NFXL1 (nuclear transcription factor, X-box binding like 1)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 152518
• Gene name: Nuclear transcription factor, X-box binding like 1
• Gene symbol: NFXL1
• Synonyms (NCBI Gene): CDZFP, HOZFP, OZFP, URCC5
• Chromosome: 4
• Chromosome location: 4p12

miRNA Show/Hide all (57)

miRTarBase ID	miRNA	Experiments	Reference
MIRT038003	hsa-miR-500a-5p	CLASH	23622248
MIRT1183654	hsa-miR-1303	CLIP-seq
MIRT1183655	hsa-miR-132	CLIP-seq
MIRT1183656	hsa-miR-143	CLIP-seq
MIRT1183657	hsa-miR-146b-3p	CLIP-seq
MIRT1183658	hsa-miR-212	CLIP-seq
MIRT1183659	hsa-miR-3065-3p	CLIP-seq
MIRT1183660	hsa-miR-3123	CLIP-seq
MIRT1183661	hsa-miR-3145-3p	CLIP-seq
MIRT1183662	hsa-miR-3173-3p	CLIP-seq
MIRT1183663	hsa-miR-34b	CLIP-seq
MIRT1183664	hsa-miR-3658	CLIP-seq
MIRT1183665	hsa-miR-3684	CLIP-seq
MIRT1183666	hsa-miR-376c	CLIP-seq
MIRT1183667	hsa-miR-3920	CLIP-seq
MIRT1183668	hsa-miR-3925-5p	CLIP-seq
MIRT1183669	hsa-miR-4428	CLIP-seq
MIRT1183670	hsa-miR-4495	CLIP-seq
MIRT1183671	hsa-miR-4511	CLIP-seq
MIRT1183672	hsa-miR-4536	CLIP-seq
MIRT1183673	hsa-miR-4684-5p	CLIP-seq
MIRT1183674	hsa-miR-4756-3p	CLIP-seq
MIRT1183675	hsa-miR-4768-5p	CLIP-seq
MIRT1183676	hsa-miR-4770	CLIP-seq
MIRT1183677	hsa-miR-4797-5p	CLIP-seq
MIRT1183678	hsa-miR-548ag	CLIP-seq
MIRT1183679	hsa-miR-548ai	CLIP-seq
MIRT1183680	hsa-miR-548b-3p	CLIP-seq
MIRT2053255	hsa-miR-135a	CLIP-seq
MIRT2053256	hsa-miR-135b	CLIP-seq
MIRT2053257	hsa-miR-217	CLIP-seq
MIRT2053258	hsa-miR-24	CLIP-seq
MIRT2053259	hsa-miR-3158-5p	CLIP-seq
MIRT2053260	hsa-miR-4264	CLIP-seq
MIRT2053261	hsa-miR-4284	CLIP-seq
MIRT2053262	hsa-miR-4418	CLIP-seq
MIRT2053263	hsa-miR-4427	CLIP-seq
MIRT2053264	hsa-miR-4680-3p	CLIP-seq
MIRT2053265	hsa-miR-509-3-5p	CLIP-seq
MIRT2053266	hsa-miR-509-5p	CLIP-seq
MIRT2053267	hsa-miR-622	CLIP-seq
MIRT2053268	hsa-miR-944	CLIP-seq
MIRT2053255	hsa-miR-135a	CLIP-seq
MIRT2053256	hsa-miR-135b	CLIP-seq
MIRT2053257	hsa-miR-217	CLIP-seq
MIRT2053259	hsa-miR-3158-5p	CLIP-seq
MIRT2053262	hsa-miR-4418	CLIP-seq
MIRT2282567	hsa-miR-4753-3p	CLIP-seq
MIRT1183675	hsa-miR-4768-5p	CLIP-seq
MIRT2053265	hsa-miR-509-3-5p	CLIP-seq
MIRT2053266	hsa-miR-509-5p	CLIP-seq
MIRT2282568	hsa-miR-550b	CLIP-seq
MIRT1183654	hsa-miR-1303	CLIP-seq
MIRT1183660	hsa-miR-3123	CLIP-seq
MIRT1183663	hsa-miR-34b	CLIP-seq
MIRT1183664	hsa-miR-3658	CLIP-seq
MIRT1183668	hsa-miR-3925-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 620488
• HGNC: 18726
• e!Ensembl: ENSG00000170448

Protein

• UniProt ID: Q6ZNB6
• Protein name: NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01422	zf-NF-X1	371 → 389	NF-X1 type zinc finger	Family
  PF01422	zf-NF-X1	318 → 336	NF-X1 type zinc finger	Family
  PF01422	zf-NF-X1	424 → 442	NF-X1 type zinc finger	Family
  PF01422	zf-NF-X1	265 → 282	NF-X1 type zinc finger	Family
  PF01422	zf-NF-X1	497 → 521	NF-X1 type zinc finger	Family
  PF01422	zf-NF-X1	775 → 793	NF-X1 type zinc finger	Family
  PF01422	zf-NF-X1	712 → 730	NF-X1 type zinc finger	Family
  PF01422	zf-NF-X1	476 → 494	NF-X1 type zinc finger	Family
  PF01422	zf-NF-X1	589 → 601	NF-X1 type zinc finger	Family
  PF01422	zf-NF-X1	664 → 681	NF-X1 type zinc finger	Family
  PF01422	zf-NF-X1	567 → 579	NF-X1 type zinc finger	Family

• Sequence:

  MEASWRQVAGGRGRSRGRATAAPSGNGVHLRGAGGGREKGSVGAVPSGTSPGGVATTAAA
  GSRHSPAGSQALQTTAASELMSQKKFEEIKKANQAAARKLVEEQFSSSSEEGDEDFEGKQ
  GKILANTFITYTTQTDGDTRELERTKQYVNEAFQAGAMTCLICIASVKRNQAVWSCSGCF
  CIFHMPCIQKWAKDSQFLVSSVTDDDFGKKDCPWPCPKCRFEYKRSETPSRYYCYCGKVE
  DPPLDPWLVPHSCGQVCEREFKPPCGHKCLLLCHPGPCPPCPKMVTTTCYCKKAKPIPRR
  CSAKEWSCQLPCGQKLLCGQHKCENPCHAGSCQPCPRVSRQKCVCGKKVAERSCASPLWH
  CDQVCGKTLPCGNHTCEQVCHVGACGECPRSGKRFCPCQKSKFSLPCTEDVPTCGDSCDK
  VLECGIHRCSQRCHRGPCETCRQEVEKHCRCGKHTKRMPCHKPYLCETKCVKMRDCQKHQ
  CRRKCCPGNCPPCDQNCGRTLGCRNHKCPSVCHRGSCYPCPETVDVKCNCGNTKVTVPCG
  RERTTRPPKCKEQCSRPPTCHHTSQEKHRCHFGSCPPCHQPCQKVLEKCGHLCPAPCHDQ
  ALIKQTGRHQPTGPWEQPSEPAFIQTALPCPPCQVPIPMECLGKHEVSPLPCHAVGPYSC
  KRVCGRILDCQNHTCMKECHKVTKTDGCTGKNKAGPECLHCEEGCSKSRPLGCLHPCILR
  CHPGECPPCVQMLRIKCHCKITSLYVECRKITTADVNEKNLLSCCKNQCPKELPCGHRCK
  EMCHPGECPFNCNQKVKLRCPCKRIKKELQCNKVRENQVSIECDTTCKEMKRKASEIKEA
  EAKAALEEEKRRQQAELEAFENRLKGRRKKNRKRDEVAVELSLWQKHKYYLISVCGVVVV
  VFAWYITHDVN

• Sequence length: 911

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (11)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Cervical cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHOLESTASIS	—	CTD	26881866	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NFXL1-related disorder	Benign; Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SMALL VESSEL STROKE	—	GWAS catalog	34031191	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (8)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Cholestasis	Cholestasis	CTD_human_DG	26881866		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Language Disorders	Language Disorders	BEFREE	25781923		★☆☆☆☆ Found in Text Mining only
Language Disorders	Language development disorders	Pubtator	25781923	Associate	★☆☆☆☆ Found in Text Mining only
NON RARE IN EUROPE: Specific language impairment	Specific Language Impairment	Orphanet			★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychotic disorders	Pubtator	40430072	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	40430072	Associate	★☆☆☆☆ Found in Text Mining only
Specific Language Disorder	Specific language disorder	Pubtator	25781923	Associate	★☆☆☆☆ Found in Text Mining only
Specific language impairment	Specific Language Impairment	BEFREE	25781923		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for NFXL1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NFXL1.