NECAB3 (N-terminal EF-hand calcium binding protein 3)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 63941
• Gene name: N-terminal EF-hand calcium binding protein 3
• Gene symbol: NECAB3
• Synonyms (NCBI Gene): APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5
• Chromosome: 20
• Chromosome location: 20q11.22
• Summary: The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of

miRNA Show/Hide all (218)

miRTarBase ID	miRNA	Experiments	Reference
MIRT719886	hsa-miR-2278	HITS-CLIP	19536157
MIRT719885	hsa-miR-6501-3p	HITS-CLIP	19536157
MIRT719884	hsa-miR-5193	HITS-CLIP	19536157
MIRT719883	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT719882	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT719881	hsa-miR-4755-3p	HITS-CLIP	19536157
MIRT719880	hsa-miR-6791-3p	HITS-CLIP	19536157
MIRT719878	hsa-miR-6829-3p	HITS-CLIP	19536157
MIRT719879	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT719877	hsa-miR-5006-5p	HITS-CLIP	19536157
MIRT637967	hsa-miR-583	HITS-CLIP	23824327
MIRT637966	hsa-miR-5693	HITS-CLIP	23824327
MIRT637965	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT637964	hsa-miR-6089	HITS-CLIP	23824327
MIRT637963	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT637962	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT637961	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT637960	hsa-miR-4284	HITS-CLIP	23824327
MIRT637959	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT637958	hsa-miR-7977	HITS-CLIP	23824327
MIRT637957	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT637967	hsa-miR-583	HITS-CLIP	23824327
MIRT637966	hsa-miR-5693	HITS-CLIP	23824327
MIRT637965	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT637964	hsa-miR-6089	HITS-CLIP	23824327
MIRT637963	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT637962	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT637961	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT637960	hsa-miR-4284	HITS-CLIP	23824327
MIRT637959	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT637958	hsa-miR-7977	HITS-CLIP	23824327
MIRT637957	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT461925	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT461924	hsa-miR-4476	PAR-CLIP	23592263
MIRT461923	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT461922	hsa-miR-4699-3p	PAR-CLIP	23592263
MIRT461921	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT461920	hsa-miR-764	PAR-CLIP	23592263
MIRT461919	hsa-miR-3934-5p	PAR-CLIP	23592263
MIRT461918	hsa-miR-3179	PAR-CLIP	23592263
MIRT461916	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT461917	hsa-miR-5004-5p	PAR-CLIP	23592263
MIRT461915	hsa-miR-5702	PAR-CLIP	23592263
MIRT461914	hsa-miR-3665	PAR-CLIP	23592263
MIRT461913	hsa-miR-657	PAR-CLIP	23592263
MIRT461912	hsa-miR-3202	PAR-CLIP	23592263
MIRT461911	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT461910	hsa-miR-8085	PAR-CLIP	23592263
MIRT461909	hsa-miR-3175	PAR-CLIP	23592263
MIRT461908	hsa-miR-4316	PAR-CLIP	23592263
MIRT461907	hsa-miR-1294	PAR-CLIP	23592263
MIRT461906	hsa-miR-5095	PAR-CLIP	23592263
MIRT461905	hsa-miR-7151-3p	PAR-CLIP	23592263
MIRT461904	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT461903	hsa-miR-3915	PAR-CLIP	23592263
MIRT461902	hsa-miR-937-5p	PAR-CLIP	23592263
MIRT461901	hsa-miR-495-5p	PAR-CLIP	23592263
MIRT461900	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT461899	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT461898	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT461897	hsa-miR-4459	PAR-CLIP	23592263
MIRT461896	hsa-miR-194-3p	PAR-CLIP	23592263
MIRT461895	hsa-miR-665	PAR-CLIP	23592263
MIRT461894	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT461893	hsa-miR-1827	PAR-CLIP	23592263
MIRT461892	hsa-miR-298	PAR-CLIP	23592263
MIRT461891	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT461890	hsa-miR-3612	PAR-CLIP	23592263
MIRT461889	hsa-miR-650	PAR-CLIP	23592263
MIRT461887	hsa-miR-6877-5p	PAR-CLIP	23592263
MIRT461888	hsa-miR-6781-5p	PAR-CLIP	23592263
MIRT461886	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT461885	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT461884	hsa-miR-1273e	PAR-CLIP	23592263
MIRT461884	hsa-miR-1273e	PAR-CLIP	27292025
MIRT461884	hsa-miR-1273e	PAR-CLIP	27292025
MIRT461893	hsa-miR-1827	PAR-CLIP	27292025
MIRT461899	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT461899	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT461896	hsa-miR-194-3p	PAR-CLIP	27292025
MIRT461896	hsa-miR-194-3p	PAR-CLIP	27292025
MIRT461892	hsa-miR-298	PAR-CLIP	27292025
MIRT461892	hsa-miR-298	PAR-CLIP	27292025
MIRT461890	hsa-miR-3612	PAR-CLIP	27292025
MIRT461890	hsa-miR-3612	PAR-CLIP	27292025
MIRT461897	hsa-miR-4459	PAR-CLIP	27292025
MIRT461886	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT461886	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT461900	hsa-miR-4695-5p	PAR-CLIP	27292025
MIRT461900	hsa-miR-4695-5p	PAR-CLIP	27292025
MIRT461901	hsa-miR-495-5p	PAR-CLIP	27292025
MIRT461901	hsa-miR-495-5p	PAR-CLIP	27292025
MIRT461891	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT461891	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT461889	hsa-miR-650	PAR-CLIP	27292025
MIRT461889	hsa-miR-650	PAR-CLIP	27292025
MIRT461898	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT461898	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT461885	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT461885	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT461895	hsa-miR-665	PAR-CLIP	27292025
MIRT461888	hsa-miR-6781-5p	PAR-CLIP	27292025
MIRT461888	hsa-miR-6781-5p	PAR-CLIP	27292025
MIRT461894	hsa-miR-6840-3p	PAR-CLIP	27292025
MIRT461894	hsa-miR-6840-3p	PAR-CLIP	27292025
MIRT461887	hsa-miR-6877-5p	PAR-CLIP	27292025
MIRT461887	hsa-miR-6877-5p	PAR-CLIP	27292025
MIRT719886	hsa-miR-2278	HITS-CLIP	19536157
MIRT719885	hsa-miR-6501-3p	HITS-CLIP	19536157
MIRT719884	hsa-miR-5193	HITS-CLIP	19536157
MIRT719883	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT719882	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT719881	hsa-miR-4755-3p	HITS-CLIP	19536157
MIRT719880	hsa-miR-6791-3p	HITS-CLIP	19536157
MIRT719878	hsa-miR-6829-3p	HITS-CLIP	19536157
MIRT719879	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT719877	hsa-miR-5006-5p	HITS-CLIP	19536157
MIRT637967	hsa-miR-583	HITS-CLIP	23824327
MIRT637966	hsa-miR-5693	HITS-CLIP	23824327
MIRT637965	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT637964	hsa-miR-6089	HITS-CLIP	23824327
MIRT637963	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT637962	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT637961	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT637960	hsa-miR-4284	HITS-CLIP	23824327
MIRT637959	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT637958	hsa-miR-7977	HITS-CLIP	23824327
MIRT637957	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT637967	hsa-miR-583	HITS-CLIP	23824327
MIRT637966	hsa-miR-5693	HITS-CLIP	23824327
MIRT637965	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT637964	hsa-miR-6089	HITS-CLIP	23824327
MIRT637963	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT637962	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT637961	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT637960	hsa-miR-4284	HITS-CLIP	23824327
MIRT637959	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT637958	hsa-miR-7977	HITS-CLIP	23824327
MIRT637957	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT461925	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT461924	hsa-miR-4476	PAR-CLIP	23592263
MIRT461923	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT461922	hsa-miR-4699-3p	PAR-CLIP	23592263
MIRT461921	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT461920	hsa-miR-764	PAR-CLIP	23592263
MIRT461919	hsa-miR-3934-5p	PAR-CLIP	23592263
MIRT461918	hsa-miR-3179	PAR-CLIP	23592263
MIRT461916	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT461917	hsa-miR-5004-5p	PAR-CLIP	23592263
MIRT461915	hsa-miR-5702	PAR-CLIP	23592263
MIRT461914	hsa-miR-3665	PAR-CLIP	23592263
MIRT461913	hsa-miR-657	PAR-CLIP	23592263
MIRT461912	hsa-miR-3202	PAR-CLIP	23592263
MIRT461911	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT461910	hsa-miR-8085	PAR-CLIP	23592263
MIRT461909	hsa-miR-3175	PAR-CLIP	23592263
MIRT461908	hsa-miR-4316	PAR-CLIP	23592263
MIRT461907	hsa-miR-1294	PAR-CLIP	23592263
MIRT461906	hsa-miR-5095	PAR-CLIP	23592263
MIRT461905	hsa-miR-7151-3p	PAR-CLIP	23592263
MIRT461904	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT461903	hsa-miR-3915	PAR-CLIP	23592263
MIRT461902	hsa-miR-937-5p	PAR-CLIP	23592263
MIRT461901	hsa-miR-495-5p	PAR-CLIP	23592263
MIRT461900	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT461899	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT461898	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT461897	hsa-miR-4459	PAR-CLIP	23592263
MIRT461896	hsa-miR-194-3p	PAR-CLIP	23592263
MIRT461895	hsa-miR-665	PAR-CLIP	23592263
MIRT461894	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT461893	hsa-miR-1827	PAR-CLIP	23592263
MIRT461892	hsa-miR-298	PAR-CLIP	23592263
MIRT461891	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT461890	hsa-miR-3612	PAR-CLIP	23592263
MIRT461889	hsa-miR-650	PAR-CLIP	23592263
MIRT461887	hsa-miR-6877-5p	PAR-CLIP	23592263
MIRT461888	hsa-miR-6781-5p	PAR-CLIP	23592263
MIRT461886	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT461885	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT461884	hsa-miR-1273e	PAR-CLIP	23592263
MIRT1179478	hsa-miR-125a-5p	CLIP-seq
MIRT1179479	hsa-miR-125b	CLIP-seq
MIRT1179480	hsa-miR-1275	CLIP-seq
MIRT1179481	hsa-miR-137	CLIP-seq
MIRT1179482	hsa-miR-296-3p	CLIP-seq
MIRT1179483	hsa-miR-3136-3p	CLIP-seq
MIRT1179484	hsa-miR-3150b-3p	CLIP-seq
MIRT1179485	hsa-miR-3163	CLIP-seq
MIRT1179486	hsa-miR-3187-3p	CLIP-seq
MIRT1179487	hsa-miR-3691-3p	CLIP-seq
MIRT1179488	hsa-miR-4319	CLIP-seq
MIRT1179489	hsa-miR-4435	CLIP-seq
MIRT1179490	hsa-miR-4665-5p	CLIP-seq
MIRT1179491	hsa-miR-4701-5p	CLIP-seq
MIRT1179492	hsa-miR-4732-3p	CLIP-seq
MIRT1179493	hsa-miR-4784	CLIP-seq
MIRT1179494	hsa-miR-548s	CLIP-seq
MIRT1179495	hsa-miR-588	CLIP-seq
MIRT1179496	hsa-miR-615-5p	CLIP-seq
MIRT1179497	hsa-miR-670	CLIP-seq
MIRT1179498	hsa-miR-765	CLIP-seq
MIRT1179499	hsa-miR-890	CLIP-seq
MIRT1179500	hsa-miR-944	CLIP-seq
MIRT1551652	hsa-miR-3616-5p	CLIP-seq
MIRT1551653	hsa-miR-3647-5p	CLIP-seq
MIRT1551654	hsa-miR-3929	CLIP-seq
MIRT1551655	hsa-miR-4419b	CLIP-seq
MIRT1551656	hsa-miR-4443	CLIP-seq
MIRT1551657	hsa-miR-4478	CLIP-seq
MIRT1551658	hsa-miR-4504	CLIP-seq
MIRT1551659	hsa-miR-4795-5p	CLIP-seq
MIRT1551660	hsa-miR-485-5p	CLIP-seq
MIRT1551661	hsa-miR-573	CLIP-seq
MIRT2281129	hsa-miR-4514	CLIP-seq
MIRT2281130	hsa-miR-4692	CLIP-seq
MIRT2438968	hsa-miR-378g	CLIP-seq
MIRT2438969	hsa-miR-4656	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000137	Component	Golgi cis cisterna	IBA
GO:0000137	Component	Golgi cis cisterna	IDA	10833507
GO:0000137	Component	Golgi cis cisterna	IEA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	10833507, 26948053, 28514442, 32814053, 33961781
GO:0005634	Component	Nucleus	NAS	10833507
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10833507
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	10833507
GO:0005794	Component	Golgi apparatus	IDA
GO:0005794	Component	Golgi apparatus	IEA
GO:0009306	Process	Protein secretion	NAS	12780348
GO:0019538	Process	Protein metabolic process	IDA	12780348
GO:0042984	Process	Regulation of amyloid precursor protein biosynthetic process	IBA
GO:0042984	Process	Regulation of amyloid precursor protein biosynthetic process	IDA	10833507
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 612478
• HGNC: 15851
• e!Ensembl: ENSG00000125967

Protein

• UniProt ID: Q96P71
• Protein name: N-terminal EF-hand calcium-binding protein 3 (Amyloid-beta A4 protein-binding family A member 2-binding protein) (Nek2-interacting protein 1) (Neuronal calcium-binding protein 3) (X11L-binding protein 51)
• Protein function: Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domai
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03992	ABM	295 → 370	Antibiotic biosynthesis monooxygenase	Domain
  PF13202	EF-hand_5	41 → 66	EF hand	Domain

• Tissue specificity: TISSUE SPECIFICITY: Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas. {ECO:0000269|PubMed:10833507, ECO:0000269|PubMed:12044471}.
• Sequence:

  MACAGLLTVCLLRPPAPQPQPQTPRHPQLAPDPGPAGHTLFQDVFRRADKNDDGKLSFEE
  FQNYFADGVLSLGELQELFSGIDGHLTDNLETEKLCDYFSEHLGVYRPVLAALESLNRAV
  LAAMDATKLEYERASKVDQFVTRFLLRETVSQLQALQSSLEGASDTLEAQAHGWRSDAES
  VEAQSRLCGSRRAGRRALRSVSRSSTWSPGSSDTGRSSEAEMQWRLQVNRLQELIDQLEC
  KVRAVGPGPHKGGPSWYPPEPGPCWRPGPHSVPSQAPRLEPLREEDLAKGPDLHILMAQR
  QVQVAEEGLQDFHRALRCYVDFTGAQSHCLHVSAQKMLDGASFTLYEFWQDEASWRRHQQ
  SPGSKAFQRILIDHLRAPDTLTTVFFPASWWIMNNN

• Sequence length: 396

Related Genes

No strongly related genes found yet for NECAB3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NECAB3.