MRRF (mitochondrial ribosome recycling factor)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 92399 |
| Gene name | Mitochondrial ribosome recycling factor |
| Gene symbol | MRRF |
| Synonyms (NCBI Gene) |
MRFFMTRRFRRF
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| Chromosome | 9 |
| Chromosome location | 9q33.2 |
| Summary | This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the termination of mitochondrial trans |
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miRNA
miRNA information provided by mirtarbase database.
579
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q96E11 | ||||||||||
| Protein name | Ribosome-recycling factor, mitochondrial (RRF) (mtRRF) (Ribosome-releasing factor, mitochondrial) | ||||||||||
| Protein function | Responsible for the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis (PubMed:19716793, PubMed:33878294). Acts in collaboration with GFM2 (PubMed:33878294). Promotes mitochondrial ribosome recyc | ||||||||||
| PDB | 6NU2 , 6ZS9 , 7L08 , 7L20 , 7NSH , 7NSI | ||||||||||
| Family and domains |
Pfam
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| Sequence |
MALGLKCFRMVHPTFRNYLAASIRPVSEVTLKTVHERQHGHRQYMAYSAVPVRHFATKKA |
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| Sequence length | 262 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with MRRF across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to MRRF (see Related Genes above), that are NOT already directly curated for MRRF itself -- a lead worth checking, not a confirmed association.
0
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