MGRN1 (mahogunin ring finger 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 23295 |
| Gene name | Mahogunin ring finger 1 |
| Gene symbol | MGRN1 |
| Synonyms (NCBI Gene) |
RNF156
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| Chromosome | 16 |
| Chromosome location | 16p13.3 |
| Summary | Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004] |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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O60291 | ||||||||||
| Protein name | E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) | ||||||||||
| Protein function | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by | ||||||||||
| Family and domains |
Pfam
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| Sequence |
MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL |
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| Sequence length | 552 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Related Genes
Genes most often co-reported with MGRN1 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to MGRN1 (see Related Genes above), that are NOT already directly curated for MGRN1 itself -- a lead worth checking, not a confirmed association.
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