NDOR1 (NADPH dependent diflavin oxidoreductase 1)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 27158
• Gene name: NADPH dependent diflavin oxidoreductase 1
• Gene symbol: NDOR1
• Synonyms (NCBI Gene): CIAE1, NR1, bA350O14.9
• Chromosome: 9
• Chromosome location: 9q34.3
• Summary: This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors

miRNA Show/Hide all (229)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045962	hsa-miR-125b-5p	CLASH	23622248
MIRT045962	hsa-miR-125b-5p	CLASH	23622248
MIRT040948	hsa-miR-18a-3p	CLASH	23622248
MIRT486830	hsa-miR-4446-3p	PAR-CLIP	23592263
MIRT486829	hsa-miR-6823-5p	PAR-CLIP	23592263
MIRT486828	hsa-miR-6132	PAR-CLIP	23592263
MIRT486826	hsa-miR-6836-5p	PAR-CLIP	23592263
MIRT486827	hsa-miR-5580-5p	PAR-CLIP	23592263
MIRT486825	hsa-miR-6090	PAR-CLIP	23592263
MIRT486824	hsa-miR-4492	PAR-CLIP	23592263
MIRT486823	hsa-miR-4498	PAR-CLIP	23592263
MIRT486822	hsa-miR-5001-5p	PAR-CLIP	23592263
MIRT486821	hsa-miR-762	PAR-CLIP	23592263
MIRT486819	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT486820	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT486818	hsa-miR-5698	PAR-CLIP	23592263
MIRT486817	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT486816	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT486815	hsa-miR-4525	PAR-CLIP	23592263
MIRT486814	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT486813	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT486812	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT486811	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT486810	hsa-miR-4447	PAR-CLIP	23592263
MIRT486808	hsa-miR-4472	PAR-CLIP	23592263
MIRT486809	hsa-miR-1275	PAR-CLIP	23592263
MIRT486807	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT486806	hsa-miR-937-5p	PAR-CLIP	23592263
MIRT444686	hsa-miR-1304-3p	PAR-CLIP	22100165
MIRT444685	hsa-miR-4795-5p	PAR-CLIP	22100165
MIRT444684	hsa-miR-653-3p	PAR-CLIP	22100165
MIRT444683	hsa-miR-3136-5p	PAR-CLIP	22100165
MIRT444681	hsa-miR-4439	PAR-CLIP	22100165
MIRT444682	hsa-miR-943	PAR-CLIP	22100165
MIRT444680	hsa-miR-5009-5p	PAR-CLIP	22100165
MIRT444679	hsa-miR-8058	PAR-CLIP	22100165
MIRT444686	hsa-miR-1304-3p	PAR-CLIP	22100165
MIRT444685	hsa-miR-4795-5p	PAR-CLIP	22100165
MIRT444684	hsa-miR-653-3p	PAR-CLIP	22100165
MIRT444683	hsa-miR-3136-5p	PAR-CLIP	22100165
MIRT444681	hsa-miR-4439	PAR-CLIP	22100165
MIRT444682	hsa-miR-943	PAR-CLIP	22100165
MIRT444680	hsa-miR-5009-5p	PAR-CLIP	22100165
MIRT444679	hsa-miR-8058	PAR-CLIP	22100165
MIRT486830	hsa-miR-4446-3p	PAR-CLIP	23592263
MIRT486829	hsa-miR-6823-5p	PAR-CLIP	23592263
MIRT486828	hsa-miR-6132	PAR-CLIP	23592263
MIRT486826	hsa-miR-6836-5p	PAR-CLIP	23592263
MIRT486827	hsa-miR-5580-5p	PAR-CLIP	23592263
MIRT486825	hsa-miR-6090	PAR-CLIP	23592263
MIRT486824	hsa-miR-4492	PAR-CLIP	23592263
MIRT486823	hsa-miR-4498	PAR-CLIP	23592263
MIRT486822	hsa-miR-5001-5p	PAR-CLIP	23592263
MIRT486821	hsa-miR-762	PAR-CLIP	23592263
MIRT486819	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT486820	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT486818	hsa-miR-5698	PAR-CLIP	23592263
MIRT486817	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT486816	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT486815	hsa-miR-4525	PAR-CLIP	23592263
MIRT486814	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT486813	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT486812	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT486811	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT486810	hsa-miR-4447	PAR-CLIP	23592263
MIRT486808	hsa-miR-4472	PAR-CLIP	23592263
MIRT486809	hsa-miR-1275	PAR-CLIP	23592263
MIRT486807	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT486806	hsa-miR-937-5p	PAR-CLIP	23592263
MIRT444686	hsa-miR-1304-3p	PAR-CLIP	22100165
MIRT444685	hsa-miR-4795-5p	PAR-CLIP	22100165
MIRT444684	hsa-miR-653-3p	PAR-CLIP	22100165
MIRT444683	hsa-miR-3136-5p	PAR-CLIP	22100165
MIRT444681	hsa-miR-4439	PAR-CLIP	22100165
MIRT444682	hsa-miR-943	PAR-CLIP	22100165
MIRT444680	hsa-miR-5009-5p	PAR-CLIP	22100165
MIRT444679	hsa-miR-8058	PAR-CLIP	22100165
MIRT444686	hsa-miR-1304-3p	PAR-CLIP	22100165
MIRT444685	hsa-miR-4795-5p	PAR-CLIP	22100165
MIRT444684	hsa-miR-653-3p	PAR-CLIP	22100165
MIRT444683	hsa-miR-3136-5p	PAR-CLIP	22100165
MIRT444681	hsa-miR-4439	PAR-CLIP	22100165
MIRT444682	hsa-miR-943	PAR-CLIP	22100165
MIRT444680	hsa-miR-5009-5p	PAR-CLIP	22100165
MIRT444679	hsa-miR-8058	PAR-CLIP	22100165
MIRT1178087	hsa-miR-1909	CLIP-seq
MIRT1178088	hsa-miR-214	CLIP-seq
MIRT1178089	hsa-miR-3064-5p	CLIP-seq
MIRT1178090	hsa-miR-3182	CLIP-seq
MIRT1178091	hsa-miR-338-3p	CLIP-seq
MIRT1178092	hsa-miR-361-3p	CLIP-seq
MIRT1178093	hsa-miR-3619-5p	CLIP-seq
MIRT1178094	hsa-miR-4283	CLIP-seq
MIRT1178095	hsa-miR-4284	CLIP-seq
MIRT1178096	hsa-miR-4437	CLIP-seq
MIRT1178097	hsa-miR-4467	CLIP-seq
MIRT1178098	hsa-miR-4530	CLIP-seq
MIRT1178099	hsa-miR-4687-3p	CLIP-seq
MIRT1178100	hsa-miR-761	CLIP-seq
MIRT1178101	hsa-miR-892b	CLIP-seq
MIRT1178102	hsa-miR-296-5p	CLIP-seq
MIRT1178103	hsa-miR-3922-5p	CLIP-seq
MIRT1178104	hsa-miR-4279	CLIP-seq
MIRT1178105	hsa-miR-4708-3p	CLIP-seq
MIRT1178106	hsa-miR-4763-5p	CLIP-seq
MIRT1178107	hsa-miR-103a	CLIP-seq
MIRT1178108	hsa-miR-107	CLIP-seq
MIRT1178109	hsa-miR-1184	CLIP-seq
MIRT1178110	hsa-miR-1234	CLIP-seq
MIRT1178111	hsa-miR-15a	CLIP-seq
MIRT1178112	hsa-miR-15b	CLIP-seq
MIRT1178113	hsa-miR-16	CLIP-seq
MIRT1178114	hsa-miR-1915	CLIP-seq
MIRT1178115	hsa-miR-195	CLIP-seq
MIRT1178088	hsa-miR-214	CLIP-seq
MIRT1178116	hsa-miR-2278	CLIP-seq
MIRT1178117	hsa-miR-2467-3p	CLIP-seq
MIRT1178118	hsa-miR-3137	CLIP-seq
MIRT1178119	hsa-miR-3616-3p	CLIP-seq
MIRT1178093	hsa-miR-3619-5p	CLIP-seq
MIRT1178120	hsa-miR-3944-5p	CLIP-seq
MIRT1178121	hsa-miR-424	CLIP-seq
MIRT1178122	hsa-miR-4268	CLIP-seq
MIRT1178123	hsa-miR-4274	CLIP-seq
MIRT1178124	hsa-miR-4323	CLIP-seq
MIRT1178125	hsa-miR-4436b-3p	CLIP-seq
MIRT1178126	hsa-miR-4524	CLIP-seq
MIRT1178098	hsa-miR-4530	CLIP-seq
MIRT1178127	hsa-miR-4660	CLIP-seq
MIRT1178128	hsa-miR-4685-5p	CLIP-seq
MIRT1178129	hsa-miR-4721	CLIP-seq
MIRT1178130	hsa-miR-4722-5p	CLIP-seq
MIRT1178131	hsa-miR-486-5p	CLIP-seq
MIRT1178132	hsa-miR-497	CLIP-seq
MIRT1178133	hsa-miR-503	CLIP-seq
MIRT1178134	hsa-miR-634	CLIP-seq
MIRT1178135	hsa-miR-646	CLIP-seq
MIRT1178136	hsa-miR-663b	CLIP-seq
MIRT1178137	hsa-miR-665	CLIP-seq
MIRT1178100	hsa-miR-761	CLIP-seq
MIRT1178138	hsa-miR-1	CLIP-seq
MIRT1178139	hsa-miR-1207-3p	CLIP-seq
MIRT1178140	hsa-miR-134	CLIP-seq
MIRT1178141	hsa-miR-206	CLIP-seq
MIRT1178089	hsa-miR-3064-5p	CLIP-seq
MIRT1178142	hsa-miR-3118	CLIP-seq
MIRT1178143	hsa-miR-34a	CLIP-seq
MIRT1178144	hsa-miR-34c-5p	CLIP-seq
MIRT1178145	hsa-miR-3605-5p	CLIP-seq
MIRT1178146	hsa-miR-3652	CLIP-seq
MIRT1178147	hsa-miR-3673	CLIP-seq
MIRT1178148	hsa-miR-4430	CLIP-seq
MIRT1178149	hsa-miR-449a	CLIP-seq
MIRT1178150	hsa-miR-449b	CLIP-seq
MIRT1178151	hsa-miR-4505	CLIP-seq
MIRT1178152	hsa-miR-4706	CLIP-seq
MIRT1178153	hsa-miR-4749-5p	CLIP-seq
MIRT1178154	hsa-miR-4751	CLIP-seq
MIRT1178155	hsa-miR-486-3p	CLIP-seq
MIRT1178156	hsa-miR-613	CLIP-seq
MIRT1178157	hsa-miR-744	CLIP-seq
MIRT1178110	hsa-miR-1234	CLIP-seq
MIRT1178111	hsa-miR-15a	CLIP-seq
MIRT1178112	hsa-miR-15b	CLIP-seq
MIRT1178113	hsa-miR-16	CLIP-seq
MIRT1178115	hsa-miR-195	CLIP-seq
MIRT1178118	hsa-miR-3137	CLIP-seq
MIRT1178119	hsa-miR-3616-3p	CLIP-seq
MIRT1178121	hsa-miR-424	CLIP-seq
MIRT1178126	hsa-miR-4524	CLIP-seq
MIRT1178129	hsa-miR-4721	CLIP-seq
MIRT1178132	hsa-miR-497	CLIP-seq
MIRT1178133	hsa-miR-503	CLIP-seq
MIRT1178135	hsa-miR-646	CLIP-seq
MIRT2051521	hsa-miR-1250	CLIP-seq
MIRT1178111	hsa-miR-15a	CLIP-seq
MIRT1178112	hsa-miR-15b	CLIP-seq
MIRT1178113	hsa-miR-16	CLIP-seq
MIRT1178087	hsa-miR-1909	CLIP-seq
MIRT1178114	hsa-miR-1915	CLIP-seq
MIRT1178115	hsa-miR-195	CLIP-seq
MIRT1178088	hsa-miR-214	CLIP-seq
MIRT2051522	hsa-miR-3189-3p	CLIP-seq
MIRT2051523	hsa-miR-3202	CLIP-seq
MIRT1178093	hsa-miR-3619-5p	CLIP-seq
MIRT2051524	hsa-miR-3907	CLIP-seq
MIRT2051525	hsa-miR-3918	CLIP-seq
MIRT2051526	hsa-miR-3960	CLIP-seq
MIRT1178121	hsa-miR-424	CLIP-seq
MIRT1178097	hsa-miR-4467	CLIP-seq
MIRT2051527	hsa-miR-4476	CLIP-seq
MIRT2051528	hsa-miR-4514	CLIP-seq
MIRT1178098	hsa-miR-4530	CLIP-seq
MIRT2051529	hsa-miR-4651	CLIP-seq
MIRT1178128	hsa-miR-4685-5p	CLIP-seq
MIRT2051530	hsa-miR-4692	CLIP-seq
MIRT2051531	hsa-miR-4746-3p	CLIP-seq
MIRT1178132	hsa-miR-497	CLIP-seq
MIRT2051532	hsa-miR-608	CLIP-seq
MIRT1178100	hsa-miR-761	CLIP-seq
MIRT1178114	hsa-miR-1915	CLIP-seq
MIRT1178120	hsa-miR-3944-5p	CLIP-seq
MIRT2051531	hsa-miR-4746-3p	CLIP-seq
MIRT2280609	hsa-miR-760	CLIP-seq
MIRT1178139	hsa-miR-1207-3p	CLIP-seq
MIRT1178111	hsa-miR-15a	CLIP-seq
MIRT1178112	hsa-miR-15b	CLIP-seq
MIRT1178113	hsa-miR-16	CLIP-seq
MIRT1178114	hsa-miR-1915	CLIP-seq
MIRT1178115	hsa-miR-195	CLIP-seq
MIRT2051524	hsa-miR-3907	CLIP-seq
MIRT2051525	hsa-miR-3918	CLIP-seq
MIRT1178121	hsa-miR-424	CLIP-seq
MIRT2280610	hsa-miR-4513	CLIP-seq
MIRT1178098	hsa-miR-4530	CLIP-seq
MIRT1178128	hsa-miR-4685-5p	CLIP-seq
MIRT2051531	hsa-miR-4746-3p	CLIP-seq
MIRT1178132	hsa-miR-497	CLIP-seq
MIRT1178114	hsa-miR-1915	CLIP-seq
MIRT1178089	hsa-miR-3064-5p	CLIP-seq
MIRT2391435	hsa-miR-3176	CLIP-seq
MIRT2391436	hsa-miR-3922-3p	CLIP-seq
MIRT1178098	hsa-miR-4530	CLIP-seq
MIRT1178099	hsa-miR-4687-3p	CLIP-seq
MIRT2391437	hsa-miR-4707-5p	CLIP-seq
MIRT2391438	hsa-miR-4726-3p	CLIP-seq
MIRT2391439	hsa-miR-485-5p	CLIP-seq
MIRT2391440	hsa-miR-615-5p	CLIP-seq
MIRT2454969	hsa-miR-3127-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003958	Function	NADPH-hemoprotein reductase activity	IDA	10625700, 12631275, 15900210
GO:0005515	Function	Protein binding	IPI	16140270, 25416956, 27519415, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	10625700
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	16140270
GO:0005829	Component	Cytosol	IEA
GO:0009055	Function	Electron transfer activity	IDA	12631275, 28648056
GO:0010181	Function	FMN binding	IBA
GO:0010181	Function	FMN binding	IDA	10625700
GO:0010181	Function	FMN binding	IEA
GO:0016226	Process	Iron-sulfur cluster assembly	IEA
GO:0016226	Process	Iron-sulfur cluster assembly	TAS	23596212
GO:0016491	Function	Oxidoreductase activity	IBA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016651	Function	Oxidoreductase activity, acting on NAD(P)H	IEA
GO:0016653	Function	Oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	IDA	12871938
GO:0022900	Process	Electron transport chain	IDA	10625700, 12631275, 15900210
GO:0045111	Component	Intermediate filament cytoskeleton	IDA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050660	Function	Flavin adenine dinucleotide binding	IBA
GO:0050660	Function	Flavin adenine dinucleotide binding	IEA
GO:0050661	Function	NADP binding	IDA	15900210
GO:0050661	Function	NADP binding	IEA
GO:0070402	Function	NADPH binding	IDA	10625700
GO:0071949	Function	FAD binding	IDA	10625700
GO:0160246	Function	NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity	IDA	23596212, 28648056
GO:0160246	Function	NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity	IEA

Other IDs

• MIM: 606073
• HGNC: 29838
• e!Ensembl: ENSG00000188566

Protein

• UniProt ID: Q9UHB4
• Protein name: NADPH-dependent diflavin oxidoreductase 1 (EC 1.18.1.-) (NADPH-dependent FMN and FAD-containing oxidoreductase) (Novel reductase 1)
• Protein function: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery (PubMed:10625700, PubMed:15900210, PubMed:20802492, PubMed:23596212, PubMed:28648056). Transfers electrons from NADPH via
• PDB: 4H2D
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00175	NAD_binding_1	455 → 561	Oxidoreductase NAD-binding domain	Domain
  PF00258	Flavodoxin_1	8 → 145	Flavodoxin	Domain
  PF00667	FAD_binding_1	201 → 421	FAD binding domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels in the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous leukemia, lymphoblastic leukem
• Sequence:

  MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT
  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG
  GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF
  LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI
  SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS
  HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF
  PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS
  WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN
  FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLD
  RQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA

• Sequence length: 597

Related Genes

No strongly related genes found yet for NDOR1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NDOR1.