NUDT14 (nudix hydrolase 14)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 256281
• Gene name: Nudix hydrolase 14
• Gene symbol: NUDT14
• Synonyms (NCBI Gene): UGPP, UGPPase
• Chromosome: 14
• Chromosome location: 14q32.33
• Summary: The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofacto

miRNA Show/Hide all (15)

miRTarBase ID	miRNA	Experiments	Reference
MIRT2057189	hsa-miR-3151	CLIP-seq
MIRT2057190	hsa-miR-342-5p	CLIP-seq
MIRT2057191	hsa-miR-3677-5p	CLIP-seq
MIRT2057192	hsa-miR-3926	CLIP-seq
MIRT2057193	hsa-miR-4447	CLIP-seq
MIRT2057194	hsa-miR-4455	CLIP-seq
MIRT2057195	hsa-miR-4472	CLIP-seq
MIRT2057196	hsa-miR-4481	CLIP-seq
MIRT2057197	hsa-miR-4651	CLIP-seq
MIRT2057198	hsa-miR-4664-5p	CLIP-seq
MIRT2057199	hsa-miR-4745-5p	CLIP-seq
MIRT2057200	hsa-miR-4758-5p	CLIP-seq
MIRT2057201	hsa-miR-491-5p	CLIP-seq
MIRT2057202	hsa-miR-548s	CLIP-seq
MIRT2057203	hsa-miR-608	CLIP-seq

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12620389, 21044950, 25416956, 31515488, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006753	Process	Nucleoside phosphate metabolic process	IBA
GO:0008768	Function	UDP-sugar diphosphatase activity	IBA
GO:0008768	Function	UDP-sugar diphosphatase activity	IEA
GO:0008768	Function	UDP-sugar diphosphatase activity	TAS
GO:0016787	Function	Hydrolase activity	IEA
GO:0016818	Function	Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEA
GO:0018279	Process	Protein N-linked glycosylation via asparagine	TAS
GO:0019693	Process	Ribose phosphate metabolic process	IBA
GO:0042802	Function	Identical protein binding	IPI	25416956, 31515488, 32296183
GO:0046872	Function	Metal ion binding	IEA
GO:0047631	Function	ADP-ribose diphosphatase activity	IEA

Other IDs

• MIM: 609219
• HGNC: 20141
• e!Ensembl: ENSG00000183828

Protein

• UniProt ID: O95848
• Protein name: Uridine diphosphate glucose pyrophosphatase NUDT14 (UDPG pyrophosphatase) (UGPPase) (EC 3.6.1.45) (Nucleoside diphosphate-linked moiety X motif 14) (Nudix motif 14)
• Protein function: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mann
• PDB: 3Q91 , 8OTV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00293	NUDIX	38 → 202	NUDIX domain	Domain

• Sequence:

  MERIEGASVGRCAASPYLRPLTLHYRQNGAQKSWDFMKTHDSVTVLLFNSSRRSLVLVKQ
  FRPAVYAGEVERRFPGSLAAVDQDGPRELQPALPGSAGVTVELCAGLVDQPGLSLEEVAC
  KEAWEECGYHLAPSDLRRVATYWSGVGLTGSRQTMFYTEVTDAQRSGPGGGLVEEGELIE
  VVHLPLEGAQAFADDPDIPKTLGVIFGVSWFLSQVAPNLDLQ

• Sequence length: 222

Pathways

Reactome Pathway:

Synthesis of dolichyl-phosphate-glucose

Related Genes

No strongly related genes found yet for NUDT14.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NUDT14.