Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	56953
Gene name	5',3'-nucleotidase, mitochondrial
Gene symbol	NT5M
Synonyms (NCBI Gene)	dNT-2dNT2mdN
Chromosome	17
Chromosome location	17p11.2
Summary	This gene encodes a 5` nucleotidase that localizes to the mitochondrial matrix. This enzyme dephosphorylates the 5`- and 2`(3`)-phosphates of uracil and thymine deoxyribonucleotides. The gene is located within the Smith-Magenis syndrome region on chromoso

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024559	hsa-miR-215-5p	Microarray	19074876
MIRT026399	hsa-miR-192-5p	Microarray	19074876
MIRT1196017	hsa-miR-1207-5p	CLIP-seq
MIRT1196018	hsa-miR-2110	CLIP-seq
MIRT1196019	hsa-miR-3202	CLIP-seq
MIRT1196020	hsa-miR-4271	CLIP-seq
MIRT1196021	hsa-miR-4446-3p	CLIP-seq
MIRT1196022	hsa-miR-4475	CLIP-seq
MIRT1196023	hsa-miR-4492	CLIP-seq
MIRT1196024	hsa-miR-4498	CLIP-seq
MIRT1196025	hsa-miR-4505	CLIP-seq
MIRT1196026	hsa-miR-4667-5p	CLIP-seq
MIRT1196027	hsa-miR-4700-5p	CLIP-seq
MIRT1196028	hsa-miR-4725-3p	CLIP-seq
MIRT1196029	hsa-miR-4731-5p	CLIP-seq
MIRT1196030	hsa-miR-4736	CLIP-seq
MIRT1196031	hsa-miR-4747-5p	CLIP-seq
MIRT1196032	hsa-miR-4763-3p	CLIP-seq
MIRT1196033	hsa-miR-762	CLIP-seq
MIRT1196017	hsa-miR-1207-5p	CLIP-seq
MIRT2056881	hsa-miR-4643	CLIP-seq
MIRT1196032	hsa-miR-4763-3p	CLIP-seq
MIRT1196017	hsa-miR-1207-5p	CLIP-seq
MIRT2285342	hsa-miR-1237	CLIP-seq
MIRT2285343	hsa-miR-320e	CLIP-seq
MIRT2285344	hsa-miR-3919	CLIP-seq
MIRT2285345	hsa-miR-3925-5p	CLIP-seq
MIRT2285346	hsa-miR-4257	CLIP-seq
MIRT2056881	hsa-miR-4643	CLIP-seq
MIRT2285347	hsa-miR-4727-5p	CLIP-seq
MIRT2285348	hsa-miR-4756-3p	CLIP-seq
MIRT1196032	hsa-miR-4763-3p	CLIP-seq
MIRT2285349	hsa-miR-539	CLIP-seq
MIRT2583413	hsa-miR-1343	CLIP-seq
MIRT2583414	hsa-miR-502-5p	CLIP-seq
MIRT2583415	hsa-miR-628-5p	CLIP-seq
MIRT2583413	hsa-miR-1343	CLIP-seq
MIRT2583414	hsa-miR-502-5p	CLIP-seq
MIRT2583415	hsa-miR-628-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	TAS	10899995
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	IEA
GO:0006260	Process	DNA replication	TAS	10899995
GO:0008252	Function	Nucleotidase activity	IEA
GO:0008252	Function	Nucleotidase activity	TAS	10899995
GO:0008253	Function	5'-nucleotidase activity	IBA
GO:0008253	Function	5'-nucleotidase activity	IEA
GO:0009117	Process	Nucleotide metabolic process	IEA
GO:0009223	Process	Pyrimidine deoxyribonucleotide catabolic process	IBA
GO:0009223	Process	Pyrimidine deoxyribonucleotide catabolic process	TAS	10899995
GO:0009264	Process	Deoxyribonucleotide catabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046079	Process	DUMP catabolic process	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
605292	15769	ENSG00000205309

Q9NPB1

Protein name

5'(3')-deoxyribonucleotidase, mitochondrial (5',3'-nucleotidase, mitochondrial) (EC 3.1.3.-) (Deoxy-5'-nucleotidase 2) (dNT-2)

Protein function

Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. {ECO:0000269|PubMed:10899995

PDB

1MH9 , 1Q91 , 1Q92 , 1Z4I , 1Z4J , 1Z4K , 1Z4L , 1Z4M , 1Z4P , 1Z4Q , 2JAU , 2JAW , 4L6A , 4L6C , 4MUM , 4MWO , 4NFL , 4YIK , 6G22 , 6G2L , 6G2M

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06941	NT5C	34 → 226		Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart, brain and skeletal muscle. Detected at very low levels in kidney and pancreas. {ECO:0000269|PubMed:10899995}.

Sequence

MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRAR
FPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMAS
LQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDI
TGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC

Sequence length

228

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Purine metabolism	Pyrimidine catabolism
Pyrimidine metabolism
Nicotinate and nicotinamide metabolism
Metabolic pathways
Nucleotide metabolism

NT5M (5',3'-nucleotidase, mitochondrial)

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