NUDT15 (nudix hydrolase 15)

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Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55270
• Gene name: Nudix hydrolase 15
• Gene symbol: NUDT15
• Synonyms (NCBI Gene): MTH2, NUDT15D
• Chromosome: 13
• Chromosome location: 13q14.2
• Summary: This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs116855232	C>T	Drug-response	Genic downstream transcript variant, non coding transcript variant, missense variant, coding sequence variant
rs147390019	G>A	Drug-response	Non coding transcript variant, missense variant, genic downstream transcript variant, coding sequence variant
rs186364861	G>A	Drug-response	Missense variant, non coding transcript variant, coding sequence variant
rs746071566	GAGTCG>-,GAGTCGGAGTCG,GAGTCGGAGTCGGAGTCG	Drug-response	Non coding transcript variant, inframe deletion, inframe insertion, coding sequence variant

miRNA Show/Hide all (258)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024551	hsa-miR-215-5p	Microarray	19074876
MIRT026659	hsa-miR-192-5p	Microarray	19074876
MIRT051689	hsa-let-7e-5p	CLASH	23622248
MIRT1197546	hsa-let-7a	CLIP-seq
MIRT1197547	hsa-let-7b	CLIP-seq
MIRT1197548	hsa-let-7c	CLIP-seq
MIRT1197549	hsa-let-7d	CLIP-seq
MIRT1197550	hsa-let-7e	CLIP-seq
MIRT1197551	hsa-let-7f	CLIP-seq
MIRT1197552	hsa-let-7g	CLIP-seq
MIRT1197553	hsa-let-7i	CLIP-seq
MIRT1197554	hsa-miR-1236	CLIP-seq
MIRT1197555	hsa-miR-1237	CLIP-seq
MIRT1197556	hsa-miR-1248	CLIP-seq
MIRT1197557	hsa-miR-202	CLIP-seq
MIRT1197558	hsa-miR-216b	CLIP-seq
MIRT1197559	hsa-miR-3065-5p	CLIP-seq
MIRT1197560	hsa-miR-3140-3p	CLIP-seq
MIRT1197561	hsa-miR-3157-5p	CLIP-seq
MIRT1197562	hsa-miR-3160-3p	CLIP-seq
MIRT1197563	hsa-miR-3180-5p	CLIP-seq
MIRT1197564	hsa-miR-338-5p	CLIP-seq
MIRT1197565	hsa-miR-33a	CLIP-seq
MIRT1197566	hsa-miR-33b	CLIP-seq
MIRT1197567	hsa-miR-3671	CLIP-seq
MIRT1197568	hsa-miR-371-5p	CLIP-seq
MIRT1197569	hsa-miR-371b-5p	CLIP-seq
MIRT1197570	hsa-miR-3926	CLIP-seq
MIRT1197571	hsa-miR-4305	CLIP-seq
MIRT1197572	hsa-miR-4432	CLIP-seq
MIRT1197573	hsa-miR-4433	CLIP-seq
MIRT1197574	hsa-miR-4458	CLIP-seq
MIRT1197575	hsa-miR-4487	CLIP-seq
MIRT1197576	hsa-miR-4500	CLIP-seq
MIRT1197577	hsa-miR-450b-5p	CLIP-seq
MIRT1197578	hsa-miR-451b	CLIP-seq
MIRT1197579	hsa-miR-4686	CLIP-seq
MIRT1197580	hsa-miR-4696	CLIP-seq
MIRT1197581	hsa-miR-4730	CLIP-seq
MIRT1197582	hsa-miR-485-5p	CLIP-seq
MIRT1197583	hsa-miR-507	CLIP-seq
MIRT1197584	hsa-miR-513c	CLIP-seq
MIRT1197585	hsa-miR-514	CLIP-seq
MIRT1197586	hsa-miR-514b-3p	CLIP-seq
MIRT1197587	hsa-miR-514b-5p	CLIP-seq
MIRT1197588	hsa-miR-520a-5p	CLIP-seq
MIRT1197589	hsa-miR-525-5p	CLIP-seq
MIRT1197590	hsa-miR-548s	CLIP-seq
MIRT1197591	hsa-miR-549	CLIP-seq
MIRT1197592	hsa-miR-556-3p	CLIP-seq
MIRT1197593	hsa-miR-556-5p	CLIP-seq
MIRT1197594	hsa-miR-557	CLIP-seq
MIRT1197595	hsa-miR-558	CLIP-seq
MIRT1197596	hsa-miR-583	CLIP-seq
MIRT1197597	hsa-miR-643	CLIP-seq
MIRT1197598	hsa-miR-656	CLIP-seq
MIRT1197599	hsa-miR-658	CLIP-seq
MIRT1197600	hsa-miR-98	CLIP-seq
MIRT1197554	hsa-miR-1236	CLIP-seq
MIRT1197558	hsa-miR-216b	CLIP-seq
MIRT1197560	hsa-miR-3140-3p	CLIP-seq
MIRT1197561	hsa-miR-3157-5p	CLIP-seq
MIRT1197565	hsa-miR-33a	CLIP-seq
MIRT1197566	hsa-miR-33b	CLIP-seq
MIRT1197570	hsa-miR-3926	CLIP-seq
MIRT1197577	hsa-miR-450b-5p	CLIP-seq
MIRT1197579	hsa-miR-4686	CLIP-seq
MIRT1197583	hsa-miR-507	CLIP-seq
MIRT1197590	hsa-miR-548s	CLIP-seq
MIRT1197594	hsa-miR-557	CLIP-seq
MIRT2057204	hsa-miR-577	CLIP-seq
MIRT1197546	hsa-let-7a	CLIP-seq
MIRT1197547	hsa-let-7b	CLIP-seq
MIRT1197548	hsa-let-7c	CLIP-seq
MIRT1197549	hsa-let-7d	CLIP-seq
MIRT1197550	hsa-let-7e	CLIP-seq
MIRT1197551	hsa-let-7f	CLIP-seq
MIRT1197552	hsa-let-7g	CLIP-seq
MIRT1197553	hsa-let-7i	CLIP-seq
MIRT2285559	hsa-miR-1273e	CLIP-seq
MIRT2285560	hsa-miR-1273f	CLIP-seq
MIRT2285561	hsa-miR-143	CLIP-seq
MIRT1197557	hsa-miR-202	CLIP-seq
MIRT2285562	hsa-miR-2964a-3p	CLIP-seq
MIRT2285563	hsa-miR-302f	CLIP-seq
MIRT2285564	hsa-miR-3122	CLIP-seq
MIRT1197563	hsa-miR-3180-5p	CLIP-seq
MIRT2285565	hsa-miR-323-5p	CLIP-seq
MIRT1197564	hsa-miR-338-5p	CLIP-seq
MIRT2285566	hsa-miR-339-5p	CLIP-seq
MIRT2285567	hsa-miR-3614-5p	CLIP-seq
MIRT2285568	hsa-miR-3661	CLIP-seq
MIRT2285569	hsa-miR-3664-3p	CLIP-seq
MIRT2285570	hsa-miR-3670	CLIP-seq
MIRT2285571	hsa-miR-3689a-3p	CLIP-seq
MIRT2285572	hsa-miR-3689c	CLIP-seq
MIRT2285573	hsa-miR-382	CLIP-seq
MIRT2285574	hsa-miR-3913-5p	CLIP-seq
MIRT1197570	hsa-miR-3926	CLIP-seq
MIRT2285575	hsa-miR-3929	CLIP-seq
MIRT2285576	hsa-miR-3934	CLIP-seq
MIRT2285577	hsa-miR-3938	CLIP-seq
MIRT2285578	hsa-miR-4419b	CLIP-seq
MIRT1197573	hsa-miR-4433	CLIP-seq
MIRT1197574	hsa-miR-4458	CLIP-seq
MIRT2285579	hsa-miR-4459	CLIP-seq
MIRT2285580	hsa-miR-4478	CLIP-seq
MIRT1197576	hsa-miR-4500	CLIP-seq
MIRT2285581	hsa-miR-4662a-5p	CLIP-seq
MIRT2285582	hsa-miR-4676-5p	CLIP-seq
MIRT2285583	hsa-miR-4684-3p	CLIP-seq
MIRT2285584	hsa-miR-4708-5p	CLIP-seq
MIRT2285585	hsa-miR-4728-5p	CLIP-seq
MIRT2285586	hsa-miR-4768-3p	CLIP-seq
MIRT2285587	hsa-miR-4770	CLIP-seq
MIRT1197582	hsa-miR-485-5p	CLIP-seq
MIRT2285588	hsa-miR-518a-5p	CLIP-seq
MIRT1197588	hsa-miR-520a-5p	CLIP-seq
MIRT1197589	hsa-miR-525-5p	CLIP-seq
MIRT2285589	hsa-miR-527	CLIP-seq
MIRT2285590	hsa-miR-541	CLIP-seq
MIRT2285591	hsa-miR-548c-3p	CLIP-seq
MIRT1197590	hsa-miR-548s	CLIP-seq
MIRT2285592	hsa-miR-575	CLIP-seq
MIRT2285593	hsa-miR-631	CLIP-seq
MIRT2285594	hsa-miR-654-5p	CLIP-seq
MIRT2285595	hsa-miR-676	CLIP-seq
MIRT2285596	hsa-miR-876-3p	CLIP-seq
MIRT1197600	hsa-miR-98	CLIP-seq
MIRT2285560	hsa-miR-1273f	CLIP-seq
MIRT2285561	hsa-miR-143	CLIP-seq
MIRT2285564	hsa-miR-3122	CLIP-seq
MIRT2285571	hsa-miR-3689a-3p	CLIP-seq
MIRT2285572	hsa-miR-3689c	CLIP-seq
MIRT2285574	hsa-miR-3913-5p	CLIP-seq
MIRT2285575	hsa-miR-3929	CLIP-seq
MIRT2285578	hsa-miR-4419b	CLIP-seq
MIRT2285580	hsa-miR-4478	CLIP-seq
MIRT2285584	hsa-miR-4708-5p	CLIP-seq
MIRT2285585	hsa-miR-4728-5p	CLIP-seq
MIRT2285587	hsa-miR-4770	CLIP-seq
MIRT1197582	hsa-miR-485-5p	CLIP-seq
MIRT2285560	hsa-miR-1273f	CLIP-seq
MIRT2285561	hsa-miR-143	CLIP-seq
MIRT2285564	hsa-miR-3122	CLIP-seq
MIRT2285571	hsa-miR-3689a-3p	CLIP-seq
MIRT2285572	hsa-miR-3689c	CLIP-seq
MIRT2285574	hsa-miR-3913-5p	CLIP-seq
MIRT1197570	hsa-miR-3926	CLIP-seq
MIRT2285575	hsa-miR-3929	CLIP-seq
MIRT2285576	hsa-miR-3934	CLIP-seq
MIRT2285578	hsa-miR-4419b	CLIP-seq
MIRT2285580	hsa-miR-4478	CLIP-seq
MIRT2285581	hsa-miR-4662a-5p	CLIP-seq
MIRT2285582	hsa-miR-4676-5p	CLIP-seq
MIRT2285584	hsa-miR-4708-5p	CLIP-seq
MIRT2285585	hsa-miR-4728-5p	CLIP-seq
MIRT2285587	hsa-miR-4770	CLIP-seq
MIRT1197582	hsa-miR-485-5p	CLIP-seq
MIRT2285591	hsa-miR-548c-3p	CLIP-seq
MIRT1197590	hsa-miR-548s	CLIP-seq
MIRT2285592	hsa-miR-575	CLIP-seq
MIRT2285581	hsa-miR-4662a-5p	CLIP-seq
MIRT2285582	hsa-miR-4676-5p	CLIP-seq
MIRT2285591	hsa-miR-548c-3p	CLIP-seq
MIRT2285592	hsa-miR-575	CLIP-seq
MIRT1197555	hsa-miR-1237	CLIP-seq
MIRT1197556	hsa-miR-1248	CLIP-seq
MIRT2285560	hsa-miR-1273f	CLIP-seq
MIRT2285561	hsa-miR-143	CLIP-seq
MIRT2583786	hsa-miR-203	CLIP-seq
MIRT2583787	hsa-miR-2964a-5p	CLIP-seq
MIRT2583788	hsa-miR-299-3p	CLIP-seq
MIRT2583789	hsa-miR-3121-3p	CLIP-seq
MIRT2285564	hsa-miR-3122	CLIP-seq
MIRT2583790	hsa-miR-3145-5p	CLIP-seq
MIRT2583791	hsa-miR-3163	CLIP-seq
MIRT2285565	hsa-miR-323-5p	CLIP-seq
MIRT2583792	hsa-miR-340	CLIP-seq
MIRT2583793	hsa-miR-3591-5p	CLIP-seq
MIRT2583794	hsa-miR-3606	CLIP-seq
MIRT2285567	hsa-miR-3614-5p	CLIP-seq
MIRT2285570	hsa-miR-3670	CLIP-seq
MIRT1197567	hsa-miR-3671	CLIP-seq
MIRT2285571	hsa-miR-3689a-3p	CLIP-seq
MIRT2285572	hsa-miR-3689c	CLIP-seq
MIRT1197568	hsa-miR-371-5p	CLIP-seq
MIRT1197569	hsa-miR-371b-5p	CLIP-seq
MIRT2285574	hsa-miR-3913-5p	CLIP-seq
MIRT2285575	hsa-miR-3929	CLIP-seq
MIRT2285576	hsa-miR-3934	CLIP-seq
MIRT2583795	hsa-miR-4252	CLIP-seq
MIRT2583796	hsa-miR-4255	CLIP-seq
MIRT2583797	hsa-miR-4265	CLIP-seq
MIRT2583798	hsa-miR-4296	CLIP-seq
MIRT2583799	hsa-miR-4322	CLIP-seq
MIRT2583800	hsa-miR-4417	CLIP-seq
MIRT2285578	hsa-miR-4419b	CLIP-seq
MIRT1197572	hsa-miR-4432	CLIP-seq
MIRT2285580	hsa-miR-4478	CLIP-seq
MIRT1197578	hsa-miR-451b	CLIP-seq
MIRT2285581	hsa-miR-4662a-5p	CLIP-seq
MIRT2285582	hsa-miR-4676-5p	CLIP-seq
MIRT1197580	hsa-miR-4696	CLIP-seq
MIRT2285584	hsa-miR-4708-5p	CLIP-seq
MIRT2285585	hsa-miR-4728-5p	CLIP-seq
MIRT2285587	hsa-miR-4770	CLIP-seq
MIRT2583801	hsa-miR-4793-3p	CLIP-seq
MIRT1197582	hsa-miR-485-5p	CLIP-seq
MIRT1197584	hsa-miR-513c	CLIP-seq
MIRT1197587	hsa-miR-514b-5p	CLIP-seq
MIRT2285590	hsa-miR-541	CLIP-seq
MIRT2285591	hsa-miR-548c-3p	CLIP-seq
MIRT2285592	hsa-miR-575	CLIP-seq
MIRT2285594	hsa-miR-654-5p	CLIP-seq
MIRT2285596	hsa-miR-876-3p	CLIP-seq
MIRT1197555	hsa-miR-1237	CLIP-seq
MIRT1197556	hsa-miR-1248	CLIP-seq
MIRT2285560	hsa-miR-1273f	CLIP-seq
MIRT2285561	hsa-miR-143	CLIP-seq
MIRT2583788	hsa-miR-299-3p	CLIP-seq
MIRT2285564	hsa-miR-3122	CLIP-seq
MIRT2583790	hsa-miR-3145-5p	CLIP-seq
MIRT2285565	hsa-miR-323-5p	CLIP-seq
MIRT2285567	hsa-miR-3614-5p	CLIP-seq
MIRT2285570	hsa-miR-3670	CLIP-seq
MIRT1197567	hsa-miR-3671	CLIP-seq
MIRT2285571	hsa-miR-3689a-3p	CLIP-seq
MIRT2285572	hsa-miR-3689c	CLIP-seq
MIRT1197568	hsa-miR-371-5p	CLIP-seq
MIRT1197569	hsa-miR-371b-5p	CLIP-seq
MIRT2285574	hsa-miR-3913-5p	CLIP-seq
MIRT2285575	hsa-miR-3929	CLIP-seq
MIRT2285576	hsa-miR-3934	CLIP-seq
MIRT2583795	hsa-miR-4252	CLIP-seq
MIRT2583797	hsa-miR-4265	CLIP-seq
MIRT2583798	hsa-miR-4296	CLIP-seq
MIRT2583799	hsa-miR-4322	CLIP-seq
MIRT2583800	hsa-miR-4417	CLIP-seq
MIRT2285578	hsa-miR-4419b	CLIP-seq
MIRT1197572	hsa-miR-4432	CLIP-seq
MIRT2285580	hsa-miR-4478	CLIP-seq
MIRT1197578	hsa-miR-451b	CLIP-seq
MIRT2285581	hsa-miR-4662a-5p	CLIP-seq
MIRT2285582	hsa-miR-4676-5p	CLIP-seq
MIRT1197580	hsa-miR-4696	CLIP-seq
MIRT2285584	hsa-miR-4708-5p	CLIP-seq
MIRT2285585	hsa-miR-4728-5p	CLIP-seq
MIRT2285587	hsa-miR-4770	CLIP-seq
MIRT2583801	hsa-miR-4793-3p	CLIP-seq
MIRT1197582	hsa-miR-485-5p	CLIP-seq
MIRT1197584	hsa-miR-513c	CLIP-seq
MIRT1197587	hsa-miR-514b-5p	CLIP-seq
MIRT2285590	hsa-miR-541	CLIP-seq
MIRT2285591	hsa-miR-548c-3p	CLIP-seq
MIRT2285592	hsa-miR-575	CLIP-seq
MIRT2285594	hsa-miR-654-5p	CLIP-seq
MIRT2285596	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000278	Process	Mitotic cell cycle	IMP	19419956
GO:0000302	Process	Response to reactive oxygen species	IEA
GO:0005515	Function	Protein binding	IPI	19419956, 32296183
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006195	Process	Purine nucleotide catabolic process	IMP	26878724
GO:0006203	Process	DGTP catabolic process	IBA
GO:0006203	Process	DGTP catabolic process	IDA	22556419
GO:0006950	Process	Response to stress	IEA
GO:0008413	Function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	IDA	22556419
GO:0008413	Function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	IEA
GO:0009217	Process	Purine deoxyribonucleoside triphosphate catabolic process	IEA
GO:0009217	Process	Purine deoxyribonucleoside triphosphate catabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0035539	Function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	EXP	22556419
GO:0035539	Function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	IBA
GO:0035539	Function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	IDA	22556419
GO:0042178	Process	Xenobiotic catabolic process	IMP	26878724
GO:0042262	Process	DNA protection	IMP	26238318
GO:0042262	Process	DNA protection	IMP	26878724
GO:0044715	Function	8-oxo-dGDP phosphatase activity	EXP	22556419
GO:0046872	Function	Metal ion binding	IEA
GO:0047429	Function	Nucleoside triphosphate diphosphatase activity	IDA	26238318
GO:0047429	Function	Nucleoside triphosphate diphosphatase activity	IEA
GO:0055086	Process	Nucleobase-containing small molecule metabolic process	TAS
GO:0061136	Process	Regulation of proteasomal protein catabolic process	IMP	19419956
GO:1901292	Process	Nucleoside phosphate catabolic process	IDA	26238318
GO:1901292	Process	Nucleoside phosphate catabolic process	IMP	26878724

Other IDs

• MIM: 615792
• HGNC: 23063
• e!Ensembl: ENSG00000136159

Protein

• UniProt ID: Q9NV35
• Protein name: Nucleotide triphosphate diphosphatase NUDT15 (EC 3.6.1.9) (MutT homolog 2) (MTH2) (Nucleoside diphosphate-linked moiety X motif 15) (Nudix motif 15) (Nucleoside diphosphate-linked to another moiety X hydrolase 15) (Nudix hydrolase 15)
• Protein function: May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of s
• PDB: 5BON , 5LPG , 6T5J , 7AOM , 7AOP , 7B63 , 7B64 , 7B65 , 7B66 , 7B67 , 7B7V , 7NR6 , 7R0D
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00293	NUDIX	11 → 144	NUDIX domain	Domain

• Sequence:

  MTASAQPRGRRPGVGVGVVVTSCKHPRCVLLGKRKGSVGAGSFQLPGGHLEFGETWEECA
  QRETWEEAALHLKNVHFASVVNSFIEKENYHYVTILMKGEVDVTHDSEPKNVEPEKNESW
  EWVPWEELPPLDQLFWGLRCLKEQGYDPFKEDLNHLVGYKGNHL

• Sequence length: 164

Pathways

Reactome Pathway:

Phosphate bond hydrolysis by NUDT proteins

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
azathioprine response - Toxicity	drug response	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
mercaptopurine response - Dosage	drug response	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NUDT15-related disorder	drug response; Likely benign; Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thiopurines, poor metabolism of, 2	drug response; Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (47)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	25624441, 26033531, 26503813, 26878724, 27193222, 27577869, 28445187, 28903549, 28963908, 29720126, 30474703, 30728528, 31635813		★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	25624441, 26503813, 28903549, 30728528, 31635813		★☆☆☆☆ Found in Text Mining only
Agranulocytosis	Agranulocytosis	BEFREE	30101994		★☆☆☆☆ Found in Text Mining only
Alopecia	Alopecia	BEFREE	26076924, 26590936, 26735160, 28566182, 29923122, 30101994		★☆☆☆☆ Found in Text Mining only
Alopecia	Alopecia	GWASCAT_DG	29923122		★☆☆☆☆ Found in Text Mining only
Alopecia totalis	Alopecia	BEFREE	26735160		★☆☆☆☆ Found in Text Mining only
Autoimmune Chronic Hepatitis	Autoimmune hepatitis	BEFREE	31024313		★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	29867468, 30639426		★☆☆☆☆ Found in Text Mining only
Bone Marrow Diseases	Bone marrow diseases	Pubtator	28445187	Associate	★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	25624441, 26503813, 27193222, 27577869, 28418010, 28903549, 30728528, 31007757, 31635813		★☆☆☆☆ Found in Text Mining only
Cirrhosis	Cirrhosis	BEFREE	31024313		★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	31601260	Associate	★☆☆☆☆ Found in Text Mining only
Cognitive Dysfunction	Cognition disorder	Pubtator	31601260	Associate	★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	32269192	Associate	★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	GWASCAT_DG	25108385		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	26503813, 26735160, 27604507, 29192347, 29206869		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	29206869, 29398872, 31636477, 32372428	Associate	★☆☆☆☆ Found in Text Mining only
Cyclic neutropenia	Cyclic neutropenia	Pubtator	26033531, 34425754	Associate	★☆☆☆☆ Found in Text Mining only
Dermatologic disorders	Dermatologic Disorders	BEFREE	30101994		★☆☆☆☆ Found in Text Mining only
Gout	Gout	Pubtator	30909691	Associate	★☆☆☆☆ Found in Text Mining only
Hematologic Diseases	Hematologic disease	Pubtator	32481505, 32611418, 33958640, 36707393	Associate	★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic neoplasm	Pubtator	28903549	Associate	★☆☆☆☆ Found in Text Mining only
Hepatitis Autoimmune	Autoimmune hepatitis	Pubtator	33846471	Associate	★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune System Diseases	BEFREE	31651720		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	31601260		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	25108385, 29210335, 29398872, 29491687, 29923122, 30806694, 33150655, 34425754, 35289057, 35984164	Associate	★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	26076924, 26590936, 28570428, 28963908, 29192347, 29210335, 29923122, 30806694, 31045285		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	GWASCAT_DG	27558924, 29923122		★☆☆☆☆ Found in Text Mining only
Irritable Bowel Syndrome	Irritable Bowel Syndrome	BEFREE	26076924		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	30639426, 31645647, 31651720		★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	32611418	Associate	★☆☆☆☆ Found in Text Mining only
Leukopenia	Leukopenia	BEFREE	25108385, 26067482, 26076924, 26590936, 26735160, 27381176, 27416873, 27577869, 27604507, 28418010, 28470355, 28566182, 28570428, 28882023, 28963908, 29071720, 29192347, 29206869, 29210335, 29702976, 29720126, 29867468, 29923122, 30048756, 30101994, 31024313, 31045285, 31342537, 31635813, 31645647, 31813937		★☆☆☆☆ Found in Text Mining only
Leukopenia	Leukopenia	GWASCAT_DG	25108385, 27558924, 29923122		★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver Cirrhosis	BEFREE	31024313		★☆☆☆☆ Found in Text Mining only
Liver Failure	Liver failure	Pubtator	35289057	Associate	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	29867468		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	27577869		★☆☆☆☆ Found in Text Mining only
Myasthenia Gravis	Myasthenia gravis	Pubtator	35984164	Associate	★☆☆☆☆ Found in Text Mining only
Neutropenia	Neutropenia	BEFREE	28882023, 29210335, 31635813		★☆☆☆☆ Found in Text Mining only
Neutropenia	Neutropenia	Pubtator	28882023, 29210335, 30927276, 33846471	Associate	★☆☆☆☆ Found in Text Mining only
NUDT15 deficiency	NUDT15 Deficiency	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Pancreatitis	Pancreatitis	BEFREE	26067482		★☆☆☆☆ Found in Text Mining only
Pancreatitis	Pancreatitis	Pubtator	34425754, 35289057	Associate	★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	25624441, 26503813, 26878724, 27193222, 27577869, 28445187, 28903549, 29720126, 30474703, 31635813		★☆☆☆☆ Found in Text Mining only
Sjogren's Syndrome	Sjogren syndrome	Pubtator	29702976	Associate	★☆☆☆☆ Found in Text Mining only
Thiopurine S methyltranferase deficiency	Thiopurine s-methyltransferase deficiency	Pubtator	30806694, 35289057	Associate	★☆☆☆☆ Found in Text Mining only
Thiopurine S methyltranferase deficiency	Thiopurine Methyltransferase Deficiency	BEFREE	31682552		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for NUDT15.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NUDT15.