NEUROD4 (neuronal differentiation 4)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 58158
• Gene name: Neuronal differentiation 4
• Gene symbol: NEUROD4
• Synonyms (NCBI Gene): ATH-3, ATH3, Atoh3, MATH-3, MATH3, bHLHa4
• Chromosome: 12
• Chromosome location: 12q13.2

miRNA Show/Hide all (60)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017092	hsa-miR-335-5p	Microarray	18185580
MIRT1181298	hsa-miR-1179	CLIP-seq
MIRT1181299	hsa-miR-1283	CLIP-seq
MIRT1181300	hsa-miR-15a	CLIP-seq
MIRT1181301	hsa-miR-15b	CLIP-seq
MIRT1181302	hsa-miR-16	CLIP-seq
MIRT1181303	hsa-miR-195	CLIP-seq
MIRT1181304	hsa-miR-2467-5p	CLIP-seq
MIRT1181305	hsa-miR-3065-3p	CLIP-seq
MIRT1181306	hsa-miR-3146	CLIP-seq
MIRT1181307	hsa-miR-3157-3p	CLIP-seq
MIRT1181308	hsa-miR-3164	CLIP-seq
MIRT1181309	hsa-miR-3188	CLIP-seq
MIRT1181310	hsa-miR-3679-3p	CLIP-seq
MIRT1181311	hsa-miR-371-5p	CLIP-seq
MIRT1181312	hsa-miR-3942-3p	CLIP-seq
MIRT1181313	hsa-miR-3975	CLIP-seq
MIRT1181314	hsa-miR-424	CLIP-seq
MIRT1181315	hsa-miR-4276	CLIP-seq
MIRT1181316	hsa-miR-4684-5p	CLIP-seq
MIRT1181317	hsa-miR-4709-5p	CLIP-seq
MIRT1181318	hsa-miR-485-5p	CLIP-seq
MIRT1181319	hsa-miR-497	CLIP-seq
MIRT1181320	hsa-miR-621	CLIP-seq
MIRT1181321	hsa-miR-874	CLIP-seq
MIRT1181300	hsa-miR-15a	CLIP-seq
MIRT1181301	hsa-miR-15b	CLIP-seq
MIRT1181302	hsa-miR-16	CLIP-seq
MIRT1181303	hsa-miR-195	CLIP-seq
MIRT1181305	hsa-miR-3065-3p	CLIP-seq
MIRT1181314	hsa-miR-424	CLIP-seq
MIRT1181319	hsa-miR-497	CLIP-seq
MIRT2052497	hsa-miR-610	CLIP-seq
MIRT2281860	hsa-miR-133a	CLIP-seq
MIRT2281861	hsa-miR-133b	CLIP-seq
MIRT2281862	hsa-miR-147	CLIP-seq
MIRT1181300	hsa-miR-15a	CLIP-seq
MIRT1181301	hsa-miR-15b	CLIP-seq
MIRT1181302	hsa-miR-16	CLIP-seq
MIRT1181303	hsa-miR-195	CLIP-seq
MIRT2281863	hsa-miR-203	CLIP-seq
MIRT2281864	hsa-miR-2052	CLIP-seq
MIRT1181305	hsa-miR-3065-3p	CLIP-seq
MIRT2281865	hsa-miR-3622a-3p	CLIP-seq
MIRT2281866	hsa-miR-3622b-3p	CLIP-seq
MIRT1181314	hsa-miR-424	CLIP-seq
MIRT1181319	hsa-miR-497	CLIP-seq
MIRT1181300	hsa-miR-15a	CLIP-seq
MIRT1181301	hsa-miR-15b	CLIP-seq
MIRT1181302	hsa-miR-16	CLIP-seq
MIRT1181303	hsa-miR-195	CLIP-seq
MIRT1181305	hsa-miR-3065-3p	CLIP-seq
MIRT1181314	hsa-miR-424	CLIP-seq
MIRT2391506	hsa-miR-4643	CLIP-seq
MIRT2391507	hsa-miR-466	CLIP-seq
MIRT2391508	hsa-miR-4789-3p	CLIP-seq
MIRT1181319	hsa-miR-497	CLIP-seq
MIRT2455073	hsa-miR-1253	CLIP-seq
MIRT2455074	hsa-miR-539	CLIP-seq
MIRT2455075	hsa-miR-583	CLIP-seq

Gene ontology (GO) Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0007405	Process	Neuroblast proliferation	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0035881	Process	Amacrine cell differentiation	IEA
GO:0035881	Process	Amacrine cell differentiation	ISS
GO:0043010	Process	Camera-type eye development	IBA
GO:0043010	Process	Camera-type eye development	IEA
GO:0045165	Process	Cell fate commitment	IEA
GO:0045597	Process	Positive regulation of cell differentiation	IEA
GO:0045597	Process	Positive regulation of cell differentiation	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0046983	Function	Protein dimerization activity	IEA
GO:0048666	Process	Neuron development	IEA
GO:0048709	Process	Oligodendrocyte differentiation	IEA
GO:0060041	Process	Retina development in camera-type eye	IEA
GO:0061564	Process	Axon development	IBA
GO:0070888	Function	E-box binding	IBA
GO:0097475	Process	Motor neuron migration	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IEA

Other IDs

• MIM: 611635
• HGNC: 13802
• e!Ensembl: ENSG00000123307

Protein

• UniProt ID: Q9HD90
• Protein name: Neurogenic differentiation factor 4 (NeuroD4) (Class A basic helix-loop-helix protein 4) (bHLHa4) (Protein atonal homolog 3) (ATH-3) (Atoh3)
• Protein function: Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00010	HLH	88 → 140	Helix-loop-helix DNA-binding domain	Domain
  PF12533	Neuro_bHLH	146 → 264	Neuronal helix-loop-helix transcription factor	Family

• Sequence:

  MSKTFVKSKEMGELVNTPSWMDKGLGSQNEVKEEESRPGTYGMLSSLTEEHDSIEEEEEE
  EEDGEKPKRRGPKKKKMTKARLERFRARRVKANARERTRMHGLNDALDNLRRVMPCYSKT
  QKLSKIETLRLARNYIWALSEVLETGQTPEGKGFVEMLCKGLSQPTSNLVAGCLQLGPQS
  VLLEKHEDKSPICDSAISVHNFNYQSPGLPSPPYGHMETHLLHLKPQVFKSLGESSFGSH
  LPDCSTPPYEGPLTPPLSISGNFSLKQDGSPDLEKSYSFMPHYPSSSLSSGHVHSTPFQA
  GTPRYDVPIDMSYDSYPHHGIGTQLNTVFTE

• Sequence length: 331

Related Genes

No strongly related genes found yet for NEUROD4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NEUROD4.