MIS18A (MIS18 kinetochore protein A)

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Gene miRNA Gene ontology Other IDs Protein Pathways Diseases linked via similar genes

Gene

• Entrez ID: 54069
• Gene name: MIS18 kinetochore protein A
• Gene symbol: MIS18A
• Synonyms (NCBI Gene): B28, C21orf45, C21orf46, FASP1, MIS18alpha, hMis18alpha
• Chromosome: 21
• Chromosome location: 21q22.11

miRNA Show/Hide all (138)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030399	hsa-miR-24-3p	Microarray	19748357
MIRT037952	hsa-miR-505-5p	CLASH	23622248
MIRT648724	hsa-miR-4418	HITS-CLIP	23824327
MIRT648723	hsa-miR-509-3-5p	HITS-CLIP	23824327
MIRT648722	hsa-miR-509-5p	HITS-CLIP	23824327
MIRT648721	hsa-miR-4714-3p	HITS-CLIP	23824327
MIRT648720	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT540669	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT540667	hsa-miR-3151-3p	HITS-CLIP	23824327
MIRT648719	hsa-miR-1184	HITS-CLIP	23824327
MIRT540666	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT540662	hsa-miR-3192-3p	HITS-CLIP	23824327
MIRT648718	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT540670	hsa-miR-1224-3p	PAR-CLIP	21572407
MIRT540669	hsa-miR-150-5p	PAR-CLIP	21572407
MIRT540668	hsa-miR-532-3p	PAR-CLIP	21572407
MIRT540667	hsa-miR-3151-3p	PAR-CLIP	21572407
MIRT540666	hsa-miR-452-3p	PAR-CLIP	21572407
MIRT540665	hsa-miR-1260a	PAR-CLIP	21572407
MIRT540664	hsa-miR-1260b	PAR-CLIP	21572407
MIRT540663	hsa-miR-6749-3p	PAR-CLIP	21572407
MIRT540662	hsa-miR-3192-3p	PAR-CLIP	21572407
MIRT441053	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT441053	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT648724	hsa-miR-4418	HITS-CLIP	23824327
MIRT648723	hsa-miR-509-3-5p	HITS-CLIP	23824327
MIRT648722	hsa-miR-509-5p	HITS-CLIP	23824327
MIRT648721	hsa-miR-4714-3p	HITS-CLIP	23824327
MIRT648720	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT540669	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT540667	hsa-miR-3151-3p	HITS-CLIP	23824327
MIRT648719	hsa-miR-1184	HITS-CLIP	23824327
MIRT540666	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT540662	hsa-miR-3192-3p	HITS-CLIP	23824327
MIRT648718	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT540670	hsa-miR-1224-3p	PAR-CLIP	21572407
MIRT540669	hsa-miR-150-5p	PAR-CLIP	21572407
MIRT540668	hsa-miR-532-3p	PAR-CLIP	21572407
MIRT540667	hsa-miR-3151-3p	PAR-CLIP	21572407
MIRT540666	hsa-miR-452-3p	PAR-CLIP	21572407
MIRT540665	hsa-miR-1260a	PAR-CLIP	21572407
MIRT540664	hsa-miR-1260b	PAR-CLIP	21572407
MIRT540663	hsa-miR-6749-3p	PAR-CLIP	21572407
MIRT540662	hsa-miR-3192-3p	PAR-CLIP	21572407
MIRT1149504	hsa-miR-105	CLIP-seq
MIRT1149505	hsa-miR-1254	CLIP-seq
MIRT1149506	hsa-miR-1267	CLIP-seq
MIRT1149507	hsa-miR-150	CLIP-seq
MIRT1149508	hsa-miR-3116	CLIP-seq
MIRT1149509	hsa-miR-3125	CLIP-seq
MIRT1149510	hsa-miR-3148	CLIP-seq
MIRT1149511	hsa-miR-3660	CLIP-seq
MIRT1149512	hsa-miR-3664-5p	CLIP-seq
MIRT1149513	hsa-miR-3689a-5p	CLIP-seq
MIRT1149514	hsa-miR-3689b	CLIP-seq
MIRT1149515	hsa-miR-3689e	CLIP-seq
MIRT1149516	hsa-miR-3689f	CLIP-seq
MIRT1149517	hsa-miR-3916	CLIP-seq
MIRT1149518	hsa-miR-3925-3p	CLIP-seq
MIRT1149519	hsa-miR-4256	CLIP-seq
MIRT1149520	hsa-miR-4284	CLIP-seq
MIRT1149521	hsa-miR-4423-5p	CLIP-seq
MIRT1149522	hsa-miR-4471	CLIP-seq
MIRT1149523	hsa-miR-4526	CLIP-seq
MIRT1149524	hsa-miR-4639-3p	CLIP-seq
MIRT1149525	hsa-miR-4685-5p	CLIP-seq
MIRT1149526	hsa-miR-4735-5p	CLIP-seq
MIRT1149527	hsa-miR-4775	CLIP-seq
MIRT1149528	hsa-miR-4794	CLIP-seq
MIRT1149529	hsa-miR-4797-5p	CLIP-seq
MIRT1149530	hsa-miR-493	CLIP-seq
MIRT1149531	hsa-miR-515-5p	CLIP-seq
MIRT1149532	hsa-miR-522	CLIP-seq
MIRT1149533	hsa-miR-590-3p	CLIP-seq
MIRT1149534	hsa-miR-661	CLIP-seq
MIRT1149535	hsa-miR-766	CLIP-seq
MIRT2042511	hsa-miR-1244	CLIP-seq
MIRT1149506	hsa-miR-1267	CLIP-seq
MIRT2042512	hsa-miR-129-5p	CLIP-seq
MIRT1149507	hsa-miR-150	CLIP-seq
MIRT2042513	hsa-miR-3117-5p	CLIP-seq
MIRT2042514	hsa-miR-3132	CLIP-seq
MIRT2042515	hsa-miR-3529	CLIP-seq
MIRT1149512	hsa-miR-3664-5p	CLIP-seq
MIRT2042516	hsa-miR-3674	CLIP-seq
MIRT2042517	hsa-miR-379	CLIP-seq
MIRT1149520	hsa-miR-4284	CLIP-seq
MIRT2042518	hsa-miR-4318	CLIP-seq
MIRT1149521	hsa-miR-4423-5p	CLIP-seq
MIRT2042519	hsa-miR-4503	CLIP-seq
MIRT1149524	hsa-miR-4639-3p	CLIP-seq
MIRT2042520	hsa-miR-4691-5p	CLIP-seq
MIRT2042521	hsa-miR-4732-5p	CLIP-seq
MIRT1149530	hsa-miR-493	CLIP-seq
MIRT2042511	hsa-miR-1244	CLIP-seq
MIRT2042519	hsa-miR-4503	CLIP-seq
MIRT2272163	hsa-miR-548a-5p	CLIP-seq
MIRT2272164	hsa-miR-548ab	CLIP-seq
MIRT2272165	hsa-miR-548ak	CLIP-seq
MIRT2272166	hsa-miR-548b-5p	CLIP-seq
MIRT2272167	hsa-miR-548c-5p	CLIP-seq
MIRT2272168	hsa-miR-548d-5p	CLIP-seq
MIRT2272169	hsa-miR-548h	CLIP-seq
MIRT2272170	hsa-miR-548i	CLIP-seq
MIRT2272171	hsa-miR-548j	CLIP-seq
MIRT2272172	hsa-miR-548n	CLIP-seq
MIRT2272173	hsa-miR-548w	CLIP-seq
MIRT2272174	hsa-miR-548y	CLIP-seq
MIRT2272175	hsa-miR-559	CLIP-seq
MIRT2390901	hsa-miR-1236	CLIP-seq
MIRT2042513	hsa-miR-3117-5p	CLIP-seq
MIRT2042514	hsa-miR-3132	CLIP-seq
MIRT2042515	hsa-miR-3529	CLIP-seq
MIRT2042517	hsa-miR-379	CLIP-seq
MIRT2390902	hsa-miR-4275	CLIP-seq
MIRT2042518	hsa-miR-4318	CLIP-seq
MIRT2390903	hsa-miR-4753-3p	CLIP-seq
MIRT1149506	hsa-miR-1267	CLIP-seq
MIRT1149512	hsa-miR-3664-5p	CLIP-seq
MIRT1149521	hsa-miR-4423-5p	CLIP-seq
MIRT1149524	hsa-miR-4639-3p	CLIP-seq
MIRT1149530	hsa-miR-493	CLIP-seq
MIRT2042513	hsa-miR-3117-5p	CLIP-seq
MIRT2042514	hsa-miR-3132	CLIP-seq
MIRT2042515	hsa-miR-3529	CLIP-seq
MIRT2571188	hsa-miR-369-3p	CLIP-seq
MIRT2571189	hsa-miR-374a	CLIP-seq
MIRT2571190	hsa-miR-374b	CLIP-seq
MIRT2042517	hsa-miR-379	CLIP-seq
MIRT2042518	hsa-miR-4318	CLIP-seq
MIRT2571191	hsa-miR-4729	CLIP-seq
MIRT1149505	hsa-miR-1254	CLIP-seq
MIRT1149508	hsa-miR-3116	CLIP-seq
MIRT1149526	hsa-miR-4735-5p	CLIP-seq
MIRT1149527	hsa-miR-4775	CLIP-seq
MIRT1149528	hsa-miR-4794	CLIP-seq
MIRT1149533	hsa-miR-590-3p	CLIP-seq
MIRT1149534	hsa-miR-661	CLIP-seq

Gene ontology (GO) Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IBA
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000775	Component	Chromosome, centromeric region	NAS	38951710
GO:0000785	Component	Chromatin	IBA
GO:0005515	Function	Protein binding	IPI	17043677, 17199038, 21516116, 25036634, 25416956, 28514442, 31413325, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0007059	Process	Chromosome segregation	IBA
GO:0007059	Process	Chromosome segregation	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	IEA
GO:0031507	Process	Heterochromatin formation	IEA
GO:0034080	Process	CENP-A containing chromatin assembly	IBA
GO:0034080	Process	CENP-A containing chromatin assembly	IEA
GO:0034080	Process	CENP-A containing chromatin assembly	NAS	38951710
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0046872	Function	Metal ion binding	IEA
GO:0051301	Process	Cell division	IEA
GO:0071459	Process	Protein localization to chromosome, centromeric region	IEA
GO:0098654	Component	CENP-A recruiting complex	IEA
GO:0098654	Component	CENP-A recruiting complex	IPI	38951710
GO:0140462	Process	Pericentric heterochromatin organization	IEA
GO:0140462	Process	Pericentric heterochromatin organization	NAS	38951710

Other IDs

• MIM: 618137
• HGNC: 1286
• e!Ensembl: ENSG00000159055

Protein

• UniProt ID: Q9NYP9
• Protein name: Protein Mis18-alpha (FAPP1-associated protein 1)
• Protein function: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
• PDB: 7SFY , 7SFZ , 8S30
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03226	Yippee-Mis18	81 → 188	Yippee zinc-binding/DNA-binding /Mis18, centromere assembly	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in testis. {ECO:0000269|PubMed:17199038}.
• Sequence:

  MAGVRSLRCSRGCAGGCECGDKGKCSDSSLLGKRLSEDSSRHQLLQKWASMWSSMSEDAS
  VADMERAQLEEEAAAAEERPLVFLCSGCRRPLGDSLSWVASQEDTNCILLRCVSCNVSVD
  KEQKLSKREKENGCVLETLCCAGCSLNLGYVYRCTPKNLDYKRDLFCLSVEAIESYVLGS
  SEKQIVSEDKELFNLESRVEIEKSLTQMEDVLKALQMKLWEAESKLSFATCKS

• Sequence length: 233

Pathways

Reactome Pathway:

Deposition of new CENPA-containing nucleosomes at the centromere

Related Genes

No strongly related genes found yet for MIS18A.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to MIS18A.