MTNAP1 (mitochondrial nucleoid associated protein 1)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55028
• Gene name: Mitochondrial nucleoid associated protein 1
• Gene symbol: MTNAP1
• Synonyms (NCBI Gene): C17orf80, HLC-8, MIG3, SPEP1
• Chromosome: 17
• Chromosome location: 17q25.1

miRNA Show/Hide all (177)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003881	hsa-miR-15a-5p	Microarray	18362358
MIRT004375	hsa-miR-16-5p	Microarray	18362358
MIRT020493	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT046098	hsa-miR-125b-5p	CLASH	23622248
MIRT045779	hsa-miR-125a-5p	CLASH	23622248
MIRT446235	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT446234	hsa-miR-8083	PAR-CLIP	22100165
MIRT446233	hsa-miR-4635	PAR-CLIP	22100165
MIRT446232	hsa-miR-1252-5p	PAR-CLIP	22100165
MIRT446231	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT446230	hsa-miR-3653-3p	PAR-CLIP	22100165
MIRT446229	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446228	hsa-miR-6126	PAR-CLIP	22100165
MIRT446227	hsa-miR-6864-5p	PAR-CLIP	22100165
MIRT446226	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT446225	hsa-miR-3658	PAR-CLIP	22100165
MIRT446235	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT446234	hsa-miR-8083	PAR-CLIP	22100165
MIRT446233	hsa-miR-4635	PAR-CLIP	22100165
MIRT446232	hsa-miR-1252-5p	PAR-CLIP	22100165
MIRT446231	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT446230	hsa-miR-3653-3p	PAR-CLIP	22100165
MIRT446229	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446228	hsa-miR-6126	PAR-CLIP	22100165
MIRT446227	hsa-miR-6864-5p	PAR-CLIP	22100165
MIRT446226	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT446225	hsa-miR-3658	PAR-CLIP	22100165
MIRT836949	hsa-miR-1249	CLIP-seq
MIRT836950	hsa-miR-3121-5p	CLIP-seq
MIRT836951	hsa-miR-103a	CLIP-seq
MIRT836952	hsa-miR-107	CLIP-seq
MIRT836953	hsa-miR-1184	CLIP-seq
MIRT836954	hsa-miR-1205	CLIP-seq
MIRT836955	hsa-miR-1237	CLIP-seq
MIRT836956	hsa-miR-3065-3p	CLIP-seq
MIRT836957	hsa-miR-3158-5p	CLIP-seq
MIRT836958	hsa-miR-4291	CLIP-seq
MIRT836959	hsa-miR-4307	CLIP-seq
MIRT836960	hsa-miR-4528	CLIP-seq
MIRT836961	hsa-miR-544	CLIP-seq
MIRT1948065	hsa-miR-3611	CLIP-seq
MIRT1948066	hsa-miR-3616-5p	CLIP-seq
MIRT1948067	hsa-miR-3647-5p	CLIP-seq
MIRT1948068	hsa-miR-4491	CLIP-seq
MIRT1948069	hsa-miR-4657	CLIP-seq
MIRT1948070	hsa-miR-4795-5p	CLIP-seq
MIRT1948071	hsa-miR-573	CLIP-seq
MIRT1948072	hsa-miR-595	CLIP-seq
MIRT2185929	hsa-miR-193a-3p	CLIP-seq
MIRT2185930	hsa-miR-193b	CLIP-seq
MIRT2185931	hsa-miR-3132	CLIP-seq
MIRT2185932	hsa-miR-3182	CLIP-seq
MIRT2185933	hsa-miR-4274	CLIP-seq
MIRT2185934	hsa-miR-4519	CLIP-seq
MIRT2185935	hsa-miR-892b	CLIP-seq
MIRT2385081	hsa-miR-1228	CLIP-seq
MIRT2385082	hsa-miR-342-3p	CLIP-seq
MIRT2385083	hsa-miR-3622a-3p	CLIP-seq
MIRT2385084	hsa-miR-3622b-3p	CLIP-seq
MIRT2385081	hsa-miR-1228	CLIP-seq
MIRT2490070	hsa-miR-1238	CLIP-seq
MIRT2490071	hsa-miR-1255a	CLIP-seq
MIRT2490072	hsa-miR-1255b	CLIP-seq
MIRT2490073	hsa-miR-127-5p	CLIP-seq
MIRT2490074	hsa-miR-1299	CLIP-seq
MIRT2490075	hsa-miR-153	CLIP-seq
MIRT2185929	hsa-miR-193a-3p	CLIP-seq
MIRT2185930	hsa-miR-193b	CLIP-seq
MIRT2490076	hsa-miR-2115	CLIP-seq
MIRT2490077	hsa-miR-218	CLIP-seq
MIRT2490078	hsa-miR-25	CLIP-seq
MIRT2185931	hsa-miR-3132	CLIP-seq
MIRT2490079	hsa-miR-3150b-3p	CLIP-seq
MIRT2185932	hsa-miR-3182	CLIP-seq
MIRT2490080	hsa-miR-32	CLIP-seq
MIRT1948065	hsa-miR-3611	CLIP-seq
MIRT1948066	hsa-miR-3616-5p	CLIP-seq
MIRT2490081	hsa-miR-3618	CLIP-seq
MIRT2490082	hsa-miR-3620	CLIP-seq
MIRT2385083	hsa-miR-3622a-3p	CLIP-seq
MIRT2385084	hsa-miR-3622b-3p	CLIP-seq
MIRT2490083	hsa-miR-363	CLIP-seq
MIRT1948067	hsa-miR-3647-5p	CLIP-seq
MIRT2490084	hsa-miR-3655	CLIP-seq
MIRT2490085	hsa-miR-367	CLIP-seq
MIRT2490086	hsa-miR-3713	CLIP-seq
MIRT2490087	hsa-miR-4254	CLIP-seq
MIRT2185933	hsa-miR-4274	CLIP-seq
MIRT2490088	hsa-miR-4294	CLIP-seq
MIRT2490089	hsa-miR-4299	CLIP-seq
MIRT2490090	hsa-miR-4303	CLIP-seq
MIRT2490091	hsa-miR-4308	CLIP-seq
MIRT2490092	hsa-miR-4456	CLIP-seq
MIRT2490093	hsa-miR-448	CLIP-seq
MIRT2490094	hsa-miR-450b-5p	CLIP-seq
MIRT2185934	hsa-miR-4519	CLIP-seq
MIRT2490095	hsa-miR-4633-3p	CLIP-seq
MIRT2490096	hsa-miR-4649-3p	CLIP-seq
MIRT2490097	hsa-miR-4663	CLIP-seq
MIRT2490098	hsa-miR-4682	CLIP-seq
MIRT2490099	hsa-miR-4689	CLIP-seq
MIRT2490100	hsa-miR-4728-3p	CLIP-seq
MIRT2490101	hsa-miR-4760-5p	CLIP-seq
MIRT2490102	hsa-miR-4782-5p	CLIP-seq
MIRT2490103	hsa-miR-4784	CLIP-seq
MIRT1948070	hsa-miR-4795-5p	CLIP-seq
MIRT2490104	hsa-miR-499-3p	CLIP-seq
MIRT2490105	hsa-miR-499a-3p	CLIP-seq
MIRT2490106	hsa-miR-507	CLIP-seq
MIRT2490107	hsa-miR-511	CLIP-seq
MIRT2490108	hsa-miR-516a-3p	CLIP-seq
MIRT2490109	hsa-miR-516b	CLIP-seq
MIRT2490110	hsa-miR-548q	CLIP-seq
MIRT2490111	hsa-miR-550b	CLIP-seq
MIRT2490112	hsa-miR-557	CLIP-seq
MIRT1948071	hsa-miR-573	CLIP-seq
MIRT1948072	hsa-miR-595	CLIP-seq
MIRT2490113	hsa-miR-636	CLIP-seq
MIRT2490114	hsa-miR-648	CLIP-seq
MIRT2490115	hsa-miR-891b	CLIP-seq
MIRT2185935	hsa-miR-892b	CLIP-seq
MIRT2490116	hsa-miR-924	CLIP-seq
MIRT2490117	hsa-miR-92a	CLIP-seq
MIRT2490118	hsa-miR-92b	CLIP-seq
MIRT2490119	hsa-miR-934	CLIP-seq
MIRT2385081	hsa-miR-1228	CLIP-seq
MIRT2490071	hsa-miR-1255a	CLIP-seq
MIRT2490072	hsa-miR-1255b	CLIP-seq
MIRT2490073	hsa-miR-127-5p	CLIP-seq
MIRT2490074	hsa-miR-1299	CLIP-seq
MIRT2490075	hsa-miR-153	CLIP-seq
MIRT2185929	hsa-miR-193a-3p	CLIP-seq
MIRT2185930	hsa-miR-193b	CLIP-seq
MIRT2490078	hsa-miR-25	CLIP-seq
MIRT2185931	hsa-miR-3132	CLIP-seq
MIRT2490079	hsa-miR-3150b-3p	CLIP-seq
MIRT2185932	hsa-miR-3182	CLIP-seq
MIRT2490080	hsa-miR-32	CLIP-seq
MIRT1948065	hsa-miR-3611	CLIP-seq
MIRT1948066	hsa-miR-3616-5p	CLIP-seq
MIRT2490081	hsa-miR-3618	CLIP-seq
MIRT2490082	hsa-miR-3620	CLIP-seq
MIRT2385083	hsa-miR-3622a-3p	CLIP-seq
MIRT2385084	hsa-miR-3622b-3p	CLIP-seq
MIRT2490083	hsa-miR-363	CLIP-seq
MIRT1948067	hsa-miR-3647-5p	CLIP-seq
MIRT2490084	hsa-miR-3655	CLIP-seq
MIRT2490085	hsa-miR-367	CLIP-seq
MIRT2490086	hsa-miR-3713	CLIP-seq
MIRT2490087	hsa-miR-4254	CLIP-seq
MIRT2185933	hsa-miR-4274	CLIP-seq
MIRT2490088	hsa-miR-4294	CLIP-seq
MIRT2490090	hsa-miR-4303	CLIP-seq
MIRT2490091	hsa-miR-4308	CLIP-seq
MIRT2490093	hsa-miR-448	CLIP-seq
MIRT2490094	hsa-miR-450b-5p	CLIP-seq
MIRT2185934	hsa-miR-4519	CLIP-seq
MIRT2490095	hsa-miR-4633-3p	CLIP-seq
MIRT2490096	hsa-miR-4649-3p	CLIP-seq
MIRT2490099	hsa-miR-4689	CLIP-seq
MIRT2490102	hsa-miR-4782-5p	CLIP-seq
MIRT2490103	hsa-miR-4784	CLIP-seq
MIRT1948070	hsa-miR-4795-5p	CLIP-seq
MIRT2490104	hsa-miR-499-3p	CLIP-seq
MIRT2490105	hsa-miR-499a-3p	CLIP-seq
MIRT2490106	hsa-miR-507	CLIP-seq
MIRT2490107	hsa-miR-511	CLIP-seq
MIRT2490109	hsa-miR-516b	CLIP-seq
MIRT2490111	hsa-miR-550b	CLIP-seq
MIRT2490112	hsa-miR-557	CLIP-seq
MIRT1948071	hsa-miR-573	CLIP-seq
MIRT2490115	hsa-miR-891b	CLIP-seq
MIRT2185935	hsa-miR-892b	CLIP-seq
MIRT2490116	hsa-miR-924	CLIP-seq
MIRT2490117	hsa-miR-92a	CLIP-seq
MIRT2490118	hsa-miR-92b	CLIP-seq
MIRT2490119	hsa-miR-934	CLIP-seq

Gene ontology (GO) Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0042645	Component	Mitochondrial nucleoid	IDA	37676315
GO:0042645	Component	Mitochondrial nucleoid	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867

Other IDs

• MIM: 620717
• HGNC: 29601
• e!Ensembl: ENSG00000141219

Protein

• UniProt ID: Q9BSJ5
• Protein name: Mitochondrial nucleoid-associated protein 1 (Cell migration-inducing gene 3 protein) (Human lung cancer oncogene 8 protein) (HLC-8) (Protein C17orf80)
• Protein function: Critical regulator of mitochondrial DNA (mtDNA) abundance (PubMed:37676315). Binds dsDNA throughout the mitochondrial genome without sequence specificity and controls mtDNA copy number by promoting its replication (PubMed:37676315). Also plays i
• Sequence:

  MSDNPPRMEVCPYCKKPFKRLKSHLPYCKMIGPTIPTDQKVYQSKPATLPRAKKMKGPIK
  DLIKAKGKELETENEERNSKLVVDKPEQTVKTFPLPAVGLERAATTKADKDIKNPIQPSF
  KMLKNTKPMTTFQEETKAQFYASEKTSPKRELAKDLPKSGESRCNPSEAGASLLVGSIEP
  SLSNQDRKYSSTLPNDVQTTSGDLKLDKIDPQRQELLVKLLDVPTGDCHISPKNVSDGVK
  RVRTLLSNERDSKGRDHLSGVPTDVTVTETPEKNTESLILSLKMSSLGKIQVMEKQEKGL
  TLGVETCGSKGNAEKSMSATEKQERTVMSHGCENFNTRDSVTGKESQGERPHLSLFIPRE
  TTYQFHSVSQSSSQSLASLATTFLQEKKAEAQNHHCVPDVKALMESPEGQLSLEPKSDSQ
  FQASHTGCQSPLCSAQRHTPQSPFTNHAAAAGRKTLRSCMGLEWFPELYPGYLGLGVLPG
  KPQCWNAMTQKPQLISPQGERLSQVSLLERSSTHIRSLEPPAGLTTSNFSLMRLLGAVQK
  GWIRCNTTIRKSGFGGITMLFTGYFVLCCSWSFRRLKKLCRPLPWKSTVPPCIGVAKTTG
  DCRSKTCLD

• Sequence length: 609

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Prostate cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Malignant neoplasm of prostate	Prostate cancer	BEFREE	25868388		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	25868388		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for MTNAP1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to MTNAP1.