NHSL2 (NHS like 2)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 340527
• Gene name: NHS like 2
• Gene symbol: NHSL2
• Synonyms (NCBI Gene): -
• Chromosome: X
• Chromosome location: Xq13.1

miRNA Show/Hide all (135)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047043	hsa-miR-183-5p	CLASH	23622248
MIRT040514	hsa-miR-577	CLASH	23622248
MIRT607510	hsa-miR-6867-5p	HITS-CLIP	22927820
MIRT607509	hsa-miR-574-5p	HITS-CLIP	22927820
MIRT687472	hsa-miR-129-1-3p	HITS-CLIP	23313552
MIRT687471	hsa-miR-129-2-3p	HITS-CLIP	23313552
MIRT687470	hsa-miR-4687-5p	HITS-CLIP	23313552
MIRT687469	hsa-miR-6779-3p	HITS-CLIP	23313552
MIRT687468	hsa-miR-6832-3p	HITS-CLIP	23313552
MIRT607509	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT607510	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT687467	hsa-miR-6818-5p	HITS-CLIP	23313552
MIRT687466	hsa-miR-147a	HITS-CLIP	23313552
MIRT687465	hsa-miR-2113	HITS-CLIP	23313552
MIRT687464	hsa-miR-5010-3p	HITS-CLIP	23313552
MIRT607509	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT607510	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627973	hsa-miR-3115	HITS-CLIP	23824327
MIRT607509	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT607510	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT607509	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT525666	hsa-miR-562	PAR-CLIP	22012620
MIRT525665	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT525664	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT525663	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT525662	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT525661	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT525660	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT525659	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT525658	hsa-miR-302e	PAR-CLIP	22012620
MIRT525657	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT525656	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT525655	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT525654	hsa-miR-520b	PAR-CLIP	22012620
MIRT525653	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT525652	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT525651	hsa-miR-520e	PAR-CLIP	22012620
MIRT525650	hsa-miR-654-3p	PAR-CLIP	22012620
MIRT525649	hsa-miR-1245b-3p	PAR-CLIP	22012620
MIRT525648	hsa-miR-517-5p	PAR-CLIP	22012620
MIRT525647	hsa-miR-4699-5p	PAR-CLIP	22012620
MIRT525646	hsa-miR-548ao-5p	PAR-CLIP	22012620
MIRT525645	hsa-miR-548ax	PAR-CLIP	22012620
MIRT525644	hsa-miR-5585-5p	PAR-CLIP	22012620
MIRT525643	hsa-miR-1301-5p	PAR-CLIP	22012620
MIRT525642	hsa-miR-6502-5p	PAR-CLIP	22012620
MIRT525641	hsa-miR-4777-5p	PAR-CLIP	22012620
MIRT687472	hsa-miR-129-1-3p	HITS-CLIP	27418678
MIRT687472	hsa-miR-129-1-3p	HITS-CLIP	27418678
MIRT687472	hsa-miR-129-1-3p	HITS-CLIP	27418678
MIRT687471	hsa-miR-129-2-3p	HITS-CLIP	27418678
MIRT687471	hsa-miR-129-2-3p	HITS-CLIP	27418678
MIRT687471	hsa-miR-129-2-3p	HITS-CLIP	27418678
MIRT687466	hsa-miR-147a	HITS-CLIP	27418678
MIRT687466	hsa-miR-147a	HITS-CLIP	27418678
MIRT687466	hsa-miR-147a	HITS-CLIP	27418678
MIRT687465	hsa-miR-2113	HITS-CLIP	27418678
MIRT687465	hsa-miR-2113	HITS-CLIP	27418678
MIRT687465	hsa-miR-2113	HITS-CLIP	27418678
MIRT627973	hsa-miR-3115	HITS-CLIP	27418678
MIRT627973	hsa-miR-3115	HITS-CLIP	27418678
MIRT627973	hsa-miR-3115	HITS-CLIP	27418678
MIRT627973	hsa-miR-3115	HITS-CLIP	27418678
MIRT627973	hsa-miR-3115	HITS-CLIP	27418678
MIRT627973	hsa-miR-3115	HITS-CLIP	27418678
MIRT687470	hsa-miR-4687-5p	HITS-CLIP	27418678
MIRT687470	hsa-miR-4687-5p	HITS-CLIP	27418678
MIRT687470	hsa-miR-4687-5p	HITS-CLIP	27418678
MIRT687464	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT687464	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT687464	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT607509	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT607509	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT607509	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT607509	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT607509	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT607509	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT687469	hsa-miR-6779-3p	HITS-CLIP	27418678
MIRT687469	hsa-miR-6779-3p	HITS-CLIP	27418678
MIRT687469	hsa-miR-6779-3p	HITS-CLIP	27418678
MIRT687467	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT687467	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT687467	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT687468	hsa-miR-6832-3p	HITS-CLIP	27418678
MIRT687468	hsa-miR-6832-3p	HITS-CLIP	27418678
MIRT687468	hsa-miR-6832-3p	HITS-CLIP	27418678
MIRT607510	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607510	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607510	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607510	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607510	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607510	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607510	hsa-miR-6867-5p	HITS-CLIP	22927820
MIRT607509	hsa-miR-574-5p	HITS-CLIP	22927820
MIRT687472	hsa-miR-129-1-3p	HITS-CLIP	23313552
MIRT687471	hsa-miR-129-2-3p	HITS-CLIP	23313552
MIRT687470	hsa-miR-4687-5p	HITS-CLIP	23313552
MIRT687469	hsa-miR-6779-3p	HITS-CLIP	23313552
MIRT687468	hsa-miR-6832-3p	HITS-CLIP	23313552
MIRT607509	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT607510	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT687467	hsa-miR-6818-5p	HITS-CLIP	23313552
MIRT687466	hsa-miR-147a	HITS-CLIP	23313552
MIRT687465	hsa-miR-2113	HITS-CLIP	23313552
MIRT687464	hsa-miR-5010-3p	HITS-CLIP	23313552
MIRT607509	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT607510	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627973	hsa-miR-3115	HITS-CLIP	23824327
MIRT607509	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT525666	hsa-miR-562	PAR-CLIP	22012620
MIRT525665	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT525664	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT525663	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT525662	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT525661	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT525660	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT525659	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT525658	hsa-miR-302e	PAR-CLIP	22012620
MIRT525657	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT525656	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT525655	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT525654	hsa-miR-520b	PAR-CLIP	22012620
MIRT525653	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT525652	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT525651	hsa-miR-520e	PAR-CLIP	22012620
MIRT525650	hsa-miR-654-3p	PAR-CLIP	22012620
MIRT525649	hsa-miR-1245b-3p	PAR-CLIP	22012620
MIRT525648	hsa-miR-517-5p	PAR-CLIP	22012620
MIRT525647	hsa-miR-4699-5p	PAR-CLIP	22012620
MIRT525646	hsa-miR-548ao-5p	PAR-CLIP	22012620
MIRT525645	hsa-miR-548ax	PAR-CLIP	22012620
MIRT525644	hsa-miR-5585-5p	PAR-CLIP	22012620
MIRT525643	hsa-miR-1301-5p	PAR-CLIP	22012620
MIRT525642	hsa-miR-6502-5p	PAR-CLIP	22012620
MIRT525641	hsa-miR-4777-5p	PAR-CLIP	22012620

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	28514442, 32296183
GO:0030154	Process	Cell differentiation	IBA

Other IDs

• MIM: 301093
• HGNC: 33737
• e!Ensembl: ENSG00000204131

Protein

• UniProt ID: Q5HYW2
• Protein name: NHS-like protein 2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15273	NHS	608 → 770	NHS-like	Family
  PF15273	NHS	490 → 615	NHS-like	Family

• Sequence:

  MPFYRRTVVPQRLCPRNPPQQLAELRDVSHLAALSLLRQLADLCGHSLALLEDLEGHLLA
  LGRRTDSLYRRTVRLRRRLPCRLLGPEEDEEELAAANSGRENATATAHSRSSWRQPVNVF
  LSSGRPPSVEELLREAQLNLQSLLQEEYEEQYSEARLVGQTFRSSDEATKPTPNPRPQSA
  RRLEFILMPTKRQLSEDETTTQGVRAPEASLSLSTTADKQTAWNSLFPLPILEEKRWPQL
  CSTQSDIVPINISGQQFDKHASLRHSLFNTETAVNPKSTLRRRRTIIGFSNFSQRDQGHS
  NSPAGSVAHSTTSDIRPSHSVPEGVHGRVAVGQDARFPSLTSPVLRTPSSEPDEPHQARS
  GPNPPGMESMGMVYSVPSSCNGPTESTFSTSWKGDAFTYMTPSATSQSNQVNENGKNPSC
  GNSWVSLNKVPPLVPKEAATLLVARDNPAGCSGSAGYPERLIQQRHMPERPSKIGLLTSG
  TSRLETGPGGASRFRERSLSVPTDSGTTDVDYDEEQKANEACALPFASTSSEGSNSADNI
  ASLSAQQEAQHRRQRSKSISLRKAKKKPSPPTRSVSLVKDEPGLLPEGGSALPKDQRPKS
  LCLSLEHQGHHSSHPDAQGHPAIPNHKDPESTQFSHHWYLTDWKSGDTYQSLSSSSTATG
  TTVIECTQVQGSSESLASPSTSRATTPSQLSIEVEAREISSPGRPPGLMSPSSGYSSQSE
  TPTPTVSMSLTLGHLPPPSSSVRVRPVVPERKSSLPPTSPMEKFPKSRLSFDLPLTSSPN
  LDLSGMSISIRSKTKVSRHHSETNFGVKLAQKTNPNQPIMPMVTQSDLRSVRLRSVSKSE
  PEDDIESPEYAEEPRAEEVFTLPERKTKPPVAEKPPVARRPPSLVHKPPSVPEEYALTSP
  TLAMPPRSSIQHARPLPQDSYTVVRKPKPSSFPDGRSPGESTAPSSLVFTPFASSSDAFF
  SGTQQPPQGSVEDEGPKVRVLPERISLQSQEEAEKKKGKIPPPVPKKPSVLYLPLTSPTA
  QMEAYVAEPRLPLSPIITLEEDTKCPATGDDLQSLGQRVTSTPQADSEREASPLGSSVEP
  GTEEKSLISDKTAEWIAEDDDDVFVASRTTEDLFTVIHRSKRKLLGWKEPGEAFVGGRTS
  SHSPIKNTAESPISESTATAGSGSSANLDAGRNDDFKALLQKKGSKATPRSRPSAAELLK
  TTNPLARRIIAQFSKDYETTDNPST

• Sequence length: 1225

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Spinocerebellar ataxia, X-linked	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Bone Diseases Metabolic	Bone disease	Pubtator	36728938	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for NHSL2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NHSL2.