NKX2-4 (NK2 homeobox 4)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 644524
• Gene name: NK2 homeobox 4
• Gene symbol: NKX2-4
• Synonyms (NCBI Gene): NKX2.4, NKX2D
• Chromosome: 20
• Chromosome location: 20p11.22

miRNA Show/Hide all (13)

miRTarBase ID	miRNA	Experiments	Reference
MIRT655835	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT655834	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT655835	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT655834	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT1186547	hsa-miR-3150b-3p	CLIP-seq
MIRT1186548	hsa-miR-4266	CLIP-seq
MIRT1186549	hsa-miR-4511	CLIP-seq
MIRT1186550	hsa-miR-4695-5p	CLIP-seq
MIRT1186551	hsa-miR-4779	CLIP-seq
MIRT1186552	hsa-miR-4784	CLIP-seq
MIRT1186553	hsa-miR-765	CLIP-seq
MIRT2054063	hsa-miR-561	CLIP-seq
MIRT2054063	hsa-miR-561	CLIP-seq

Gene ontology (GO) Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0030154	Process	Cell differentiation	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048513	Process	Animal organ development	IEA

Other IDs

• MIM: 607808
• HGNC: 7837
• e!Ensembl: ENSG00000125816

Protein

• UniProt ID: Q9H2Z4
• Protein name: Homeobox protein Nkx-2.4 (Homeobox protein NK-2 homolog D)
• Protein function: Probable transcription factor.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00046	Homeodomain	190 → 246	Homeodomain	Domain

• Sequence:

  MSLSPKHTTPFSVSDILSPIEETYKKFSGAMDGAPPGLGAPLGAAAAYRAPPPGPSSQAA
  TVAGMQPSHAMAGHNAAAAAAAAAAAAAAAATYHMPPGVSQFPHGAMGSYCNGGLGNMGE
  LPAYTDGMRGGAATGWYGANPDPRYSSISRFMGPSAGVNVAGMGSLTGIADAAKSLGPLH
  AAAAAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNH
  RYKMKRQAKDKAAQQLQQEGGLGPPPPPPPSPRRVAVPVLVKDGKPCQNGASTPTPGQAG
  PQPPAPTPAPELEELSPSPPALHGPGGGLAALDAAAGEYSGGVLGANLLYGRTW

• Sequence length: 354

Related Genes

No strongly related genes found yet for NKX2-4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NKX2-4.