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Gene Gene information from NCBI Gene database.
Entrez ID 440145
Gene name Mitotic spindle organizing protein 1
Gene symbol MZT1
Synonyms (NCBI Gene)
C13orf37MOZART1
Chromosome 13
Chromosome location 13q21.33
miRNA miRNA information provided by mirtarbase database.
301 Show/Hide all (301)
miRTarBase ID miRNA Experiments Reference
MIRT016672 hsa-miR-425-5p Sequencing 20371350
MIRT028059 hsa-miR-93-5p Sequencing 20371350
MIRT114143 hsa-miR-4282 PAR-CLIP 21572407
MIRT485321 hsa-miR-548an PAR-CLIP 21572407
MIRT485320 hsa-miR-6768-3p PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18 Show/Hide all (18)
GO ID Ontology Definition Evidence Reference
GO:0000931 Component Gamma-tubulin ring complex IBA
GO:0000931 Component Gamma-tubulin ring complex IDA 20360068
GO:0000931 Component Gamma-tubulin ring complex IEA
GO:0005515 Function Protein binding IPI 20360068, 26496610, 28514442, 32296183, 33961781
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613448 33830 ENSG00000204899
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q08AG7
Protein name Mitotic-spindle organizing protein 1 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1)
Protein function Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that g
PDB 6L81 , 6M33 , 6X0U , 7AS4 , 7QJ0 , 7QJ1 , 7QJ2 , 7QJ3 , 7QJ4 , 7QJ5 , 7QJ6 , 7QJ7 , 7QJ8 , 7QJ9 , 7QJA , 7QJB , 7QJC , 7QJD , 8RX1 , 8VRD , 8VRJ , 8VRK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12554 MOZART1 22 → 68 Mitotic-spindle organizing gamma-tubulin ring associated Family
Sequence
MASSSGAGAAAAAAAANLNAVRETMDVLLEISRILNTGLDMETLSICVRLCEQGINPEAL
SSVIKELR
KATEALKAAENMTS
Sequence length 82
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Recruitment of mitotic centrosome proteins and complexes
Recruitment of NuMA to mitotic centrosomes