-miR-15b	CLIP-seq
MIRT1202900	hsa-miR-16	CLIP-seq
MIRT1202901	hsa-miR-195	CLIP-seq
MIRT1202902	hsa-miR-217	CLIP-seq
MIRT1202903	hsa-miR-3065-3p	CLIP-seq
MIRT1202904	hsa-miR-3121-3p	CLIP-seq
MIRT1202905	hsa-miR-3148	CLIP-seq
MIRT1202906	hsa-miR-323-3p	CLIP-seq
MIRT1202907	hsa-miR-3679-3p	CLIP-seq
MIRT1202908	hsa-miR-3978	CLIP-seq
MIRT1202909	hsa-miR-424	CLIP-seq
MIRT1202910	hsa-miR-4269	CLIP-seq
MIRT1202911	hsa-miR-4477a	CLIP-seq
MIRT1202912	hsa-miR-4509	CLIP-seq
MIRT1202913	hsa-miR-4514	CLIP-seq
MIRT1202914	hsa-miR-4635	CLIP-seq
MIRT1202915	hsa-miR-4692	CLIP-seq
MIRT1202916	hsa-miR-4709-3p	CLIP-seq
MIRT1202917	hsa-miR-4738-3p	CLIP-seq
MIRT1202918	hsa-miR-4742-5p	CLIP-seq
MIRT1202919	hsa-miR-497	CLIP-seq
MIRT1202920	hsa-miR-526b	CLIP-seq
MIRT1202921	hsa-miR-548ag	CLIP-seq
MIRT1202922	hsa-miR-548ai	CLIP-seq
MIRT1202923	hsa-miR-548m	CLIP-seq
MIRT1202924	hsa-miR-653	CLIP-seq
MIRT2058628	hsa-miR-1263	CLIP-seq
MIRT2058629	hsa-miR-3117-5p	CLIP-seq
MIRT1202906	hsa-miR-323-3p	CLIP-seq
MIRT2058630	hsa-miR-4700-3p	CLIP-seq
MIRT2058631	hsa-miR-9	CLIP-seq
MIRT2058628	hsa-miR-1263	CLIP-seq
MIRT2058629	hsa-miR-3117-5p	CLIP-seq
MIRT2058630	hsa-miR-4700-3p	CLIP-seq
MIRT2058631	hsa-miR-9	CLIP-seq
MIRT2391899	hsa-miR-4760-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IBA
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000775	Component	Chromosome, centromeric region	NAS	38951710
GO:0000785	Component	Chromatin	IBA
GO:0000785	Component	Chromatin	IDA	17284516
GO:0005515	Function	Protein binding	IPI	12620389, 17199038, 21516116, 25036634, 25416956, 25910212, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	17284516
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0007059	Process	Chromosome segregation	IBA
GO:0007154	Process	Cell communication	NAS	9466265
GO:0010369	Component	Chromocenter	IEA
GO:0015030	Component	Cajal body	IDA	17284516
GO:0016607	Component	Nuclear speck	IDA
GO:0034080	Process	CENP-A containing chromatin assembly	IBA
GO:0034080	Process	CENP-A containing chromatin assembly	NAS	38951710
GO:0042802	Function	Identical protein binding	IPI	17199038, 32296183
GO:0046872	Function	Metal ion binding	IEA
GO:0051301	Process	Cell division	IEA
GO:0098654	Component	CENP-A recruiting complex	IPI	38951710
GO:0140462	Process	Pericentric heterochromatin organization	NAS	38951710

Other IDs

• MIM: 606020
• HGNC: 20300
• e!Ensembl: ENSG00000104147

Protein

• UniProt ID: O43482
• Protein name: Protein Mis18-beta (Cancer/testis antigen 86) (CT86) (Opa-interacting protein 5) (OIP-5)
• Protein function: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
• PDB: 7SFY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03226	Yippee-Mis18	76 → 184	Yippee zinc-binding/DNA-binding /Mis18, centromere assembly	Domain

• Sequence:

  MAAQPLRHRSRCATPPRGDFCGGTERAIDQASFTTSMEWDTQVVKGSSPLGPAGLGAEEP
  AAGPQLPSWLQPERCAVFQCAQCHAVLADSVHLAWDLSRSLGAVVFSRVTNNVVLEAPFL
  VGIEGSLKGSTYNLLFCGSCGIPVGFHLYSTHAALAALRGHFCLSSDKMVCYLLKTKAIV
  NASEMDIQNVPLSEKIAELKEKIVLTHNRLKSLMKILSEVTPDQSKPEN

• Sequence length: 229

Pathways

Reactome Pathway:

Deposition of new CENPA-containing nucleosomes at the centromere

Related Genes

No strongly related genes found yet for OIP5.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to OIP5.