NECAP2 (NECAP endocytosis associated 2)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55707
• Gene name: NECAP endocytosis associated 2
• Gene symbol: NECAP2
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1p36.13
• Summary: This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by R

miRNA Show/Hide all (181)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004907	hsa-miR-124-3p	Microarray	15685193
MIRT004907	hsa-miR-124-3p	Microarray	18668037
MIRT045422	hsa-miR-149-5p	CLASH	23622248
MIRT1179586	hsa-miR-1200	CLIP-seq
MIRT1179587	hsa-miR-1252	CLIP-seq
MIRT1179588	hsa-miR-128	CLIP-seq
MIRT1179589	hsa-miR-185	CLIP-seq
MIRT1179590	hsa-miR-27a	CLIP-seq
MIRT1179591	hsa-miR-27b	CLIP-seq
MIRT1179592	hsa-miR-3140-5p	CLIP-seq
MIRT1179593	hsa-miR-3150b-3p	CLIP-seq
MIRT1179594	hsa-miR-3173-3p	CLIP-seq
MIRT1179595	hsa-miR-4306	CLIP-seq
MIRT1179596	hsa-miR-4428	CLIP-seq
MIRT1179597	hsa-miR-4644	CLIP-seq
MIRT1179598	hsa-miR-4784	CLIP-seq
MIRT1179599	hsa-miR-513a-5p	CLIP-seq
MIRT1179600	hsa-miR-765	CLIP-seq
MIRT1179589	hsa-miR-185	CLIP-seq
MIRT1179593	hsa-miR-3150b-3p	CLIP-seq
MIRT1179594	hsa-miR-3173-3p	CLIP-seq
MIRT1179595	hsa-miR-4306	CLIP-seq
MIRT1179597	hsa-miR-4644	CLIP-seq
MIRT1179598	hsa-miR-4784	CLIP-seq
MIRT1179600	hsa-miR-765	CLIP-seq
MIRT2051912	hsa-miR-1273e	CLIP-seq
MIRT2051913	hsa-miR-1275	CLIP-seq
MIRT2051914	hsa-miR-3158-5p	CLIP-seq
MIRT2051915	hsa-miR-3166	CLIP-seq
MIRT2051916	hsa-miR-3202	CLIP-seq
MIRT2051917	hsa-miR-3690	CLIP-seq
MIRT2051918	hsa-miR-378	CLIP-seq
MIRT2051919	hsa-miR-378b	CLIP-seq
MIRT2051920	hsa-miR-378c	CLIP-seq
MIRT2051921	hsa-miR-378d	CLIP-seq
MIRT2051922	hsa-miR-378e	CLIP-seq
MIRT2051923	hsa-miR-378f	CLIP-seq
MIRT2051924	hsa-miR-378h	CLIP-seq
MIRT2051925	hsa-miR-378i	CLIP-seq
MIRT2051926	hsa-miR-421	CLIP-seq
MIRT2051927	hsa-miR-422a	CLIP-seq
MIRT2051928	hsa-miR-4292	CLIP-seq
MIRT2051929	hsa-miR-4308	CLIP-seq
MIRT2051930	hsa-miR-4427	CLIP-seq
MIRT2051931	hsa-miR-4446-3p	CLIP-seq
MIRT2051932	hsa-miR-4530	CLIP-seq
MIRT2051933	hsa-miR-4646-5p	CLIP-seq
MIRT2051934	hsa-miR-4656	CLIP-seq
MIRT2051935	hsa-miR-4665-5p	CLIP-seq
MIRT2051936	hsa-miR-4680-3p	CLIP-seq
MIRT2051937	hsa-miR-4709-5p	CLIP-seq
MIRT2051938	hsa-miR-4714-3p	CLIP-seq
MIRT2051939	hsa-miR-4725-5p	CLIP-seq
MIRT2051940	hsa-miR-4747-5p	CLIP-seq
MIRT2051941	hsa-miR-4771	CLIP-seq
MIRT2051942	hsa-miR-4778-3p	CLIP-seq
MIRT2051943	hsa-miR-504	CLIP-seq
MIRT2051944	hsa-miR-505	CLIP-seq
MIRT2051945	hsa-miR-545	CLIP-seq
MIRT2051946	hsa-miR-581	CLIP-seq
MIRT2051947	hsa-miR-885-3p	CLIP-seq
MIRT1179588	hsa-miR-128	CLIP-seq
MIRT2281163	hsa-miR-1324	CLIP-seq
MIRT2281164	hsa-miR-188-3p	CLIP-seq
MIRT2051914	hsa-miR-3158-5p	CLIP-seq
MIRT2051915	hsa-miR-3166	CLIP-seq
MIRT2051916	hsa-miR-3202	CLIP-seq
MIRT2051928	hsa-miR-4292	CLIP-seq
MIRT2051930	hsa-miR-4427	CLIP-seq
MIRT2051931	hsa-miR-4446-3p	CLIP-seq
MIRT2281165	hsa-miR-4504	CLIP-seq
MIRT2051933	hsa-miR-4646-5p	CLIP-seq
MIRT2051934	hsa-miR-4656	CLIP-seq
MIRT2051936	hsa-miR-4680-3p	CLIP-seq
MIRT2281166	hsa-miR-4699-3p	CLIP-seq
MIRT2051939	hsa-miR-4725-5p	CLIP-seq
MIRT2051940	hsa-miR-4747-5p	CLIP-seq
MIRT2051941	hsa-miR-4771	CLIP-seq
MIRT2281167	hsa-miR-4797-5p	CLIP-seq
MIRT2051943	hsa-miR-504	CLIP-seq
MIRT2281168	hsa-miR-532-3p	CLIP-seq
MIRT2281169	hsa-miR-542-3p	CLIP-seq
MIRT2281170	hsa-miR-759	CLIP-seq
MIRT2051914	hsa-miR-3158-5p	CLIP-seq
MIRT2051915	hsa-miR-3166	CLIP-seq
MIRT2051916	hsa-miR-3202	CLIP-seq
MIRT2051928	hsa-miR-4292	CLIP-seq
MIRT2051930	hsa-miR-4427	CLIP-seq
MIRT2051931	hsa-miR-4446-3p	CLIP-seq
MIRT2051933	hsa-miR-4646-5p	CLIP-seq
MIRT2051934	hsa-miR-4656	CLIP-seq
MIRT2051936	hsa-miR-4680-3p	CLIP-seq
MIRT2051939	hsa-miR-4725-5p	CLIP-seq
MIRT2051940	hsa-miR-4747-5p	CLIP-seq
MIRT2051941	hsa-miR-4771	CLIP-seq
MIRT2051943	hsa-miR-504	CLIP-seq
MIRT2051947	hsa-miR-885-3p	CLIP-seq
MIRT2051914	hsa-miR-3158-5p	CLIP-seq
MIRT2051915	hsa-miR-3166	CLIP-seq
MIRT2051916	hsa-miR-3202	CLIP-seq
MIRT2051928	hsa-miR-4292	CLIP-seq
MIRT2051930	hsa-miR-4427	CLIP-seq
MIRT2051931	hsa-miR-4446-3p	CLIP-seq
MIRT2051933	hsa-miR-4646-5p	CLIP-seq
MIRT2051934	hsa-miR-4656	CLIP-seq
MIRT2051936	hsa-miR-4680-3p	CLIP-seq
MIRT2051939	hsa-miR-4725-5p	CLIP-seq
MIRT2051940	hsa-miR-4747-5p	CLIP-seq
MIRT2051941	hsa-miR-4771	CLIP-seq
MIRT2051943	hsa-miR-504	CLIP-seq
MIRT2051945	hsa-miR-545	CLIP-seq
MIRT2051947	hsa-miR-885-3p	CLIP-seq
MIRT2051912	hsa-miR-1273e	CLIP-seq
MIRT2051913	hsa-miR-1275	CLIP-seq
MIRT1179593	hsa-miR-3150b-3p	CLIP-seq
MIRT2051914	hsa-miR-3158-5p	CLIP-seq
MIRT2051915	hsa-miR-3166	CLIP-seq
MIRT1179594	hsa-miR-3173-3p	CLIP-seq
MIRT2579526	hsa-miR-3185	CLIP-seq
MIRT2051916	hsa-miR-3202	CLIP-seq
MIRT2579527	hsa-miR-374c	CLIP-seq
MIRT2051926	hsa-miR-421	CLIP-seq
MIRT2051928	hsa-miR-4292	CLIP-seq
MIRT2579528	hsa-miR-4317	CLIP-seq
MIRT2579529	hsa-miR-4330	CLIP-seq
MIRT2051930	hsa-miR-4427	CLIP-seq
MIRT2051931	hsa-miR-4446-3p	CLIP-seq
MIRT2579530	hsa-miR-4462	CLIP-seq
MIRT2051933	hsa-miR-4646-5p	CLIP-seq
MIRT2051934	hsa-miR-4656	CLIP-seq
MIRT2051935	hsa-miR-4665-5p	CLIP-seq
MIRT2051936	hsa-miR-4680-3p	CLIP-seq
MIRT2281166	hsa-miR-4699-3p	CLIP-seq
MIRT2051937	hsa-miR-4709-5p	CLIP-seq
MIRT2051938	hsa-miR-4714-3p	CLIP-seq
MIRT2051939	hsa-miR-4725-5p	CLIP-seq
MIRT2051940	hsa-miR-4747-5p	CLIP-seq
MIRT2051941	hsa-miR-4771	CLIP-seq
MIRT2051942	hsa-miR-4778-3p	CLIP-seq
MIRT1179598	hsa-miR-4784	CLIP-seq
MIRT2051943	hsa-miR-504	CLIP-seq
MIRT2051944	hsa-miR-505	CLIP-seq
MIRT2051945	hsa-miR-545	CLIP-seq
MIRT2579531	hsa-miR-552	CLIP-seq
MIRT2051946	hsa-miR-581	CLIP-seq
MIRT2579532	hsa-miR-616	CLIP-seq
MIRT2579533	hsa-miR-655	CLIP-seq
MIRT2579534	hsa-miR-7	CLIP-seq
MIRT1179600	hsa-miR-765	CLIP-seq
MIRT2051947	hsa-miR-885-3p	CLIP-seq
MIRT2051912	hsa-miR-1273e	CLIP-seq
MIRT2051913	hsa-miR-1275	CLIP-seq
MIRT2051914	hsa-miR-3158-5p	CLIP-seq
MIRT2051915	hsa-miR-3166	CLIP-seq
MIRT2051916	hsa-miR-3202	CLIP-seq
MIRT2579527	hsa-miR-374c	CLIP-seq
MIRT2051926	hsa-miR-421	CLIP-seq
MIRT2051928	hsa-miR-4292	CLIP-seq
MIRT2579528	hsa-miR-4317	CLIP-seq
MIRT2051930	hsa-miR-4427	CLIP-seq
MIRT2051931	hsa-miR-4446-3p	CLIP-seq
MIRT2579530	hsa-miR-4462	CLIP-seq
MIRT2051933	hsa-miR-4646-5p	CLIP-seq
MIRT2051934	hsa-miR-4656	CLIP-seq
MIRT2051935	hsa-miR-4665-5p	CLIP-seq
MIRT2051936	hsa-miR-4680-3p	CLIP-seq
MIRT2281166	hsa-miR-4699-3p	CLIP-seq
MIRT2051937	hsa-miR-4709-5p	CLIP-seq
MIRT2051938	hsa-miR-4714-3p	CLIP-seq
MIRT2051939	hsa-miR-4725-5p	CLIP-seq
MIRT2051940	hsa-miR-4747-5p	CLIP-seq
MIRT2051941	hsa-miR-4771	CLIP-seq
MIRT2051942	hsa-miR-4778-3p	CLIP-seq
MIRT2051943	hsa-miR-504	CLIP-seq
MIRT2051944	hsa-miR-505	CLIP-seq
MIRT2051945	hsa-miR-545	CLIP-seq
MIRT2579531	hsa-miR-552	CLIP-seq
MIRT2051946	hsa-miR-581	CLIP-seq
MIRT2579532	hsa-miR-616	CLIP-seq
MIRT2579533	hsa-miR-655	CLIP-seq
MIRT2051947	hsa-miR-885-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 33961781, 35271311
GO:0005886	Component	Plasma membrane	IEA
GO:0005905	Component	Clathrin-coated pit	ISS
GO:0006897	Process	Endocytosis	IEA
GO:0006897	Process	Endocytosis	ISS
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IBA
GO:0030125	Component	Clathrin vesicle coat	IBA
GO:0030125	Component	Clathrin vesicle coat	IEA
GO:0030125	Component	Clathrin vesicle coat	ISS
GO:0030665	Component	Clathrin-coated vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA

Other IDs

• MIM: 611624
• HGNC: 25528
• e!Ensembl: ENSG00000157191

Protein

• UniProt ID: Q9NVZ3
• Protein name: Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2)
• Protein function: Involved in endocytosis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07933	DUF1681	6 → 163	Protein of unknown function (DUF1681)	Domain

• Sequence:

  MEESGYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSGRLRITAKGQMAYIKLE
  DRTSGELFAQAPVDQFPGTAVESVTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFNV
  ALQDHFKWVKQQCEFAKQAQNPDQGPKLDLGFKEGQTIKLNIANMKKKEGAAGNPRVRPA
  STGGLSLLPPPPGGKTSTLIPPPGEQLAVGGSLVQPAVAPSSGGAPVPWPQPNPATADIW
  GDFTKSTGSTSSQTQPGTGWVQF

• Sequence length: 263

Pathways

Reactome Pathway

Cargo recognition for clathrin-mediated endocytosis

Clathrin-mediated endocytosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Prostate cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adult type dermatomyositis	Dermatomyositis	BEFREE	30523707		★☆☆☆☆ Found in Text Mining only
Dermatomyositis	Dermatomyositis	BEFREE	30523707		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	36531205	Stimulate	★☆☆☆☆ Found in Text Mining only
Polymyositis	Polymyositis	BEFREE	30523707		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

STON1 2 shared pathwaysClathrin-mediated endocytosis, Cargo recognition for clathrin-mediated endocytosis Related via 2 shared pathways including Clathrin-mediated endocytosis, Cargo recognition for clathrin-mediated endocytosis. FCHO2 2 shared pathwaysClathrin-mediated endocytosis, Cargo recognition for clathrin-mediated endocytosis Related via 2 shared pathways including Clathrin-mediated endocytosis, Cargo recognition for clathrin-mediated endocytosis. SYT9 2 shared pathwaysClathrin-mediated endocytosis, Cargo recognition for clathrin-mediated endocytosis Related via 2 shared pathways including Clathrin-mediated endocytosis, Cargo recognition for clathrin-mediated endocytosis. AAK1 2 shared pathwaysClathrin-mediated endocytosis, Cargo recognition for clathrin-mediated endocytosis Related via 2 shared pathways including Clathrin-mediated endocytosis, Cargo recognition for clathrin-mediated endocytosis. FCHO1 2 shared pathwaysClathrin-mediated endocytosis, Cargo recognition for clathrin-mediated endocytosis Related via 2 shared pathways including Clathrin-mediated endocytosis, Cargo recognition for clathrin-mediated endocytosis.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
STON1	0	[]	2	["Clathrin-mediated endocytosis","Cargo recognition for clathrin-mediated endocytosis"]	0	[]
FCHO2	0	[]	2	["Clathrin-mediated endocytosis","Cargo recognition for clathrin-mediated endocytosis"]	0	[]
SYT9	0	[]	2	["Clathrin-mediated endocytosis","Cargo recognition for clathrin-mediated endocytosis"]	0	[]
AAK1	0	[]	2	["Clathrin-mediated endocytosis","Cargo recognition for clathrin-mediated endocytosis"]	0	[]
FCHO1	0	[]	2	["Clathrin-mediated endocytosis","Cargo recognition for clathrin-mediated endocytosis"]	0	[]

Diseases Linked via Similar Genes

Coronary artery disease Linked via 3 of 5 related genesFCHO2, AAK1, FCHO1 Periodontal disease Linked via 2 of 5 related genesFCHO2, AAK1 Periodontitis Linked via 2 of 5 related genesFCHO2, AAK1 Post-operative atrial fibrillation Linked via 1 of 5 related genesSTON1 Amyotrophic lateral sclerosis Linked via 1 of 5 related genesSTON1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Coronary artery disease	3	["FCHO2","AAK1","FCHO1"]
Periodontal disease	2	["FCHO2","AAK1"]
Periodontitis	2	["FCHO2","AAK1"]
Post-operative atrial fibrillation	1	["STON1"]
Amyotrophic lateral sclerosis	1	["STON1"]