OGDH (oxoglutarate dehydrogenase)

Gene

• Entrez ID: 4967
• Gene name: Oxoglutarate dehydrogenase
• Gene symbol: OGDH
• Synonyms (NCBI Gene): AKGDH, E1k, E1o, HsOGDH, KGD1, OGDC, OGDH-E1, OGDH2, OGDHD
• Chromosome: 7
• Chromosome location: 7p13
• Summary: This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018112	hsa-miR-335-5p	Microarray	18185580
MIRT028586	hsa-miR-30a-5p	Proteomics	18668040
MIRT031751	hsa-miR-16-5p	Proteomics	18668040
MIRT044084	hsa-miR-361-5p	CLASH	23622248
MIRT701221	hsa-miR-4326	HITS-CLIP	23313552
MIRT701220	hsa-miR-552-5p	HITS-CLIP	23313552
MIRT701221	hsa-miR-4326	HITS-CLIP	23313552
MIRT701220	hsa-miR-552-5p	HITS-CLIP	23313552
MIRT1202594	hsa-miR-106a	CLIP-seq
MIRT1202595	hsa-miR-106b	CLIP-seq
MIRT1202596	hsa-miR-17	CLIP-seq
MIRT1202597	hsa-miR-20a	CLIP-seq
MIRT1202598	hsa-miR-20b	CLIP-seq
MIRT1202599	hsa-miR-302a	CLIP-seq
MIRT1202600	hsa-miR-302b	CLIP-seq
MIRT1202601	hsa-miR-302c	CLIP-seq
MIRT1202602	hsa-miR-302d	CLIP-seq
MIRT1202603	hsa-miR-302e	CLIP-seq
MIRT1202604	hsa-miR-3672	CLIP-seq
MIRT1202605	hsa-miR-372	CLIP-seq
MIRT1202606	hsa-miR-373	CLIP-seq
MIRT1202607	hsa-miR-4438	CLIP-seq
MIRT1202608	hsa-miR-4731-5p	CLIP-seq
MIRT1202609	hsa-miR-4797-5p	CLIP-seq
MIRT1202610	hsa-miR-5095	CLIP-seq
MIRT1202611	hsa-miR-512-3p	CLIP-seq
MIRT1202612	hsa-miR-519d	CLIP-seq
MIRT1202613	hsa-miR-520a-3p	CLIP-seq
MIRT1202614	hsa-miR-520b	CLIP-seq
MIRT1202615	hsa-miR-520c-3p	CLIP-seq
MIRT1202616	hsa-miR-520d-3p	CLIP-seq
MIRT1202617	hsa-miR-520e	CLIP-seq
MIRT1202618	hsa-miR-520g	CLIP-seq
MIRT1202619	hsa-miR-520h	CLIP-seq
MIRT1202620	hsa-miR-93	CLIP-seq
MIRT1202621	hsa-miR-1289	CLIP-seq
MIRT1202622	hsa-miR-3150a-3p	CLIP-seq
MIRT1202623	hsa-miR-3175	CLIP-seq
MIRT1202624	hsa-miR-3689d	CLIP-seq
MIRT1202625	hsa-miR-939	CLIP-seq
MIRT1202621	hsa-miR-1289	CLIP-seq
MIRT1202626	hsa-miR-136	CLIP-seq
MIRT1202627	hsa-miR-24	CLIP-seq
MIRT1202628	hsa-miR-3115	CLIP-seq
MIRT1202629	hsa-miR-3155	CLIP-seq
MIRT1202630	hsa-miR-3155b	CLIP-seq
MIRT1202624	hsa-miR-3689d	CLIP-seq
MIRT1202631	hsa-miR-382	CLIP-seq
MIRT1202632	hsa-miR-3940-5p	CLIP-seq
MIRT1202633	hsa-miR-4263	CLIP-seq
MIRT1202634	hsa-miR-4428	CLIP-seq
MIRT1202635	hsa-miR-4507	CLIP-seq
MIRT1202636	hsa-miR-4521	CLIP-seq
MIRT1202637	hsa-miR-4652-3p	CLIP-seq
MIRT1202638	hsa-miR-484	CLIP-seq
MIRT1202639	hsa-miR-518a-5p	CLIP-seq
MIRT1202640	hsa-miR-527	CLIP-seq
MIRT2058488	hsa-miR-1238	CLIP-seq
MIRT2058489	hsa-miR-1285	CLIP-seq
MIRT2058490	hsa-miR-151-5p	CLIP-seq
MIRT2058491	hsa-miR-1827	CLIP-seq
MIRT2058492	hsa-miR-1976	CLIP-seq
MIRT2058493	hsa-miR-214	CLIP-seq
MIRT2058494	hsa-miR-2277-3p	CLIP-seq
MIRT1202628	hsa-miR-3115	CLIP-seq
MIRT2058495	hsa-miR-3158-5p	CLIP-seq
MIRT2058496	hsa-miR-3187-5p	CLIP-seq
MIRT2058497	hsa-miR-339-5p	CLIP-seq
MIRT2058498	hsa-miR-3611	CLIP-seq
MIRT2058499	hsa-miR-3619-5p	CLIP-seq
MIRT2058500	hsa-miR-3650	CLIP-seq
MIRT2058501	hsa-miR-370	CLIP-seq
MIRT2058502	hsa-miR-3974	CLIP-seq
MIRT2058503	hsa-miR-4265	CLIP-seq
MIRT2058504	hsa-miR-4291	CLIP-seq
MIRT2058505	hsa-miR-4296	CLIP-seq
MIRT2058506	hsa-miR-4322	CLIP-seq
MIRT2058507	hsa-miR-4417	CLIP-seq
MIRT2058508	hsa-miR-4418	CLIP-seq
MIRT2058509	hsa-miR-4649-3p	CLIP-seq
MIRT2058510	hsa-miR-4691-5p	CLIP-seq
MIRT2058511	hsa-miR-4707-5p	CLIP-seq
MIRT1202608	hsa-miR-4731-5p	CLIP-seq
MIRT2058512	hsa-miR-493	CLIP-seq
MIRT2058513	hsa-miR-509-3-5p	CLIP-seq
MIRT2058514	hsa-miR-509-5p	CLIP-seq
MIRT2058515	hsa-miR-542-3p	CLIP-seq
MIRT2058516	hsa-miR-612	CLIP-seq
MIRT2058517	hsa-miR-644	CLIP-seq
MIRT2058518	hsa-miR-661	CLIP-seq
MIRT2058519	hsa-miR-663b	CLIP-seq
MIRT2058520	hsa-miR-761	CLIP-seq
MIRT2058521	hsa-miR-885-3p	CLIP-seq
MIRT2058522	hsa-miR-922	CLIP-seq
MIRT2286728	hsa-miR-1254	CLIP-seq
MIRT2286729	hsa-miR-1273g	CLIP-seq
MIRT1202621	hsa-miR-1289	CLIP-seq
MIRT2286730	hsa-miR-1343	CLIP-seq
MIRT2286731	hsa-miR-140-5p	CLIP-seq
MIRT2058490	hsa-miR-151-5p	CLIP-seq
MIRT2058491	hsa-miR-1827	CLIP-seq
MIRT2058494	hsa-miR-2277-3p	CLIP-seq
MIRT2286732	hsa-miR-296-5p	CLIP-seq
MIRT1202628	hsa-miR-3115	CLIP-seq
MIRT2286733	hsa-miR-3116	CLIP-seq
MIRT1202622	hsa-miR-3150a-3p	CLIP-seq
MIRT2286734	hsa-miR-3160-3p	CLIP-seq
MIRT2286735	hsa-miR-3170	CLIP-seq
MIRT1202623	hsa-miR-3175	CLIP-seq
MIRT2286736	hsa-miR-3183	CLIP-seq
MIRT2286737	hsa-miR-329	CLIP-seq
MIRT2286738	hsa-miR-342-5p	CLIP-seq
MIRT2286739	hsa-miR-361-3p	CLIP-seq
MIRT2286740	hsa-miR-362-3p	CLIP-seq
MIRT2058500	hsa-miR-3650	CLIP-seq
MIRT2286741	hsa-miR-3941	CLIP-seq
MIRT2286742	hsa-miR-4253	CLIP-seq
MIRT2058503	hsa-miR-4265	CLIP-seq
MIRT2058505	hsa-miR-4296	CLIP-seq
MIRT2058506	hsa-miR-4322	CLIP-seq
MIRT2058507	hsa-miR-4417	CLIP-seq
MIRT2286743	hsa-miR-4435	CLIP-seq
MIRT2286744	hsa-miR-4457	CLIP-seq
MIRT2286745	hsa-miR-4508	CLIP-seq
MIRT2058509	hsa-miR-4649-3p	CLIP-seq
MIRT2286746	hsa-miR-4664-5p	CLIP-seq
MIRT2286747	hsa-miR-4667-3p	CLIP-seq
MIRT2286748	hsa-miR-4723-3p	CLIP-seq
MIRT2286749	hsa-miR-4731-3p	CLIP-seq
MIRT2286750	hsa-miR-4749-3p	CLIP-seq
MIRT2286751	hsa-miR-4758-3p	CLIP-seq
MIRT2286752	hsa-miR-4786-3p	CLIP-seq
MIRT2286753	hsa-miR-4794	CLIP-seq
MIRT2286754	hsa-miR-4801	CLIP-seq
MIRT2286755	hsa-miR-491-5p	CLIP-seq
MIRT2286756	hsa-miR-516a-3p	CLIP-seq
MIRT2286757	hsa-miR-603	CLIP-seq
MIRT2286758	hsa-miR-635	CLIP-seq
MIRT2058519	hsa-miR-663b	CLIP-seq
MIRT2286759	hsa-miR-671-5p	CLIP-seq
MIRT2058521	hsa-miR-885-3p	CLIP-seq
MIRT1202625	hsa-miR-939	CLIP-seq
MIRT2391884	hsa-miR-122	CLIP-seq
MIRT2391885	hsa-miR-130a	CLIP-seq
MIRT2391886	hsa-miR-130b	CLIP-seq
MIRT2391887	hsa-miR-216a	CLIP-seq
MIRT2391888	hsa-miR-216b	CLIP-seq
MIRT2391889	hsa-miR-301a	CLIP-seq
MIRT2391890	hsa-miR-301b	CLIP-seq
MIRT2391891	hsa-miR-3135b	CLIP-seq
MIRT2391892	hsa-miR-3136-3p	CLIP-seq
MIRT2391893	hsa-miR-328	CLIP-seq
MIRT2391894	hsa-miR-3652	CLIP-seq
MIRT2391895	hsa-miR-3666	CLIP-seq
MIRT2391896	hsa-miR-4295	CLIP-seq
MIRT2391897	hsa-miR-4430	CLIP-seq
MIRT2391898	hsa-miR-454	CLIP-seq
MIRT2585035	hsa-miR-1202	CLIP-seq
MIRT2585036	hsa-miR-1227	CLIP-seq
MIRT2058488	hsa-miR-1238	CLIP-seq
MIRT2286728	hsa-miR-1254	CLIP-seq
MIRT2286729	hsa-miR-1273g	CLIP-seq
MIRT2585037	hsa-miR-127-5p	CLIP-seq
MIRT2058489	hsa-miR-1285	CLIP-seq
MIRT1202621	hsa-miR-1289	CLIP-seq
MIRT1202626	hsa-miR-136	CLIP-seq
MIRT2286731	hsa-miR-140-5p	CLIP-seq
MIRT2585038	hsa-miR-1913	CLIP-seq
MIRT2585039	hsa-miR-1972	CLIP-seq
MIRT2058492	hsa-miR-1976	CLIP-seq
MIRT2058493	hsa-miR-214	CLIP-seq
MIRT2585040	hsa-miR-22	CLIP-seq
MIRT2286732	hsa-miR-296-5p	CLIP-seq
MIRT2286733	hsa-miR-3116	CLIP-seq
MIRT2585041	hsa-miR-3120-3p	CLIP-seq
MIRT2585042	hsa-miR-3124-3p	CLIP-seq
MIRT2585043	hsa-miR-3148	CLIP-seq
MIRT1202622	hsa-miR-3150a-3p	CLIP-seq
MIRT2585044	hsa-miR-3151	CLIP-seq
MIRT2286734	hsa-miR-3160-3p	CLIP-seq
MIRT2286735	hsa-miR-3170	CLIP-seq
MIRT1202623	hsa-miR-3175	CLIP-seq
MIRT2058496	hsa-miR-3187-5p	CLIP-seq
MIRT2585045	hsa-miR-3194-5p	CLIP-seq
MIRT2585046	hsa-miR-324-3p	CLIP-seq
MIRT2286738	hsa-miR-342-5p	CLIP-seq
MIRT2058499	hsa-miR-3619-5p	CLIP-seq
MIRT2585047	hsa-miR-3664-5p	CLIP-seq
MIRT1202604	hsa-miR-3672	CLIP-seq
MIRT1202624	hsa-miR-3689d	CLIP-seq
MIRT2585048	hsa-miR-3690	CLIP-seq
MIRT2058501	hsa-miR-370	CLIP-seq
MIRT1202632	hsa-miR-3940-5p	CLIP-seq
MIRT2585049	hsa-miR-3972	CLIP-seq
MIRT2585050	hsa-miR-4254	CLIP-seq
MIRT2058503	hsa-miR-4265	CLIP-seq
MIRT2585051	hsa-miR-4277	CLIP-seq
MIRT2058504	hsa-miR-4291	CLIP-seq
MIRT2058505	hsa-miR-4296	CLIP-seq
MIRT2058506	hsa-miR-4322	CLIP-seq
MIRT2058507	hsa-miR-4417	CLIP-seq
MIRT1202634	hsa-miR-4428	CLIP-seq
MIRT2286743	hsa-miR-4435	CLIP-seq
MIRT2585052	hsa-miR-4437	CLIP-seq
MIRT2585053	hsa-miR-4447	CLIP-seq
MIRT2585054	hsa-miR-4456	CLIP-seq
MIRT2585055	hsa-miR-4459	CLIP-seq
MIRT2585056	hsa-miR-4463	CLIP-seq
MIRT2585057	hsa-miR-4472	CLIP-seq
MIRT2585058	hsa-miR-4474-3p	CLIP-seq
MIRT2585059	hsa-miR-4489	CLIP-seq
MIRT2585060	hsa-miR-4505	CLIP-seq
MIRT1202635	hsa-miR-4507	CLIP-seq
MIRT2585061	hsa-miR-4522	CLIP-seq
MIRT2585062	hsa-miR-4650-5p	CLIP-seq
MIRT1202637	hsa-miR-4652-3p	CLIP-seq
MIRT2585063	hsa-miR-4655-3p	CLIP-seq
MIRT2286746	hsa-miR-4664-5p	CLIP-seq
MIRT2585064	hsa-miR-4674	CLIP-seq
MIRT2058510	hsa-miR-4691-5p	CLIP-seq
MIRT2058511	hsa-miR-4707-5p	CLIP-seq
MIRT2585065	hsa-miR-4711-5p	CLIP-seq
MIRT2585066	hsa-miR-4722-3p	CLIP-seq
MIRT2585067	hsa-miR-4727-5p	CLIP-seq
MIRT1202608	hsa-miR-4731-5p	CLIP-seq
MIRT2585068	hsa-miR-4755-3p	CLIP-seq
MIRT2585069	hsa-miR-4769-3p	CLIP-seq
MIRT2585070	hsa-miR-4787-5p	CLIP-seq
MIRT2585071	hsa-miR-4793-5p	CLIP-seq
MIRT2585072	hsa-miR-486-3p	CLIP-seq
MIRT2286755	hsa-miR-491-5p	CLIP-seq
MIRT2585073	hsa-miR-541	CLIP-seq
MIRT2585074	hsa-miR-545	CLIP-seq
MIRT2585075	hsa-miR-548a-3p	CLIP-seq
MIRT2585076	hsa-miR-548ad	CLIP-seq
MIRT2585077	hsa-miR-548e	CLIP-seq
MIRT2585078	hsa-miR-548f	CLIP-seq
MIRT2058516	hsa-miR-612	CLIP-seq
MIRT2058517	hsa-miR-644	CLIP-seq
MIRT2585079	hsa-miR-654-5p	CLIP-seq
MIRT2058518	hsa-miR-661	CLIP-seq
MIRT2058519	hsa-miR-663b	CLIP-seq
MIRT2585080	hsa-miR-665	CLIP-seq
MIRT2058520	hsa-miR-761	CLIP-seq
MIRT2585081	hsa-miR-764	CLIP-seq
MIRT2585082	hsa-miR-767-3p	CLIP-seq
MIRT2585083	hsa-miR-875-3p	CLIP-seq
MIRT2058521	hsa-miR-885-3p	CLIP-seq
MIRT2058522	hsa-miR-922	CLIP-seq
MIRT2585084	hsa-miR-938	CLIP-seq
MIRT1202625	hsa-miR-939	CLIP-seq
MIRT2585035	hsa-miR-1202	CLIP-seq
MIRT2585036	hsa-miR-1227	CLIP-seq
MIRT2058488	hsa-miR-1238	CLIP-seq
MIRT2286728	hsa-miR-1254	CLIP-seq
MIRT2286729	hsa-miR-1273g	CLIP-seq
MIRT2585037	hsa-miR-127-5p	CLIP-seq
MIRT1202621	hsa-miR-1289	CLIP-seq
MIRT1202626	hsa-miR-136	CLIP-seq
MIRT2286731	hsa-miR-140-5p	CLIP-seq
MIRT2585038	hsa-miR-1913	CLIP-seq
MIRT2585039	hsa-miR-1972	CLIP-seq
MIRT2058492	hsa-miR-1976	CLIP-seq
MIRT2585040	hsa-miR-22	CLIP-seq
MIRT2286732	hsa-miR-296-5p	CLIP-seq
MIRT2286733	hsa-miR-3116	CLIP-seq
MIRT2585041	hsa-miR-3120-3p	CLIP-seq
MIRT2585042	hsa-miR-3124-3p	CLIP-seq
MIRT2585043	hsa-miR-3148	CLIP-seq
MIRT1202622	hsa-miR-3150a-3p	CLIP-seq
MIRT2286734	hsa-miR-3160-3p	CLIP-seq
MIRT2286735	hsa-miR-3170	CLIP-seq
MIRT1202623	hsa-miR-3175	CLIP-seq
MIRT2585045	hsa-miR-3194-5p	CLIP-seq
MIRT2585046	hsa-miR-324-3p	CLIP-seq
MIRT2286738	hsa-miR-342-5p	CLIP-seq
MIRT2585047	hsa-miR-3664-5p	CLIP-seq
MIRT1202604	hsa-miR-3672	CLIP-seq
MIRT1202624	hsa-miR-3689d	CLIP-seq
MIRT2585048	hsa-miR-3690	CLIP-seq
MIRT2058501	hsa-miR-370	CLIP-seq
MIRT1202632	hsa-miR-3940-5p	CLIP-seq
MIRT2585049	hsa-miR-3972	CLIP-seq
MIRT2585050	hsa-miR-4254	CLIP-seq
MIRT2058503	hsa-miR-4265	CLIP-seq
MIRT2585051	hsa-miR-4277	CLIP-seq
MIRT2058505	hsa-miR-4296	CLIP-seq
MIRT2058506	hsa-miR-4322	CLIP-seq
MIRT2058507	hsa-miR-4417	CLIP-seq
MIRT1202634	hsa-miR-4428	CLIP-seq
MIRT2286743	hsa-miR-4435	CLIP-seq
MIRT2585052	hsa-miR-4437	CLIP-seq
MIRT2585054	hsa-miR-4456	CLIP-seq
MIRT2585055	hsa-miR-4459	CLIP-seq
MIRT2585056	hsa-miR-4463	CLIP-seq
MIRT2585058	hsa-miR-4474-3p	CLIP-seq
MIRT2585059	hsa-miR-4489	CLIP-seq
MIRT2585060	hsa-miR-4505	CLIP-seq
MIRT1202635	hsa-miR-4507	CLIP-seq
MIRT2585061	hsa-miR-4522	CLIP-seq
MIRT2585062	hsa-miR-4650-5p	CLIP-seq
MIRT1202637	hsa-miR-4652-3p	CLIP-seq
MIRT2585063	hsa-miR-4655-3p	CLIP-seq
MIRT2286746	hsa-miR-4664-5p	CLIP-seq
MIRT2585064	hsa-miR-4674	CLIP-seq
MIRT2058510	hsa-miR-4691-5p	CLIP-seq
MIRT2686788	hsa-miR-4700-3p	CLIP-seq
MIRT2058511	hsa-miR-4707-5p	CLIP-seq
MIRT2585065	hsa-miR-4711-5p	CLIP-seq
MIRT2585066	hsa-miR-4722-3p	CLIP-seq
MIRT2585067	hsa-miR-4727-5p	CLIP-seq
MIRT1202608	hsa-miR-4731-5p	CLIP-seq
MIRT2585068	hsa-miR-4755-3p	CLIP-seq
MIRT2585069	hsa-miR-4769-3p	CLIP-seq
MIRT2585070	hsa-miR-4787-5p	CLIP-seq
MIRT2585071	hsa-miR-4793-5p	CLIP-seq
MIRT2286755	hsa-miR-491-5p	CLIP-seq
MIRT2585073	hsa-miR-541	CLIP-seq
MIRT2585074	hsa-miR-545	CLIP-seq
MIRT2585075	hsa-miR-548a-3p	CLIP-seq
MIRT2585076	hsa-miR-548ad	CLIP-seq
MIRT2585077	hsa-miR-548e	CLIP-seq
MIRT2585078	hsa-miR-548f	CLIP-seq
MIRT2585079	hsa-miR-654-5p	CLIP-seq
MIRT2058518	hsa-miR-661	CLIP-seq
MIRT2058519	hsa-miR-663b	CLIP-seq
MIRT2585080	hsa-miR-665	CLIP-seq
MIRT2585081	hsa-miR-764	CLIP-seq
MIRT2585082	hsa-miR-767-3p	CLIP-seq
MIRT2585083	hsa-miR-875-3p	CLIP-seq
MIRT2585084	hsa-miR-938	CLIP-seq
MIRT1202625	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004591	Function	Oxoglutarate dehydrogenase (succinyl-transferring) activity	IBA
GO:0004591	Function	Oxoglutarate dehydrogenase (succinyl-transferring) activity	IDA	24495017, 29211711
GO:0004591	Function	Oxoglutarate dehydrogenase (succinyl-transferring) activity	IEA
GO:0004591	Function	Oxoglutarate dehydrogenase (succinyl-transferring) activity	ISS
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005634	Component	Nucleus	IDA	29211711
GO:0005634	Component	Nucleus	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	29211711
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006091	Process	Generation of precursor metabolites and energy	ISS
GO:0006096	Process	Glycolytic process	IEA
GO:0006099	Process	Tricarboxylic acid cycle	IBA
GO:0006099	Process	Tricarboxylic acid cycle	IEA
GO:0006103	Process	2-oxoglutarate metabolic process	IDA	24495017, 29211711
GO:0006103	Process	2-oxoglutarate metabolic process	IEA
GO:0006104	Process	Succinyl-CoA metabolic process	IDA	24495017, 29211711
GO:0006104	Process	Succinyl-CoA metabolic process	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016624	Function	Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	IEA
GO:0016903	Function	Oxidoreductase activity, acting on the aldehyde or oxo group of donors	IEA
GO:0019674	Process	NAD+ metabolic process	IEA
GO:0021695	Process	Cerebellar cortex development	IEA
GO:0021756	Process	Striatum development	IEA
GO:0021766	Process	Hippocampus development	IEA
GO:0021794	Process	Thalamus development	IEA
GO:0021860	Process	Pyramidal neuron development	IEA
GO:0022028	Process	Tangential migration from the subventricular zone to the olfactory bulb	IEA
GO:0030976	Function	Thiamine pyrophosphate binding	IDA	24495017
GO:0030976	Function	Thiamine pyrophosphate binding	IEA
GO:0031072	Function	Heat shock protein binding	IEA
GO:0031966	Component	Mitochondrial membrane	ISS
GO:0045252	Component	Oxoglutarate dehydrogenase complex	IBA
GO:0045252	Component	Oxoglutarate dehydrogenase complex	IDA	29211711
GO:0045252	Component	Oxoglutarate dehydrogenase complex	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051087	Function	Protein-folding chaperone binding	IEA
GO:0061034	Process	Olfactory bulb mitral cell layer development	IEA

Other IDs

• MIM: 613022
• HGNC: 8124
• e!Ensembl: ENSG00000105953

Protein

• UniProt ID: Q02218
• Protein name: 2-oxoglutarate dehydrogenase complex component E1 (E1o) (HsOGDH) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehyd
• Protein function: 2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC) (PubMed:24495017, PubMed:25210035, PubMed:28435050). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to s
• PDB: 3ERY, 7WGR, 8I0K
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16078	2-oxogl_dehyd_N	47 → 87	2-oxoglutarate dehydrogenase N-terminus	Family
  PF00676	E1_dh	256 → 582	Dehydrogenase E1 component	Family
  PF02779	Transket_pyr	649 → 866	Transketolase, pyrimidine binding domain	Domain
  PF16870	OxoGdeHyase_C	869 → 1014	2-oxoglutarate dehydrogenase C-terminal	Family

• Sequence:

  MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTSSNYVEE
  MYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVEAQPNV
  DKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLDES
  DLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFET
  PGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSEN
  GVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINR
  VTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIV
  YETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDP
  EAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKY
  AELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPR
  SMSCPSTGLTEDILTHIGNVASSVPVENFTIHGGLSRILKTRGEMVKNRTVDWALAEYMA
  FGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSL
  SEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLP
  HGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFH
  VLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKR
  LLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAELAWCQEEH
  KNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTAFDLDVFK
  NFS

• Sequence length: 1023

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Oxoglutaricaciduria	Pathogenic	rs2116163953, rs2484850454, rs2484805251, rs2116155540	RCV001806691 RCV003152437 RCV003152438 RCV003152439	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Uncertain significance; Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OGDH-related disorder	Likely benign; Benign; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
ALPHA-KETOGLUTARATE DEHYDROGENASE DEFICIENCY	Oxoglutaricaciduria	GENOMICS_ENGLAND_DG	27604308		★☆☆☆☆ Found in Text Mining only
ALPHA-KETOGLUTARATE DEHYDROGENASE DEFICIENCY	Oxoglutaricaciduria	ORPHANET_DG			★☆☆☆☆ Found in Text Mining only
ALPHA-KETOGLUTARATE DEHYDROGENASE DEFICIENCY	Oxoglutaricaciduria	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	8020988	Inhibit	★☆☆☆☆ Found in Text Mining only
Barth Syndrome	Barth syndrome	Pubtator	30251684	Associate	★☆☆☆☆ Found in Text Mining only
Basal Ganglia Diseases	Basal ganglia disease	Pubtator	26637184	Associate	★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar disorder	Pubtator	35821008	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	29988033		★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	33564363	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	27468871		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	28105922, 36879117	Associate	★☆☆☆☆ Found in Text Mining only
Congenital lactic acidosis	Congenital lactic acidosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	31836543		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	20226836		★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	20226836		★☆☆☆☆ Found in Text Mining only
Demyelinating Diseases	Demyelinating diseases	Pubtator	26637184	Associate	★☆☆☆☆ Found in Text Mining only
Depressive Disorder Major	Major depressive disorder	Pubtator	35821008	Associate	★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Familial Alzheimer Disease (FAD)	Alzheimer disease	BEFREE	8122883, 9461055		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	27027236	Associate	★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	31836543		★☆☆☆☆ Found in Text Mining only
Hepatitis C	Hepatitis c	Pubtator	27769799	Associate	★☆☆☆☆ Found in Text Mining only
Hydrocephalus	Hydrocephalus	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hyperphenylalaninaemia	Hyperphenylalaninemia	BEFREE	29454001		★☆☆☆☆ Found in Text Mining only
Leigh Disease	Leigh Syndrome	BEFREE	24341803		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29988033		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29970880		★☆☆☆☆ Found in Text Mining only
Movement Disorders	Movement Disorders	HPO_DG			★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	24496750, 29211711, 31175094, 31534224		★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	10672230		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	28084591		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	10676873		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	11945122, 30208076, 9450778		★☆☆☆☆ Found in Text Mining only
Primary biliary cirrhosis	Biliary Cirrhosis	BEFREE	10385636, 11050037, 8527402, 8617422		★☆☆☆☆ Found in Text Mining only
Pyruvate Carboxylase Deficiency Disease	Pyruvate Carboxylase Deficiency Disease	BEFREE	8884572		★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	BEFREE	4045602		★☆☆☆☆ Found in Text Mining only
Status Epilepticus	Status Epilepticus	BEFREE	29222946		★☆☆☆☆ Found in Text Mining only
Thyroid Carcinoma Anaplastic	Thyroid cancer	Pubtator	26680454	Associate	★☆☆☆☆ Found in Text Mining only