NDUFB1 (NADH:ubiquinone oxidoreductase subunit B1)

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Gene Gene information from NCBI Gene database.
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Entrez ID 4707
Gene name NADH:ubiquinone oxidoreductase subunit B1
Gene symbol NDUFB1
Synonyms (NCBI Gene)
CI-MNLLCI-SGDHMNLL
Chromosome 14
Chromosome location 14q32.12
miRNA miRNA information provided by mirtarbase database.
1
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miRTarBase ID miRNA Experiments Reference
MIRT029976 hsa-miR-26b-5p Microarray 19088304
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19 Show/Hide all (19)
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GO ID Ontology Definition Evidence Reference
GO:0005739 Component Mitochondrion HTP 34800366
GO:0005739 Component Mitochondrion IDA
GO:0005739 Component Mitochondrion IEA
GO:0005743 Component Mitochondrial inner membrane IDA 28844695
GO:0005743 Component Mitochondrial inner membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
603837 7695 ENSG00000183648
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75438
Protein name NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (Complex I-MNLL) (CI-MNLL) (NADH-ubiquinone oxidoreductase MNLL subunit)
Protein function Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate
PDB 5XTC , 5XTD , 5XTH , 5XTI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08040 NADH_oxidored 1 → 58 MNLL subunit Family
Sequence 
MVNLLQIVRDHWVHVLVPMGFVIGCYLDRKSDERLTAFRNKSMLFKRELQPSEEVTWK
Sequence length 58
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
Oxidative phosphorylation Respiratory electron transport
Metabolic pathways Complex I biogenesis
Thermogenesis  
Retrograde endocannabinoid signaling  
Non-alcoholic fatty liver disease  
Alzheimer disease  
Parkinson disease  
Amyotrophic lateral sclerosis  
Huntington disease  
Prion disease  
Pathways of neurodegeneration - multiple diseases  
Chemical carcinogenesis - reactive oxygen species  
Diabetic cardiomyopathy  
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NDUFA11 10 shared pathwaysOxidative phosphorylation, Thermogenesis, Retrograde endocannabinoid signaling, Non-alcoholic fatty liver disease, Parkinson disease, Prion disease, Chemical carcinogenesis - reactive oxygen species, Diabetic cardiomyopathy, Respiratory electron transport, Complex I biogenesis Related via 10 shared pathways including Oxidative phosphorylation, Thermogenesis. NDUFS7 10 shared pathwaysOxidative phosphorylation, Thermogenesis, Retrograde endocannabinoid signaling, Non-alcoholic fatty liver disease, Parkinson disease, Prion disease, Chemical carcinogenesis - reactive oxygen species, Diabetic cardiomyopathy, Respiratory electron transport, Complex I biogenesis Related via 10 shared pathways including Oxidative phosphorylation, Thermogenesis. NDUFA1 10 shared pathwaysOxidative phosphorylation, Thermogenesis, Retrograde endocannabinoid signaling, Non-alcoholic fatty liver disease, Parkinson disease, Prion disease, Chemical carcinogenesis - reactive oxygen species, Diabetic cardiomyopathy, Respiratory electron transport, Complex I biogenesis Related via 10 shared pathways including Oxidative phosphorylation, Thermogenesis. NDUFA2 10 shared pathwaysOxidative phosphorylation, Thermogenesis, Retrograde endocannabinoid signaling, Non-alcoholic fatty liver disease, Parkinson disease, Prion disease, Chemical carcinogenesis - reactive oxygen species, Diabetic cardiomyopathy, Respiratory electron transport, Complex I biogenesis Related via 10 shared pathways including Oxidative phosphorylation, Thermogenesis. NDUFA3 10 shared pathwaysOxidative phosphorylation, Thermogenesis, Retrograde endocannabinoid signaling, Non-alcoholic fatty liver disease, Parkinson disease, Prion disease, Chemical carcinogenesis - reactive oxygen species, Diabetic cardiomyopathy, Respiratory electron transport, Complex I biogenesis Related via 10 shared pathways including Oxidative phosphorylation, Thermogenesis.
Mitochondrial complex deficiency Linked via 4 of 5 related genesNDUFA11, NDUFS7, NDUFA1, NDUFA2 Mitochondrial disease Linked via 4 of 5 related genesNDUFA11, NDUFS7, NDUFA1, NDUFA2 Leigh syndrome Linked via 4 of 5 related genesNDUFS7, NDUFA1, NDUFA2, NDUFA3 Attention deficit hyperactivity disorder Linked via 1 of 5 related genesNDUFA2 Autism Linked via 1 of 5 related genesNDUFA2