MRPL18 (mitochondrial ribosomal protein L18)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 29074
• Gene name: Mitochondrial ribosomal protein L18
• Gene symbol: MRPL18
• Synonyms (NCBI Gene): HSPC071, L18mt, MRP-L18, uL18m
• Chromosome: 6
• Chromosome location: 6q25.3
• Summary: This nuclear gene encodes a protein component of the larger 39S subunit of mitochondrial ribosome. This protein may also aid in the import of nuclear-encoded 5S rRNA into mitochondria. Alternative splicing results in multiple transcript variants, most of

miRNA Show/Hide all (114)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020849	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT029683	hsa-miR-26b-5p	Microarray	19088304
MIRT218176	hsa-miR-548at-5p	PAR-CLIP	21572407
MIRT544330	hsa-miR-944	PAR-CLIP	21572407
MIRT544329	hsa-miR-5002-3p	PAR-CLIP	21572407
MIRT218174	hsa-miR-938	PAR-CLIP	21572407
MIRT218177	hsa-miR-6886-3p	PAR-CLIP	21572407
MIRT218169	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT218173	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT218170	hsa-miR-488-3p	PAR-CLIP	21572407
MIRT218175	hsa-miR-3157-3p	PAR-CLIP	21572407
MIRT218172	hsa-miR-874-3p	PAR-CLIP	21572407
MIRT544328	hsa-miR-510-3p	PAR-CLIP	21572407
MIRT456515	hsa-miR-5681a	PAR-CLIP	23592263
MIRT456514	hsa-miR-6759-3p	PAR-CLIP	23592263
MIRT456513	hsa-miR-3605-5p	PAR-CLIP	23592263
MIRT456512	hsa-miR-765	PAR-CLIP	23592263
MIRT456511	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT456510	hsa-miR-6744-5p	PAR-CLIP	23592263
MIRT456509	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT456508	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT218176	hsa-miR-548at-5p	PAR-CLIP	21572407
MIRT544330	hsa-miR-944	PAR-CLIP	21572407
MIRT544329	hsa-miR-5002-3p	PAR-CLIP	21572407
MIRT218174	hsa-miR-938	PAR-CLIP	21572407
MIRT218177	hsa-miR-6886-3p	PAR-CLIP	21572407
MIRT218169	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT218173	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT218170	hsa-miR-488-3p	PAR-CLIP	21572407
MIRT218175	hsa-miR-3157-3p	PAR-CLIP	21572407
MIRT218172	hsa-miR-874-3p	PAR-CLIP	21572407
MIRT544328	hsa-miR-510-3p	PAR-CLIP	21572407
MIRT456515	hsa-miR-5681a	PAR-CLIP	23592263
MIRT456514	hsa-miR-6759-3p	PAR-CLIP	23592263
MIRT456513	hsa-miR-3605-5p	PAR-CLIP	23592263
MIRT456512	hsa-miR-765	PAR-CLIP	23592263
MIRT456511	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT456510	hsa-miR-6744-5p	PAR-CLIP	23592263
MIRT456509	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT456508	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT1158528	hsa-miR-1283	CLIP-seq
MIRT1158529	hsa-miR-1323	CLIP-seq
MIRT1158530	hsa-miR-142-3p	CLIP-seq
MIRT1158531	hsa-miR-155	CLIP-seq
MIRT1158532	hsa-miR-340	CLIP-seq
MIRT1158533	hsa-miR-345	CLIP-seq
MIRT1158534	hsa-miR-3660	CLIP-seq
MIRT1158535	hsa-miR-3677-5p	CLIP-seq
MIRT1158536	hsa-miR-4256	CLIP-seq
MIRT1158537	hsa-miR-4436b-5p	CLIP-seq
MIRT1158538	hsa-miR-4526	CLIP-seq
MIRT1158539	hsa-miR-4666-5p	CLIP-seq
MIRT1158540	hsa-miR-4687-3p	CLIP-seq
MIRT1158541	hsa-miR-4699-3p	CLIP-seq
MIRT1158542	hsa-miR-4772-3p	CLIP-seq
MIRT1158543	hsa-miR-548o	CLIP-seq
MIRT1158530	hsa-miR-142-3p	CLIP-seq
MIRT1158534	hsa-miR-3660	CLIP-seq
MIRT1158535	hsa-miR-3677-5p	CLIP-seq
MIRT1158538	hsa-miR-4526	CLIP-seq
MIRT1158540	hsa-miR-4687-3p	CLIP-seq
MIRT1158529	hsa-miR-1323	CLIP-seq
MIRT1158533	hsa-miR-345	CLIP-seq
MIRT1158536	hsa-miR-4256	CLIP-seq
MIRT1158539	hsa-miR-4666-5p	CLIP-seq
MIRT1158543	hsa-miR-548o	CLIP-seq
MIRT1158529	hsa-miR-1323	CLIP-seq
MIRT2573310	hsa-miR-137	CLIP-seq
MIRT1158530	hsa-miR-142-3p	CLIP-seq
MIRT1158531	hsa-miR-155	CLIP-seq
MIRT2573311	hsa-miR-2115	CLIP-seq
MIRT2573312	hsa-miR-2116	CLIP-seq
MIRT2573313	hsa-miR-3064-5p	CLIP-seq
MIRT2573314	hsa-miR-3180-5p	CLIP-seq
MIRT2573315	hsa-miR-320e	CLIP-seq
MIRT2573316	hsa-miR-3607-3p	CLIP-seq
MIRT1158535	hsa-miR-3677-5p	CLIP-seq
MIRT1158539	hsa-miR-4666-5p	CLIP-seq
MIRT2573317	hsa-miR-4677-5p	CLIP-seq
MIRT1158540	hsa-miR-4687-3p	CLIP-seq
MIRT1158541	hsa-miR-4699-3p	CLIP-seq
MIRT2573318	hsa-miR-4718	CLIP-seq
MIRT2573319	hsa-miR-4753-3p	CLIP-seq
MIRT2573320	hsa-miR-516a-3p	CLIP-seq
MIRT2573321	hsa-miR-520a-5p	CLIP-seq
MIRT2573322	hsa-miR-525-5p	CLIP-seq
MIRT2573323	hsa-miR-548a-3p	CLIP-seq
MIRT2573324	hsa-miR-548e	CLIP-seq
MIRT2573325	hsa-miR-548f	CLIP-seq
MIRT1158543	hsa-miR-548o	CLIP-seq
MIRT1158529	hsa-miR-1323	CLIP-seq
MIRT2573310	hsa-miR-137	CLIP-seq
MIRT1158530	hsa-miR-142-3p	CLIP-seq
MIRT1158531	hsa-miR-155	CLIP-seq
MIRT2573311	hsa-miR-2115	CLIP-seq
MIRT2573312	hsa-miR-2116	CLIP-seq
MIRT2573313	hsa-miR-3064-5p	CLIP-seq
MIRT2573314	hsa-miR-3180-5p	CLIP-seq
MIRT2573315	hsa-miR-320e	CLIP-seq
MIRT2573316	hsa-miR-3607-3p	CLIP-seq
MIRT1158535	hsa-miR-3677-5p	CLIP-seq
MIRT1158539	hsa-miR-4666-5p	CLIP-seq
MIRT2573317	hsa-miR-4677-5p	CLIP-seq
MIRT1158540	hsa-miR-4687-3p	CLIP-seq
MIRT1158541	hsa-miR-4699-3p	CLIP-seq
MIRT2573318	hsa-miR-4718	CLIP-seq
MIRT2573319	hsa-miR-4753-3p	CLIP-seq
MIRT2573320	hsa-miR-516a-3p	CLIP-seq
MIRT2573321	hsa-miR-520a-5p	CLIP-seq
MIRT2573322	hsa-miR-525-5p	CLIP-seq
MIRT2573323	hsa-miR-548a-3p	CLIP-seq
MIRT2573324	hsa-miR-548e	CLIP-seq
MIRT2573325	hsa-miR-548f	CLIP-seq
MIRT1158543	hsa-miR-548o	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	IEA
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	11543634
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 33961781
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	28892042
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005761	Component	Mitochondrial ribosome	NAS	11543634
GO:0005762	Component	Mitochondrial large ribosomal subunit	IDA	25278503, 28892042
GO:0005762	Component	Mitochondrial large ribosomal subunit	NAS	25278503
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	11543634
GO:0008097	Function	5S rRNA binding	IBA
GO:0008097	Function	5S rRNA binding	IDA	21685364
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:0035928	Process	RRNA import into mitochondrion	IDA	21685364
GO:1990904	Component	Ribonucleoprotein complex	IEA

Other IDs

• MIM: 611831
• HGNC: 14477
• e!Ensembl: ENSG00000112110

Protein

• UniProt ID: Q9H0U6
• Protein name: Large ribosomal subunit protein uL18m (39S ribosomal protein L18, mitochondrial) (L18mt) (MRP-L18)
• Protein function: Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recogn
• PDB: 3J7Y , 5OOL , 5OOM , 6NU2 , 6NU3 , 6ZM5 , 6ZM6 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5J , 7ODR , 7ODS , 7ODT , 7OF0 , 7OF2 , 7OF3 , 7OF4 , 7OF5 , 7OF6 , 7OF7 , 7OG4 , 7OI6 , 7OI7 , 7OI8 , 7OI9 , 7OIA , 7OIB , 7OIC , 7OID , 7OIE , 7PD3 , 7PO4 , 7QH6 , 7QH7 , 7QI4 , 7QI5 , 7QI6 , 8ANY , 8K2A , 8K2B , 8OIR , 8OIT , 8PK0 , 8QSJ , 8QU1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00861	Ribosomal_L18p	59 → 170	Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast	Family

• Sequence:

  MALRSRFWGLFSVCRNPGCRFAALSTSSEPAAKPEVDPVENEAVAPEFTNRNPRNLELLS
  VARKERGWRTVFPSREFWHRLRVIRTQHHVEALVEHQNGKVVVSASTREWAIKKHLYSTR
  NVVACESIGRVLAQRCLEAGINFMVYQPTPWEAASDSMKRLQSAMTEGGVVLREPQRIYE
  

• Sequence length: 180

Pathways

KEGG Pathway	Reactome Pathway
Ribosome	Mitochondrial translation elongation
	Mitochondrial translation termination

Related Genes

Sort by: Blended Diseases Pathways Evidence source

MRPL28 3 shared pathwaysRibosome, Mitochondrial translation elongation, Mitochondrial translation termination Related via 3 shared pathways including Ribosome, Mitochondrial translation elongation. MRPL3 3 shared pathwaysRibosome, Mitochondrial translation elongation, Mitochondrial translation termination Related via 3 shared pathways including Ribosome, Mitochondrial translation elongation. MRPL10 3 shared pathwaysRibosome, Mitochondrial translation elongation, Mitochondrial translation termination Related via 3 shared pathways including Ribosome, Mitochondrial translation elongation. MRPL21 3 shared pathwaysRibosome, Mitochondrial translation elongation, Mitochondrial translation termination Related via 3 shared pathways including Ribosome, Mitochondrial translation elongation. MRPL13 3 shared pathwaysRibosome, Mitochondrial translation elongation, Mitochondrial translation termination Related via 3 shared pathways including Ribosome, Mitochondrial translation elongation.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
MRPL28	0	[]	3	["Ribosome","Mitochondrial translation elongation","Mitochondrial translation termination"]	0	[]
MRPL3	0	[]	3	["Ribosome","Mitochondrial translation elongation","Mitochondrial translation termination"]	0	[]
MRPL10	0	[]	3	["Ribosome","Mitochondrial translation elongation","Mitochondrial translation termination"]	0	[]
MRPL21	0	[]	3	["Ribosome","Mitochondrial translation elongation","Mitochondrial translation termination"]	0	[]
MRPL13	0	[]	3	["Ribosome","Mitochondrial translation elongation","Mitochondrial translation termination"]	0	[]

Diseases Linked via Similar Genes

Diabetes mellitus type 2 Linked via 2 of 5 related genesMRPL10, MRPL21 Bone fracture Linked via 1 of 5 related genesMRPL28 Combined oxidative phosphorylation deficiency Linked via 1 of 5 related genesMRPL3 Mitochondrial disease Linked via 1 of 5 related genesMRPL3 Metabolic syndrome Linked via 1 of 5 related genesMRPL21

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Diabetes mellitus type 2	2	["MRPL10","MRPL21"]
Bone fracture	1	["MRPL28"]
Combined oxidative phosphorylation deficiency	1	["MRPL3"]
Mitochondrial disease	1	["MRPL3"]
Metabolic syndrome	1	["MRPL21"]