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Gene Gene information from NCBI Gene database.
Entrez ID 9761
Gene name Malectin
Gene symbol MLEC
Synonyms (NCBI Gene)
KIAA0152
Chromosome 12
Chromosome location 12q24.31
Summary This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic
miRNA miRNA information provided by mirtarbase database.
1606 Show/Hide all (1606)
miRTarBase ID miRNA Experiments Reference
MIRT003889 hsa-miR-24-3p Luciferase reporter assay 15131085
MIRT019896 hsa-miR-375 Microarray 20215506
MIRT022943 hsa-miR-124-3p Microarray 18668037
MIRT003889 hsa-miR-24-3p Reporter assay;Western blot;Other 19748357
MIRT050275 hsa-miR-25-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15 Show/Hide all (15)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 30021884, 31831667, 35271311
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005783 Component Endoplasmic reticulum ISS
GO:0005789 Component Endoplasmic reticulum membrane IEA
GO:0005789 Component Endoplasmic reticulum membrane NAS 31831667
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613802 28973 ENSG00000110917
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14165
Protein name Malectin
Protein function Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).
PDB 6S7T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF11721 Malectin 48 → 208 Malectin domain Domain
Sequence
MLGAWAVEGTAVALLRLLLLLLPPAIRGPGLGVAGVAGAAGAGLPESVIWAVNAGGEAHV
DVHGIHFRKDPLEGRVGRASDYGMKLPILRSNPEDQILYQTERYNEETFGYEVPIKEEGD
YVLVLKFAEVYFAQSQQKVFDVRLNGHVVVKDLDIFDRVGHSTAHDEIIPMSIRKGKLSV
QGEVSTFTGKLYIEFVKGYYDNPKVCAL
YIMAGTVDDVPKLQPHPGLEKKEEEEEEEEYD
EGSNLKKQTNKNRVQSGPRTPNPYASDNSSLMFPILVAFGVFIPTLFCLCRL
Sequence length 292
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Neutrophil degranulation