NTPCR (nucleoside-triphosphatase, cancer-related)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 84284
• Gene name: Nucleoside-triphosphatase, cancer-related
• Gene symbol: NTPCR
• Synonyms (NCBI Gene): C1orf57, HCR-NTPase, THEP1
• Chromosome: 1
• Chromosome location: 1q42.2
• Summary: The protein encoded by this gene is a non-specific nucleoside triphosphatase that is slow-acting in vitro. This gene is overexpressed in many tumor tissues, and while it is not essential for the cell, overexpression is cytotoxic. However, the cytotoxicity

miRNA Show/Hide all (244)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049086	hsa-miR-92a-3p	CLASH	23622248
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT625992	hsa-miR-564	HITS-CLIP	23824327
MIRT619410	hsa-miR-4284	HITS-CLIP	23824327
MIRT619409	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614062	hsa-miR-3929	HITS-CLIP	23824327
MIRT614061	hsa-miR-4419b	HITS-CLIP	23824327
MIRT614060	hsa-miR-4478	HITS-CLIP	23824327
MIRT619410	hsa-miR-4284	HITS-CLIP	23824327
MIRT619409	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT619410	hsa-miR-4284	HITS-CLIP	23824327
MIRT619409	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614062	hsa-miR-3929	HITS-CLIP	23824327
MIRT614061	hsa-miR-4419b	HITS-CLIP	23824327
MIRT614060	hsa-miR-4478	HITS-CLIP	23824327
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT625992	hsa-miR-564	HITS-CLIP	23824327
MIRT619410	hsa-miR-4284	HITS-CLIP	23824327
MIRT619409	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614062	hsa-miR-3929	HITS-CLIP	23824327
MIRT614061	hsa-miR-4419b	HITS-CLIP	23824327
MIRT614060	hsa-miR-4478	HITS-CLIP	23824327
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614062	hsa-miR-3929	HITS-CLIP	23824327
MIRT614061	hsa-miR-4419b	HITS-CLIP	23824327
MIRT614060	hsa-miR-4478	HITS-CLIP	23824327
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT625992	hsa-miR-564	HITS-CLIP	23824327
MIRT619410	hsa-miR-4284	HITS-CLIP	23824327
MIRT619409	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT625992	hsa-miR-564	HITS-CLIP	23824327
MIRT619410	hsa-miR-4284	HITS-CLIP	23824327
MIRT619409	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614062	hsa-miR-3929	HITS-CLIP	23824327
MIRT614061	hsa-miR-4419b	HITS-CLIP	23824327
MIRT614060	hsa-miR-4478	HITS-CLIP	23824327
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT625992	hsa-miR-564	HITS-CLIP	23824327
MIRT619410	hsa-miR-4284	HITS-CLIP	23824327
MIRT619409	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614062	hsa-miR-3929	HITS-CLIP	23824327
MIRT614061	hsa-miR-4419b	HITS-CLIP	23824327
MIRT614060	hsa-miR-4478	HITS-CLIP	23824327
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT619410	hsa-miR-4284	HITS-CLIP	23824327
MIRT619409	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614062	hsa-miR-3929	HITS-CLIP	23824327
MIRT614061	hsa-miR-4419b	HITS-CLIP	23824327
MIRT614060	hsa-miR-4478	HITS-CLIP	23824327
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	27418678
MIRT619409	hsa-miR-24-3p	HITS-CLIP	27418678
MIRT614055	hsa-miR-3674	HITS-CLIP	27418678
MIRT614059	hsa-miR-383-3p	HITS-CLIP	27418678
MIRT619410	hsa-miR-4284	HITS-CLIP	27418678
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	27418678
MIRT614057	hsa-miR-7977	HITS-CLIP	27418678
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT625992	hsa-miR-564	HITS-CLIP	23824327
MIRT619410	hsa-miR-4284	HITS-CLIP	23824327
MIRT619409	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614062	hsa-miR-3929	HITS-CLIP	23824327
MIRT614061	hsa-miR-4419b	HITS-CLIP	23824327
MIRT614060	hsa-miR-4478	HITS-CLIP	23824327
MIRT619410	hsa-miR-4284	HITS-CLIP	23824327
MIRT619409	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT619410	hsa-miR-4284	HITS-CLIP	23824327
MIRT619409	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614062	hsa-miR-3929	HITS-CLIP	23824327
MIRT614061	hsa-miR-4419b	HITS-CLIP	23824327
MIRT614060	hsa-miR-4478	HITS-CLIP	23824327
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT625992	hsa-miR-564	HITS-CLIP	23824327
MIRT619410	hsa-miR-4284	HITS-CLIP	23824327
MIRT619409	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614062	hsa-miR-3929	HITS-CLIP	23824327
MIRT614061	hsa-miR-4419b	HITS-CLIP	23824327
MIRT614060	hsa-miR-4478	HITS-CLIP	23824327
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614062	hsa-miR-3929	HITS-CLIP	23824327
MIRT614061	hsa-miR-4419b	HITS-CLIP	23824327
MIRT614060	hsa-miR-4478	HITS-CLIP	23824327
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT625992	hsa-miR-564	HITS-CLIP	23824327
MIRT619410	hsa-miR-4284	HITS-CLIP	23824327
MIRT619409	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT625992	hsa-miR-564	HITS-CLIP	23824327
MIRT619410	hsa-miR-4284	HITS-CLIP	23824327
MIRT619409	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614062	hsa-miR-3929	HITS-CLIP	23824327
MIRT614061	hsa-miR-4419b	HITS-CLIP	23824327
MIRT614060	hsa-miR-4478	HITS-CLIP	23824327
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT625992	hsa-miR-564	HITS-CLIP	23824327
MIRT619410	hsa-miR-4284	HITS-CLIP	23824327
MIRT619409	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614062	hsa-miR-3929	HITS-CLIP	23824327
MIRT614061	hsa-miR-4419b	HITS-CLIP	23824327
MIRT614060	hsa-miR-4478	HITS-CLIP	23824327
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT619410	hsa-miR-4284	HITS-CLIP	23824327
MIRT619409	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT614062	hsa-miR-3929	HITS-CLIP	23824327
MIRT614061	hsa-miR-4419b	HITS-CLIP	23824327
MIRT614060	hsa-miR-4478	HITS-CLIP	23824327
MIRT614059	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT614058	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT614057	hsa-miR-7977	HITS-CLIP	23824327
MIRT614056	hsa-miR-135b-3p	HITS-CLIP	23824327
MIRT614055	hsa-miR-3674	HITS-CLIP	23824327
MIRT1196207	hsa-miR-1285	CLIP-seq
MIRT1196208	hsa-miR-205	CLIP-seq
MIRT1196209	hsa-miR-3187-5p	CLIP-seq
MIRT1196210	hsa-miR-3545-3p	CLIP-seq
MIRT1196211	hsa-miR-3714	CLIP-seq
MIRT1196212	hsa-miR-483-3p	CLIP-seq
MIRT1196213	hsa-miR-612	CLIP-seq
MIRT1196214	hsa-miR-940	CLIP-seq
MIRT2285377	hsa-miR-338-3p	CLIP-seq
MIRT2285378	hsa-miR-4530	CLIP-seq
MIRT2285379	hsa-miR-643	CLIP-seq
MIRT2583480	hsa-miR-1207-5p	CLIP-seq
MIRT2583481	hsa-miR-1251	CLIP-seq
MIRT2583482	hsa-miR-1267	CLIP-seq
MIRT2583483	hsa-miR-3115	CLIP-seq
MIRT2583484	hsa-miR-3153	CLIP-seq
MIRT2583485	hsa-miR-3155	CLIP-seq
MIRT2583486	hsa-miR-3155b	CLIP-seq
MIRT2285377	hsa-miR-338-3p	CLIP-seq
MIRT2583487	hsa-miR-4261	CLIP-seq
MIRT2583488	hsa-miR-4310	CLIP-seq
MIRT2583489	hsa-miR-4457	CLIP-seq
MIRT2583490	hsa-miR-4514	CLIP-seq
MIRT2285378	hsa-miR-4530	CLIP-seq
MIRT2583491	hsa-miR-4668-5p	CLIP-seq
MIRT2583492	hsa-miR-4684-5p	CLIP-seq
MIRT2583493	hsa-miR-4692	CLIP-seq
MIRT2583494	hsa-miR-4735-5p	CLIP-seq
MIRT2583495	hsa-miR-4763-3p	CLIP-seq
MIRT2583496	hsa-miR-4768-5p	CLIP-seq
MIRT2583497	hsa-miR-484	CLIP-seq
MIRT2583498	hsa-miR-587	CLIP-seq
MIRT2583499	hsa-miR-624	CLIP-seq
MIRT1196214	hsa-miR-940	CLIP-seq
MIRT2583480	hsa-miR-1207-5p	CLIP-seq
MIRT2583481	hsa-miR-1251	CLIP-seq
MIRT2583482	hsa-miR-1267	CLIP-seq
MIRT2583483	hsa-miR-3115	CLIP-seq
MIRT2583484	hsa-miR-3153	CLIP-seq
MIRT2285377	hsa-miR-338-3p	CLIP-seq
MIRT2583487	hsa-miR-4261	CLIP-seq
MIRT2583488	hsa-miR-4310	CLIP-seq
MIRT2583489	hsa-miR-4457	CLIP-seq
MIRT2583490	hsa-miR-4514	CLIP-seq
MIRT2285378	hsa-miR-4530	CLIP-seq
MIRT2583491	hsa-miR-4668-5p	CLIP-seq
MIRT2583492	hsa-miR-4684-5p	CLIP-seq
MIRT2583493	hsa-miR-4692	CLIP-seq
MIRT2583494	hsa-miR-4735-5p	CLIP-seq
MIRT2583495	hsa-miR-4763-3p	CLIP-seq
MIRT2583496	hsa-miR-4768-5p	CLIP-seq
MIRT2583498	hsa-miR-587	CLIP-seq
MIRT2583499	hsa-miR-624	CLIP-seq
MIRT1196214	hsa-miR-940	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003924	Function	GTPase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0016020	Component	Membrane	HDA	19946888
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0017111	Function	Ribonucleoside triphosphate phosphatase activity	IEA
GO:0017111	Function	Ribonucleoside triphosphate phosphatase activity	IMP	17291528
GO:0043273	Function	CTPase activity	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9BSD7
• Protein name: Cancer-related nucleoside-triphosphatase (NTPase) (EC 3.6.1.15) (Nucleoside triphosphate phosphohydrolase)
• Protein function: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.
• PDB: 2I3B
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03266	NTPase_1	4 → 182	NTPase	Domain

• Sequence:

  MARHVFLTGPPGVGKTTLIHKASEVLKSSGVPVDGFYTEEVRQGGRRIGFDVVTLSGTRG
  PLSRVGLEPPPGKRECRVGQYVVDLTSFEQLALPVLRNADCSSGPGQRVCVIDEIGKMEL
  FSQLFIQAVRQTLSTPGTIILGTIPVPKGKPLALVEEIRNRKDVKVFNVTKENRNHLLPD
  IVTCVQSSRK

• Sequence length: 190

Pathways

KEGG Pathway

Purine metabolism

Thiamine metabolism

Metabolic pathways

Nucleotide metabolism

Related Genes

Sort by: Blended Diseases Pathways Evidence source

AK7 3 shared pathwaysPurine metabolism, Thiamine metabolism, Nucleotide metabolism Related via 3 shared pathways including Purine metabolism, Thiamine metabolism. AK8 3 shared pathwaysPurine metabolism, Thiamine metabolism, Nucleotide metabolism Related via 3 shared pathways including Purine metabolism, Thiamine metabolism. AK1 3 shared pathwaysPurine metabolism, Thiamine metabolism, Nucleotide metabolism Related via 3 shared pathways including Purine metabolism, Thiamine metabolism. AK2 3 shared pathwaysPurine metabolism, Thiamine metabolism, Nucleotide metabolism Related via 3 shared pathways including Purine metabolism, Thiamine metabolism. AK4 3 shared pathwaysPurine metabolism, Thiamine metabolism, Nucleotide metabolism Related via 3 shared pathways including Purine metabolism, Thiamine metabolism.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
AK7	0	[]	3	["Purine metabolism","Thiamine metabolism","Nucleotide metabolism"]	0	[]
AK8	0	[]	3	["Purine metabolism","Thiamine metabolism","Nucleotide metabolism"]	0	[]
AK1	0	[]	3	["Purine metabolism","Thiamine metabolism","Nucleotide metabolism"]	0	[]
AK2	0	[]	3	["Purine metabolism","Thiamine metabolism","Nucleotide metabolism"]	0	[]
AK4	0	[]	3	["Purine metabolism","Thiamine metabolism","Nucleotide metabolism"]	0	[]

Diseases Linked via Similar Genes

Diabetes mellitus type 2 Linked via 2 of 5 related genesAK1, AK4 Ciliary dyskinesia Linked via 1 of 5 related genesAK7 Congenital impairment of spermatozoa motility Linked via 1 of 5 related genesAK7 Spermatogenic failure Linked via 1 of 5 related genesAK7 Attention deficit hyperactivity disorder Linked via 1 of 5 related genesAK8

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Diabetes mellitus type 2	2	["AK1","AK4"]
Ciliary dyskinesia	1	["AK7"]
Congenital impairment of spermatozoa motility	1	["AK7"]
Spermatogenic failure	1	["AK7"]
Attention deficit hyperactivity disorder	1	["AK8"]