Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	4717
Gene name	NADH:ubiquinone oxidoreductase subunit C1
Gene symbol	NDUFC1
Synonyms (NCBI Gene)	KFYI
Chromosome	4
Chromosome location	4q31.1
Summary	The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. [provid

57 Show/Hide all (57)

miRTarBase ID	miRNA	Experiments
MIRT1179069	hsa-miR-3125	CLIP-seq
MIRT1179070	hsa-miR-34b	CLIP-seq
MIRT1179071	hsa-miR-34c-3p	CLIP-seq
MIRT1179072	hsa-miR-3916	CLIP-seq
MIRT1179073	hsa-miR-3928	CLIP-seq
MIRT1179074	hsa-miR-4705	CLIP-seq
MIRT1179075	hsa-miR-520a-5p	CLIP-seq
MIRT1179076	hsa-miR-525-5p	CLIP-seq
MIRT1179077	hsa-miR-23a	CLIP-seq
MIRT1179078	hsa-miR-23b	CLIP-seq
MIRT1179079	hsa-miR-23c	CLIP-seq
MIRT1179069	hsa-miR-3125	CLIP-seq
MIRT1179080	hsa-miR-342-3p	CLIP-seq
MIRT1179070	hsa-miR-34b	CLIP-seq
MIRT1179071	hsa-miR-34c-3p	CLIP-seq
MIRT1179072	hsa-miR-3916	CLIP-seq
MIRT1179073	hsa-miR-3928	CLIP-seq
MIRT1179081	hsa-miR-410	CLIP-seq
MIRT1179082	hsa-miR-421	CLIP-seq
MIRT1179074	hsa-miR-4705	CLIP-seq
MIRT1179083	hsa-miR-4709-5p	CLIP-seq
MIRT1179084	hsa-miR-4768-5p	CLIP-seq
MIRT1179075	hsa-miR-520a-5p	CLIP-seq
MIRT1179076	hsa-miR-525-5p	CLIP-seq
MIRT1179077	hsa-miR-23a	CLIP-seq
MIRT1179078	hsa-miR-23b	CLIP-seq
MIRT1179079	hsa-miR-23c	CLIP-seq
MIRT1179069	hsa-miR-3125	CLIP-seq
MIRT2051765	hsa-miR-323-3p	CLIP-seq
MIRT1179080	hsa-miR-342-3p	CLIP-seq
MIRT1179070	hsa-miR-34b	CLIP-seq
MIRT1179071	hsa-miR-34c-3p	CLIP-seq
MIRT2051766	hsa-miR-3591-5p	CLIP-seq
MIRT1179072	hsa-miR-3916	CLIP-seq
MIRT1179073	hsa-miR-3928	CLIP-seq
MIRT1179082	hsa-miR-421	CLIP-seq
MIRT2051767	hsa-miR-4255	CLIP-seq
MIRT1179074	hsa-miR-4705	CLIP-seq
MIRT1179083	hsa-miR-4709-5p	CLIP-seq
MIRT1179084	hsa-miR-4768-5p	CLIP-seq
MIRT1179075	hsa-miR-520a-5p	CLIP-seq
MIRT1179076	hsa-miR-525-5p	CLIP-seq
MIRT1179077	hsa-miR-23a	CLIP-seq
MIRT1179078	hsa-miR-23b	CLIP-seq
MIRT1179079	hsa-miR-23c	CLIP-seq
MIRT1179069	hsa-miR-3125	CLIP-seq
MIRT2051765	hsa-miR-323-3p	CLIP-seq
MIRT1179080	hsa-miR-342-3p	CLIP-seq
MIRT1179070	hsa-miR-34b	CLIP-seq
MIRT1179071	hsa-miR-34c-3p	CLIP-seq
MIRT1179072	hsa-miR-3916	CLIP-seq
MIRT1179073	hsa-miR-3928	CLIP-seq
MIRT1179082	hsa-miR-421	CLIP-seq
MIRT1179074	hsa-miR-4705	CLIP-seq
MIRT1179083	hsa-miR-4709-5p	CLIP-seq
MIRT1179075	hsa-miR-520a-5p	CLIP-seq
MIRT1179076	hsa-miR-525-5p	CLIP-seq

18 Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IDA	28844695
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006120	Process	Mitochondrial electron transport, NADH to ubiquinone	NAS	9878551
GO:0006120	Process	Mitochondrial electron transport, NADH to ubiquinone	TAS	9425316
GO:0008137	Function	NADH dehydrogenase (ubiquinone) activity	NAS	9878551
GO:0008137	Function	NADH dehydrogenase (ubiquinone) activity	TAS	9425316
GO:0009060	Process	Aerobic respiration	NAS	30030361
GO:0016020	Component	Membrane	IEA
GO:0042776	Process	Proton motive force-driven mitochondrial ATP synthesis	NAS	30030361
GO:0045271	Component	Respiratory chain complex I	IBA
GO:0045271	Component	Respiratory chain complex I	IDA	27626371
GO:0045271	Component	Respiratory chain complex I	IEA
GO:0045271	Component	Respiratory chain complex I	NAS	9878551
GO:1902600	Process	Proton transmembrane transport	IEA

MIM	HGNC	e!Ensembl
603844	7705	ENSG00000109390

O43677

Protein name

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial (Complex I-KFYI) (CI-KFYI) (NADH-ubiquinone oxidoreductase KFYI subunit)

Protein function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediat

PDB

5XTC , 5XTD , 5XTH , 5XTI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15088	NADH_dh_m_C1	28 → 76	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	Family

Sequence

MAPSALLRPLSRLLAPARLPSGPSVRSKFYVREPPNAKPDWLKVGFTLGTTVFLWIYLIK
QHNEDILEYKRRNGLE

Sequence length

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Oxidative phosphorylation	Respiratory electron transport
Metabolic pathways	Complex I biogenesis
Thermogenesis
Retrograde endocannabinoid signaling
Non-alcoholic fatty liver disease
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Chemical carcinogenesis - reactive oxygen species
Diabetic cardiomyopathy

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
NDUFA11	[]	10	["Oxidative phosphorylation","Thermogenesis","Retrograde endocannabinoid signaling","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","Respiratory electron transport","Complex I biogenesis"]	[]
NDUFS7	[]	10	["Oxidative phosphorylation","Thermogenesis","Retrograde endocannabinoid signaling","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","Respiratory electron transport","Complex I biogenesis"]	[]
NDUFA1	[]	10	["Oxidative phosphorylation","Thermogenesis","Retrograde endocannabinoid signaling","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","Respiratory electron transport","Complex I biogenesis"]	[]
NDUFA2	[]	10	["Oxidative phosphorylation","Thermogenesis","Retrograde endocannabinoid signaling","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","Respiratory electron transport","Complex I biogenesis"]	[]
NDUFA3	[]	10	["Oxidative phosphorylation","Thermogenesis","Retrograde endocannabinoid signaling","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","Respiratory electron transport","Complex I biogenesis"]	[]

NDUFC1 (NADH:ubiquinone oxidoreductase subunit C1)

Save This Analysis