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Gene Gene information from NCBI Gene database.
Entrez ID 92399
Gene name Mitochondrial ribosome recycling factor
Gene symbol MRRF
Synonyms (NCBI Gene)
MRFFMTRRFRRF
Chromosome 9
Chromosome location 9q33.2
Summary This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the termination of mitochondrial trans
miRNA miRNA information provided by mirtarbase database.
579 Show/Hide all (579)
miRTarBase ID miRNA Experiments Reference
MIRT031902 hsa-miR-16-5p Proteomics 18668040
MIRT607038 hsa-miR-8485 HITS-CLIP 22927820
MIRT607037 hsa-miR-329-3p HITS-CLIP 22927820
MIRT607036 hsa-miR-362-3p HITS-CLIP 22927820
MIRT607035 hsa-miR-4524b-3p HITS-CLIP 22927820
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10 Show/Hide all (10)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 28514442, 32296183, 33961781
GO:0005739 Component Mitochondrion HTP 34800366
GO:0005739 Component Mitochondrion IBA
GO:0005739 Component Mitochondrion IDA 18782833
GO:0005739 Component Mitochondrion IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604602 7234 ENSG00000148187
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96E11
Protein name Ribosome-recycling factor, mitochondrial (RRF) (mtRRF) (Ribosome-releasing factor, mitochondrial)
Protein function Responsible for the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis (PubMed:19716793, PubMed:33878294). Acts in collaboration with GFM2 (PubMed:33878294). Promotes mitochondrial ribosome recyc
PDB 6NU2 , 6ZS9 , 7L08 , 7L20 , 7NSH , 7NSI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01765 RRF 99 → 261 Ribosome recycling factor Domain
Sequence
Sequence length 262
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Mitochondrial translation termination
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Myoepithelial tumor Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Cytochrome-c Oxidase Deficiency Cytochrome-C Oxidase Deficiency BEFREE 18504129, 8064325
★★★★★
★☆☆☆☆
Found in Text Mining only
Mitochondrial Diseases Mitochondrial disease Pubtator 18782833 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Myopathy Myopathy BEFREE 11382203
★★★★★
★☆☆☆☆
Found in Text Mining only
Trifunctional Protein Deficiency With Myopathy And Neuropathy Mitochondrial trifunctional protein deficiency BEFREE 20425236
★★★★★
★☆☆☆☆
Found in Text Mining only