NAAA (N-acylethanolamine acid amidase)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 27163
• Gene name: N-acylethanolamine acid amidase
• Gene symbol: NAAA
• Synonyms (NCBI Gene): ASAHL, PLT
• Chromosome: 4
• Chromosome location: 4q21.1
• Summary: This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

miRNA Show/Hide all (117)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1172260	hsa-miR-1208	CLIP-seq
MIRT1172261	hsa-miR-1236	CLIP-seq
MIRT1172262	hsa-miR-1272	CLIP-seq
MIRT1172263	hsa-miR-1322	CLIP-seq
MIRT1172264	hsa-miR-135a	CLIP-seq
MIRT1172265	hsa-miR-135b	CLIP-seq
MIRT1172266	hsa-miR-1587	CLIP-seq
MIRT1172267	hsa-miR-1972	CLIP-seq
MIRT1172268	hsa-miR-203	CLIP-seq
MIRT1172269	hsa-miR-2113	CLIP-seq
MIRT1172270	hsa-miR-24	CLIP-seq
MIRT1172271	hsa-miR-3171	CLIP-seq
MIRT1172272	hsa-miR-34c-3p	CLIP-seq
MIRT1172273	hsa-miR-3665	CLIP-seq
MIRT1172274	hsa-miR-3691-5p	CLIP-seq
MIRT1172275	hsa-miR-377	CLIP-seq
MIRT1172276	hsa-miR-3945	CLIP-seq
MIRT1172277	hsa-miR-3977	CLIP-seq
MIRT1172278	hsa-miR-4257	CLIP-seq
MIRT1172279	hsa-miR-4437	CLIP-seq
MIRT1172280	hsa-miR-4453	CLIP-seq
MIRT1172281	hsa-miR-4529-5p	CLIP-seq
MIRT1172282	hsa-miR-4538	CLIP-seq
MIRT1172283	hsa-miR-4650-5p	CLIP-seq
MIRT1172284	hsa-miR-4674	CLIP-seq
MIRT1172285	hsa-miR-4752	CLIP-seq
MIRT1172286	hsa-miR-4753-3p	CLIP-seq
MIRT1172287	hsa-miR-4761-3p	CLIP-seq
MIRT1172288	hsa-miR-4764-5p	CLIP-seq
MIRT1172289	hsa-miR-4768-5p	CLIP-seq
MIRT1172290	hsa-miR-4778-3p	CLIP-seq
MIRT1172291	hsa-miR-4782-5p	CLIP-seq
MIRT1172292	hsa-miR-4794	CLIP-seq
MIRT1172293	hsa-miR-513a-5p	CLIP-seq
MIRT1172294	hsa-miR-635	CLIP-seq
MIRT1172295	hsa-miR-657	CLIP-seq
MIRT1172296	hsa-miR-892b	CLIP-seq
MIRT1172297	hsa-miR-1301	CLIP-seq
MIRT1172298	hsa-miR-18a	CLIP-seq
MIRT1172299	hsa-miR-18b	CLIP-seq
MIRT1172300	hsa-miR-27a	CLIP-seq
MIRT1172301	hsa-miR-27b	CLIP-seq
MIRT1172302	hsa-miR-3182	CLIP-seq
MIRT1172303	hsa-miR-3944-5p	CLIP-seq
MIRT1172304	hsa-miR-4477b	CLIP-seq
MIRT1172305	hsa-miR-4660	CLIP-seq
MIRT1172306	hsa-miR-4735-3p	CLIP-seq
MIRT1172307	hsa-miR-5047	CLIP-seq
MIRT1172308	hsa-miR-511	CLIP-seq
MIRT1172293	hsa-miR-513a-5p	CLIP-seq
MIRT1172309	hsa-miR-548c-3p	CLIP-seq
MIRT1172310	hsa-miR-579	CLIP-seq
MIRT1172311	hsa-miR-628-5p	CLIP-seq
MIRT2049820	hsa-miR-4762-5p	CLIP-seq
MIRT2278727	hsa-miR-1202	CLIP-seq
MIRT2278728	hsa-miR-1286	CLIP-seq
MIRT2278729	hsa-miR-1303	CLIP-seq
MIRT2278730	hsa-miR-193a-3p	CLIP-seq
MIRT2278731	hsa-miR-193b	CLIP-seq
MIRT2278732	hsa-miR-194	CLIP-seq
MIRT1172267	hsa-miR-1972	CLIP-seq
MIRT2278733	hsa-miR-1976	CLIP-seq
MIRT1172300	hsa-miR-27a	CLIP-seq
MIRT1172301	hsa-miR-27b	CLIP-seq
MIRT2278734	hsa-miR-3145-5p	CLIP-seq
MIRT2278735	hsa-miR-3179	CLIP-seq
MIRT1172302	hsa-miR-3182	CLIP-seq
MIRT2278736	hsa-miR-3194-5p	CLIP-seq
MIRT2278737	hsa-miR-3202	CLIP-seq
MIRT2278738	hsa-miR-338-5p	CLIP-seq
MIRT2278739	hsa-miR-33a	CLIP-seq
MIRT2278740	hsa-miR-33b	CLIP-seq
MIRT2278741	hsa-miR-3646	CLIP-seq
MIRT2278742	hsa-miR-365	CLIP-seq
MIRT2278743	hsa-miR-3690	CLIP-seq
MIRT2278744	hsa-miR-369-3p	CLIP-seq
MIRT2278745	hsa-miR-374c	CLIP-seq
MIRT2278746	hsa-miR-3915	CLIP-seq
MIRT2278747	hsa-miR-3928	CLIP-seq
MIRT2278748	hsa-miR-3972	CLIP-seq
MIRT2278749	hsa-miR-4254	CLIP-seq
MIRT1172278	hsa-miR-4257	CLIP-seq
MIRT2278750	hsa-miR-4267	CLIP-seq
MIRT2278751	hsa-miR-431	CLIP-seq
MIRT2278752	hsa-miR-4436a	CLIP-seq
MIRT2278753	hsa-miR-4470	CLIP-seq
MIRT2278754	hsa-miR-4476	CLIP-seq
MIRT2278755	hsa-miR-4533	CLIP-seq
MIRT2278756	hsa-miR-4641	CLIP-seq
MIRT1172283	hsa-miR-4650-5p	CLIP-seq
MIRT2278757	hsa-miR-4666-3p	CLIP-seq
MIRT2278758	hsa-miR-4722-5p	CLIP-seq
MIRT2278759	hsa-miR-4747-5p	CLIP-seq
MIRT2049820	hsa-miR-4762-5p	CLIP-seq
MIRT2278760	hsa-miR-4803	CLIP-seq
MIRT1172293	hsa-miR-513a-5p	CLIP-seq
MIRT2278761	hsa-miR-513b	CLIP-seq
MIRT2278762	hsa-miR-561	CLIP-seq
MIRT2278763	hsa-miR-596	CLIP-seq
MIRT1172311	hsa-miR-628-5p	CLIP-seq
MIRT2278764	hsa-miR-655	CLIP-seq
MIRT2278765	hsa-miR-711	CLIP-seq
MIRT2278766	hsa-miR-885-5p	CLIP-seq
MIRT1172296	hsa-miR-892b	CLIP-seq
MIRT2454804	hsa-miR-3973	CLIP-seq
MIRT2454805	hsa-miR-4724-3p	CLIP-seq
MIRT2454806	hsa-miR-513c	CLIP-seq
MIRT2454807	hsa-miR-514b-5p	CLIP-seq
MIRT2454808	hsa-miR-520d-5p	CLIP-seq
MIRT2454809	hsa-miR-524-5p	CLIP-seq
MIRT2454810	hsa-miR-548k	CLIP-seq
MIRT2278729	hsa-miR-1303	CLIP-seq
MIRT1172267	hsa-miR-1972	CLIP-seq
MIRT2577043	hsa-miR-4424	CLIP-seq
MIRT1172283	hsa-miR-4650-5p	CLIP-seq
MIRT2577044	hsa-miR-4786-5p	CLIP-seq
MIRT2577045	hsa-miR-769-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IDA	10610717
GO:0005764	Component	Lysosome	IDA	15655246
GO:0005764	Component	Lysosome	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IDA	15655246, 30301806
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006670	Process	Sphingosine metabolic process	IDA	15655246
GO:0016020	Component	Membrane	IDA	30301806
GO:0016020	Component	Membrane	IEA
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016810	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IBA
GO:0016810	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IDA	17980170
GO:0017040	Function	N-acylsphingosine amidohydrolase activity	IDA	15655246
GO:0017040	Function	N-acylsphingosine amidohydrolase activity	IEA
GO:0017064	Function	Fatty acid amide hydrolase activity	IDA	15655246, 30301806
GO:0017064	Function	Fatty acid amide hydrolase activity	IEA
GO:0043202	Component	Lysosomal lumen	TAS
GO:0047412	Function	N-(long-chain-acyl)ethanolamine deacylase activity	IDA	15655246, 22825852
GO:0047412	Function	N-(long-chain-acyl)ethanolamine deacylase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0070291	Process	N-acylethanolamine metabolic process	IDA	15655246, 30301806
GO:0070291	Process	N-acylethanolamine metabolic process	IEA
GO:0070292	Process	N-acylphosphatidylethanolamine metabolic process	IDA	22825852
GO:0140297	Function	DNA-binding transcription factor binding	IPI	21106534

Other IDs

• MIM: 607469
• HGNC: 736
• e!Ensembl: ENSG00000138744

Protein

• UniProt ID: Q02083
• Protein name: N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.60) (Acid ceramidase-like protein) (Acylsphingosine deacylase NAAA) (EC 3.5.1.23) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase
• Protein function: Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolam
• PDB: 6DXW , 6DXX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02275	CBAH	126 → 312	Linear amide C-N hydrolases, choloylglycine hydrolase family	Domain
  PF15508	NAAA-beta	31 → 91	beta subunit of N-acylethanolamine-hydrolyzing acid amidase	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas. {ECO:0000269|PubMed:10610717}.
• Sequence:

  MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLV
  RAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAY
  ESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGL
  WTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKT
  PLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDR
  RTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK

• Sequence length: 359

Pathways

Reactome Pathway:

Neurotransmitter release cycle

Related Genes

No strongly related genes found yet for NAAA.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to NAAA.