NOMO1 (NODAL modulator 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 23420 |
| Gene name | NODAL modulator 1 |
| Gene symbol | NOMO1 |
| Synonyms (NCBI Gene) |
NomoPM5
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| Chromosome | 16 |
| Chromosome location | 16p13.11 |
| Summary | This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins |
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miRNA
miRNA information provided by mirtarbase database.
269
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q15155 | |||||||||||||||
| Protein name | BOS complex subunit NOMO1 (Nodal modulator 1) (pM5 protein) | |||||||||||||||
| Protein function | Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following me | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in colon tumor tissue and in adjacent normal colonic mucosa. {ECO:0000269|PubMed:1310294}. | |||||||||||||||
| Sequence |
MLVGQGAGPLGPAVVTAAVVLLLSGVGPAHGSEDIVVGCGGFVKSDVEINYSLIEIKLYT |
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| Sequence length | 1222 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with NOMO1 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to NOMO1 (see Related Genes above), that are NOT already directly curated for NOMO1 itself -- a lead worth checking, not a confirmed association.
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