Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	4725
Gene name	NADH:ubiquinone oxidoreductase subunit S5
Gene symbol	NDUFS5
Synonyms (NCBI Gene)	CI-15kCI15K
Chromosome	1
Chromosome location	1p34.3
Summary	This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mito

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miRTarBase ID	miRNA	Experiments	Reference
MIRT051532	hsa-let-7e-5p	CLASH	23622248
MIRT036146	hsa-miR-1296-5p	CLASH	23622248
MIRT692773	hsa-miR-1255b-2-3p	HITS-CLIP	23313552
MIRT692772	hsa-miR-890	HITS-CLIP	23313552
MIRT692771	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT692770	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT692769	hsa-miR-940	HITS-CLIP	23313552
MIRT692768	hsa-miR-3929	HITS-CLIP	23313552
MIRT692767	hsa-miR-4419b	HITS-CLIP	23313552
MIRT692766	hsa-miR-4478	HITS-CLIP	23313552
MIRT692765	hsa-miR-5588-3p	HITS-CLIP	23313552
MIRT692764	hsa-miR-2114-5p	HITS-CLIP	23313552
MIRT692763	hsa-miR-5690	HITS-CLIP	23313552
MIRT692762	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT692761	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT692760	hsa-miR-589-5p	HITS-CLIP	23313552
MIRT692759	hsa-miR-1827	HITS-CLIP	23313552
MIRT692758	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT692757	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT692756	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT692755	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT692754	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT692753	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT692752	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT692751	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT692750	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT692749	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT692748	hsa-miR-7977	HITS-CLIP	23313552
MIRT692747	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT692746	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT692745	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT692744	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT692743	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT692742	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT692741	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT692740	hsa-miR-3689c	HITS-CLIP	23313552
MIRT692739	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT692738	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT692737	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT692736	hsa-miR-665	HITS-CLIP	23313552
MIRT692773	hsa-miR-1255b-2-3p	HITS-CLIP	23313552
MIRT692772	hsa-miR-890	HITS-CLIP	23313552
MIRT692771	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT692770	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT692769	hsa-miR-940	HITS-CLIP	23313552
MIRT692768	hsa-miR-3929	HITS-CLIP	23313552
MIRT692767	hsa-miR-4419b	HITS-CLIP	23313552
MIRT692766	hsa-miR-4478	HITS-CLIP	23313552
MIRT692765	hsa-miR-5588-3p	HITS-CLIP	23313552
MIRT692764	hsa-miR-2114-5p	HITS-CLIP	23313552
MIRT692763	hsa-miR-5690	HITS-CLIP	23313552
MIRT692762	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT692761	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT692760	hsa-miR-589-5p	HITS-CLIP	23313552
MIRT692759	hsa-miR-1827	HITS-CLIP	23313552
MIRT692758	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT692757	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT692756	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT692755	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT692754	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT692753	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT692752	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT692751	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT692750	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT692749	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT692748	hsa-miR-7977	HITS-CLIP	23313552
MIRT692747	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT692746	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT692745	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT692744	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT692743	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT692742	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT692741	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT692740	hsa-miR-3689c	HITS-CLIP	23313552
MIRT692739	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT692738	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT692737	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT692736	hsa-miR-665	HITS-CLIP	23313552
MIRT1179223	hsa-miR-1265	CLIP-seq
MIRT1179224	hsa-miR-2392	CLIP-seq
MIRT1179225	hsa-miR-3173-3p	CLIP-seq
MIRT1179226	hsa-miR-329	CLIP-seq
MIRT1179227	hsa-miR-362-3p	CLIP-seq
MIRT1179228	hsa-miR-3941	CLIP-seq
MIRT1179229	hsa-miR-4464	CLIP-seq
MIRT1179230	hsa-miR-4534	CLIP-seq
MIRT1179231	hsa-miR-466	CLIP-seq
MIRT1179232	hsa-miR-4672	CLIP-seq
MIRT1179233	hsa-miR-4748	CLIP-seq
MIRT1179234	hsa-miR-500a	CLIP-seq
MIRT1179235	hsa-miR-501-5p	CLIP-seq
MIRT1179236	hsa-miR-514	CLIP-seq
MIRT1179237	hsa-miR-514b-3p	CLIP-seq
MIRT1179238	hsa-miR-603	CLIP-seq
MIRT2051771	hsa-miR-214	CLIP-seq
MIRT2051772	hsa-miR-3194-3p	CLIP-seq
MIRT2051773	hsa-miR-3619-5p	CLIP-seq
MIRT2051774	hsa-miR-3913-3p	CLIP-seq
MIRT2051775	hsa-miR-3925-5p	CLIP-seq
MIRT2051776	hsa-miR-4291	CLIP-seq
MIRT2051777	hsa-miR-4773	CLIP-seq
MIRT2051778	hsa-miR-646	CLIP-seq
MIRT2051779	hsa-miR-761	CLIP-seq
MIRT2051780	hsa-miR-922	CLIP-seq
MIRT2051771	hsa-miR-214	CLIP-seq
MIRT2051772	hsa-miR-3194-3p	CLIP-seq
MIRT2051773	hsa-miR-3619-5p	CLIP-seq
MIRT2051774	hsa-miR-3913-3p	CLIP-seq
MIRT2051776	hsa-miR-4291	CLIP-seq
MIRT2051778	hsa-miR-646	CLIP-seq
MIRT2051779	hsa-miR-761	CLIP-seq
MIRT2051780	hsa-miR-922	CLIP-seq
MIRT2579355	hsa-miR-145	CLIP-seq
MIRT2579356	hsa-miR-1825	CLIP-seq
MIRT2579357	hsa-miR-199a-5p	CLIP-seq
MIRT2579358	hsa-miR-199b-5p	CLIP-seq
MIRT2051771	hsa-miR-214	CLIP-seq
MIRT2579359	hsa-miR-30a	CLIP-seq
MIRT2579360	hsa-miR-30b	CLIP-seq
MIRT2579361	hsa-miR-30c	CLIP-seq
MIRT2579362	hsa-miR-30d	CLIP-seq
MIRT2579363	hsa-miR-30e	CLIP-seq
MIRT1179225	hsa-miR-3173-3p	CLIP-seq
MIRT2579364	hsa-miR-3180-5p	CLIP-seq
MIRT2051772	hsa-miR-3194-3p	CLIP-seq
MIRT2051773	hsa-miR-3619-5p	CLIP-seq
MIRT2051774	hsa-miR-3913-3p	CLIP-seq
MIRT2579365	hsa-miR-3919	CLIP-seq
MIRT2051775	hsa-miR-3925-5p	CLIP-seq
MIRT2051776	hsa-miR-4291	CLIP-seq
MIRT2579366	hsa-miR-4434	CLIP-seq
MIRT1179229	hsa-miR-4464	CLIP-seq
MIRT2579367	hsa-miR-4516	CLIP-seq
MIRT2579368	hsa-miR-4531	CLIP-seq
MIRT1179233	hsa-miR-4748	CLIP-seq
MIRT2051777	hsa-miR-4773	CLIP-seq
MIRT2051778	hsa-miR-646	CLIP-seq
MIRT2051779	hsa-miR-761	CLIP-seq
MIRT2051780	hsa-miR-922	CLIP-seq
MIRT2579355	hsa-miR-145	CLIP-seq
MIRT2579356	hsa-miR-1825	CLIP-seq
MIRT2579357	hsa-miR-199a-5p	CLIP-seq
MIRT2579358	hsa-miR-199b-5p	CLIP-seq
MIRT2051771	hsa-miR-214	CLIP-seq
MIRT2579359	hsa-miR-30a	CLIP-seq
MIRT2579360	hsa-miR-30b	CLIP-seq
MIRT2579361	hsa-miR-30c	CLIP-seq
MIRT2579362	hsa-miR-30d	CLIP-seq
MIRT2579363	hsa-miR-30e	CLIP-seq
MIRT1179225	hsa-miR-3173-3p	CLIP-seq
MIRT2579364	hsa-miR-3180-5p	CLIP-seq
MIRT2051772	hsa-miR-3194-3p	CLIP-seq
MIRT2051773	hsa-miR-3619-5p	CLIP-seq
MIRT2051774	hsa-miR-3913-3p	CLIP-seq
MIRT2579365	hsa-miR-3919	CLIP-seq
MIRT2051775	hsa-miR-3925-5p	CLIP-seq
MIRT2051776	hsa-miR-4291	CLIP-seq
MIRT2579366	hsa-miR-4434	CLIP-seq
MIRT1179229	hsa-miR-4464	CLIP-seq
MIRT2579367	hsa-miR-4516	CLIP-seq
MIRT2579368	hsa-miR-4531	CLIP-seq
MIRT1179233	hsa-miR-4748	CLIP-seq
MIRT2051777	hsa-miR-4773	CLIP-seq
MIRT2051778	hsa-miR-646	CLIP-seq
MIRT2051779	hsa-miR-761	CLIP-seq
MIRT2051780	hsa-miR-922	CLIP-seq

21 Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17500595, 32814053
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	16826196
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IDA	28844695
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005758	Component	Mitochondrial intermembrane space	IEA
GO:0006120	Process	Mitochondrial electron transport, NADH to ubiquinone	NAS	9878551, 10070614
GO:0008137	Function	NADH dehydrogenase (ubiquinone) activity	NAS	9878551, 10070614
GO:0009060	Process	Aerobic respiration	NAS	30030361
GO:0016020	Component	Membrane	IEA
GO:0032981	Process	Mitochondrial respiratory chain complex I assembly	IBA
GO:0032981	Process	Mitochondrial respiratory chain complex I assembly	IMP	11112787
GO:0042776	Process	Proton motive force-driven mitochondrial ATP synthesis	NAS	30030361
GO:0045271	Component	Respiratory chain complex I	IBA
GO:0045271	Component	Respiratory chain complex I	IDA	12611891, 27626371
GO:0045271	Component	Respiratory chain complex I	IEA
GO:0045271	Component	Respiratory chain complex I	NAS	9878551, 10070614
GO:1902600	Process	Proton transmembrane transport	IEA

MIM	HGNC	e!Ensembl
603847	7712	ENSG00000168653

O43920

Protein name

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (Complex I-15 kDa) (CI-15 kDa) (NADH-ubiquinone oxidoreductase 15 kDa subunit)

Protein function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediat

PDB

5XTC , 5XTD , 5XTH , 5XTI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10200	Ndufs5	1 → 96	NADH:ubiquinone oxidoreductase, NDUFS5-15kDa	Family

Sequence

MPFLDIQKRFGLNIDRWLTIQSGEQPYKMAGRCHAFEKEWIECAHGIGYTRAEKECKIEY
DDFVECLLRQKTMRRAGTIRKQRDKLIKEGKYTPPPHHIGKGEPRP

Sequence length

106

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Oxidative phosphorylation	Respiratory electron transport
Metabolic pathways	Complex I biogenesis
Thermogenesis
Retrograde endocannabinoid signaling
Non-alcoholic fatty liver disease
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Chemical carcinogenesis - reactive oxygen species
Diabetic cardiomyopathy

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
METABOLIC SYNDROME	—	GWAS catalog	39349817	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SKIN DISEASE	—	GWAS catalog	39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	39349817	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (9)
Alzheimer Disease	Alzheimer disease	Pubtator	37334608	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	37545529	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Dilated	Dilated cardiomyopathy	Pubtator	32138671	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognitive Dysfunction	Cognition disorder	Pubtator	37334608	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	34863158	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Failure	Heart failure	Pubtator	32138671	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial Diseases	GENOMICS_ENGLAND_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	30782949	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ventricular Remodeling	Ventricular remodeling	Pubtator	32138671	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
NDUFA11	[]	10	["Oxidative phosphorylation","Thermogenesis","Retrograde endocannabinoid signaling","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","Respiratory electron transport","Complex I biogenesis"]	[]
NDUFS7	[]	10	["Oxidative phosphorylation","Thermogenesis","Retrograde endocannabinoid signaling","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","Respiratory electron transport","Complex I biogenesis"]	[]
NDUFA1	[]	10	["Oxidative phosphorylation","Thermogenesis","Retrograde endocannabinoid signaling","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","Respiratory electron transport","Complex I biogenesis"]	[]
NDUFA2	[]	10	["Oxidative phosphorylation","Thermogenesis","Retrograde endocannabinoid signaling","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","Respiratory electron transport","Complex I biogenesis"]	[]
NDUFA3	[]	10	["Oxidative phosphorylation","Thermogenesis","Retrograde endocannabinoid signaling","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","Respiratory electron transport","Complex I biogenesis"]	[]

NDUFS5 (NADH:ubiquinone oxidoreductase subunit S5)

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