NOMO2 (NODAL modulator 2)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 283820
• Gene name: NODAL modulator 2
• Gene symbol: NOMO2
• Synonyms (NCBI Gene): Nomo, PM5
• Chromosome: 16
• Chromosome location: 16p12.3
• Summary: This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins

miRNA Show/Hide all (244)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1189113	hsa-miR-1185	CLIP-seq
MIRT1189114	hsa-miR-128	CLIP-seq
MIRT1189115	hsa-miR-1286	CLIP-seq
MIRT1189116	hsa-miR-214	CLIP-seq
MIRT1189117	hsa-miR-2392	CLIP-seq
MIRT1189118	hsa-miR-25	CLIP-seq
MIRT1189119	hsa-miR-3064-3p	CLIP-seq
MIRT1189120	hsa-miR-3064-5p	CLIP-seq
MIRT1189121	hsa-miR-3184	CLIP-seq
MIRT1189122	hsa-miR-32	CLIP-seq
MIRT1189123	hsa-miR-331-3p	CLIP-seq
MIRT1189124	hsa-miR-33a	CLIP-seq
MIRT1189125	hsa-miR-33b	CLIP-seq
MIRT1189126	hsa-miR-342-5p	CLIP-seq
MIRT1189127	hsa-miR-3605-5p	CLIP-seq
MIRT1189128	hsa-miR-3619-5p	CLIP-seq
MIRT1189129	hsa-miR-363	CLIP-seq
MIRT1189130	hsa-miR-367	CLIP-seq
MIRT1189131	hsa-miR-3672	CLIP-seq
MIRT1189132	hsa-miR-3677-5p	CLIP-seq
MIRT1189133	hsa-miR-3679-5p	CLIP-seq
MIRT1189134	hsa-miR-423-5p	CLIP-seq
MIRT1189135	hsa-miR-4283	CLIP-seq
MIRT1189136	hsa-miR-4291	CLIP-seq
MIRT1189137	hsa-miR-4317	CLIP-seq
MIRT1189138	hsa-miR-4459	CLIP-seq
MIRT1189139	hsa-miR-4466	CLIP-seq
MIRT1189140	hsa-miR-4475	CLIP-seq
MIRT1189141	hsa-miR-4504	CLIP-seq
MIRT1189142	hsa-miR-4651	CLIP-seq
MIRT1189143	hsa-miR-4664-5p	CLIP-seq
MIRT1189144	hsa-miR-4687-3p	CLIP-seq
MIRT1189145	hsa-miR-4710	CLIP-seq
MIRT1189146	hsa-miR-4722-5p	CLIP-seq
MIRT1189147	hsa-miR-4733-5p	CLIP-seq
MIRT1189148	hsa-miR-4743	CLIP-seq
MIRT1189149	hsa-miR-4767	CLIP-seq
MIRT1189150	hsa-miR-4779	CLIP-seq
MIRT1189151	hsa-miR-542-3p	CLIP-seq
MIRT1189152	hsa-miR-608	CLIP-seq
MIRT1189153	hsa-miR-662	CLIP-seq
MIRT1189154	hsa-miR-663b	CLIP-seq
MIRT1189155	hsa-miR-664	CLIP-seq
MIRT1189156	hsa-miR-675	CLIP-seq
MIRT1189157	hsa-miR-759	CLIP-seq
MIRT1189158	hsa-miR-761	CLIP-seq
MIRT1189159	hsa-miR-922	CLIP-seq
MIRT1189160	hsa-miR-92a	CLIP-seq
MIRT1189161	hsa-miR-92b	CLIP-seq
MIRT1189113	hsa-miR-1185	CLIP-seq
MIRT1189117	hsa-miR-2392	CLIP-seq
MIRT1189118	hsa-miR-25	CLIP-seq
MIRT1189121	hsa-miR-3184	CLIP-seq
MIRT1189122	hsa-miR-32	CLIP-seq
MIRT1189124	hsa-miR-33a	CLIP-seq
MIRT1189125	hsa-miR-33b	CLIP-seq
MIRT1189127	hsa-miR-3605-5p	CLIP-seq
MIRT1189129	hsa-miR-363	CLIP-seq
MIRT1189130	hsa-miR-367	CLIP-seq
MIRT1189133	hsa-miR-3679-5p	CLIP-seq
MIRT1189134	hsa-miR-423-5p	CLIP-seq
MIRT1189135	hsa-miR-4283	CLIP-seq
MIRT1189137	hsa-miR-4317	CLIP-seq
MIRT1189145	hsa-miR-4710	CLIP-seq
MIRT1189155	hsa-miR-664	CLIP-seq
MIRT1189160	hsa-miR-92a	CLIP-seq
MIRT1189161	hsa-miR-92b	CLIP-seq
MIRT1189113	hsa-miR-1185	CLIP-seq
MIRT1189115	hsa-miR-1286	CLIP-seq
MIRT1189117	hsa-miR-2392	CLIP-seq
MIRT1189118	hsa-miR-25	CLIP-seq
MIRT1189121	hsa-miR-3184	CLIP-seq
MIRT1189122	hsa-miR-32	CLIP-seq
MIRT1189124	hsa-miR-33a	CLIP-seq
MIRT1189125	hsa-miR-33b	CLIP-seq
MIRT1189127	hsa-miR-3605-5p	CLIP-seq
MIRT1189129	hsa-miR-363	CLIP-seq
MIRT1189130	hsa-miR-367	CLIP-seq
MIRT1189133	hsa-miR-3679-5p	CLIP-seq
MIRT2283850	hsa-miR-3682-5p	CLIP-seq
MIRT1189134	hsa-miR-423-5p	CLIP-seq
MIRT1189135	hsa-miR-4283	CLIP-seq
MIRT1189145	hsa-miR-4710	CLIP-seq
MIRT1189146	hsa-miR-4722-5p	CLIP-seq
MIRT2283851	hsa-miR-514	CLIP-seq
MIRT2283852	hsa-miR-514b-3p	CLIP-seq
MIRT1189160	hsa-miR-92a	CLIP-seq
MIRT1189161	hsa-miR-92b	CLIP-seq
MIRT2391646	hsa-miR-3646	CLIP-seq
MIRT2391647	hsa-miR-4719	CLIP-seq
MIRT2391648	hsa-miR-610	CLIP-seq
MIRT2439032	hsa-miR-15a	CLIP-seq
MIRT2439033	hsa-miR-15b	CLIP-seq
MIRT2439034	hsa-miR-16	CLIP-seq
MIRT2439035	hsa-miR-195	CLIP-seq
MIRT1189118	hsa-miR-25	CLIP-seq
MIRT1189121	hsa-miR-3184	CLIP-seq
MIRT1189122	hsa-miR-32	CLIP-seq
MIRT1189124	hsa-miR-33a	CLIP-seq
MIRT1189125	hsa-miR-33b	CLIP-seq
MIRT1189126	hsa-miR-342-5p	CLIP-seq
MIRT1189129	hsa-miR-363	CLIP-seq
MIRT1189130	hsa-miR-367	CLIP-seq
MIRT1189134	hsa-miR-423-5p	CLIP-seq
MIRT2439036	hsa-miR-424	CLIP-seq
MIRT1189135	hsa-miR-4283	CLIP-seq
MIRT1189137	hsa-miR-4317	CLIP-seq
MIRT2439037	hsa-miR-4438	CLIP-seq
MIRT1189138	hsa-miR-4459	CLIP-seq
MIRT1189139	hsa-miR-4466	CLIP-seq
MIRT1189140	hsa-miR-4475	CLIP-seq
MIRT2439038	hsa-miR-4530	CLIP-seq
MIRT1189142	hsa-miR-4651	CLIP-seq
MIRT1189143	hsa-miR-4664-5p	CLIP-seq
MIRT1189149	hsa-miR-4767	CLIP-seq
MIRT1189150	hsa-miR-4779	CLIP-seq
MIRT2439039	hsa-miR-497	CLIP-seq
MIRT1189152	hsa-miR-608	CLIP-seq
MIRT1189155	hsa-miR-664	CLIP-seq
MIRT1189156	hsa-miR-675	CLIP-seq
MIRT1189160	hsa-miR-92a	CLIP-seq
MIRT1189161	hsa-miR-92b	CLIP-seq
MIRT1189118	hsa-miR-25	CLIP-seq
MIRT1189122	hsa-miR-32	CLIP-seq
MIRT1189124	hsa-miR-33a	CLIP-seq
MIRT1189125	hsa-miR-33b	CLIP-seq
MIRT1189129	hsa-miR-363	CLIP-seq
MIRT1189130	hsa-miR-367	CLIP-seq
MIRT1189137	hsa-miR-4317	CLIP-seq
MIRT1189138	hsa-miR-4459	CLIP-seq
MIRT1189150	hsa-miR-4779	CLIP-seq
MIRT1189155	hsa-miR-664	CLIP-seq
MIRT1189160	hsa-miR-92a	CLIP-seq
MIRT1189161	hsa-miR-92b	CLIP-seq
MIRT1189113	hsa-miR-1185	CLIP-seq
MIRT2581997	hsa-miR-1228	CLIP-seq
MIRT1189114	hsa-miR-128	CLIP-seq
MIRT1189115	hsa-miR-1286	CLIP-seq
MIRT2581998	hsa-miR-140-3p	CLIP-seq
MIRT2439032	hsa-miR-15a	CLIP-seq
MIRT2439033	hsa-miR-15b	CLIP-seq
MIRT2439034	hsa-miR-16	CLIP-seq
MIRT2439035	hsa-miR-195	CLIP-seq
MIRT1189117	hsa-miR-2392	CLIP-seq
MIRT1189118	hsa-miR-25	CLIP-seq
MIRT1189119	hsa-miR-3064-3p	CLIP-seq
MIRT1189121	hsa-miR-3184	CLIP-seq
MIRT1189122	hsa-miR-32	CLIP-seq
MIRT1189124	hsa-miR-33a	CLIP-seq
MIRT1189125	hsa-miR-33b	CLIP-seq
MIRT1189126	hsa-miR-342-5p	CLIP-seq
MIRT1189127	hsa-miR-3605-5p	CLIP-seq
MIRT1189129	hsa-miR-363	CLIP-seq
MIRT1189130	hsa-miR-367	CLIP-seq
MIRT1189133	hsa-miR-3679-5p	CLIP-seq
MIRT2283850	hsa-miR-3682-5p	CLIP-seq
MIRT2581999	hsa-miR-3929	CLIP-seq
MIRT1189134	hsa-miR-423-5p	CLIP-seq
MIRT2439036	hsa-miR-424	CLIP-seq
MIRT1189135	hsa-miR-4283	CLIP-seq
MIRT1189136	hsa-miR-4291	CLIP-seq
MIRT1189137	hsa-miR-4317	CLIP-seq
MIRT2582000	hsa-miR-4419b	CLIP-seq
MIRT2439037	hsa-miR-4438	CLIP-seq
MIRT1189138	hsa-miR-4459	CLIP-seq
MIRT1189139	hsa-miR-4466	CLIP-seq
MIRT1189140	hsa-miR-4475	CLIP-seq
MIRT2582001	hsa-miR-4478	CLIP-seq
MIRT1189141	hsa-miR-4504	CLIP-seq
MIRT2439038	hsa-miR-4530	CLIP-seq
MIRT1189142	hsa-miR-4651	CLIP-seq
MIRT2582002	hsa-miR-4652-3p	CLIP-seq
MIRT1189143	hsa-miR-4664-5p	CLIP-seq
MIRT2582003	hsa-miR-4670-3p	CLIP-seq
MIRT1189145	hsa-miR-4710	CLIP-seq
MIRT1189146	hsa-miR-4722-5p	CLIP-seq
MIRT1189149	hsa-miR-4767	CLIP-seq
MIRT2582004	hsa-miR-4778-5p	CLIP-seq
MIRT1189150	hsa-miR-4779	CLIP-seq
MIRT2439039	hsa-miR-497	CLIP-seq
MIRT2283851	hsa-miR-514	CLIP-seq
MIRT2283852	hsa-miR-514b-3p	CLIP-seq
MIRT1189152	hsa-miR-608	CLIP-seq
MIRT1189155	hsa-miR-664	CLIP-seq
MIRT1189156	hsa-miR-675	CLIP-seq
MIRT1189160	hsa-miR-92a	CLIP-seq
MIRT1189161	hsa-miR-92b	CLIP-seq
MIRT1189113	hsa-miR-1185	CLIP-seq
MIRT2581997	hsa-miR-1228	CLIP-seq
MIRT1189114	hsa-miR-128	CLIP-seq
MIRT1189115	hsa-miR-1286	CLIP-seq
MIRT2581998	hsa-miR-140-3p	CLIP-seq
MIRT2439032	hsa-miR-15a	CLIP-seq
MIRT2439033	hsa-miR-15b	CLIP-seq
MIRT2439034	hsa-miR-16	CLIP-seq
MIRT2439035	hsa-miR-195	CLIP-seq
MIRT1189116	hsa-miR-214	CLIP-seq
MIRT1189117	hsa-miR-2392	CLIP-seq
MIRT1189118	hsa-miR-25	CLIP-seq
MIRT1189119	hsa-miR-3064-3p	CLIP-seq
MIRT1189121	hsa-miR-3184	CLIP-seq
MIRT1189122	hsa-miR-32	CLIP-seq
MIRT1189124	hsa-miR-33a	CLIP-seq
MIRT1189125	hsa-miR-33b	CLIP-seq
MIRT1189126	hsa-miR-342-5p	CLIP-seq
MIRT1189127	hsa-miR-3605-5p	CLIP-seq
MIRT1189128	hsa-miR-3619-5p	CLIP-seq
MIRT1189129	hsa-miR-363	CLIP-seq
MIRT1189130	hsa-miR-367	CLIP-seq
MIRT1189133	hsa-miR-3679-5p	CLIP-seq
MIRT2283850	hsa-miR-3682-5p	CLIP-seq
MIRT2581999	hsa-miR-3929	CLIP-seq
MIRT1189134	hsa-miR-423-5p	CLIP-seq
MIRT2439036	hsa-miR-424	CLIP-seq
MIRT1189135	hsa-miR-4283	CLIP-seq
MIRT1189136	hsa-miR-4291	CLIP-seq
MIRT1189137	hsa-miR-4317	CLIP-seq
MIRT2582000	hsa-miR-4419b	CLIP-seq
MIRT2439037	hsa-miR-4438	CLIP-seq
MIRT1189138	hsa-miR-4459	CLIP-seq
MIRT1189139	hsa-miR-4466	CLIP-seq
MIRT1189140	hsa-miR-4475	CLIP-seq
MIRT2582001	hsa-miR-4478	CLIP-seq
MIRT1189141	hsa-miR-4504	CLIP-seq
MIRT2439038	hsa-miR-4530	CLIP-seq
MIRT1189142	hsa-miR-4651	CLIP-seq
MIRT2582002	hsa-miR-4652-3p	CLIP-seq
MIRT1189143	hsa-miR-4664-5p	CLIP-seq
MIRT2582003	hsa-miR-4670-3p	CLIP-seq
MIRT1189145	hsa-miR-4710	CLIP-seq
MIRT1189146	hsa-miR-4722-5p	CLIP-seq
MIRT1189149	hsa-miR-4767	CLIP-seq
MIRT2582004	hsa-miR-4778-5p	CLIP-seq
MIRT1189150	hsa-miR-4779	CLIP-seq
MIRT2439039	hsa-miR-497	CLIP-seq
MIRT2283851	hsa-miR-514	CLIP-seq
MIRT2283852	hsa-miR-514b-3p	CLIP-seq
MIRT1189152	hsa-miR-608	CLIP-seq
MIRT1189155	hsa-miR-664	CLIP-seq
MIRT1189156	hsa-miR-675	CLIP-seq
MIRT1189158	hsa-miR-761	CLIP-seq
MIRT1189159	hsa-miR-922	CLIP-seq
MIRT1189160	hsa-miR-92a	CLIP-seq
MIRT1189161	hsa-miR-92b	CLIP-seq

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17261586, 20538592, 32820719, 33961781, 35271311
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	17261586, 20538592
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0032991	Component	Protein-containing complex	IDA	20538592
GO:0043022	Function	Ribosome binding	IDA	32820719
GO:0043022	Function	Ribosome binding	IEA
GO:0160063	Process	Multi-pass transmembrane protein insertion into ER membrane	IDA	36261522
GO:0160063	Process	Multi-pass transmembrane protein insertion into ER membrane	IEA
GO:0160064	Component	Multi-pass translocon complex	IDA	36261522
GO:0160064	Component	Multi-pass translocon complex	IEA

Other IDs

• MIM: 609158
• HGNC: 22652
• e!Ensembl: ENSG00000185164

Protein

• UniProt ID: Q5JPE7
• Protein name: BOS complex subunit NOMO2 (Nodal modulator 2) (pM5 protein 2)
• Protein function: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following me
• PDB: 9C7U , 9C7V
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13620	CarboxypepD_reg	330 → 406		Domain
  PF17802	SpaA	871 → 928	Prealbumin-like fold domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart. {ECO:0000269|PubMed:15257293}.
• Sequence:

  MLVGQGAGLLGPAVVTAAVVLLLSGVGPAHGSEDIVVGCGGFVKSDVEINYSLIEIKLYT
  KHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTTVELHVDGVSDICTKGG
  DINFVFTGFSVNGKVLSKGQPLGPAGVQVSLRNTGTEAKIQSTVTQPGGKFAFFKVLPGD
  YEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYNVSGSVRSDGEPMKGVKFLLFSS
  LVTKEDVLGCNVSPVPGFQPQDESLVYLCYTVSREDGSFSFYSLPSGGYTVIPFYRGERI
  TFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGDGVPEAVVTLNNQIKVKTK
  ADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIVATGFSVCGRISIIRFP
  DTVKQMNKYKVVLSSQDKDKSLVTVETDAHGSFCFKAKPGTYKVQVMVPEAETRAGLTLK
  PQTFPLTVTDRPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLQLSGKV
  NAMTFTFDNVLPGKYKISIMHEDWCWKNKSLEVEVLEDDVSAVEFRQTGYMLRCSLSHAI
  TLEFYQDGNGRENVGIYNLSKGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILT
  LTAIRHHVLGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSVQELRREQQLAEIEARRQE
  REKNGNEEGEERMTKPPVQEMVDELQGPFSYDFSYWARSGEKITVTPSSKELLFYPPSME
  AVVSGESCPGKLIEIHGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSV
  GPLHSDLEYTVTSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGG
  LFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTA
  YSCYGTVSSLNGEPEQGVAMEAVGQNDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKA
  EGNDHIERALPHHRVIEVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKS
  ENLDNPIQTVSLGQSLFFHFPPLLRDGENYVVLLDSTLPRSQYDYILPQVSFTAVGYHKH
  ITLIFNPTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVGALGQA
  ASDNSGPEDAKRQAKKQKTRRTLRLQEEFQLMWCLVPWRGTLGIHLFSSLPFASEILLET
  TATCIHY

• Sequence length: 1267

Related Genes

No strongly related genes found yet for NOMO2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NOMO2.