Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	4712
Gene name	NADH:ubiquinone oxidoreductase subunit B6
Gene symbol	NDUFB6
Synonyms (NCBI Gene)	B17CI
Chromosome	9
Chromosome location	9p21.1
Summary	The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase act

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021295	hsa-miR-125a-5p	Sequencing	20371350
MIRT025612	hsa-miR-10a-5p	Sequencing	20371350
MIRT044986	hsa-miR-186-5p	CLASH	23622248
MIRT044986	hsa-miR-186-5p	CLASH	23622248
MIRT454746	hsa-miR-495-3p	PAR-CLIP	23592263
MIRT454745	hsa-miR-5688	PAR-CLIP	23592263
MIRT454744	hsa-miR-1277-5p	PAR-CLIP	23592263
MIRT454743	hsa-miR-5583-3p	PAR-CLIP	23592263
MIRT454742	hsa-miR-3914	PAR-CLIP	23592263
MIRT454741	hsa-miR-5579-5p	PAR-CLIP	23592263
MIRT454740	hsa-miR-545-5p	PAR-CLIP	23592263
MIRT454739	hsa-miR-222-5p	PAR-CLIP	23592263
MIRT454746	hsa-miR-495-3p	PAR-CLIP	23592263
MIRT454745	hsa-miR-5688	PAR-CLIP	23592263
MIRT454744	hsa-miR-1277-5p	PAR-CLIP	23592263
MIRT454743	hsa-miR-5583-3p	PAR-CLIP	23592263
MIRT454742	hsa-miR-3914	PAR-CLIP	23592263
MIRT454741	hsa-miR-5579-5p	PAR-CLIP	23592263
MIRT454740	hsa-miR-545-5p	PAR-CLIP	23592263
MIRT454739	hsa-miR-222-5p	PAR-CLIP	23592263
MIRT1179034	hsa-miR-1208	CLIP-seq
MIRT1179035	hsa-miR-153	CLIP-seq
MIRT1179036	hsa-miR-3145-3p	CLIP-seq
MIRT1179037	hsa-miR-3180-5p	CLIP-seq
MIRT1179038	hsa-miR-3647-3p	CLIP-seq
MIRT1179039	hsa-miR-3689a-5p	CLIP-seq
MIRT1179040	hsa-miR-3689b	CLIP-seq
MIRT1179041	hsa-miR-3689e	CLIP-seq
MIRT1179042	hsa-miR-3689f	CLIP-seq
MIRT1179043	hsa-miR-4420	CLIP-seq
MIRT1179044	hsa-miR-4477a	CLIP-seq
MIRT1179045	hsa-miR-448	CLIP-seq
MIRT1179046	hsa-miR-4684-3p	CLIP-seq
MIRT1179047	hsa-miR-520a-5p	CLIP-seq
MIRT1179048	hsa-miR-525-5p	CLIP-seq
MIRT1179049	hsa-miR-561	CLIP-seq
MIRT1179037	hsa-miR-3180-5p	CLIP-seq
MIRT1179038	hsa-miR-3647-3p	CLIP-seq
MIRT2579328	hsa-miR-4251	CLIP-seq
MIRT2579329	hsa-miR-4303	CLIP-seq
MIRT2579330	hsa-miR-4329	CLIP-seq
MIRT1179044	hsa-miR-4477a	CLIP-seq
MIRT2579331	hsa-miR-4762-3p	CLIP-seq
MIRT2579332	hsa-miR-495	CLIP-seq
MIRT1179047	hsa-miR-520a-5p	CLIP-seq
MIRT1179048	hsa-miR-525-5p	CLIP-seq
MIRT1179049	hsa-miR-561	CLIP-seq
MIRT1179037	hsa-miR-3180-5p	CLIP-seq
MIRT1179038	hsa-miR-3647-3p	CLIP-seq
MIRT2579328	hsa-miR-4251	CLIP-seq
MIRT2579329	hsa-miR-4303	CLIP-seq
MIRT2579330	hsa-miR-4329	CLIP-seq
MIRT1179044	hsa-miR-4477a	CLIP-seq
MIRT2579331	hsa-miR-4762-3p	CLIP-seq
MIRT2579332	hsa-miR-495	CLIP-seq
MIRT1179047	hsa-miR-520a-5p	CLIP-seq
MIRT1179048	hsa-miR-525-5p	CLIP-seq
MIRT1179049	hsa-miR-561	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IDA	28844695
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006120	Process	Mitochondrial electron transport, NADH to ubiquinone	IEA
GO:0006120	Process	Mitochondrial electron transport, NADH to ubiquinone	NAS	9878551
GO:0006120	Process	Mitochondrial electron transport, NADH to ubiquinone	TAS	9760212
GO:0008137	Function	NADH dehydrogenase (ubiquinone) activity	NAS	9878551
GO:0008137	Function	NADH dehydrogenase (ubiquinone) activity	TAS	9760212
GO:0009060	Process	Aerobic respiration	NAS	30030361
GO:0016020	Component	Membrane	IEA
GO:0031966	Component	Mitochondrial membrane	IDA	17209039
GO:0042775	Process	Mitochondrial ATP synthesis coupled electron transport	IBA
GO:0042775	Process	Mitochondrial ATP synthesis coupled electron transport	IMP	24746669
GO:0042776	Process	Proton motive force-driven mitochondrial ATP synthesis	NAS	30030361
GO:0045271	Component	Respiratory chain complex I	IBA
GO:0045271	Component	Respiratory chain complex I	IDA	12611891, 17209039, 27626371
GO:0045271	Component	Respiratory chain complex I	IEA
GO:0045271	Component	Respiratory chain complex I	IMP	24746669
GO:0045271	Component	Respiratory chain complex I	NAS	9878551
GO:1902600	Process	Proton transmembrane transport	IEA

MIM	HGNC	e!Ensembl
603322	7701	ENSG00000165264

O95139

Protein name

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (Complex I-B17) (CI-B17) (NADH-ubiquinone oxidoreductase B17 subunit)

Protein function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediat

PDB

5XTC , 5XTD , 5XTH , 5XTI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09782	NDUF_B6	1 → 128	NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit	Family

Sequence

MTGYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPQKMGPMEKFWNKFLENKSPWRKM
VHGVYKKSIFVFTHVLVPVWIIHYYMKYHVSEKPYGIVEKKSRIFPGDTILETGEVIPPM
KEFPDQHH

Sequence length

128

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Oxidative phosphorylation	Respiratory electron transport
Metabolic pathways	Complex I biogenesis
Thermogenesis
Retrograde endocannabinoid signaling
Non-alcoholic fatty liver disease
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Chemical carcinogenesis - reactive oxygen species
Diabetic cardiomyopathy

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cervical cancer	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (13)
Arthritis	Arthritis	Pubtator	2344212	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	25315157	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	25315157		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	17948130	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Failure	Heart failure	Pubtator	36782329	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	38253683	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	29992774		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myoclonic Epilepsy Juvenile	Myoclonic epilepsy	Pubtator	7670762	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myotonic Dystrophy	Myotonic dystrophy	Pubtator	38240888	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25315157		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	29992774		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	29992774	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
NDUFA11	[]	10	["Oxidative phosphorylation","Thermogenesis","Retrograde endocannabinoid signaling","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","Respiratory electron transport","Complex I biogenesis"]	[]
NDUFS7	[]	10	["Oxidative phosphorylation","Thermogenesis","Retrograde endocannabinoid signaling","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","Respiratory electron transport","Complex I biogenesis"]	[]
NDUFA1	[]	10	["Oxidative phosphorylation","Thermogenesis","Retrograde endocannabinoid signaling","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","Respiratory electron transport","Complex I biogenesis"]	[]
NDUFA2	[]	10	["Oxidative phosphorylation","Thermogenesis","Retrograde endocannabinoid signaling","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","Respiratory electron transport","Complex I biogenesis"]	[]
NDUFA3	[]	10	["Oxidative phosphorylation","Thermogenesis","Retrograde endocannabinoid signaling","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","Respiratory electron transport","Complex I biogenesis"]	[]

NDUFB6 (NADH:ubiquinone oxidoreductase subunit B6)

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