NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10003
• Gene name: N-acetylated alpha-linked acidic dipeptidase 2
• Gene symbol: NAALAD2
• Synonyms (NCBI Gene): GCP3, GCPIII, GPCIII
• Chromosome: 11
• Chromosome location: 11q14.3
• Summary: This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and

miRNA Show/Hide all (86)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019039	hsa-miR-335-5p	Microarray	18185580
MIRT1172312	hsa-miR-1231	CLIP-seq
MIRT1172313	hsa-miR-1323	CLIP-seq
MIRT1172314	hsa-miR-149	CLIP-seq
MIRT1172315	hsa-miR-205	CLIP-seq
MIRT1172316	hsa-miR-25	CLIP-seq
MIRT1172317	hsa-miR-2909	CLIP-seq
MIRT1172318	hsa-miR-3064-5p	CLIP-seq
MIRT1172319	hsa-miR-3065-5p	CLIP-seq
MIRT1172320	hsa-miR-3119	CLIP-seq
MIRT1172321	hsa-miR-3162-5p	CLIP-seq
MIRT1172322	hsa-miR-32	CLIP-seq
MIRT1172323	hsa-miR-33a	CLIP-seq
MIRT1172324	hsa-miR-33b	CLIP-seq
MIRT1172325	hsa-miR-363	CLIP-seq
MIRT1172326	hsa-miR-367	CLIP-seq
MIRT1172327	hsa-miR-3682-5p	CLIP-seq
MIRT1172328	hsa-miR-421	CLIP-seq
MIRT1172329	hsa-miR-4288	CLIP-seq
MIRT1172330	hsa-miR-4496	CLIP-seq
MIRT1172331	hsa-miR-452	CLIP-seq
MIRT1172332	hsa-miR-4676-3p	CLIP-seq
MIRT1172333	hsa-miR-4729	CLIP-seq
MIRT1172334	hsa-miR-4738-3p	CLIP-seq
MIRT1172335	hsa-miR-4794	CLIP-seq
MIRT1172336	hsa-miR-488	CLIP-seq
MIRT1172337	hsa-miR-548g	CLIP-seq
MIRT1172338	hsa-miR-548o	CLIP-seq
MIRT1172339	hsa-miR-632	CLIP-seq
MIRT1172340	hsa-miR-92a	CLIP-seq
MIRT1172341	hsa-miR-92b	CLIP-seq
MIRT2049821	hsa-miR-3064-3p	CLIP-seq
MIRT2049822	hsa-miR-4252	CLIP-seq
MIRT2049823	hsa-miR-4715-3p	CLIP-seq
MIRT2049824	hsa-miR-4776-3p	CLIP-seq
MIRT2049821	hsa-miR-3064-3p	CLIP-seq
MIRT2278767	hsa-miR-3121-3p	CLIP-seq
MIRT2049822	hsa-miR-4252	CLIP-seq
MIRT2049823	hsa-miR-4715-3p	CLIP-seq
MIRT2049824	hsa-miR-4776-3p	CLIP-seq
MIRT2278768	hsa-miR-4799-5p	CLIP-seq
MIRT2577046	hsa-miR-141	CLIP-seq
MIRT2577047	hsa-miR-200a	CLIP-seq
MIRT2049821	hsa-miR-3064-3p	CLIP-seq
MIRT2278767	hsa-miR-3121-3p	CLIP-seq
MIRT2577048	hsa-miR-3136-3p	CLIP-seq
MIRT2577049	hsa-miR-328	CLIP-seq
MIRT2577050	hsa-miR-34b	CLIP-seq
MIRT2577051	hsa-miR-34c-3p	CLIP-seq
MIRT2577052	hsa-miR-3614-5p	CLIP-seq
MIRT2049822	hsa-miR-4252	CLIP-seq
MIRT2577053	hsa-miR-4645-5p	CLIP-seq
MIRT2577054	hsa-miR-4673	CLIP-seq
MIRT2577055	hsa-miR-4705	CLIP-seq
MIRT2049823	hsa-miR-4715-3p	CLIP-seq
MIRT2577056	hsa-miR-4735-5p	CLIP-seq
MIRT2577057	hsa-miR-4742-5p	CLIP-seq
MIRT2577058	hsa-miR-4775	CLIP-seq
MIRT2049824	hsa-miR-4776-3p	CLIP-seq
MIRT2278768	hsa-miR-4799-5p	CLIP-seq
MIRT2577059	hsa-miR-494	CLIP-seq
MIRT2577060	hsa-miR-590-3p	CLIP-seq
MIRT2577046	hsa-miR-141	CLIP-seq
MIRT2577047	hsa-miR-200a	CLIP-seq
MIRT2049821	hsa-miR-3064-3p	CLIP-seq
MIRT2278767	hsa-miR-3121-3p	CLIP-seq
MIRT2577048	hsa-miR-3136-3p	CLIP-seq
MIRT2577049	hsa-miR-328	CLIP-seq
MIRT2577050	hsa-miR-34b	CLIP-seq
MIRT2577051	hsa-miR-34c-3p	CLIP-seq
MIRT2577052	hsa-miR-3614-5p	CLIP-seq
MIRT2685714	hsa-miR-3668	CLIP-seq
MIRT2685715	hsa-miR-3924	CLIP-seq
MIRT2049822	hsa-miR-4252	CLIP-seq
MIRT2577053	hsa-miR-4645-5p	CLIP-seq
MIRT2577054	hsa-miR-4673	CLIP-seq
MIRT2685716	hsa-miR-4703-3p	CLIP-seq
MIRT2577055	hsa-miR-4705	CLIP-seq
MIRT2049823	hsa-miR-4715-3p	CLIP-seq
MIRT2577056	hsa-miR-4735-5p	CLIP-seq
MIRT2577057	hsa-miR-4742-5p	CLIP-seq
MIRT2577058	hsa-miR-4775	CLIP-seq
MIRT2049824	hsa-miR-4776-3p	CLIP-seq
MIRT2278768	hsa-miR-4799-5p	CLIP-seq
MIRT2577059	hsa-miR-494	CLIP-seq
MIRT2577060	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004180	Function	Carboxypeptidase activity	IBA
GO:0004180	Function	Carboxypeptidase activity	IEA
GO:0004180	Function	Carboxypeptidase activity	NAS	10085079
GO:0004181	Function	Metallocarboxypeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	NAS	10085079
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	NAS	10085079
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008239	Function	Dipeptidyl-peptidase activity	NAS	10085079
GO:0009056	Process	Catabolic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	10085079
GO:0016787	Function	Hydrolase activity	IEA
GO:0016805	Function	Dipeptidase activity	IEA
GO:0016805	Function	Dipeptidase activity	NAS	10085079
GO:0046395	Process	Carboxylic acid catabolic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050129	Function	N-formylglutamate deformylase activity	IEA

Other IDs

• MIM: 611636
• HGNC: 14526
• e!Ensembl: ENSG00000077616

Protein

• UniProt ID: Q9Y3Q0
• Protein name: N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II)
• Protein function: Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate.
• PDB: 3FEC , 3FED , 3FEE , 3FF3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02225	PA	160 → 251	PA domain	Family
  PF04253	TFR_dimer	617 → 737	Transferrin receptor-like dimerisation domain	Domain
  PF04389	Peptidase_M28	347 → 556	Peptidase family M28	Family

• Tissue specificity: TISSUE SPECIFICITY: Highest expression in the testis. Also found in ovary and spleen. Weak expression in prostate, heart and placenta. In brain, expressed in striatum, parietal cortex and ventral striatum with lower levels in hippocampus, brain stem, puta
• Sequence:

  MAESRGRLYLWMCLAAALASFLMGFMVGWFIKPLKETTTSVRYHQSIRWKLVSEMKAENI
  KSFLRSFTKLPHLAGTEQNFLLAKKIQTQWKKFGLDSAKLVHYDVLLSYPNETNANYISI
  VDEHETEIFKTSYLEPPPDGYENVTNIVPPYNAFSAQGMPEGDLVYVNYARTEDFFKLER
  EMGINCTGKIVIARYGKIFRGNKVKNAMLAGAIGIILYSDPADYFAPEVQPYPKGWNLPG
  TAAQRGNVLNLNGAGDPLTPGYPAKEYTFRLDVEEGVGIPRIPVHPIGYNDAEILLRYLG
  GIAPPDKSWKGALNVSYSIGPGFTGSDSFRKVRMHVYNINKITRIYNVVGTIRGSVEPDR
  YVILGGHRDSWVFGAIDPTSGVAVLQEIARSFGKLMSKGWRPRRTIIFASWDAEEFGLLG
  STEWAEENVKILQERSIAYINSDSSIEGNYTLRVDCTPLLYQLVYKLTKEIPSPDDGFES
  KSLYESWLEKDPSPENKNLPRINKLGSGSDFEAYFQRLGIASGRARYTKNKKTDKYSSYP
  VYHTIYETFELVEKFYDPTFKKQLSVAQLRGALVYELVDSKIIPFNIQDYAEALKNYAAS
  IYNLSKKHDQQLTDHGVSFDSLFSAVKNFSEAASDFHKRLIQVDLNNPIAVRMMNDQLML
  LERAFIDPLGLPGKLFYRHIIFAPSSHNKYAGESFPGIYDAIFDIENKANSRLAWKEVKK
  HISIAAFTIQAAAGTLKEVL

• Sequence length: 740

Pathways

Reactome Pathway:

Aspartate and asparagine metabolism

Related Genes

No strongly related genes found yet for NAALAD2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NAALAD2.