NOP2 (NOP2 nucleolar protein)

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Gene miRNA Gene ontology Other IDs Protein Pathways Diseases linked via similar genes

Gene

• Entrez ID: 4839
• Gene name: NOP2 nucleolar protein
• Gene symbol: NOP2
• Synonyms (NCBI Gene): NOL1, NOP120, NSUN1, p120
• Chromosome: 12
• Chromosome location: 12p13.31

miRNA Show/Hide all (40)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022000	hsa-miR-128-3p	Sequencing	20371350
MIRT027322	hsa-miR-101-3p	Sequencing	20371350
MIRT029532	hsa-miR-26b-5p	Microarray	19088304
MIRT051348	hsa-miR-15a-5p	CLASH	23622248
MIRT048389	hsa-miR-100-5p	CLASH	23622248
MIRT047626	hsa-miR-10a-5p	CLASH	23622248
MIRT044113	hsa-miR-361-5p	CLASH	23622248
MIRT043682	hsa-miR-342-3p	CLASH	23622248
MIRT043501	hsa-miR-331-3p	CLASH	23622248
MIRT040113	hsa-miR-615-3p	CLASH	23622248
MIRT040113	hsa-miR-615-3p	CLASH	23622248
MIRT040113	hsa-miR-615-3p	CLASH	23622248
MIRT038501	hsa-miR-296-3p	CLASH	23622248
MIRT037432	hsa-miR-744-5p	CLASH	23622248
MIRT036665	hsa-miR-935	CLASH	23622248
MIRT036456	hsa-miR-1226-3p	CLASH	23622248
MIRT036055	hsa-miR-1301-3p	CLASH	23622248
MIRT1189320	hsa-miR-31	CLIP-seq
MIRT1189321	hsa-miR-3123	CLIP-seq
MIRT1189322	hsa-miR-3910	CLIP-seq
MIRT1189323	hsa-miR-3925-5p	CLIP-seq
MIRT1189324	hsa-miR-501-3p	CLIP-seq
MIRT1189325	hsa-miR-502-3p	CLIP-seq
MIRT1189326	hsa-miR-936	CLIP-seq
MIRT1189327	hsa-miR-1305	CLIP-seq
MIRT1189320	hsa-miR-31	CLIP-seq
MIRT1189328	hsa-miR-34a	CLIP-seq
MIRT1189329	hsa-miR-34c-5p	CLIP-seq
MIRT1189330	hsa-miR-4299	CLIP-seq
MIRT1189331	hsa-miR-449a	CLIP-seq
MIRT1189332	hsa-miR-449b	CLIP-seq
MIRT1189333	hsa-miR-4504	CLIP-seq
MIRT1189334	hsa-miR-490-3p	CLIP-seq
MIRT1189328	hsa-miR-34a	CLIP-seq
MIRT1189329	hsa-miR-34c-5p	CLIP-seq
MIRT1189330	hsa-miR-4299	CLIP-seq
MIRT1189331	hsa-miR-449a	CLIP-seq
MIRT1189332	hsa-miR-449b	CLIP-seq
MIRT1189333	hsa-miR-4504	CLIP-seq
MIRT1189334	hsa-miR-490-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000027	Process	Ribosomal large subunit assembly	IMP	24120868
GO:0000470	Process	Maturation of LSU-rRNA	IBA
GO:0001510	Process	RNA methylation	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	12080348, 25416956, 30021884, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	36161484
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	HDA	16791210
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	8089149, 36161484
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IDA	36161484
GO:0006364	Process	RRNA processing	IEA
GO:0006396	Process	RNA processing	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008173	Function	RNA methyltransferase activity	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	1394192
GO:0008757	Function	S-adenosylmethionine-dependent methyltransferase activity	IEA
GO:0009383	Function	RRNA (cytosine-C5-)-methyltransferase activity	IBA
GO:0009383	Function	RRNA (cytosine-C5-)-methyltransferase activity	IDA	26196125
GO:0009383	Function	RRNA (cytosine-C5-)-methyltransferase activity	IMP	36161484
GO:0016740	Function	Transferase activity	IEA
GO:0032259	Process	Methylation	IEA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042273	Process	Ribosomal large subunit biogenesis	IDA	36161484
GO:0070475	Process	RRNA base methylation	IBA
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	IMP	24120868

Other IDs

• MIM: 164031
• HGNC: 7867
• e!Ensembl: ENSG00000111641

Protein

• UniProt ID: P46087
• Protein name: 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120)
• Protein function: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubM
• PDB: 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01189	Methyltr_RsmB-F	377 → 585	16S rRNA methyltransferase RsmB/F	Family
  PF08062	P120R	683 → 705	P120R (NUC006) repeat	Repeat
  PF08062	P120R	749 → 768	P120R (NUC006) repeat	Repeat
  PF08062	P120R	623 → 644	P120R (NUC006) repeat	Repeat
  PF17125	Methyltr_RsmF_N	284 → 374	N-terminal domain of 16S rRNA methyltransferase RsmF	Domain

• Sequence:

  MGRKLDPTKEKRGPGRKARKQKGAETELVRFLPAVSDENSKRLSSRARKRAAKRRLGSVE
  APKTNKSPEAKPLPGKLPKGISAGAVQTAGKKGPQSLFNAPRGKKRPAPGSDEEEEEEDS
  EEDGMVNHGDLWGSEDDADTVDDYGADSNSEDEEEGEALLPIERAARKQKAREAAAGIQW
  SEEETEDEEEEKEVTPESGPPKVEEADGGLQINVDEEPFVLPPAGEMEQDAQAPDLQRVH
  KRIQDIVGILRDFGAQREEGRSRSEYLNRLKKDLAIYYSYGDFLLGKLMDLFPLSELVEF
  LEANEVPRPVTLRTNTLKTRRRDLAQALINRGVNLDPLGKWSKTGLVVYDSSVPIGATPE
  YLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYMAQLMKNTGVILANDANAE
  RLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGGFDRVLLDAPCSGTGVISKDPAVKTNKD
  EKDILRCAHLQKELLLSAIDSVNATSKTGGYLVYCTCSITVEENEWVVDYALKKRNVRLV
  PTGLDFGQEGFTRFRERRFHPSLRSTRRFYPHTHNMDGFFIAKFKKFSNSIPQSQTGNSE
  TATPTNVDLPQVIPKSENSSQPAKKAKGAAKTKQQLQKQQHPKKASFQKLNGISKGADSE
  LSTVPSVTKTQASSSFQDSSQPAGKAEGIREPKVTGKLKQRSPKLQSSKKVAFLRQNAPP
  KGTDTQTPAVLSPSKTQATLKPKDHHQPLGRAKGVEKQQLPEQPFEKAAFQKQNDTPKGP
  QPPTVSPIRSSRPPPAKRKKSQSRGNSQLLLS

• Sequence length: 812

Pathways

Reactome Pathway:

TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation

Related Genes

No strongly related genes found yet for NOP2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NOP2.