NKTR (natural killer cell triggering receptor)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 4820 |
| Gene name | Natural killer cell triggering receptor |
| Gene symbol | NKTR |
| Synonyms (NCBI Gene) |
CypNKp104
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| Chromosome | 3 |
| Chromosome location | 3p22.1 |
| Summary | This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P30414 | ||||||||||
| Protein name | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | ||||||||||
| Protein function | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells | ||||||||||
| PDB | 2HE9 | ||||||||||
| Family and domains |
Pfam
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| Sequence |
MGAQDRPQCHFDIEINREPVGRIMFQLFSDICPKTCKNFLCLCSGEKGLGKTTGKKLCYK |
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| Sequence length | 1462 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with NKTR across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to NKTR (see Related Genes above), that are NOT already directly curated for NKTR itself -- a lead worth checking, not a confirmed association.
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