NUB1 (negative regulator of ubiquitin like proteins 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 51667
• Gene name: Negative regulator of ubiquitin like proteins 1
• Gene symbol: NUB1
• Synonyms (NCBI Gene): BS4, NUB1L, NYREN18
• Chromosome: 7
• Chromosome location: 7q36.1
• Summary: This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation

miRNA Show/Hide all (242)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022286	hsa-miR-124-3p	Microarray	18668037
MIRT025004	hsa-miR-183-5p	Sequencing	20371350
MIRT047588	hsa-miR-10a-5p	CLASH	23622248
MIRT1196583	hsa-miR-1207-3p	CLIP-seq
MIRT1196584	hsa-miR-1224-5p	CLIP-seq
MIRT1196585	hsa-miR-1276	CLIP-seq
MIRT1196586	hsa-miR-1285	CLIP-seq
MIRT1196587	hsa-miR-139-5p	CLIP-seq
MIRT1196588	hsa-miR-185	CLIP-seq
MIRT1196589	hsa-miR-2277-3p	CLIP-seq
MIRT1196590	hsa-miR-2355-5p	CLIP-seq
MIRT1196591	hsa-miR-3125	CLIP-seq
MIRT1196592	hsa-miR-3135b	CLIP-seq
MIRT1196593	hsa-miR-3156-3p	CLIP-seq
MIRT1196594	hsa-miR-3187-5p	CLIP-seq
MIRT1196595	hsa-miR-3650	CLIP-seq
MIRT1196596	hsa-miR-3690	CLIP-seq
MIRT1196597	hsa-miR-3916	CLIP-seq
MIRT1196598	hsa-miR-3922-5p	CLIP-seq
MIRT1196599	hsa-miR-425	CLIP-seq
MIRT1196600	hsa-miR-4301	CLIP-seq
MIRT1196601	hsa-miR-4306	CLIP-seq
MIRT1196602	hsa-miR-4308	CLIP-seq
MIRT1196603	hsa-miR-4534	CLIP-seq
MIRT1196604	hsa-miR-4638-3p	CLIP-seq
MIRT1196605	hsa-miR-4644	CLIP-seq
MIRT1196606	hsa-miR-4738-5p	CLIP-seq
MIRT1196607	hsa-miR-4751	CLIP-seq
MIRT1196608	hsa-miR-4753-5p	CLIP-seq
MIRT1196609	hsa-miR-4797-5p	CLIP-seq
MIRT1196610	hsa-miR-532-3p	CLIP-seq
MIRT1196611	hsa-miR-548c-3p	CLIP-seq
MIRT1196612	hsa-miR-612	CLIP-seq
MIRT1196613	hsa-miR-644	CLIP-seq
MIRT1196614	hsa-miR-663b	CLIP-seq
MIRT1556744	hsa-miR-3064-5p	CLIP-seq
MIRT1556745	hsa-miR-604	CLIP-seq
MIRT1556746	hsa-miR-647	CLIP-seq
MIRT2057009	hsa-miR-1915	CLIP-seq
MIRT2057010	hsa-miR-3117-5p	CLIP-seq
MIRT2057011	hsa-miR-3189-5p	CLIP-seq
MIRT2057012	hsa-miR-3202	CLIP-seq
MIRT2057013	hsa-miR-3614-5p	CLIP-seq
MIRT1196595	hsa-miR-3650	CLIP-seq
MIRT2057014	hsa-miR-3661	CLIP-seq
MIRT1196596	hsa-miR-3690	CLIP-seq
MIRT1196598	hsa-miR-3922-5p	CLIP-seq
MIRT2057015	hsa-miR-3929	CLIP-seq
MIRT2057016	hsa-miR-4419b	CLIP-seq
MIRT2057017	hsa-miR-4452	CLIP-seq
MIRT2057018	hsa-miR-4478	CLIP-seq
MIRT2057019	hsa-miR-4488	CLIP-seq
MIRT2057020	hsa-miR-4533	CLIP-seq
MIRT2057021	hsa-miR-4539	CLIP-seq
MIRT2057022	hsa-miR-4633-5p	CLIP-seq
MIRT2057023	hsa-miR-4635	CLIP-seq
MIRT2057024	hsa-miR-4697-5p	CLIP-seq
MIRT2057025	hsa-miR-4724-5p	CLIP-seq
MIRT2057026	hsa-miR-4726-3p	CLIP-seq
MIRT2057027	hsa-miR-4758-3p	CLIP-seq
MIRT2057028	hsa-miR-4786-3p	CLIP-seq
MIRT2057029	hsa-miR-4787-5p	CLIP-seq
MIRT2057030	hsa-miR-585	CLIP-seq
MIRT2057031	hsa-miR-631	CLIP-seq
MIRT1196613	hsa-miR-644	CLIP-seq
MIRT1196614	hsa-miR-663b	CLIP-seq
MIRT2057032	hsa-miR-890	CLIP-seq
MIRT2285419	hsa-miR-1273f	CLIP-seq
MIRT1196586	hsa-miR-1285	CLIP-seq
MIRT2285420	hsa-miR-1910	CLIP-seq
MIRT2057010	hsa-miR-3117-5p	CLIP-seq
MIRT1196591	hsa-miR-3125	CLIP-seq
MIRT1196593	hsa-miR-3156-3p	CLIP-seq
MIRT2285421	hsa-miR-3174	CLIP-seq
MIRT1196594	hsa-miR-3187-5p	CLIP-seq
MIRT2285422	hsa-miR-3620	CLIP-seq
MIRT1196597	hsa-miR-3916	CLIP-seq
MIRT2285423	hsa-miR-4274	CLIP-seq
MIRT1196600	hsa-miR-4301	CLIP-seq
MIRT2057017	hsa-miR-4452	CLIP-seq
MIRT2057019	hsa-miR-4488	CLIP-seq
MIRT2285424	hsa-miR-4519	CLIP-seq
MIRT2285425	hsa-miR-455-3p	CLIP-seq
MIRT2057023	hsa-miR-4635	CLIP-seq
MIRT2057024	hsa-miR-4697-5p	CLIP-seq
MIRT2285426	hsa-miR-4699-5p	CLIP-seq
MIRT2057025	hsa-miR-4724-5p	CLIP-seq
MIRT2285427	hsa-miR-4756-3p	CLIP-seq
MIRT2057029	hsa-miR-4787-5p	CLIP-seq
MIRT1196610	hsa-miR-532-3p	CLIP-seq
MIRT2057030	hsa-miR-585	CLIP-seq
MIRT1196612	hsa-miR-612	CLIP-seq
MIRT2285428	hsa-miR-621	CLIP-seq
MIRT2285429	hsa-miR-885-3p	CLIP-seq
MIRT2057010	hsa-miR-3117-5p	CLIP-seq
MIRT2057017	hsa-miR-4452	CLIP-seq
MIRT2057019	hsa-miR-4488	CLIP-seq
MIRT2057021	hsa-miR-4539	CLIP-seq
MIRT2057023	hsa-miR-4635	CLIP-seq
MIRT2057024	hsa-miR-4697-5p	CLIP-seq
MIRT2057025	hsa-miR-4724-5p	CLIP-seq
MIRT2057029	hsa-miR-4787-5p	CLIP-seq
MIRT2057030	hsa-miR-585	CLIP-seq
MIRT2285419	hsa-miR-1273f	CLIP-seq
MIRT2285422	hsa-miR-3620	CLIP-seq
MIRT2455532	hsa-miR-3974	CLIP-seq
MIRT2455533	hsa-miR-4476	CLIP-seq
MIRT2455534	hsa-miR-4747-5p	CLIP-seq
MIRT2285427	hsa-miR-4756-3p	CLIP-seq
MIRT2455535	hsa-miR-493	CLIP-seq
MIRT2285429	hsa-miR-885-3p	CLIP-seq
MIRT1196584	hsa-miR-1224-5p	CLIP-seq
MIRT2285419	hsa-miR-1273f	CLIP-seq
MIRT1196585	hsa-miR-1276	CLIP-seq
MIRT1196586	hsa-miR-1285	CLIP-seq
MIRT2583507	hsa-miR-1286	CLIP-seq
MIRT2583508	hsa-miR-1287	CLIP-seq
MIRT1196587	hsa-miR-139-5p	CLIP-seq
MIRT2583509	hsa-miR-141	CLIP-seq
MIRT2583510	hsa-miR-1827	CLIP-seq
MIRT2057009	hsa-miR-1915	CLIP-seq
MIRT2583511	hsa-miR-200a	CLIP-seq
MIRT1196589	hsa-miR-2277-3p	CLIP-seq
MIRT2583512	hsa-miR-3065-5p	CLIP-seq
MIRT2057010	hsa-miR-3117-5p	CLIP-seq
MIRT2583513	hsa-miR-3127-5p	CLIP-seq
MIRT1196592	hsa-miR-3135b	CLIP-seq
MIRT1196593	hsa-miR-3156-3p	CLIP-seq
MIRT1196594	hsa-miR-3187-5p	CLIP-seq
MIRT2583514	hsa-miR-320e	CLIP-seq
MIRT2583515	hsa-miR-34a	CLIP-seq
MIRT2583516	hsa-miR-34c-5p	CLIP-seq
MIRT2583517	hsa-miR-3612	CLIP-seq
MIRT2583518	hsa-miR-3613-3p	CLIP-seq
MIRT2285422	hsa-miR-3620	CLIP-seq
MIRT1196595	hsa-miR-3650	CLIP-seq
MIRT2057014	hsa-miR-3661	CLIP-seq
MIRT2583519	hsa-miR-3918	CLIP-seq
MIRT1196598	hsa-miR-3922-5p	CLIP-seq
MIRT2057015	hsa-miR-3929	CLIP-seq
MIRT2455532	hsa-miR-3974	CLIP-seq
MIRT1196599	hsa-miR-425	CLIP-seq
MIRT2583520	hsa-miR-4254	CLIP-seq
MIRT1196600	hsa-miR-4301	CLIP-seq
MIRT2057016	hsa-miR-4419b	CLIP-seq
MIRT2583521	hsa-miR-4434	CLIP-seq
MIRT2583522	hsa-miR-4436b-3p	CLIP-seq
MIRT2057017	hsa-miR-4452	CLIP-seq
MIRT2583523	hsa-miR-4459	CLIP-seq
MIRT2455533	hsa-miR-4476	CLIP-seq
MIRT2057018	hsa-miR-4478	CLIP-seq
MIRT2057019	hsa-miR-4488	CLIP-seq
MIRT2583524	hsa-miR-449a	CLIP-seq
MIRT2583525	hsa-miR-449b	CLIP-seq
MIRT2583526	hsa-miR-4516	CLIP-seq
MIRT2583527	hsa-miR-4531	CLIP-seq
MIRT1196603	hsa-miR-4534	CLIP-seq
MIRT2583528	hsa-miR-4537	CLIP-seq
MIRT2057021	hsa-miR-4539	CLIP-seq
MIRT2057023	hsa-miR-4635	CLIP-seq
MIRT2583529	hsa-miR-4695-5p	CLIP-seq
MIRT2057024	hsa-miR-4697-5p	CLIP-seq
MIRT2583530	hsa-miR-4717-3p	CLIP-seq
MIRT2583531	hsa-miR-4722-5p	CLIP-seq
MIRT2057025	hsa-miR-4724-5p	CLIP-seq
MIRT2057026	hsa-miR-4726-3p	CLIP-seq
MIRT1196606	hsa-miR-4738-5p	CLIP-seq
MIRT2583532	hsa-miR-4742-5p	CLIP-seq
MIRT2455534	hsa-miR-4747-5p	CLIP-seq
MIRT1196607	hsa-miR-4751	CLIP-seq
MIRT1196608	hsa-miR-4753-5p	CLIP-seq
MIRT2285427	hsa-miR-4756-3p	CLIP-seq
MIRT2583533	hsa-miR-4773	CLIP-seq
MIRT2057028	hsa-miR-4786-3p	CLIP-seq
MIRT2057029	hsa-miR-4787-5p	CLIP-seq
MIRT1196609	hsa-miR-4797-5p	CLIP-seq
MIRT2583534	hsa-miR-490-3p	CLIP-seq
MIRT2455535	hsa-miR-493	CLIP-seq
MIRT2583535	hsa-miR-548ac	CLIP-seq
MIRT1196611	hsa-miR-548c-3p	CLIP-seq
MIRT2583536	hsa-miR-548d-3p	CLIP-seq
MIRT2583537	hsa-miR-548z	CLIP-seq
MIRT2057030	hsa-miR-585	CLIP-seq
MIRT1196612	hsa-miR-612	CLIP-seq
MIRT2583538	hsa-miR-619	CLIP-seq
MIRT2057031	hsa-miR-631	CLIP-seq
MIRT1196613	hsa-miR-644	CLIP-seq
MIRT2583539	hsa-miR-650	CLIP-seq
MIRT1196614	hsa-miR-663b	CLIP-seq
MIRT2285429	hsa-miR-885-3p	CLIP-seq
MIRT2583540	hsa-miR-940	CLIP-seq
MIRT1196583	hsa-miR-1207-3p	CLIP-seq
MIRT1196584	hsa-miR-1224-5p	CLIP-seq
MIRT2285419	hsa-miR-1273f	CLIP-seq
MIRT1196585	hsa-miR-1276	CLIP-seq
MIRT1196586	hsa-miR-1285	CLIP-seq
MIRT2583507	hsa-miR-1286	CLIP-seq
MIRT2583508	hsa-miR-1287	CLIP-seq
MIRT1196587	hsa-miR-139-5p	CLIP-seq
MIRT2583510	hsa-miR-1827	CLIP-seq
MIRT1196588	hsa-miR-185	CLIP-seq
MIRT1196589	hsa-miR-2277-3p	CLIP-seq
MIRT2583512	hsa-miR-3065-5p	CLIP-seq
MIRT1196591	hsa-miR-3125	CLIP-seq
MIRT2583513	hsa-miR-3127-5p	CLIP-seq
MIRT1196592	hsa-miR-3135b	CLIP-seq
MIRT1196593	hsa-miR-3156-3p	CLIP-seq
MIRT1196594	hsa-miR-3187-5p	CLIP-seq
MIRT2583514	hsa-miR-320e	CLIP-seq
MIRT2583515	hsa-miR-34a	CLIP-seq
MIRT2583516	hsa-miR-34c-5p	CLIP-seq
MIRT2583517	hsa-miR-3612	CLIP-seq
MIRT2285422	hsa-miR-3620	CLIP-seq
MIRT1196597	hsa-miR-3916	CLIP-seq
MIRT2583519	hsa-miR-3918	CLIP-seq
MIRT2455532	hsa-miR-3974	CLIP-seq
MIRT1196599	hsa-miR-425	CLIP-seq
MIRT1196600	hsa-miR-4301	CLIP-seq
MIRT1196601	hsa-miR-4306	CLIP-seq
MIRT2583522	hsa-miR-4436b-3p	CLIP-seq
MIRT2583523	hsa-miR-4459	CLIP-seq
MIRT2455533	hsa-miR-4476	CLIP-seq
MIRT2583524	hsa-miR-449a	CLIP-seq
MIRT2583525	hsa-miR-449b	CLIP-seq
MIRT1196603	hsa-miR-4534	CLIP-seq
MIRT2583528	hsa-miR-4537	CLIP-seq
MIRT1196605	hsa-miR-4644	CLIP-seq
MIRT2583529	hsa-miR-4695-5p	CLIP-seq
MIRT2583530	hsa-miR-4717-3p	CLIP-seq
MIRT2583531	hsa-miR-4722-5p	CLIP-seq
MIRT2583532	hsa-miR-4742-5p	CLIP-seq
MIRT2455534	hsa-miR-4747-5p	CLIP-seq
MIRT1196607	hsa-miR-4751	CLIP-seq
MIRT2285427	hsa-miR-4756-3p	CLIP-seq
MIRT2583533	hsa-miR-4773	CLIP-seq
MIRT1196609	hsa-miR-4797-5p	CLIP-seq
MIRT2455535	hsa-miR-493	CLIP-seq
MIRT1196611	hsa-miR-548c-3p	CLIP-seq
MIRT1196612	hsa-miR-612	CLIP-seq
MIRT2583539	hsa-miR-650	CLIP-seq
MIRT2285429	hsa-miR-885-3p	CLIP-seq
MIRT2583540	hsa-miR-940	CLIP-seq

Gene ontology (GO) Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12374762, 14757770, 16707496, 25416956, 25422469, 27214791, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IMP	16707496
GO:0010498	Process	Proteasomal protein catabolic process	IEA
GO:0016567	Process	Protein ubiquitination	IMP	16707496
GO:0032436	Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	16707496
GO:0034341	Process	Response to type II interferon	IEP	16707496
GO:0034612	Process	Response to tumor necrosis factor	IEP	16707496
GO:0051603	Process	Proteolysis involved in protein catabolic process	IEA
GO:0097413	Component	Lewy body	IEA
GO:2000058	Process	Regulation of ubiquitin-dependent protein catabolic process	IBA

Other IDs

• MIM: 607981
• HGNC: 17623
• e!Ensembl: ENSG00000013374

Protein

• UniProt ID: Q9Y5A7
• Protein name: NEDD8 ultimate buster 1 (Negative regulator of ubiquitin-like proteins 1) (Renal carcinoma antigen NY-REN-18)
• Protein function: Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.
• PDB: 1WJU , 8USC , 8USD , 9E8G , 9E8H , 9E8I , 9E8J , 9E8L , 9E8N
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00627	UBA	375 → 411	UBA/TS-N domain	Domain
  PF00627	UBA	490 → 526	UBA/TS-N domain	Domain
  PF18037	Ubiquitin_5	70 → 163	Ubiquitin-like domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2.
• Sequence:

  MAQKKYLQAKLTQFLREDRIQLWKPPYTDENKKVGLALKDLAKQYSDRLECCENEVEKVI
  EEIRCKAIERGTGNDNYRTTGIATIEVFLPPRLKKDRKNLLETRLHITGRELRSKIAETF
  GLQENYIKIVINKKQLQLGKTLEEQGVAHNVKAMVLELKQSEEDARKNFQLEEEEQNEAK
  LKEKQIQRTKRGLEILAKRAAETVVDPEMTPYLDIANQTGRSIRIPPSERKALMLAMGYH
  EKGRAFLKRKEYGIALPCLLDADKYFCECCRELLDTVDNYAVLQLDIVWCYFRLEQLECL
  DDAEKKLNLAQKCFKNCYGENHQRLVHIKGNCGKEKVLFLRLYLLQGIRNYHSGNDVEAY
  EYLNKARQLFKELYIDPSKVDNLLQLGFTAQEARLGLRACDGNVDHAATHITNRREELAQ
  IRKEEKEKKRRRLENIRFLKGMGYSTHAAQQVLHAASGNLDEALKILLSNPQMWWLNDSN
  PETDNRQESPSQENIDRLVYMGFDALVAEAALRVFRGNVQLAAQTLAHNGGSLPPELPLS
  PEDSLSPPATSPSDSAGTSSASTDEDMETEAVNEILEDIPEHEEDYLDSTLEDEEIIIAE
  YLSYVENRKSATKKN

• Sequence length: 615

Pathways

Reactome Pathway:

Neddylation

Related Genes

No strongly related genes found yet for NUB1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NUB1.