NFKBID (NFKB inhibitor delta)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 84807
• Gene name: NFKB inhibitor delta
• Gene symbol: NFKBID
• Synonyms (NCBI Gene): IkBNS, IkappaBNS, TA-NFKBH
• Chromosome: 19
• Chromosome location: 19q13.12

miRNA Show/Hide all (124)

miRTarBase ID	miRNA	Experiments	Reference
MIRT662283	hsa-miR-4705	HITS-CLIP	23824327
MIRT662282	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT662281	hsa-miR-3182	HITS-CLIP	23824327
MIRT395438	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT395440	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT662280	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT662279	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT662278	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT662277	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT662276	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT644325	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT644324	hsa-miR-1245a	HITS-CLIP	23824327
MIRT644323	hsa-miR-8079	HITS-CLIP	23824327
MIRT644322	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT644321	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT644320	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT644319	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT644318	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT644317	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT644316	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT644315	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT644314	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT644313	hsa-miR-4454	HITS-CLIP	23824327
MIRT644312	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT644311	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT644310	hsa-miR-6131	HITS-CLIP	23824327
MIRT644309	hsa-miR-548s	HITS-CLIP	23824327
MIRT644308	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT644307	hsa-miR-588	HITS-CLIP	23824327
MIRT644306	hsa-miR-4435	HITS-CLIP	23824327
MIRT644305	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT644304	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT644303	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT635197	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT635196	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT635195	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT635193	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT635194	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT635192	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT635191	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT635190	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT635189	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT635188	hsa-miR-6844	HITS-CLIP	23824327
MIRT635187	hsa-miR-3672	HITS-CLIP	23824327
MIRT635186	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT635185	hsa-miR-8055	HITS-CLIP	23824327
MIRT635194	hsa-miR-130b-5p	HITS-CLIP	27418678
MIRT635187	hsa-miR-3672	HITS-CLIP	27418678
MIRT635192	hsa-miR-4524a-3p	HITS-CLIP	27418678
MIRT635189	hsa-miR-4753-3p	HITS-CLIP	27418678
MIRT635197	hsa-miR-4797-5p	HITS-CLIP	27418678
MIRT635196	hsa-miR-5007-5p	HITS-CLIP	27418678
MIRT635193	hsa-miR-6817-3p	HITS-CLIP	27418678
MIRT635188	hsa-miR-6844	HITS-CLIP	27418678
MIRT635186	hsa-miR-6864-3p	HITS-CLIP	27418678
MIRT635190	hsa-miR-6873-3p	HITS-CLIP	27418678
MIRT635191	hsa-miR-6895-3p	HITS-CLIP	27418678
MIRT635195	hsa-miR-7110-3p	HITS-CLIP	27418678
MIRT635185	hsa-miR-8055	HITS-CLIP	27418678
MIRT662283	hsa-miR-4705	HITS-CLIP	23824327
MIRT662282	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT662281	hsa-miR-3182	HITS-CLIP	23824327
MIRT395438	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT395440	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT662280	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT662279	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT662278	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT662277	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT662276	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT644325	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT644324	hsa-miR-1245a	HITS-CLIP	23824327
MIRT644323	hsa-miR-8079	HITS-CLIP	23824327
MIRT644322	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT644321	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT644320	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT644319	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT644318	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT644317	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT644316	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT644315	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT644314	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT644313	hsa-miR-4454	HITS-CLIP	23824327
MIRT644312	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT644311	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT644310	hsa-miR-6131	HITS-CLIP	23824327
MIRT644309	hsa-miR-548s	HITS-CLIP	23824327
MIRT644308	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT644307	hsa-miR-588	HITS-CLIP	23824327
MIRT644306	hsa-miR-4435	HITS-CLIP	23824327
MIRT644305	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT644304	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT644303	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT635197	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT635196	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT635195	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT635193	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT635194	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT635192	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT635191	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT635190	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT635189	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT635188	hsa-miR-6844	HITS-CLIP	23824327
MIRT635187	hsa-miR-3672	HITS-CLIP	23824327
MIRT635186	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT635185	hsa-miR-8055	HITS-CLIP	23824327
MIRT1183541	hsa-miR-1184	CLIP-seq
MIRT1183542	hsa-miR-1205	CLIP-seq
MIRT1183543	hsa-miR-1207-5p	CLIP-seq
MIRT1183544	hsa-miR-3158-5p	CLIP-seq
MIRT1183545	hsa-miR-3170	CLIP-seq
MIRT1183546	hsa-miR-323-3p	CLIP-seq
MIRT1183547	hsa-miR-3692	CLIP-seq
MIRT1183548	hsa-miR-4314	CLIP-seq
MIRT1183549	hsa-miR-4495	CLIP-seq
MIRT1183550	hsa-miR-4667-5p	CLIP-seq
MIRT1183551	hsa-miR-4700-5p	CLIP-seq
MIRT1183552	hsa-miR-4736	CLIP-seq
MIRT1183553	hsa-miR-4763-3p	CLIP-seq
MIRT1183554	hsa-miR-548aa	CLIP-seq
MIRT1183555	hsa-miR-637	CLIP-seq
MIRT2282491	hsa-miR-27a	CLIP-seq
MIRT2282492	hsa-miR-27b	CLIP-seq
MIRT2282493	hsa-miR-513a-5p	CLIP-seq
MIRT2282494	hsa-miR-609	CLIP-seq

Gene ontology (GO) Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0010468	Process	Regulation of gene expression	IBA
GO:0050852	Process	T cell receptor signaling pathway	ISS
GO:2000321	Process	Positive regulation of T-helper 17 cell differentiation	ISS

Other IDs

• MIM: 618887
• HGNC: 15671
• e!Ensembl: ENSG00000167604

Protein

• UniProt ID: Q8NI38
• Protein name: NF-kappa-B inhibitor delta (NFKB inhibitor delta) (I-kappa-B-delta) (IkB-delta) (IkappaBdelta) (IkappaBNS) (T-cell activation NFKB-like protein) (TA-NFKBH)
• Protein function: Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00023	Ank	84 → 116	Ankyrin repeat	Repeat
  PF12796	Ank_2	178 → 278	Ankyrin repeats (3 copies)	Repeat

• Sequence:

  MEAGPWRVSAPPSGPPQFPAVVPGPSLEVARAHMLALGPQQLLAQDEEGDTLLHLFAARG
  LRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRS
  VLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLST
  QARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNM
  KAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQL
  LKRSRVAPPGLSS

• Sequence length: 313

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Immunodeficiency, common variable, 12	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Neurofibromatosis 2	Neurofibromatosis	Pubtator	37938781	Inhibit	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for NFKBID.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NFKBID.