NIFK (nucleolar protein interacting with the FHA domain of MKI67)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 84365
• Gene name: Nucleolar protein interacting with the FHA domain of MKI67
• Gene symbol: NIFK
• Synonyms (NCBI Gene): MKI67IP, Nopp34
• Chromosome: 2
• Chromosome location: 2q14.3
• Summary: This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 1

miRNA Show/Hide all (42)

miRTarBase ID	miRNA	Experiments	Reference
MIRT664557	hsa-miR-96-3p	HITS-CLIP	23824327
MIRT664556	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT664555	hsa-miR-5695	HITS-CLIP	23824327
MIRT664554	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT664553	hsa-miR-6131	HITS-CLIP	23824327
MIRT664552	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT664551	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT664550	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT664549	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT664548	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT664547	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT664546	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT620826	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT620825	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT620824	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT620823	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT620822	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT620821	hsa-miR-3672	HITS-CLIP	23824327
MIRT620820	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT620819	hsa-miR-8055	HITS-CLIP	23824327
MIRT620818	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT741763	hsa-miR-96-3p	HITS-CLIP	23824327
MIRT741764	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT741765	hsa-miR-5695	HITS-CLIP	23824327
MIRT741766	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT741767	hsa-miR-6131	HITS-CLIP	23824327
MIRT741768	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT741769	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT741770	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT741771	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT741772	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT741773	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT741774	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT742456	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT742457	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT742458	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT742459	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT742460	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT742461	hsa-miR-3672	HITS-CLIP	23824327
MIRT742462	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT742463	hsa-miR-8055	HITS-CLIP	23824327
MIRT742464	hsa-miR-129-5p	HITS-CLIP	23824327

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000794	Component	Condensed nuclear chromosome	IDA	11342549
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IDA	11342549
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	11342549, 16244663, 25416956, 26949251
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	11342549
GO:0005694	Component	Chromosome	IDA
GO:0005694	Component	Chromosome	IEA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	11342549
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IDA	11342549
GO:0009303	Process	RRNA transcription	NAS	11342549
GO:0016072	Process	RRNA metabolic process	NAS	11342549
GO:0065003	Process	Protein-containing complex assembly	NAS	11342549

Other IDs

• MIM: 611970
• HGNC: 17838
• e!Ensembl: ENSG00000155438

Protein

• UniProt ID: Q9BYG3
• Protein name: MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK)
• PDB: 2AFF , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ , 8FL2 , 8FL3 , 8FL6 , 8FL7 , 8FLA , 8FLB , 8FLD , 8FLE , 8INE , 8INF , 8IPX , 8IPY , 8IR3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	47 → 117	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF12196	hNIFK_binding	227 → 266	FHA Ki67 binding domain of hNIFK	Domain

• Sequence:

  MATFSGPAGPILSLNPQEDVEFQKEVAQVRKRITQRKKQEQLTPGVVYVRHLPNLLDETQ
  IFSYFSQFGTVTRFRLSRSKRTGNSKGYAFVEFESEDVAKIVAETMNNYLFGERLLECHF
  MPPEKVHKELFKDWNIPFKQPSYPSVKRYNRNRTLTQKLRMEERFKKKERLLRKKLAKKG
  IDYDFPSLILQKTESISKTNRQTSTKGQVLRKKKKKVSGTLDTPEKTVDSQGPTPVCTPT
  FLERRKSQVAELNDDDKDDEIVFKQPISCVKEEIQETQTPTHSRKKRRRSSNQ

• Sequence length: 293

Related Genes

No strongly related genes found yet for NIFK.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NIFK.