MLDHR (mitochondrial lactate dehydrogenase regulator)

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Gene Gene information from NCBI Gene database.
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Entrez ID 133834869
Gene name Mitochondrial lactate dehydrogenase regulator
Gene symbol MLDHR
Synonyms (NCBI Gene)
MP31PTENURF
Chromosome 10
Chromosome location 10q23.31
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
5
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GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 33406399
GO:0005739 Component Mitochondrion IDA 33406399
GO:0005739 Component Mitochondrion IEA
GO:0090324 Process Negative regulation of oxidative phosphorylation IMP 33406399
GO:0160193 Function L-lactate dehydrogenase inhibitor activity IDA 33406399
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
620760 55481 HGNC
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
C0HLV8
Protein name PTEN upstream open reading frame MP31 (Micropeptide 31) (Mitochondrial lactate dehydrogenase regulator)
Protein function Inhibits lactate dehydrogenase (LDH)-mediated conversion of lactate to pyruvate in mitochondria by competing with mitochondrial LDH for binding to NAD(+) (PubMed:33406399). Also inhibits cellular lactate utilization (PubMed:33406399). {ECO:00002
Family and domains
Tissue specificity TISSUE SPECIFICITY: Expressed in brain (at protein level) (PubMed:33406399). Expressed at lower levels in glioblastomas than in normal brain tissue (at protein level) (PubMed:33406399). {ECO:0000269|PubMed:33406399}.
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No strongly related genes found yet for MLDHR.

              		
    

  

  
  
      

    
    

      
                
No additional diseases found yet through genes similar to MLDHR.