MORN3 (MORN repeat containing 3)

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Gene Gene information from NCBI Gene database.
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Entrez ID 283385
Gene name MORN repeat containing 3
Gene symbol MORN3
Synonyms (NCBI Gene)
-
Chromosome 12
Chromosome location 12q24.31
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT496376 hsa-miR-4747-3p PAR-CLIP 22291592
MIRT496375 hsa-miR-1295b-3p PAR-CLIP 22291592
MIRT496374 hsa-miR-4733-5p PAR-CLIP 22291592
MIRT496376 hsa-miR-4747-3p PAR-CLIP 22291592
MIRT496375 hsa-miR-1295b-3p PAR-CLIP 22291592
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0001669 Component Acrosomal vesicle IEA
GO:0005515 Function Protein binding IPI 25416956, 27107012, 28514442, 31515488, 32296183, 33961781
GO:0005634 Component Nucleus HDA 21630459
GO:0030674 Function Protein-macromolecule adaptor activity IDA 29681526
GO:0031410 Component Cytoplasmic vesicle IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6PF18
Protein name MORN repeat-containing protein 3
Protein function Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, o
PDB 8J07
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02493 MORN 62 → 84 MORN repeat Repeat
PF02493 MORN 137 → 159 MORN repeat Repeat
PF02493 MORN 38 → 59 MORN repeat Repeat
PF02493 MORN 160 → 176 MORN repeat Repeat
Sequence 
MPVSKCPKKSESLWKGWDRKAQRNGLRSQVYAVNGDYYVGEWKDNVKHGKGTQVWKKKGA
IYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCG
SQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDH
GQLFEGFWVDNMAKCGTMIDFGRDEAPEPTQFPIPEVKILDPDGVLAEALAMFRKTEEGD
Sequence length 240
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
ALZHEIMER DISEASE — GWAS catalog 39998322
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Neoplasms Neoplasms BEFREE 29681526
★★★★★
★☆☆☆☆
Found in Text Mining only

No strongly related genes found yet for MORN3.

No additional diseases found yet through genes similar to MORN3.