MIR145 (microRNA 145)

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Gene Gene information from NCBI Gene database.
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Entrez ID 406937
Gene name MicroRNA 145
Gene symbol MIR145
Synonyms (NCBI Gene)
MIRN145miR-145miRNA145
Chromosome 5
Chromosome location 5q32
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0003730 Function MRNA 3'-UTR binding IDA 23076445, 23128394, 26823772, 31150684
GO:0006940 Process Regulation of smooth muscle contraction ISS
GO:0010614 Process Negative regulation of cardiac muscle hypertrophy ISS
GO:0010667 Process Negative regulation of cardiac muscle cell apoptotic process IDA 23028672
GO:0010667 Process Negative regulation of cardiac muscle cell apoptotic process ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
611795 31532 ENSG00000276365
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway
MicroRNAs in cancer
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
MIR145-related multisystemic smooth muscle dysfunction Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (421)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
5q-syndrome 5q-syndrome BEFREE 19898489, 20211165, 20469997, 20733155, 21873545, 21943668, 22571696, 30651631
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute Cerebrovascular Accidents Stroke BEFREE 26663183
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute monocytic leukemia Monocytic Leukemia BEFREE 22093444
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 18676867, 26465597
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 31496744
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 25551563, 29632636
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 19493678, 21479367, 22285547, 24026105, 24903381, 26582602, 28120164, 28347234, 29137392, 30082847
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 27765914
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 26465597, 30258124
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia T-Cell Lymphoma/Leukemia BEFREE 24745613
★★★★★
★☆☆☆☆
Found in Text Mining only

No strongly related genes found yet for MIR145.

No additional diseases found yet through genes similar to MIR145.