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Gene Gene information from NCBI Gene database.
Entrez ID 93380
Gene name Membrane magnesium transporter 1
Gene symbol MMGT1
Synonyms (NCBI Gene)
EMC5TMEM32
Chromosome X
Chromosome location Xq26.3
miRNA miRNA information provided by mirtarbase database.
979 Show/Hide all (979)
miRTarBase ID miRNA Experiments Reference
MIRT701913 hsa-miR-217 HITS-CLIP 23313552
MIRT701912 hsa-miR-6807-3p HITS-CLIP 23313552
MIRT701911 hsa-miR-23c HITS-CLIP 23313552
MIRT701910 hsa-miR-23b-3p HITS-CLIP 23313552
MIRT701909 hsa-miR-130a-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
43 Show/Hide all (43)
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0005515 Function Protein binding IPI 22119785, 26496610, 28514442, 32296183, 32439656, 33961781, 35271311
GO:0005737 Component Cytoplasm IEA
GO:0005768 Component Endosome IEA
GO:0005769 Component Early endosome IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
301098 28100 ENSG00000169446
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8N4V1
Protein name ER membrane protein complex subunit 5 (Membrane magnesium transporter 1) (Transmembrane protein 32)
Protein function Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed
PDB 6WW7 , 6Z3W , 7ADO , 7ADP , 8EOI , 8J0N , 8J0O , 8S9S , 9C7V
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10270 MMgT 10 → 99 Membrane magnesium transporter Family
Sequence
Sequence length 131
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Thyroid cancer, nonmedullary, 1 Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations