MIR1-1 (microRNA 1-1)

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Gene Gene ontology Other IDs Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 406904
• Gene name: MicroRNA 1-1
• Gene symbol: MIR1-1
• Synonyms (NCBI Gene): MIRN1-1, hsa-mir-1-1, miRNA1-1, mir-1-1
• Chromosome: 20
• Chromosome location: 20q13.33
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO) Show/Hide all (50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003730	Function	MRNA 3'-UTR binding	IDA	25802280, 28042875
GO:0003730	Function	MRNA 3'-UTR binding	IMP	28042875
GO:0005615	Component	Extracellular space	IDA	20159880
GO:0010455	Process	Positive regulation of cell fate commitment	ISS
GO:0010460	Process	Positive regulation of heart rate	ISS
GO:0010614	Process	Negative regulation of cardiac muscle hypertrophy	IMP	19933931
GO:0010614	Process	Negative regulation of cardiac muscle hypertrophy	ISS
GO:0010831	Process	Positive regulation of myotube differentiation	ISS
GO:0010880	Process	Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA	19131648
GO:0010880	Process	Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA	19131648
GO:0010881	Process	Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISS
GO:0016442	Component	RISC complex	IEA
GO:0030336	Process	Negative regulation of cell migration	IMP	25802280
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IDA	17397913, 17401374, 19131648, 19188439, 19933931, 20081117, 22569256, 22880819, 23352489, 23625462, 23939491, 24804980, 25802280, 25995211, 26166810, 28042875
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IEA
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IGI	24804980
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IMP	23157812
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IDA	19933931, 21051663, 24804980
GO:0035279	Process	MiRNA-mediated gene silencing by mRNA destabilization	IDA	23499676, 25802280
GO:0040037	Process	Negative regulation of fibroblast growth factor receptor signaling pathway	IGI	23939491
GO:0043569	Process	Negative regulation of insulin-like growth factor receptor signaling pathway	ISS
GO:0045602	Process	Negative regulation of endothelial cell differentiation	IDA	23939491
GO:0051055	Process	Negative regulation of lipid biosynthetic process	IGI	23499676
GO:0055117	Process	Regulation of cardiac muscle contraction	IDA	19131648
GO:0060044	Process	Negative regulation of cardiac muscle cell proliferation	ISS
GO:0060298	Process	Positive regulation of sarcomere organization	ISS
GO:0060373	Process	Regulation of ventricular cardiac muscle cell membrane depolarization	ISS
GO:0060412	Process	Ventricular septum morphogenesis	ISS
GO:0060452	Process	Positive regulation of cardiac muscle contraction	ISS
GO:0060980	Process	Cell migration involved in coronary vasculogenesis	IDA	23625462
GO:0071879	Process	Positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	IDA	19131648
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IGI	23939491
GO:0090677	Process	Reversible differentiation	IMP	21051663
GO:1902532	Process	Negative regulation of intracellular signal transduction	ISS
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IDA	17397913, 17401374, 19131648, 19188439, 19933931, 20081117, 21051663, 22569256, 22880819, 23352489, 23499676, 23625462, 23939491, 25802280, 26166810, 28042875
GO:1903672	Process	Positive regulation of sprouting angiogenesis	IDA	23625462
GO:1903780	Process	Negative regulation of cardiac conduction	ISS
GO:1904706	Process	Negative regulation of vascular associated smooth muscle cell proliferation	IDA	26166810
GO:1904706	Process	Negative regulation of vascular associated smooth muscle cell proliferation	IMP	21051663
GO:1904879	Process	Positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IDA	19131648
GO:1905024	Process	Regulation of membrane repolarization during ventricular cardiac muscle cell action potential	ISS
GO:1905032	Process	Negative regulation of membrane repolarization during cardiac muscle cell action potential	IMP	23157812
GO:1905461	Process	Positive regulation of vascular associated smooth muscle cell apoptotic process	IDA	26166810
GO:1905700	Process	Negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane	IMP	28042875
GO:1905904	Process	Positive regulation of mesoderm formation	IDA	23939491
GO:1905913	Process	Negative regulation of calcium ion export across plasma membrane	ISS
GO:2000724	Process	Positive regulation of cardiac vascular smooth muscle cell differentiation	ISS
GO:2000727	Process	Positive regulation of cardiac muscle cell differentiation	IDA	20081117, 23939491
GO:2000818	Process	Negative regulation of myoblast proliferation	IDA	20081117
GO:2001016	Process	Positive regulation of skeletal muscle cell differentiation	ISS

Other IDs

• MIM: 609326
• HGNC: 31499
• e!Ensembl: ENSG00000199017

Interactions View interactions

Pathways

KEGG Pathway:

MicroRNAs in cancer

Related Genes

No strongly related genes found yet for MIR1-1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to MIR1-1.