NSUN5 (NOP2/Sun RNA methyltransferase 5)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55695
• Gene name: NOP2/Sun RNA methyltransferase 5
• Gene symbol: NSUN5
• Synonyms (NCBI Gene): NOL1, NOL1R, NSUN5A, WBSCR20, WBSCR20A, p120, p120(NOL1)
• Chromosome: 7
• Chromosome location: 7q11.23
• Summary: This gene encodes a member of an evolutionarily conserved family of proteins that may function as methyltransferases. This gene is located in a larger region of chromosome 7 that is deleted in Williams-Beuren syndrome, a multisystem developmental disorder

miRNA Show/Hide all (115)

miRTarBase ID	miRNA	Experiments	Reference
MIRT007211	hsa-miR-197-3p	Immunohistochemistry, In situ hybridization, Luciferase reporter assay, Western blot	23139153
MIRT020938	hsa-miR-155-5p	Proteomics	18668040
MIRT025357	hsa-miR-34a-5p	Proteomics	21566225
MIRT025357	hsa-miR-34a-5p	Proteomics	21566225
MIRT025357	hsa-miR-34a-5p	Proteomics	21566225
MIRT046634	hsa-miR-222-3p	CLASH	23622248
MIRT1195470	hsa-miR-101	CLIP-seq
MIRT1195471	hsa-miR-1182	CLIP-seq
MIRT1195472	hsa-miR-1224-3p	CLIP-seq
MIRT1195473	hsa-miR-1258	CLIP-seq
MIRT1195474	hsa-miR-1260	CLIP-seq
MIRT1195475	hsa-miR-1260b	CLIP-seq
MIRT1195476	hsa-miR-1267	CLIP-seq
MIRT1195477	hsa-miR-1280	CLIP-seq
MIRT1195478	hsa-miR-1293	CLIP-seq
MIRT1195479	hsa-miR-129-5p	CLIP-seq
MIRT1195480	hsa-miR-134	CLIP-seq
MIRT1195481	hsa-miR-144	CLIP-seq
MIRT1195482	hsa-miR-188-3p	CLIP-seq
MIRT1195483	hsa-miR-3118	CLIP-seq
MIRT1195484	hsa-miR-3136-5p	CLIP-seq
MIRT1195485	hsa-miR-3150b-3p	CLIP-seq
MIRT1195486	hsa-miR-3151	CLIP-seq
MIRT1195487	hsa-miR-3156-3p	CLIP-seq
MIRT1195488	hsa-miR-3159	CLIP-seq
MIRT1195489	hsa-miR-3164	CLIP-seq
MIRT1195490	hsa-miR-3174	CLIP-seq
MIRT1195491	hsa-miR-3177-5p	CLIP-seq
MIRT1195492	hsa-miR-323-5p	CLIP-seq
MIRT1195493	hsa-miR-3659	CLIP-seq
MIRT1195494	hsa-miR-3667-3p	CLIP-seq
MIRT1195495	hsa-miR-3691-5p	CLIP-seq
MIRT1195496	hsa-miR-3911	CLIP-seq
MIRT1195497	hsa-miR-4259	CLIP-seq
MIRT1195498	hsa-miR-4268	CLIP-seq
MIRT1195499	hsa-miR-4283	CLIP-seq
MIRT1195500	hsa-miR-4419a	CLIP-seq
MIRT1195501	hsa-miR-4439	CLIP-seq
MIRT1195502	hsa-miR-4443	CLIP-seq
MIRT1195503	hsa-miR-4448	CLIP-seq
MIRT1195504	hsa-miR-4481	CLIP-seq
MIRT1195505	hsa-miR-4483	CLIP-seq
MIRT1195506	hsa-miR-4489	CLIP-seq
MIRT1195507	hsa-miR-4501	CLIP-seq
MIRT1195508	hsa-miR-450b-5p	CLIP-seq
MIRT1195509	hsa-miR-4510	CLIP-seq
MIRT1195510	hsa-miR-4513	CLIP-seq
MIRT1195511	hsa-miR-4658	CLIP-seq
MIRT1195512	hsa-miR-4689	CLIP-seq
MIRT1195513	hsa-miR-4715-5p	CLIP-seq
MIRT1195514	hsa-miR-4733-3p	CLIP-seq
MIRT1195515	hsa-miR-4742-5p	CLIP-seq
MIRT1195516	hsa-miR-4745-5p	CLIP-seq
MIRT1195517	hsa-miR-4752	CLIP-seq
MIRT1195518	hsa-miR-4758-5p	CLIP-seq
MIRT1195519	hsa-miR-4764-5p	CLIP-seq
MIRT1195520	hsa-miR-4765	CLIP-seq
MIRT1195521	hsa-miR-4779	CLIP-seq
MIRT1195522	hsa-miR-4784	CLIP-seq
MIRT1195523	hsa-miR-507	CLIP-seq
MIRT1195524	hsa-miR-541	CLIP-seq
MIRT1195525	hsa-miR-544	CLIP-seq
MIRT1195526	hsa-miR-557	CLIP-seq
MIRT1195527	hsa-miR-574-5p	CLIP-seq
MIRT1195528	hsa-miR-627	CLIP-seq
MIRT1195529	hsa-miR-651	CLIP-seq
MIRT1195530	hsa-miR-654-5p	CLIP-seq
MIRT1195531	hsa-miR-876-3p	CLIP-seq
MIRT1195532	hsa-miR-924	CLIP-seq
MIRT1195470	hsa-miR-101	CLIP-seq
MIRT2056744	hsa-miR-1178	CLIP-seq
MIRT2056745	hsa-miR-1226	CLIP-seq
MIRT1195481	hsa-miR-144	CLIP-seq
MIRT2056746	hsa-miR-1539	CLIP-seq
MIRT2056747	hsa-miR-1915	CLIP-seq
MIRT2056748	hsa-miR-2115	CLIP-seq
MIRT2056749	hsa-miR-3074-5p	CLIP-seq
MIRT1195491	hsa-miR-3177-5p	CLIP-seq
MIRT2056750	hsa-miR-3193	CLIP-seq
MIRT2056751	hsa-miR-3616-3p	CLIP-seq
MIRT1195495	hsa-miR-3691-5p	CLIP-seq
MIRT1195496	hsa-miR-3911	CLIP-seq
MIRT2056752	hsa-miR-4691-5p	CLIP-seq
MIRT2056753	hsa-miR-4710	CLIP-seq
MIRT2056754	hsa-miR-4721	CLIP-seq
MIRT1195514	hsa-miR-4733-3p	CLIP-seq
MIRT2056755	hsa-miR-4746-3p	CLIP-seq
MIRT1195517	hsa-miR-4752	CLIP-seq
MIRT1195519	hsa-miR-4764-5p	CLIP-seq
MIRT2056756	hsa-miR-4777-3p	CLIP-seq
MIRT2056757	hsa-miR-516a-3p	CLIP-seq
MIRT2056758	hsa-miR-521	CLIP-seq
MIRT2056759	hsa-miR-634	CLIP-seq
MIRT2455495	hsa-miR-3653	CLIP-seq
MIRT2455496	hsa-miR-3658	CLIP-seq
MIRT2455497	hsa-miR-4679	CLIP-seq
MIRT2455498	hsa-miR-548a-3p	CLIP-seq
MIRT2455499	hsa-miR-548ae	CLIP-seq
MIRT2455500	hsa-miR-548aj	CLIP-seq
MIRT2455501	hsa-miR-548am	CLIP-seq
MIRT2455502	hsa-miR-548e	CLIP-seq
MIRT2455503	hsa-miR-548f	CLIP-seq
MIRT2455504	hsa-miR-548g	CLIP-seq
MIRT2455505	hsa-miR-548x	CLIP-seq
MIRT2455495	hsa-miR-3653	CLIP-seq
MIRT2455496	hsa-miR-3658	CLIP-seq
MIRT2455497	hsa-miR-4679	CLIP-seq
MIRT2455498	hsa-miR-548a-3p	CLIP-seq
MIRT2455499	hsa-miR-548ae	CLIP-seq
MIRT2455500	hsa-miR-548aj	CLIP-seq
MIRT2455501	hsa-miR-548am	CLIP-seq
MIRT2455502	hsa-miR-548e	CLIP-seq
MIRT2455503	hsa-miR-548f	CLIP-seq
MIRT2455504	hsa-miR-548g	CLIP-seq
MIRT2455505	hsa-miR-548x	CLIP-seq

Gene ontology (GO) Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001510	Process	RNA methylation	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	31722427
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008173	Function	RNA methyltransferase activity	IEA
GO:0009383	Function	RRNA (cytosine-C5-)-methyltransferase activity	IDA	31428936, 31722427
GO:0009383	Function	RRNA (cytosine-C5-)-methyltransferase activity	IEA
GO:0014003	Process	Oligodendrocyte development	IEA
GO:0014003	Process	Oligodendrocyte development	ISS
GO:0016740	Function	Transferase activity	IEA
GO:0021987	Process	Cerebral cortex development	IEA
GO:0021987	Process	Cerebral cortex development	ISS
GO:0022038	Process	Corpus callosum development	IEA
GO:0022038	Process	Corpus callosum development	ISS
GO:0031641	Process	Regulation of myelination	IEA
GO:0031641	Process	Regulation of myelination	ISS
GO:0032259	Process	Methylation	IEA
GO:0045727	Process	Positive regulation of translation	IMP	31428936, 31722427
GO:0050890	Process	Cognition	IEA
GO:0050890	Process	Cognition	ISS
GO:0070475	Process	RRNA base methylation	IBA
GO:0070475	Process	RRNA base methylation	IDA	31428936, 31722427
GO:0070475	Process	RRNA base methylation	IEA

Other IDs

• MIM: 615732
• HGNC: 16385
• e!Ensembl: ENSG00000130305

Protein

• UniProt ID: Q96P11
• Protein name: 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein)
• Protein function: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA (PubMed:23913415, PubMed:31428936, PubMed:31722427). m5C3782 promotes protein translation without affecting
• PDB: 2B9E
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01189	Methyltr_RsmB-F	219 → 423	16S rRNA methyltransferase RsmB/F	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous (PubMed:11978965, PubMed:12073013). Detected in placenta, heart and skeletal muscle (PubMed:11978965, PubMed:12073013). {ECO:0000269|PubMed:11978965, ECO:0000269|PubMed:12073013}.
• Sequence:

  MGLYAAAAGVLAGVESRQGSIKGLVYSSNFQNVKQLYALVCETQRYSAVLDAVIASAGLL
  RAEKKLRPHLAKVLVYELLLGKGFRGGGGRWKALLGRHQARLKAELARLKVHRGVSRNED
  LLEVGSRPGPASQLPRFVRVNTLKTCSDDVVDYFKRQGFSYQGRASSLDDLRALKGKHFL
  LDPLMPELLVFPAQTDLHEHPLYRAGHLILQDRASCLPAMLLDPPPGSHVIDACAAPGNK
  TSHLAALLKNQGKIFAFDLDAKRLASMATLLARAGVSCCELAEEDFLAVSPSDPRYHEVH
  YILLDPSCSGSGMPSRQLEEPGAGTPSPVRLHALAGFQQRALCHALTFPSLQRLVYSTCS
  LCQEENEDVVRDALQQNPGAFRLAPALPAWPHRGLSTFPGAEHCLRASPETTLSSGFFVA
  VIERVEVPR

• Sequence length: 429

Related Genes

No strongly related genes found yet for NSUN5.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NSUN5.