MMS19 (MMS19 cytosolic iron-sulfur assembly component)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 64210
• Gene name: MMS19 cytosolic iron-sulfur assembly component
• Gene symbol: MMS19
• Synonyms (NCBI Gene): CIAO4, MET18, MMS19L, hMMS19
• Chromosome: 10
• Chromosome location: 10q24.1

miRNA Show/Hide all (151)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005262	hsa-miR-16-5p	pSILAC	18668040
MIRT025507	hsa-miR-34a-5p	Proteomics	21566225
MIRT025507	hsa-miR-34a-5p	Proteomics	21566225
MIRT030607	hsa-miR-24-3p	Microarray	19748357
MIRT005262	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT005262	hsa-miR-16-5p	Microarray	21199864
MIRT044232	hsa-miR-29c-3p	CLASH	23622248
MIRT040621	hsa-miR-92b-3p	CLASH	23622248
MIRT737170	hsa-miR-501-5p	RNA-seq, qRT-PCR	34148372
MIRT1153591	hsa-miR-1179	CLIP-seq
MIRT1153592	hsa-miR-1202	CLIP-seq
MIRT1153593	hsa-miR-1266	CLIP-seq
MIRT1153594	hsa-miR-132	CLIP-seq
MIRT1153595	hsa-miR-1915	CLIP-seq
MIRT1153596	hsa-miR-212	CLIP-seq
MIRT1153597	hsa-miR-214	CLIP-seq
MIRT1153598	hsa-miR-219-5p	CLIP-seq
MIRT1153599	hsa-miR-3127-5p	CLIP-seq
MIRT1153600	hsa-miR-3169	CLIP-seq
MIRT1153601	hsa-miR-3194-5p	CLIP-seq
MIRT1153602	hsa-miR-3529	CLIP-seq
MIRT1153603	hsa-miR-3616-3p	CLIP-seq
MIRT1153604	hsa-miR-3619-5p	CLIP-seq
MIRT1153605	hsa-miR-379	CLIP-seq
MIRT1153606	hsa-miR-3918	CLIP-seq
MIRT1153607	hsa-miR-3927	CLIP-seq
MIRT1153608	hsa-miR-3972	CLIP-seq
MIRT1153609	hsa-miR-421	CLIP-seq
MIRT1153610	hsa-miR-4291	CLIP-seq
MIRT1153611	hsa-miR-4518	CLIP-seq
MIRT1153612	hsa-miR-4709-5p	CLIP-seq
MIRT1153613	hsa-miR-4717-5p	CLIP-seq
MIRT1153614	hsa-miR-4721	CLIP-seq
MIRT1153615	hsa-miR-4726-3p	CLIP-seq
MIRT1153616	hsa-miR-4727-5p	CLIP-seq
MIRT1153617	hsa-miR-4740-5p	CLIP-seq
MIRT1153618	hsa-miR-4760-5p	CLIP-seq
MIRT1153619	hsa-miR-4769-3p	CLIP-seq
MIRT1153620	hsa-miR-4773	CLIP-seq
MIRT1153621	hsa-miR-4782-3p	CLIP-seq
MIRT1153622	hsa-miR-645	CLIP-seq
MIRT1153623	hsa-miR-761	CLIP-seq
MIRT1153624	hsa-miR-922	CLIP-seq
MIRT1153591	hsa-miR-1179	CLIP-seq
MIRT1153592	hsa-miR-1202	CLIP-seq
MIRT1153593	hsa-miR-1266	CLIP-seq
MIRT2043945	hsa-miR-2113	CLIP-seq
MIRT1153597	hsa-miR-214	CLIP-seq
MIRT2043946	hsa-miR-218	CLIP-seq
MIRT2043947	hsa-miR-2682	CLIP-seq
MIRT1153599	hsa-miR-3127-5p	CLIP-seq
MIRT2043948	hsa-miR-3153	CLIP-seq
MIRT1153601	hsa-miR-3194-5p	CLIP-seq
MIRT1153602	hsa-miR-3529	CLIP-seq
MIRT1153604	hsa-miR-3619-5p	CLIP-seq
MIRT2043949	hsa-miR-3714	CLIP-seq
MIRT1153605	hsa-miR-379	CLIP-seq
MIRT1153606	hsa-miR-3918	CLIP-seq
MIRT2043950	hsa-miR-3919	CLIP-seq
MIRT1153607	hsa-miR-3927	CLIP-seq
MIRT1153608	hsa-miR-3972	CLIP-seq
MIRT1153610	hsa-miR-4291	CLIP-seq
MIRT2043951	hsa-miR-449c	CLIP-seq
MIRT1153611	hsa-miR-4518	CLIP-seq
MIRT2043952	hsa-miR-4648	CLIP-seq
MIRT2043953	hsa-miR-4654	CLIP-seq
MIRT2043954	hsa-miR-4668-5p	CLIP-seq
MIRT2043955	hsa-miR-4711-3p	CLIP-seq
MIRT1153616	hsa-miR-4727-5p	CLIP-seq
MIRT2043956	hsa-miR-4756-3p	CLIP-seq
MIRT1153619	hsa-miR-4769-3p	CLIP-seq
MIRT2043957	hsa-miR-4769-5p	CLIP-seq
MIRT2043958	hsa-miR-4786-5p	CLIP-seq
MIRT2043959	hsa-miR-520d-5p	CLIP-seq
MIRT2043960	hsa-miR-524-5p	CLIP-seq
MIRT2043961	hsa-miR-548an	CLIP-seq
MIRT1153623	hsa-miR-761	CLIP-seq
MIRT1153624	hsa-miR-922	CLIP-seq
MIRT1153591	hsa-miR-1179	CLIP-seq
MIRT1153594	hsa-miR-132	CLIP-seq
MIRT2043945	hsa-miR-2113	CLIP-seq
MIRT2273354	hsa-miR-2116	CLIP-seq
MIRT1153596	hsa-miR-212	CLIP-seq
MIRT2043946	hsa-miR-218	CLIP-seq
MIRT1153598	hsa-miR-219-5p	CLIP-seq
MIRT2043948	hsa-miR-3153	CLIP-seq
MIRT2273355	hsa-miR-3660	CLIP-seq
MIRT2273356	hsa-miR-4256	CLIP-seq
MIRT2273357	hsa-miR-4526	CLIP-seq
MIRT2043952	hsa-miR-4648	CLIP-seq
MIRT2043953	hsa-miR-4654	CLIP-seq
MIRT2043954	hsa-miR-4668-5p	CLIP-seq
MIRT2273358	hsa-miR-4677-5p	CLIP-seq
MIRT2043955	hsa-miR-4711-3p	CLIP-seq
MIRT1153618	hsa-miR-4760-5p	CLIP-seq
MIRT2273359	hsa-miR-4762-3p	CLIP-seq
MIRT2043957	hsa-miR-4769-5p	CLIP-seq
MIRT1153620	hsa-miR-4773	CLIP-seq
MIRT1153621	hsa-miR-4782-3p	CLIP-seq
MIRT2043959	hsa-miR-520d-5p	CLIP-seq
MIRT2043960	hsa-miR-524-5p	CLIP-seq
MIRT1153622	hsa-miR-645	CLIP-seq
MIRT1153591	hsa-miR-1179	CLIP-seq
MIRT1153591	hsa-miR-1179	CLIP-seq
MIRT2572224	hsa-miR-140-5p	CLIP-seq
MIRT2043945	hsa-miR-2113	CLIP-seq
MIRT2273354	hsa-miR-2116	CLIP-seq
MIRT2043946	hsa-miR-218	CLIP-seq
MIRT2043947	hsa-miR-2682	CLIP-seq
MIRT2043948	hsa-miR-3153	CLIP-seq
MIRT2043949	hsa-miR-3714	CLIP-seq
MIRT2572225	hsa-miR-377	CLIP-seq
MIRT2043950	hsa-miR-3919	CLIP-seq
MIRT2572226	hsa-miR-4446-5p	CLIP-seq
MIRT2043951	hsa-miR-449c	CLIP-seq
MIRT2043952	hsa-miR-4648	CLIP-seq
MIRT2043953	hsa-miR-4654	CLIP-seq
MIRT2043954	hsa-miR-4668-5p	CLIP-seq
MIRT2273358	hsa-miR-4677-5p	CLIP-seq
MIRT2572227	hsa-miR-4696	CLIP-seq
MIRT2043955	hsa-miR-4711-3p	CLIP-seq
MIRT2572228	hsa-miR-4755-5p	CLIP-seq
MIRT2043956	hsa-miR-4756-3p	CLIP-seq
MIRT2043957	hsa-miR-4769-5p	CLIP-seq
MIRT2043958	hsa-miR-4786-5p	CLIP-seq
MIRT2043959	hsa-miR-520d-5p	CLIP-seq
MIRT2043960	hsa-miR-524-5p	CLIP-seq
MIRT2043961	hsa-miR-548an	CLIP-seq
MIRT2572229	hsa-miR-603	CLIP-seq
MIRT2572230	hsa-miR-670	CLIP-seq
MIRT1153591	hsa-miR-1179	CLIP-seq
MIRT2043945	hsa-miR-2113	CLIP-seq
MIRT2273354	hsa-miR-2116	CLIP-seq
MIRT2043946	hsa-miR-218	CLIP-seq
MIRT2043947	hsa-miR-2682	CLIP-seq
MIRT2043948	hsa-miR-3153	CLIP-seq
MIRT2043949	hsa-miR-3714	CLIP-seq
MIRT2572225	hsa-miR-377	CLIP-seq
MIRT2043950	hsa-miR-3919	CLIP-seq
MIRT2043951	hsa-miR-449c	CLIP-seq
MIRT2043952	hsa-miR-4648	CLIP-seq
MIRT2043953	hsa-miR-4654	CLIP-seq
MIRT2043954	hsa-miR-4668-5p	CLIP-seq
MIRT2273358	hsa-miR-4677-5p	CLIP-seq
MIRT2043955	hsa-miR-4711-3p	CLIP-seq
MIRT2043956	hsa-miR-4756-3p	CLIP-seq
MIRT2043957	hsa-miR-4769-5p	CLIP-seq
MIRT2043959	hsa-miR-520d-5p	CLIP-seq
MIRT2043960	hsa-miR-524-5p	CLIP-seq
MIRT2043961	hsa-miR-548an	CLIP-seq
MIRT2572229	hsa-miR-603	CLIP-seq

Gene ontology (GO) Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IMP	11279242
GO:0005515	Function	Protein binding	IPI	11279242, 20797633, 21516116, 23585563, 23891004, 24981860, 25416956, 28178521, 28514442, 30742009, 33961781
GO:0005634	Component	Nucleus	IDA	20797633
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	11071939
GO:0005654	Component	Nucleoplasm	IDA
GO:0005675	Component	Transcription factor TFIIH holo complex	NAS	11279242
GO:0005737	Component	Cytoplasm	IDA	20797633, 22678361
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005819	Component	Spindle	IDA	20797633
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0007059	Process	Chromosome segregation	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0019899	Function	Enzyme binding	IEA
GO:0030159	Function	Signaling receptor complex adaptor activity	NAS	11279242
GO:0030331	Function	Nuclear estrogen receptor binding	IPI	11279242
GO:0030674	Function	Protein-macromolecule adaptor activity	NAS	11279242
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0051604	Process	Protein maturation	IBA
GO:0051604	Process	Protein maturation	IDA	29225034
GO:0051604	Process	Protein maturation	IEA
GO:0051604	Process	Protein maturation	IMP	22678361
GO:0071817	Component	MMXD complex	IBA
GO:0071817	Component	MMXD complex	IDA	20797633
GO:0097361	Component	Cytosolic [4Fe-4S] assembly targeting complex	IBA
GO:0097361	Component	Cytosolic [4Fe-4S] assembly targeting complex	IDA	22678361, 22678362, 23585563
GO:0097361	Component	Cytosolic [4Fe-4S] assembly targeting complex	IEA

Other IDs

• MIM: 614777
• HGNC: 13824
• e!Ensembl: ENSG00000155229

Protein

• UniProt ID: Q96T76
• Protein name: MMS19 nucleotide excision repair protein homolog (hMMS19) (MET18 homolog) (MMS19-like protein)
• Protein function: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity (PubMed:29848
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12460	MMS19_C	537 → 962	RNAPII transcription regulator C-terminal	Domain
  PF14500	MMS19_N	50 → 311	Dos2-interacting transcription regulator of RNA-Pol-II	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed with higher expression in testis. {ECO:0000269|PubMed:11071939, ECO:0000269|PubMed:11328871}.
• Sequence:

  MAAAAAVEAAAPMGALWGLVHDFVVGQQEGPADQVAADVKSGNYTVLQVVEALGSSLENP
  EPRTRARAIQLLSQVLLHCHTLLLEKEVVHLILFYENRLKDHHLVIPSVLQGLKALSLCV
  ALPPGLAVSVLKAIFQEVHVQSLPQVDRHTVYNIITNFMRTREEELKSLGADFTFGFIQV
  MDGEKDPRNLLVAFRIVHDLISRDYSLGPFVEELFEVTSCYFPIDFTPPPNDPHGIQRED
  LILSLRAVLASTPRFAEFLLPLLIEKVDSEVLSAKLDSLQTLNACCAVYGQKELKDFLPS
  LWASIRREVFQTASERVEAEGLAALHSLTACLSRSVLRADAEDLLDSFLSNILQDCRHHL
  CEPDMKLVWPSAKLLQAAAGASARACDSVTSNVLPLLLEQFHKHSQSSQRRTILEMLLGF
  LKLQQKWSYEDKDQRPLNGFKDQLCSLVFMALTDPSTQLQLVGIRTLTVLGAQPDLLSYE
  DLELAVGHLYRLSFLKEDSQSCRVAALEASGTLAALYPVAFSSHLVPKLAEELRVGESNL
  TNGDEPTQCSRHLCCLQALSAVSTHPSIVKETLPLLLQHLWQVNRGNMVAQSSDVIAVCQ
  SLRQMAEKCQQDPESCWYFHQTAIPCLLALAVQASMPEKEPSVLRKVLLEDEVLAAMVSV
  IGTATTHLSPELAAQSVTHIVPLFLDGNVSFLPENSFPSRFQPFQDGSSGQRRLIALLMA
  FVCSLPRNVEIPQLNQLMRELLELSCCHSCPFSSTAAAKCFAGLLNKHPAGQQLDEFLQL
  AVDKVEAGLGSGPCRSQAFTLLLWVTKALVLRYHPLSSCLTARLMGLLSDPELGPAAADG
  FSLLMSDCTDVLTRAGHAEVRIMFRQRFFTDNVPALVQGFHAAPQDVKPNYLKGLSHVLN
  RLPKPVLLPELPTLLSLLLEALSCPDCVVQLSTLSCLQPLLLEAPQVMSLHVDTLVTKFL
  NLSSSPSMAVRIAALQCMHALTRLPTPVLLPYKPQVIRALAKPLDDKKRLVRKEAVSARG
  EWFLLGSPGS

• Sequence length: 1030

Related Genes

No strongly related genes found yet for MMS19.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to MMS19.