MYOM3 (myomesin 3)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 127294
• Gene name: Myomesin 3
• Gene symbol: MYOM3
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1p36.11

miRNA Show/Hide all (115)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1170306	hsa-miR-1207-3p	CLIP-seq
MIRT1170307	hsa-miR-125a-3p	CLIP-seq
MIRT1170308	hsa-miR-150	CLIP-seq
MIRT1170309	hsa-miR-1913	CLIP-seq
MIRT1170310	hsa-miR-22	CLIP-seq
MIRT1170311	hsa-miR-324-3p	CLIP-seq
MIRT1170312	hsa-miR-361-5p	CLIP-seq
MIRT1170313	hsa-miR-3689d	CLIP-seq
MIRT1170314	hsa-miR-3934	CLIP-seq
MIRT1170315	hsa-miR-409-5p	CLIP-seq
MIRT1170316	hsa-miR-4254	CLIP-seq
MIRT1170317	hsa-miR-4267	CLIP-seq
MIRT1170318	hsa-miR-4308	CLIP-seq
MIRT1170319	hsa-miR-4707-3p	CLIP-seq
MIRT1170320	hsa-miR-4757-5p	CLIP-seq
MIRT1170321	hsa-miR-4775	CLIP-seq
MIRT1170322	hsa-miR-495	CLIP-seq
MIRT1170323	hsa-miR-590-3p	CLIP-seq
MIRT1170324	hsa-miR-599	CLIP-seq
MIRT1170325	hsa-miR-634	CLIP-seq
MIRT1170326	hsa-miR-764	CLIP-seq
MIRT2049066	hsa-miR-1224-3p	CLIP-seq
MIRT2049067	hsa-miR-1254	CLIP-seq
MIRT2049068	hsa-miR-1260	CLIP-seq
MIRT2049069	hsa-miR-1260b	CLIP-seq
MIRT2049070	hsa-miR-1280	CLIP-seq
MIRT1170308	hsa-miR-150	CLIP-seq
MIRT1170309	hsa-miR-1913	CLIP-seq
MIRT2049071	hsa-miR-3116	CLIP-seq
MIRT2049072	hsa-miR-3189-3p	CLIP-seq
MIRT1170311	hsa-miR-324-3p	CLIP-seq
MIRT2049073	hsa-miR-3619-3p	CLIP-seq
MIRT2049074	hsa-miR-4320	CLIP-seq
MIRT2049075	hsa-miR-4438	CLIP-seq
MIRT2049076	hsa-miR-4535	CLIP-seq
MIRT1170319	hsa-miR-4707-3p	CLIP-seq
MIRT2049077	hsa-miR-4713-5p	CLIP-seq
MIRT1170320	hsa-miR-4757-5p	CLIP-seq
MIRT2049078	hsa-miR-4776-5p	CLIP-seq
MIRT2049079	hsa-miR-5095	CLIP-seq
MIRT2049080	hsa-miR-532-3p	CLIP-seq
MIRT2049067	hsa-miR-1254	CLIP-seq
MIRT1170309	hsa-miR-1913	CLIP-seq
MIRT2049071	hsa-miR-3116	CLIP-seq
MIRT2278143	hsa-miR-3187-3p	CLIP-seq
MIRT1170311	hsa-miR-324-3p	CLIP-seq
MIRT2278144	hsa-miR-3663-5p	CLIP-seq
MIRT2278145	hsa-miR-4435	CLIP-seq
MIRT2278146	hsa-miR-4701-5p	CLIP-seq
MIRT2278147	hsa-miR-4735-5p	CLIP-seq
MIRT2278148	hsa-miR-4755-3p	CLIP-seq
MIRT1170321	hsa-miR-4775	CLIP-seq
MIRT2278149	hsa-miR-4781-3p	CLIP-seq
MIRT2278150	hsa-miR-548a-3p	CLIP-seq
MIRT2278151	hsa-miR-548e	CLIP-seq
MIRT2278152	hsa-miR-548f	CLIP-seq
MIRT2278153	hsa-miR-548s	CLIP-seq
MIRT2278154	hsa-miR-588	CLIP-seq
MIRT1170323	hsa-miR-590-3p	CLIP-seq
MIRT2278155	hsa-miR-601	CLIP-seq
MIRT2049067	hsa-miR-1254	CLIP-seq
MIRT2391293	hsa-miR-1255a	CLIP-seq
MIRT2391294	hsa-miR-1255b	CLIP-seq
MIRT2049071	hsa-miR-3116	CLIP-seq
MIRT2391295	hsa-miR-493	CLIP-seq
MIRT2049067	hsa-miR-1254	CLIP-seq
MIRT2049071	hsa-miR-3116	CLIP-seq
MIRT2454740	hsa-miR-3149	CLIP-seq
MIRT2454741	hsa-miR-411	CLIP-seq
MIRT2454742	hsa-miR-4715-3p	CLIP-seq
MIRT2454743	hsa-miR-4722-3p	CLIP-seq
MIRT2278147	hsa-miR-4735-5p	CLIP-seq
MIRT1170321	hsa-miR-4775	CLIP-seq
MIRT2454744	hsa-miR-4794	CLIP-seq
MIRT1170323	hsa-miR-590-3p	CLIP-seq
MIRT2454745	hsa-miR-661	CLIP-seq
MIRT2049067	hsa-miR-1254	CLIP-seq
MIRT1170307	hsa-miR-125a-3p	CLIP-seq
MIRT1170309	hsa-miR-1913	CLIP-seq
MIRT2049071	hsa-miR-3116	CLIP-seq
MIRT2454740	hsa-miR-3149	CLIP-seq
MIRT1170311	hsa-miR-324-3p	CLIP-seq
MIRT1170314	hsa-miR-3934	CLIP-seq
MIRT2454741	hsa-miR-411	CLIP-seq
MIRT1170319	hsa-miR-4707-3p	CLIP-seq
MIRT2454742	hsa-miR-4715-3p	CLIP-seq
MIRT2454743	hsa-miR-4722-3p	CLIP-seq
MIRT2278147	hsa-miR-4735-5p	CLIP-seq
MIRT1170320	hsa-miR-4757-5p	CLIP-seq
MIRT1170321	hsa-miR-4775	CLIP-seq
MIRT2454744	hsa-miR-4794	CLIP-seq
MIRT1170323	hsa-miR-590-3p	CLIP-seq
MIRT2454745	hsa-miR-661	CLIP-seq
MIRT1170326	hsa-miR-764	CLIP-seq
MIRT2049067	hsa-miR-1254	CLIP-seq
MIRT1170307	hsa-miR-125a-3p	CLIP-seq
MIRT1170309	hsa-miR-1913	CLIP-seq
MIRT2049071	hsa-miR-3116	CLIP-seq
MIRT2454740	hsa-miR-3149	CLIP-seq
MIRT1170311	hsa-miR-324-3p	CLIP-seq
MIRT1170314	hsa-miR-3934	CLIP-seq
MIRT2454741	hsa-miR-411	CLIP-seq
MIRT2685705	hsa-miR-4269	CLIP-seq
MIRT2049075	hsa-miR-4438	CLIP-seq
MIRT1170319	hsa-miR-4707-3p	CLIP-seq
MIRT2454742	hsa-miR-4715-3p	CLIP-seq
MIRT2454743	hsa-miR-4722-3p	CLIP-seq
MIRT2278147	hsa-miR-4735-5p	CLIP-seq
MIRT1170320	hsa-miR-4757-5p	CLIP-seq
MIRT1170321	hsa-miR-4775	CLIP-seq
MIRT2454744	hsa-miR-4794	CLIP-seq
MIRT2049079	hsa-miR-5095	CLIP-seq
MIRT1170323	hsa-miR-590-3p	CLIP-seq
MIRT2454745	hsa-miR-661	CLIP-seq
MIRT1170326	hsa-miR-764	CLIP-seq

Gene ontology (GO) Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0031430	Component	M band	IBA
GO:0031430	Component	M band	IEA
GO:0031430	Component	M band	ISS
GO:0042802	Function	Identical protein binding	IEA
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0045214	Process	Sarcomere organization	IBA

Other IDs

• MIM: 616832
• HGNC: 26679
• e!Ensembl: ENSG00000142661

Protein

• UniProt ID: Q5VTT5
• Protein name: Myomesin-3 (Myomesin family member 3)
• Protein function: May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00041	fn3	803 → 888	Fibronectin type III domain	Domain
  PF00041	fn3	603 → 685	Fibronectin type III domain	Domain
  PF00041	fn3	374 → 459	Fibronectin type III domain	Domain
  PF00041	fn3	502 → 587	Fibronectin type III domain	Domain
  PF00041	fn3	701 → 786	Fibronectin type III domain	Domain
  PF00047	ig	1127 → 1200	Immunoglobulin domain	Domain
  PF07679	I-set	1335 → 1424	Immunoglobulin I-set domain	Domain
  PF07679	I-set	154 → 247	Immunoglobulin I-set domain	Domain
  PF07679	I-set	271 → 362	Immunoglobulin I-set domain	Domain

• Sequence:

  MTLPHSLGGAGDPRPPQAMEVHRLEHRQEEEQKEERQHSLRMGSSVRRRTFRSSEEEHEF
  SAADYALAAALALTASSELSWEAQLRRQTSAVELEERGQKRVGFGNDWERTEIAFLQTHR
  LLRQRRDWKTLRRRTEEKVQEAKELRELCYGRGPWFWIPLRSHAVWEHTTVLLTCTVQAS
  PPPQVTWYKNDTRIDPRLFRAGKYRITNNYGLLSLEIRRCAIEDSATYTVRVKNAHGQAS
  SFAKVLVRTYLGKDAGFDSEIFKRSTFGPSVEFTSVLKPVFAREKEPFSLSCLFSEDVLD
  AESIQWFRDGSLLRSSRRRKILYTDRQASLKVSCTYKEDEGLYMVRVPSPFGPREQSTYV
  LVRDAEAENPGAPGSPLNVRCLDVNRDCLILTWAPPSDTRGNPITAYTIERCQGESGEWI
  ACHEAPGGTCRCPIQGLVEGQSYRFRVRAISRVGSSVPSKASELVVMGDHDAARRKTEIP
  FDLGNKITISTDAFEDTVTIPSPPTNVHASEIREAYVVLAWEEPSPRDRAPLTYSLEKSV
  IGSGTWEAISSESPVRSPRFAVLDLEKKKSYVFRVRAMNQYGLSDPSEPSEPIALRGPPA
  TLPPPAQVQAFRDTQTSVSLTWDPVKDPELLGYYIYSRKVGTSEWQTVNNKPIQGTRFTV
  PGLRTGKEYEFCVRSVSEAGVGESSAATEPIRVKQALATPSAPYGFALLNCGKNEMVIGW
  KPPKRRGGGKILGYFLDQHDSEELDWHAVNQQPIPTRVCKVSDLHEGHFYEFRARAANWA
  GVGELSAPSSLFECKEWTMPQPGPPYDVRASEVRATSLVLQWEPPLYMGAGPVTGYHVSF
  QEEGSEQWKPVTPGPISGTHLRVSDLQPGKSYVFQVQAMNSAGLGQPSMPTDPVLLEDKP
  GAHEIEVGVDEEGFIYLAFEAPEAPDSSEFQWSKDYKGPLDPQRVKIEDKVNKSKVILKE
  PGLEDLGTYSVIVTDADEDISASHTLTEEELEKLKKLSHEIRNPVIKLISGWNIDILERG
  EVRLWLEVEKLSPAAELHLIFNNKEIFSSPNRKINFDREKGLVEVIIQNLSEEDKGSYTA
  QLQDGKAKNQITLTLVDDDFDKLLRKADAKRRDWKRKQGPYFERPLQWKVTEDCQVQLTC
  KVTNTKKETRFQWFFQRAEMPDGQYDPETGTGLLCIEELSKKDKGIYRAMVSDDRGEDDT
  ILDLTGDALDAIFTELGRIGALSATPLKIQGTEEGIRIFSKVKYYNVEYMKTTWFHKDKR
  LESGDRIRTGTTLDEIWLHILDPKDSDKGKYTLEIAAGKEVRQLSTDLSGQAFEDAMAEH
  QRLKTLAIIEKNRAKVVRGLPDVATIMEDKTLCLTCIVSGDPTPEISWLKNDQPVTFLDR
  YRMEVRGTEVTITIEKVNSEDSGRYGVFVKNKYGSETGQVTISVFKHGDEPKELKSM

• Sequence length: 1437

Pathways

KEGG Pathway:

Cytoskeleton in muscle cells

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
BIPOLAR DISORDER	—	GWAS catalog	23092984	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Flexion contracture	Uncertain significance; Benign; Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	38374256	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (6)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Cardiomyopathy, Familial Idiopathic	Cardiomyopathy	BEFREE	29886034		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37434131	Associate	★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	30798618		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	37130628	Associate	★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	30798618		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	37130628	Stimulate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for MYOM3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to MYOM3.