NR2C2AP (nuclear receptor 2C2 associated protein)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 126382
• Gene name: Nuclear receptor 2C2 associated protein
• Gene symbol: NR2C2AP
• Synonyms (NCBI Gene): TRA16
• Chromosome: 19
• Chromosome location: 19p13.11

miRNA Show/Hide all (132)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020167	hsa-miR-130b-3p	Sequencing	20371350
MIRT024142	hsa-miR-221-3p	Sequencing	20371350
MIRT027991	hsa-miR-93-5p	Sequencing	20371350
MIRT028208	hsa-miR-33a-5p	Sequencing	20371350
MIRT1192446	hsa-miR-106a	CLIP-seq
MIRT1192447	hsa-miR-106b	CLIP-seq
MIRT1192448	hsa-miR-1343	CLIP-seq
MIRT1192449	hsa-miR-150	CLIP-seq
MIRT1192450	hsa-miR-17	CLIP-seq
MIRT1192451	hsa-miR-1914	CLIP-seq
MIRT1192452	hsa-miR-20a	CLIP-seq
MIRT1192453	hsa-miR-20b	CLIP-seq
MIRT1192454	hsa-miR-3175	CLIP-seq
MIRT1192455	hsa-miR-342-5p	CLIP-seq
MIRT1192456	hsa-miR-3936	CLIP-seq
MIRT1192457	hsa-miR-4271	CLIP-seq
MIRT1192458	hsa-miR-4278	CLIP-seq
MIRT1192459	hsa-miR-4651	CLIP-seq
MIRT1192460	hsa-miR-4664-5p	CLIP-seq
MIRT1192461	hsa-miR-4713-5p	CLIP-seq
MIRT1192462	hsa-miR-4725-3p	CLIP-seq
MIRT1192463	hsa-miR-519a	CLIP-seq
MIRT1192464	hsa-miR-519b-3p	CLIP-seq
MIRT1192465	hsa-miR-519c-3p	CLIP-seq
MIRT1192466	hsa-miR-519d	CLIP-seq
MIRT1192467	hsa-miR-520d-5p	CLIP-seq
MIRT1192468	hsa-miR-524-5p	CLIP-seq
MIRT1192469	hsa-miR-532-3p	CLIP-seq
MIRT1192470	hsa-miR-548t	CLIP-seq
MIRT1192471	hsa-miR-608	CLIP-seq
MIRT1192472	hsa-miR-657	CLIP-seq
MIRT1192473	hsa-miR-93	CLIP-seq
MIRT2055906	hsa-miR-1224-3p	CLIP-seq
MIRT2055907	hsa-miR-1324	CLIP-seq
MIRT2055908	hsa-miR-1912	CLIP-seq
MIRT2055909	hsa-miR-2110	CLIP-seq
MIRT2055910	hsa-miR-2276	CLIP-seq
MIRT2055911	hsa-miR-2355-3p	CLIP-seq
MIRT1192454	hsa-miR-3175	CLIP-seq
MIRT2055912	hsa-miR-3194-3p	CLIP-seq
MIRT2055913	hsa-miR-339-5p	CLIP-seq
MIRT2055914	hsa-miR-3607-3p	CLIP-seq
MIRT2055915	hsa-miR-3665	CLIP-seq
MIRT2055916	hsa-miR-3686	CLIP-seq
MIRT1192456	hsa-miR-3936	CLIP-seq
MIRT1192457	hsa-miR-4271	CLIP-seq
MIRT2055917	hsa-miR-4487	CLIP-seq
MIRT2055918	hsa-miR-4646-3p	CLIP-seq
MIRT2055919	hsa-miR-4652-5p	CLIP-seq
MIRT2055920	hsa-miR-4667-5p	CLIP-seq
MIRT2055921	hsa-miR-4700-5p	CLIP-seq
MIRT2055922	hsa-miR-4708-3p	CLIP-seq
MIRT1192462	hsa-miR-4725-3p	CLIP-seq
MIRT2055923	hsa-miR-4731-5p	CLIP-seq
MIRT2055924	hsa-miR-4763-5p	CLIP-seq
MIRT2055925	hsa-miR-4772-3p	CLIP-seq
MIRT2055926	hsa-miR-516a-3p	CLIP-seq
MIRT1192470	hsa-miR-548t	CLIP-seq
MIRT2055927	hsa-miR-593	CLIP-seq
MIRT1192472	hsa-miR-657	CLIP-seq
MIRT1192448	hsa-miR-1343	CLIP-seq
MIRT1192457	hsa-miR-4271	CLIP-seq
MIRT1192458	hsa-miR-4278	CLIP-seq
MIRT1192462	hsa-miR-4725-3p	CLIP-seq
MIRT2455411	hsa-miR-1237	CLIP-seq
MIRT2455412	hsa-miR-1299	CLIP-seq
MIRT2455413	hsa-miR-298	CLIP-seq
MIRT2455414	hsa-miR-3125	CLIP-seq
MIRT2455415	hsa-miR-3144-5p	CLIP-seq
MIRT2455416	hsa-miR-3182	CLIP-seq
MIRT2455417	hsa-miR-3689a-3p	CLIP-seq
MIRT2455418	hsa-miR-3689c	CLIP-seq
MIRT2455419	hsa-miR-3714	CLIP-seq
MIRT2455420	hsa-miR-378	CLIP-seq
MIRT2455421	hsa-miR-378b	CLIP-seq
MIRT2455422	hsa-miR-378c	CLIP-seq
MIRT2455423	hsa-miR-378d	CLIP-seq
MIRT2455424	hsa-miR-378e	CLIP-seq
MIRT2455425	hsa-miR-378f	CLIP-seq
MIRT2455426	hsa-miR-378h	CLIP-seq
MIRT2455427	hsa-miR-378i	CLIP-seq
MIRT2455428	hsa-miR-3914	CLIP-seq
MIRT2455429	hsa-miR-3916	CLIP-seq
MIRT2455430	hsa-miR-3928	CLIP-seq
MIRT2455431	hsa-miR-3944-5p	CLIP-seq
MIRT2455432	hsa-miR-422a	CLIP-seq
MIRT2455433	hsa-miR-4520a-3p	CLIP-seq
MIRT2455434	hsa-miR-4638-3p	CLIP-seq
MIRT2455435	hsa-miR-4728-5p	CLIP-seq
MIRT2455436	hsa-miR-4782-5p	CLIP-seq
MIRT2455437	hsa-miR-516b	CLIP-seq
MIRT2455438	hsa-miR-541	CLIP-seq
MIRT2455439	hsa-miR-548an	CLIP-seq
MIRT2455440	hsa-miR-552	CLIP-seq
MIRT2455441	hsa-miR-617	CLIP-seq
MIRT2455442	hsa-miR-654-5p	CLIP-seq
MIRT2455412	hsa-miR-1299	CLIP-seq
MIRT2455419	hsa-miR-3714	CLIP-seq
MIRT2455420	hsa-miR-378	CLIP-seq
MIRT2455421	hsa-miR-378b	CLIP-seq
MIRT2455422	hsa-miR-378c	CLIP-seq
MIRT2455423	hsa-miR-378d	CLIP-seq
MIRT2455424	hsa-miR-378e	CLIP-seq
MIRT2455425	hsa-miR-378f	CLIP-seq
MIRT2455426	hsa-miR-378h	CLIP-seq
MIRT2455427	hsa-miR-378i	CLIP-seq
MIRT2455432	hsa-miR-422a	CLIP-seq
MIRT2455433	hsa-miR-4520a-3p	CLIP-seq
MIRT2455434	hsa-miR-4638-3p	CLIP-seq
MIRT2455436	hsa-miR-4782-5p	CLIP-seq
MIRT2455437	hsa-miR-516b	CLIP-seq
MIRT2455438	hsa-miR-541	CLIP-seq
MIRT2455440	hsa-miR-552	CLIP-seq
MIRT2455442	hsa-miR-654-5p	CLIP-seq
MIRT2455412	hsa-miR-1299	CLIP-seq
MIRT2455419	hsa-miR-3714	CLIP-seq
MIRT2455420	hsa-miR-378	CLIP-seq
MIRT2455421	hsa-miR-378b	CLIP-seq
MIRT2455422	hsa-miR-378c	CLIP-seq
MIRT2455423	hsa-miR-378d	CLIP-seq
MIRT2455424	hsa-miR-378e	CLIP-seq
MIRT2455425	hsa-miR-378f	CLIP-seq
MIRT2455426	hsa-miR-378h	CLIP-seq
MIRT2455427	hsa-miR-378i	CLIP-seq
MIRT2455432	hsa-miR-422a	CLIP-seq
MIRT2455433	hsa-miR-4520a-3p	CLIP-seq
MIRT2455434	hsa-miR-4638-3p	CLIP-seq
MIRT2455436	hsa-miR-4782-5p	CLIP-seq
MIRT2455437	hsa-miR-516b	CLIP-seq
MIRT2455439	hsa-miR-548an	CLIP-seq
MIRT2455440	hsa-miR-552	CLIP-seq
MIRT2455441	hsa-miR-617	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12486131, 25416956, 32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS

Other IDs

• MIM: 608719
• HGNC: 30763
• e!Ensembl: ENSG00000184162

Protein

• UniProt ID: Q86WQ0
• Protein name: Nuclear receptor 2C2-associated protein (TR4 orphan receptor-associated 16 kDa protein)
• Protein function: May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.
• Tissue specificity: TISSUE SPECIFICITY: Expressed in all tissues examined, with highest expression in heart, skeletal muscle and pancreas. {ECO:0000269|PubMed:12486131}.
• Sequence:

  MTHSLVCPETVSRVSSVLNRNTRQFGKKHLFDQDEETCWNSDQGPSQWVTLEFPQLIRVS
  QLQIQFQGGFSSRRGCLEGSQGTQALHKIVDFYPEDNNSLQTFPIPAAEVDRLKVTFEDA
  TDFFGRVVIYHLRVLGEKV

• Sequence length: 139

Pathways

Reactome Pathway:

Nuclear Receptor transcription pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	38374256	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Neoplasms	Neoplasms	BEFREE	23129017		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	23129017		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for NR2C2AP.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NR2C2AP.