NOP14 (NOP14 nucleolar protein)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 8602
• Gene name: NOP14 nucleolar protein
• Gene symbol: NOP14
• Synonyms (NCBI Gene): C4orf9, NOL14, RES4-25, RES425, UTP2
• Chromosome: 4
• Chromosome location: 4p16.3
• Summary: This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in mul

miRNA Show/Hide all (35)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028573	hsa-miR-30a-5p	Proteomics	18668040
MIRT030569	hsa-miR-24-3p	Microarray	19748357
MIRT031738	hsa-miR-16-5p	Proteomics	18668040
MIRT032426	hsa-let-7b-5p	Proteomics	18668040
MIRT608281	hsa-miR-6808-5p	HITS-CLIP	24906430
MIRT608280	hsa-miR-6893-5p	HITS-CLIP	24906430
MIRT608279	hsa-miR-940	HITS-CLIP	24906430
MIRT608278	hsa-miR-4768-3p	HITS-CLIP	24906430
MIRT608277	hsa-miR-4459	HITS-CLIP	24906430
MIRT608276	hsa-miR-665	HITS-CLIP	24906430
MIRT608275	hsa-miR-6840-3p	HITS-CLIP	24906430
MIRT608274	hsa-miR-4649-3p	HITS-CLIP	24906430
MIRT608273	hsa-miR-1827	HITS-CLIP	24906430
MIRT608272	hsa-miR-6134	HITS-CLIP	24906430
MIRT608271	hsa-miR-377-5p	HITS-CLIP	24906430
MIRT608270	hsa-miR-6086	HITS-CLIP	24906430
MIRT608269	hsa-miR-4722-5p	HITS-CLIP	24906430
MIRT608268	hsa-miR-7160-5p	HITS-CLIP	24906430
MIRT608267	hsa-miR-3689d	HITS-CLIP	24906430
MIRT608266	hsa-miR-6851-5p	HITS-CLIP	24906430
MIRT608265	hsa-miR-6880-5p	HITS-CLIP	24906430
MIRT608264	hsa-miR-1227-3p	HITS-CLIP	24906430
MIRT608263	hsa-miR-7847-3p	HITS-CLIP	24906430
MIRT608262	hsa-miR-550b-2-5p	HITS-CLIP	24906430
MIRT608261	hsa-miR-1273e	HITS-CLIP	24906430
MIRT1189310	hsa-miR-21	CLIP-seq
MIRT1189311	hsa-miR-3163	CLIP-seq
MIRT1189312	hsa-miR-340	CLIP-seq
MIRT1189313	hsa-miR-3662	CLIP-seq
MIRT1189314	hsa-miR-380	CLIP-seq
MIRT1189315	hsa-miR-4300	CLIP-seq
MIRT1189316	hsa-miR-4723-5p	CLIP-seq
MIRT1189317	hsa-miR-590-5p	CLIP-seq
MIRT1189318	hsa-miR-920	CLIP-seq
MIRT1189319	hsa-miR-939	CLIP-seq

Gene ontology (GO) Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000447	Process	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISS
GO:0000462	Process	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISS
GO:0000472	Process	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISS
GO:0000480	Process	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0005730	Component	Nucleolus	ISS
GO:0006364	Process	RRNA processing	IEA
GO:0006364	Process	RRNA processing	ISS
GO:0016020	Component	Membrane	HDA	19946888
GO:0019899	Function	Enzyme binding	IPI	23382074
GO:0030490	Process	Maturation of SSU-rRNA	IBA
GO:0030515	Function	SnoRNA binding	ISS
GO:0030686	Component	90S preribosome	ISS
GO:0030692	Component	Noc4p-Nop14p complex	IBA
GO:0030692	Component	Noc4p-Nop14p complex	ISS
GO:0032040	Component	Small-subunit processome	IBA
GO:0032040	Component	Small-subunit processome	IEA
GO:0032040	Component	Small-subunit processome	ISS
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042274	Process	Ribosomal small subunit biogenesis	ISS

Other IDs

• MIM: 611526
• HGNC: 16821
• e!Ensembl: ENSG00000087269

Protein

• UniProt ID: P78316
• Protein name: Nucleolar protein 14 (Nucleolar complex protein 14)
• Protein function: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04147	Nop14	23 → 846	Nop14-like family	Family

• Sequence:

  MAKAKKVGARRKASGAPAGARGGPAKANSNPFEVKVNRQKFQILGRKTRHDVGLPGVSRA
  RALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYN
  LNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEG
  EEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSE
  NRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGK
  DEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEE
  EGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKERAGKATRD
  ELPYTFAAPESYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKAKLEKLFGFLLEY
  VGDLATDDPPDLTVIDKLVVHLYHLCQMFPESASDAIKFVLRDAMHEMEEMIETKGRAAL
  PGLDVLIYLKITGLLFPTSDFWHPVVTPALVCLSQLLTKCPILSLQDVVKGLFVCCLFLE
  YVALSQRFIPELINFLLGILYIATPNKASQGSTLVHPFRALGKNSELLVVSAREDVATWQ
  QSSLSLRWASRLRAPTSTEANHIRLSCLAVGLALLKRCVLMYGSLPSFHAIMGPLQALLT
  DHLADCSHPQELQELCQSTLTEMESQKQLCRPLTCEKSKPVPLKLFTPRLVKVLEFGRKQ
  GSSKEEQERKRLIHKHKREFKGAVREIRKDNQFLARMQLSEIMERDAERKRKVKQLFNSL
  ATQEGEWKALKRKKFKK

• Sequence length: 857

Pathways

Reactome Pathway:

Major pathway of rRNA processing in the nucleolus and cytosol

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Adrenocortical carcinoma, hereditary	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (21)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	28280038		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	26213846		★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	22797009	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	32828126, 34218653, 35473611, 37441804	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	38538274	Stimulate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	38538274	Associate	★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington disease	Pubtator	9734812	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	30484495	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	26213846		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	22425761		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26213846, 28280038, 30484495		★☆☆☆☆ Found in Text Mining only
Melanocytic nevus	Melanocytic nevus	BEFREE	30484495		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	30484495	Inhibit	★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	30484495		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	35282769	Associate	★☆☆☆☆ Found in Text Mining only
Miscarriage	Miscarriage	BEFREE	29440706		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28280038, 30484495		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	24961659	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	22425761		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	37506248	Associate	★☆☆☆☆ Found in Text Mining only
Severe Combined Immunodeficiency	Severe combined immunodeficiency	Pubtator	35282769	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for NOP14.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NOP14.