NCKAP5L (NCK associated protein 5 like)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 57701
• Gene name: NCK associated protein 5 like
• Gene symbol: NCKAP5L
• Synonyms (NCBI Gene): Cep169, FP1193, KIAA1602
• Chromosome: 12
• Chromosome location: 12q13.12

miRNA Show/Hide all (39)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031503	hsa-miR-16-5p	Sequencing	20371350
MIRT051620	hsa-let-7e-5p	CLASH	23622248
MIRT046593	hsa-miR-222-3p	CLASH	23622248
MIRT037671	hsa-miR-744-5p	CLASH	23622248
MIRT1176518	hsa-miR-1262	CLIP-seq
MIRT1176519	hsa-miR-128	CLIP-seq
MIRT1176520	hsa-miR-1827	CLIP-seq
MIRT1176521	hsa-miR-2114	CLIP-seq
MIRT1176522	hsa-miR-2278	CLIP-seq
MIRT1176523	hsa-miR-3154	CLIP-seq
MIRT1176524	hsa-miR-326	CLIP-seq
MIRT1176525	hsa-miR-330-5p	CLIP-seq
MIRT1176526	hsa-miR-361-3p	CLIP-seq
MIRT1176527	hsa-miR-3664-5p	CLIP-seq
MIRT1176528	hsa-miR-3677-5p	CLIP-seq
MIRT1176529	hsa-miR-4701-3p	CLIP-seq
MIRT1176530	hsa-miR-4714-5p	CLIP-seq
MIRT1176531	hsa-miR-550b	CLIP-seq
MIRT1176532	hsa-miR-665	CLIP-seq
MIRT1176533	hsa-miR-940	CLIP-seq
MIRT1176522	hsa-miR-2278	CLIP-seq
MIRT2051134	hsa-miR-4281	CLIP-seq
MIRT2051135	hsa-miR-4789-3p	CLIP-seq
MIRT2578745	hsa-miR-1321	CLIP-seq
MIRT2578746	hsa-miR-4270	CLIP-seq
MIRT2578747	hsa-miR-4436b-3p	CLIP-seq
MIRT2578748	hsa-miR-4441	CLIP-seq
MIRT2578749	hsa-miR-4685-5p	CLIP-seq
MIRT2578750	hsa-miR-4739	CLIP-seq
MIRT2578751	hsa-miR-4751	CLIP-seq
MIRT2578752	hsa-miR-4756-5p	CLIP-seq
MIRT2578745	hsa-miR-1321	CLIP-seq
MIRT2578746	hsa-miR-4270	CLIP-seq
MIRT2578747	hsa-miR-4436b-3p	CLIP-seq
MIRT2578748	hsa-miR-4441	CLIP-seq
MIRT2578749	hsa-miR-4685-5p	CLIP-seq
MIRT2578750	hsa-miR-4739	CLIP-seq
MIRT2578751	hsa-miR-4751	CLIP-seq
MIRT2578752	hsa-miR-4756-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001578	Process	Microtubule bundle formation	IBA
GO:0001578	Process	Microtubule bundle formation	IDA	26485573
GO:0005515	Function	Protein binding	IPI	26485573
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	26485573
GO:0005813	Component	Centrosome	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0007019	Process	Microtubule depolymerization	IBA
GO:0007019	Process	Microtubule depolymerization	IMP	26485573
GO:0035371	Component	Microtubule plus-end	IBA
GO:0035371	Component	Microtubule plus-end	IDA	26485573

Other IDs

• MIM: 615104
• HGNC: 29321
• e!Ensembl: ENSG00000167566

Protein

• UniProt ID: Q9HCH0
• Protein name: Nck-associated protein 5-like (NCKAP5-like) (Centrosomal protein of 169 kDa) (Cep169)
• Protein function: Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and h
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15246	NCKAP5	875 → 1179	Nck-associated protein 5, Peripheral clock protein	Family

• Sequence:

  MSEAMDQPAGGPGNPRPGEGDDGSMEPGTCQELLHRLRELEAENSALAQANENQRETYER
  CLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQMLSALFQQKLQLTTGSLPQIPL
  TPLQPPSEPPASPSLSSTEGPAAPLPLGHCAGQREVCWEQQLRPGGPGPPAAPPPALDAL
  SPFLRKKAQILEVLRALEETDPLLLCSPATPWRPPGQGPGSPEPINGELCGPPQPEPSPW
  APCLLLGPGNLGGLLHWERLLGGLGGEEDTGRPWGPSRGPPQAQGTSSGPNCAPGSSSSS
  SSDEAGDPNEAPSPDTLLGALARRQLNLGQLLEDTESYLQAFLAGAAGPLNGDHPGPGQS
  SSPDQAPPQLSKSKGLPKSAWGGGTPEAHRPGFGATSEGQGPLPFLSMFMGAGDAPLGSR
  PGHPHSSSQVKSKLQIGPPSPGEAQGPLLPSPARGLKFLKLPPTSEKSPSPGGPQLSPQL
  PRNSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGAQGLPTSPSPCYTTPDSTQLRPPQS
  ALSTTLSPGPVVSPCYENILDLSRSTFRGPSPEPPPSPLQVPTYPQLTLEVPQAPEVLRS
  PGVPPSPCLPESYPYGSPQEKSLDKAGSESPHPGRRTPGNSSKKPSQGSGRRPGDPGSTP
  LRDRLAALGKLKTGPEGALGSEKNGVPARPGTEKTRGPGKSGESAGDMVPSIHRPLEQLE
  AKGGIRGAVALGTNSLKQQEPGLMGDPGARVYSSHSMGARVDLEPVSPRSCLTKVELAKS
  RLAGALCPQVPRTPAKVPTSAPSLGKPNKSPHSSPTKLPSKSPTKVVPRPGAPLVTKESP
  KPDKGKGPPWADCGSTTAQSTPLVPGPTDPSQGPEGLAPHSAIEEKVMKGIEENVLRLQG
  QERAPGAEVKHRNTSSIASWFGLKKSKLPALNRRTEATKNKEGAGGGSPLRREVKMEARK
  LEAESLNISKLMAKAEDLRRALEEEKAYLSSRARPRPGGPAPGPNTGLGQVQGQLAGMYQ
  GADTFMQQLLNRVDGKELPSKSWREPKPEYGDFQPVSSDPKSPWPACGPRNGLVGPLQGC
  GKPPGKPSSEPGRREETPSEDSLAEPVPTSHFTACGSLTRTLDSGIGTFPPPDHGSSGTP
  SKNLPKTKPPRLDPPPGVPPARPPPLTKVPRRAHTLEREVPGIEELLVSGRHPSMPAFPA
  LLPAAPGHRGHETCPDDPCEDPGPTPPVQLAKNWTFPNTRAAGSSSDPLMCPPRQLEGLP
  RTPMALPVDRKRSQEPSRPSPTPQGPPFGGSRTPSTSDMAEEGRVASGGPPGLETSESLS
  DSLYDSLSSCGSQG

• Sequence length: 1334

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Malignant tumor of esophagus	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	38162683	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autistic Disorder	Autism	Pubtator	22511880	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	24455749	Associate	★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	24455749	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for NCKAP5L.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NCKAP5L.