NKRF (NFKB repressing factor)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55922
• Gene name: NFKB repressing factor
• Gene symbol: NKRF
• Synonyms (NCBI Gene): ITBA4, NRF
• Chromosome: X
• Chromosome location: Xq24
• Summary: This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a s

miRNA Show/Hide all (184)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004113	hsa-miR-301a-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	21113131
MIRT004113	hsa-miR-301a-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	21113131
MIRT016042	hsa-miR-374b-5p	Sequencing	20371350
MIRT019542	hsa-miR-340-5p	Sequencing	20371350
MIRT024508	hsa-miR-215-5p	Microarray	19074876
MIRT026214	hsa-miR-192-5p	Microarray	19074876
MIRT046801	hsa-miR-222-3p	CLASH	23622248
MIRT043642	hsa-miR-326	CLASH	23622248
MIRT701416	hsa-miR-890	HITS-CLIP	23313552
MIRT701415	hsa-miR-5690	HITS-CLIP	23313552
MIRT701414	hsa-miR-3656	HITS-CLIP	23313552
MIRT701413	hsa-miR-1908-5p	HITS-CLIP	23313552
MIRT701412	hsa-miR-663a	HITS-CLIP	23313552
MIRT701411	hsa-miR-6787-5p	HITS-CLIP	23313552
MIRT701410	hsa-miR-1268a	HITS-CLIP	23313552
MIRT701409	hsa-miR-1268b	HITS-CLIP	23313552
MIRT701408	hsa-miR-1271-3p	HITS-CLIP	23313552
MIRT701407	hsa-miR-550a-3-5p	HITS-CLIP	23313552
MIRT701406	hsa-miR-550a-5p	HITS-CLIP	23313552
MIRT674645	hsa-miR-7977	HITS-CLIP	23313552
MIRT674657	hsa-miR-6760-5p	HITS-CLIP	23824327
MIRT674656	hsa-miR-1321	HITS-CLIP	23824327
MIRT674655	hsa-miR-4739	HITS-CLIP	23824327
MIRT674654	hsa-miR-4756-5p	HITS-CLIP	23824327
MIRT674653	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT674652	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT674651	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT674650	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT674649	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT674648	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT674647	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT674646	hsa-miR-3162-5p	HITS-CLIP	23824327
MIRT674645	hsa-miR-7977	HITS-CLIP	23824327
MIRT674644	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT674643	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT674642	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT674641	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT674640	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT674639	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT674638	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT674637	hsa-miR-3689c	HITS-CLIP	23824327
MIRT674636	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT674635	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT674634	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT674633	hsa-miR-3122	HITS-CLIP	23824327
MIRT674632	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT674631	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT674630	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT522271	hsa-miR-3174	PAR-CLIP	23446348
MIRT522270	hsa-miR-4459	PAR-CLIP	23446348
MIRT522269	hsa-miR-665	PAR-CLIP	23446348
MIRT522268	hsa-miR-6840-3p	PAR-CLIP	23446348
MIRT522267	hsa-miR-493-3p	PAR-CLIP	23446348
MIRT522266	hsa-miR-7854-3p	PAR-CLIP	23446348
MIRT522265	hsa-miR-4785	PAR-CLIP	23446348
MIRT522264	hsa-miR-6499-3p	PAR-CLIP	23446348
MIRT522263	hsa-miR-3689d	PAR-CLIP	23446348
MIRT522262	hsa-miR-6851-5p	PAR-CLIP	23446348
MIRT522261	hsa-miR-455-3p	PAR-CLIP	23446348
MIRT522260	hsa-miR-1273e	PAR-CLIP	23446348
MIRT522259	hsa-miR-6516-5p	PAR-CLIP	23446348
MIRT522260	hsa-miR-1273e	PAR-CLIP	27292025
MIRT522271	hsa-miR-3174	PAR-CLIP	27292025
MIRT522263	hsa-miR-3689d	PAR-CLIP	27292025
MIRT522270	hsa-miR-4459	PAR-CLIP	27292025
MIRT522261	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT522265	hsa-miR-4785	PAR-CLIP	27292025
MIRT522267	hsa-miR-493-3p	PAR-CLIP	27292025
MIRT522264	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT522259	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT522269	hsa-miR-665	PAR-CLIP	27292025
MIRT522268	hsa-miR-6840-3p	PAR-CLIP	27292025
MIRT522262	hsa-miR-6851-5p	PAR-CLIP	27292025
MIRT522266	hsa-miR-7854-3p	PAR-CLIP	27292025
MIRT004113	hsa-miR-301a-3p	Luciferase reporter assay, Western blotting, RNA-seq, Immunofluorescence, qRT-PCR	32468020
MIRT701416	hsa-miR-890	HITS-CLIP	23313552
MIRT701415	hsa-miR-5690	HITS-CLIP	23313552
MIRT701414	hsa-miR-3656	HITS-CLIP	23313552
MIRT701413	hsa-miR-1908-5p	HITS-CLIP	23313552
MIRT701412	hsa-miR-663a	HITS-CLIP	23313552
MIRT701411	hsa-miR-6787-5p	HITS-CLIP	23313552
MIRT701410	hsa-miR-1268a	HITS-CLIP	23313552
MIRT701409	hsa-miR-1268b	HITS-CLIP	23313552
MIRT701408	hsa-miR-1271-3p	HITS-CLIP	23313552
MIRT701407	hsa-miR-550a-3-5p	HITS-CLIP	23313552
MIRT701406	hsa-miR-550a-5p	HITS-CLIP	23313552
MIRT674645	hsa-miR-7977	HITS-CLIP	23313552
MIRT674657	hsa-miR-6760-5p	HITS-CLIP	23824327
MIRT674656	hsa-miR-1321	HITS-CLIP	23824327
MIRT674655	hsa-miR-4739	HITS-CLIP	23824327
MIRT674654	hsa-miR-4756-5p	HITS-CLIP	23824327
MIRT674653	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT674652	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT674651	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT674650	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT674649	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT674648	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT674647	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT674646	hsa-miR-3162-5p	HITS-CLIP	23824327
MIRT674645	hsa-miR-7977	HITS-CLIP	23824327
MIRT674644	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT674643	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT674642	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT674641	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT674640	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT674639	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT674638	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT674637	hsa-miR-3689c	HITS-CLIP	23824327
MIRT674636	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT674635	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT674634	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT674633	hsa-miR-3122	HITS-CLIP	23824327
MIRT674632	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT674631	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT674630	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT522271	hsa-miR-3174	PAR-CLIP	23446348
MIRT522270	hsa-miR-4459	PAR-CLIP	23446348
MIRT522269	hsa-miR-665	PAR-CLIP	23446348
MIRT522268	hsa-miR-6840-3p	PAR-CLIP	23446348
MIRT522267	hsa-miR-493-3p	PAR-CLIP	23446348
MIRT522266	hsa-miR-7854-3p	PAR-CLIP	23446348
MIRT522265	hsa-miR-4785	PAR-CLIP	23446348
MIRT522264	hsa-miR-6499-3p	PAR-CLIP	23446348
MIRT522263	hsa-miR-3689d	PAR-CLIP	23446348
MIRT522262	hsa-miR-6851-5p	PAR-CLIP	23446348
MIRT522261	hsa-miR-455-3p	PAR-CLIP	23446348
MIRT522260	hsa-miR-1273e	PAR-CLIP	23446348
MIRT522259	hsa-miR-6516-5p	PAR-CLIP	23446348
MIRT1186429	hsa-miR-1273d	CLIP-seq
MIRT1186430	hsa-miR-203	CLIP-seq
MIRT1186431	hsa-miR-2053	CLIP-seq
MIRT1186432	hsa-miR-29a	CLIP-seq
MIRT1186433	hsa-miR-29b	CLIP-seq
MIRT1186434	hsa-miR-29c	CLIP-seq
MIRT1186435	hsa-miR-3074-3p	CLIP-seq
MIRT1186436	hsa-miR-3119	CLIP-seq
MIRT1186437	hsa-miR-3126-5p	CLIP-seq
MIRT1186438	hsa-miR-3155	CLIP-seq
MIRT1186439	hsa-miR-3155b	CLIP-seq
MIRT1186440	hsa-miR-330-3p	CLIP-seq
MIRT1186441	hsa-miR-3646	CLIP-seq
MIRT1186442	hsa-miR-4501	CLIP-seq
MIRT1186443	hsa-miR-4715-5p	CLIP-seq
MIRT1186444	hsa-miR-4761-5p	CLIP-seq
MIRT1186445	hsa-miR-484	CLIP-seq
MIRT1186446	hsa-miR-520d-5p	CLIP-seq
MIRT1186447	hsa-miR-524-5p	CLIP-seq
MIRT1186448	hsa-miR-548aa	CLIP-seq
MIRT1186449	hsa-miR-622	CLIP-seq
MIRT1186450	hsa-miR-624	CLIP-seq
MIRT1186451	hsa-miR-1273g	CLIP-seq
MIRT1186452	hsa-miR-1287	CLIP-seq
MIRT1186453	hsa-miR-140-3p	CLIP-seq
MIRT1186454	hsa-miR-1537	CLIP-seq
MIRT1186436	hsa-miR-3119	CLIP-seq
MIRT1186455	hsa-miR-3120-3p	CLIP-seq
MIRT1186437	hsa-miR-3126-5p	CLIP-seq
MIRT1186456	hsa-miR-3135b	CLIP-seq
MIRT1186438	hsa-miR-3155	CLIP-seq
MIRT1186439	hsa-miR-3155b	CLIP-seq
MIRT1186457	hsa-miR-338-5p	CLIP-seq
MIRT1186458	hsa-miR-3942-5p	CLIP-seq
MIRT1186459	hsa-miR-4312	CLIP-seq
MIRT1186460	hsa-miR-4423-5p	CLIP-seq
MIRT1186461	hsa-miR-4686	CLIP-seq
MIRT1186462	hsa-miR-4703-5p	CLIP-seq
MIRT1186463	hsa-miR-4764-5p	CLIP-seq
MIRT1186445	hsa-miR-484	CLIP-seq
MIRT1186449	hsa-miR-622	CLIP-seq
MIRT1186451	hsa-miR-1273g	CLIP-seq
MIRT1186454	hsa-miR-1537	CLIP-seq
MIRT1186455	hsa-miR-3120-3p	CLIP-seq
MIRT1186437	hsa-miR-3126-5p	CLIP-seq
MIRT2054000	hsa-miR-3200-5p	CLIP-seq
MIRT1186458	hsa-miR-3942-5p	CLIP-seq
MIRT1186459	hsa-miR-4312	CLIP-seq
MIRT2054001	hsa-miR-4419a	CLIP-seq
MIRT1186460	hsa-miR-4423-5p	CLIP-seq
MIRT2054002	hsa-miR-4510	CLIP-seq
MIRT2054003	hsa-miR-4649-3p	CLIP-seq
MIRT1186462	hsa-miR-4703-5p	CLIP-seq
MIRT1186443	hsa-miR-4715-5p	CLIP-seq
MIRT1186463	hsa-miR-4764-5p	CLIP-seq
MIRT2054004	hsa-miR-561	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	10562553
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	10562553
GO:0001671	Function	ATPase activator activity	IDA	32179686
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	21900206, 21903422, 29021621, 32296183, 32838362, 33961781, 36217029
GO:0005634	Component	Nucleus	IDA	10562553
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IBA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	10562553
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	10562553

Other IDs

• MIM: 300440
• HGNC: 19374
• e!Ensembl: ENSG00000186416

Protein

• UniProt ID: O15226
• Protein name: NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4)
• Protein function: Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the i
• PDB: 6SH6 , 6SH7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01424	R3H	602 → 662	R3H domain	Domain
  PF01585	G-patch	551 → 594	G-patch domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely and constitutively expressed (PubMed:10562553). Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney (PubMed:10562553). {ECO:0000269|PubMed:10562553}.
• Sequence:

  MEKILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLSTCDGQNPPKKQAGSKFHARPRFEPV
  HFVASSSKDERQEDPYGPQTKEVNEQTHFASMPRDIYQDYTQDSFSIQDGNSQYCDSSGF
  ILTKDQPVTANMYFDSGNPAPSTTSQQANSQSTPEPSPSQTFPESVVAEKQYFIEKLTAT
  IWKNLSNPEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGY
  ACEVRCQNIYLTTGYAGSKNGSRDRATELAVKLLQKRIEVRVVRRKFKHTFGEDLVVCQI
  GMSSYEFPPALKPPEDLVVLGKDASGQPIFNASAKHWTNFVITENANDAIGILNNSASFN
  KMSIEYKYEMMPNRTWRCRVFLQDHCLAEGYGTKKTSKHAAADEALKILQKTQPTYPSVK
  SSQCHTGSSPRGSGKKKDIKDLVVYENSSNPVCTLNDTAQFNRMTVEYVYERMTGLRWKC
  KVILESEVIAEAVGVKKTVKYEAAGEAVKTLKKTQPTVINNLKKGAVEDVISRNEIQGRS
  AEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEGIREPISVKEQHKREGLGLDVERVNK
  IAKRDIEQIIRNYARSESHTDLTFSRELTNDERKQIHQIAQKYGLKSKSHGVGHDRYLVV
  GRKRRKEDLLDQLKQEGQVGHYELVMPQAN

• Sequence length: 690

Related Genes

No strongly related genes found yet for NKRF.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NKRF.