MGAT3 (beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 4248
• Gene name: Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
• Gene symbol: MGAT3
• Synonyms (NCBI Gene): GNT-III, GNT3
• Chromosome: 22
• Chromosome location: 22q13.1
• Summary: There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of

miRNA Show/Hide all (182)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018035	hsa-miR-335-5p	Microarray	18185580
MIRT755360	hsa-miR-199a-5p	Luciferase reporter assay, RNA pull down assay	38521909
MIRT1146892	hsa-miR-127-3p	CLIP-seq
MIRT1146893	hsa-miR-1973	CLIP-seq
MIRT1146894	hsa-miR-2467-3p	CLIP-seq
MIRT1146895	hsa-miR-3678-3p	CLIP-seq
MIRT1146896	hsa-miR-1236	CLIP-seq
MIRT1146897	hsa-miR-125a-5p	CLIP-seq
MIRT1146898	hsa-miR-125b	CLIP-seq
MIRT1146892	hsa-miR-127-3p	CLIP-seq
MIRT1146899	hsa-miR-128	CLIP-seq
MIRT1146900	hsa-miR-129-3p	CLIP-seq
MIRT1146901	hsa-miR-1302	CLIP-seq
MIRT737765	hsa-miR-1324	CLIP-seq
MIRT1146902	hsa-miR-134	CLIP-seq
MIRT1146903	hsa-miR-136	CLIP-seq
MIRT1146904	hsa-miR-138	CLIP-seq
MIRT1146905	hsa-miR-146b-3p	CLIP-seq
MIRT1146906	hsa-miR-185	CLIP-seq
MIRT1146907	hsa-miR-18a	CLIP-seq
MIRT1146908	hsa-miR-18b	CLIP-seq
MIRT1146909	hsa-miR-1912	CLIP-seq
MIRT1146910	hsa-miR-1914	CLIP-seq
MIRT1146894	hsa-miR-2467-3p	CLIP-seq
MIRT1146911	hsa-miR-2861	CLIP-seq
MIRT1146912	hsa-miR-3118	CLIP-seq
MIRT1146913	hsa-miR-3120-3p	CLIP-seq
MIRT1146914	hsa-miR-3126-3p	CLIP-seq
MIRT1146915	hsa-miR-3126-5p	CLIP-seq
MIRT1146916	hsa-miR-3130-3p	CLIP-seq
MIRT1146917	hsa-miR-3130-5p	CLIP-seq
MIRT1146918	hsa-miR-3136-3p	CLIP-seq
MIRT1146919	hsa-miR-3138	CLIP-seq
MIRT1146920	hsa-miR-3150a-3p	CLIP-seq
MIRT1146921	hsa-miR-3160-3p	CLIP-seq
MIRT1146922	hsa-miR-3164	CLIP-seq
MIRT1146923	hsa-miR-3173-5p	CLIP-seq
MIRT1146924	hsa-miR-3175	CLIP-seq
MIRT1146925	hsa-miR-3176	CLIP-seq
MIRT1146926	hsa-miR-3177-5p	CLIP-seq
MIRT1146927	hsa-miR-3185	CLIP-seq
MIRT1146928	hsa-miR-3202	CLIP-seq
MIRT1146929	hsa-miR-335	CLIP-seq
MIRT1146930	hsa-miR-342-5p	CLIP-seq
MIRT1146931	hsa-miR-3660	CLIP-seq
MIRT1146932	hsa-miR-3908	CLIP-seq
MIRT1146933	hsa-miR-3922-3p	CLIP-seq
MIRT1146934	hsa-miR-3944-5p	CLIP-seq
MIRT1146935	hsa-miR-4254	CLIP-seq
MIRT1146936	hsa-miR-4257	CLIP-seq
MIRT1146937	hsa-miR-4261	CLIP-seq
MIRT1146938	hsa-miR-4298	CLIP-seq
MIRT1146939	hsa-miR-4306	CLIP-seq
MIRT1146940	hsa-miR-4308	CLIP-seq
MIRT1146941	hsa-miR-4319	CLIP-seq
MIRT1146942	hsa-miR-4320	CLIP-seq
MIRT1146943	hsa-miR-4323	CLIP-seq
MIRT1146944	hsa-miR-4419a	CLIP-seq
MIRT1146945	hsa-miR-4476	CLIP-seq
MIRT1146946	hsa-miR-4482	CLIP-seq
MIRT1146947	hsa-miR-4487	CLIP-seq
MIRT1146948	hsa-miR-4494	CLIP-seq
MIRT737769	hsa-miR-4499	CLIP-seq
MIRT1146949	hsa-miR-4510	CLIP-seq
MIRT1146950	hsa-miR-4520a-3p	CLIP-seq
MIRT1146951	hsa-miR-4526	CLIP-seq
MIRT1146952	hsa-miR-4530	CLIP-seq
MIRT1146953	hsa-miR-4533	CLIP-seq
MIRT1146954	hsa-miR-455-3p	CLIP-seq
MIRT1146955	hsa-miR-4644	CLIP-seq
MIRT1146956	hsa-miR-4650-5p	CLIP-seq
MIRT1146957	hsa-miR-4651	CLIP-seq
MIRT1146958	hsa-miR-4664-5p	CLIP-seq
MIRT1146959	hsa-miR-4687-5p	CLIP-seq
MIRT1146960	hsa-miR-4690-3p	CLIP-seq
MIRT1146961	hsa-miR-4712-3p	CLIP-seq
MIRT1146962	hsa-miR-4714-5p	CLIP-seq
MIRT737768	hsa-miR-4725-5p	CLIP-seq
MIRT1146963	hsa-miR-4728-5p	CLIP-seq
MIRT1146964	hsa-miR-4735-3p	CLIP-seq
MIRT1146965	hsa-miR-4755-3p	CLIP-seq
MIRT1146966	hsa-miR-4757-5p	CLIP-seq
MIRT737766	hsa-miR-4766-5p	CLIP-seq
MIRT1146967	hsa-miR-4792	CLIP-seq
MIRT1146968	hsa-miR-488	CLIP-seq
MIRT1146969	hsa-miR-499a-5p	CLIP-seq
MIRT737767	hsa-miR-504	CLIP-seq
MIRT1146970	hsa-miR-548q	CLIP-seq
MIRT1146971	hsa-miR-558	CLIP-seq
MIRT1146972	hsa-miR-608	CLIP-seq
MIRT1146973	hsa-miR-617	CLIP-seq
MIRT1146974	hsa-miR-661	CLIP-seq
MIRT1146975	hsa-miR-874	CLIP-seq
MIRT1146976	hsa-miR-922	CLIP-seq
MIRT1146977	hsa-miR-939	CLIP-seq
MIRT1551302	hsa-miR-149	CLIP-seq
MIRT1551303	hsa-miR-24	CLIP-seq
MIRT1551304	hsa-miR-3064-5p	CLIP-seq
MIRT1551305	hsa-miR-4284	CLIP-seq
MIRT1551306	hsa-miR-4722-3p	CLIP-seq
MIRT1551307	hsa-miR-4763-5p	CLIP-seq
MIRT1551308	hsa-miR-4794	CLIP-seq
MIRT1551309	hsa-miR-596	CLIP-seq
MIRT2041834	hsa-miR-1226	CLIP-seq
MIRT2041835	hsa-miR-324-5p	CLIP-seq
MIRT2041836	hsa-miR-4279	CLIP-seq
MIRT2041837	hsa-miR-942	CLIP-seq
MIRT2041838	hsa-miR-3654	CLIP-seq
MIRT2041839	hsa-miR-378	CLIP-seq
MIRT2041840	hsa-miR-378b	CLIP-seq
MIRT2041841	hsa-miR-378c	CLIP-seq
MIRT2041842	hsa-miR-378d	CLIP-seq
MIRT2041843	hsa-miR-378e	CLIP-seq
MIRT2041844	hsa-miR-378f	CLIP-seq
MIRT2041845	hsa-miR-378h	CLIP-seq
MIRT2041846	hsa-miR-378i	CLIP-seq
MIRT2041847	hsa-miR-422a	CLIP-seq
MIRT2271388	hsa-miR-204	CLIP-seq
MIRT2271389	hsa-miR-211	CLIP-seq
MIRT2041838	hsa-miR-3654	CLIP-seq
MIRT2271390	hsa-miR-3690	CLIP-seq
MIRT2041839	hsa-miR-378	CLIP-seq
MIRT2041840	hsa-miR-378b	CLIP-seq
MIRT2041841	hsa-miR-378c	CLIP-seq
MIRT2041842	hsa-miR-378d	CLIP-seq
MIRT2041843	hsa-miR-378e	CLIP-seq
MIRT2041844	hsa-miR-378f	CLIP-seq
MIRT2041845	hsa-miR-378h	CLIP-seq
MIRT2041846	hsa-miR-378i	CLIP-seq
MIRT2271391	hsa-miR-3915	CLIP-seq
MIRT2271392	hsa-miR-3928	CLIP-seq
MIRT2041847	hsa-miR-422a	CLIP-seq
MIRT1146935	hsa-miR-4254	CLIP-seq
MIRT1146944	hsa-miR-4419a	CLIP-seq
MIRT1146948	hsa-miR-4494	CLIP-seq
MIRT1146949	hsa-miR-4510	CLIP-seq
MIRT2271393	hsa-miR-4691-5p	CLIP-seq
MIRT1146963	hsa-miR-4728-5p	CLIP-seq
MIRT2271394	hsa-miR-516a-3p	CLIP-seq
MIRT2271395	hsa-miR-646	CLIP-seq
MIRT2271396	hsa-miR-711	CLIP-seq
MIRT2390853	hsa-miR-1913	CLIP-seq
MIRT2390854	hsa-miR-324-3p	CLIP-seq
MIRT2390855	hsa-miR-4688	CLIP-seq
MIRT2570564	hsa-miR-1470	CLIP-seq
MIRT2570565	hsa-miR-150	CLIP-seq
MIRT2570566	hsa-miR-3689d	CLIP-seq
MIRT2570567	hsa-miR-4286	CLIP-seq
MIRT2570568	hsa-miR-4447	CLIP-seq
MIRT2570569	hsa-miR-4469	CLIP-seq
MIRT2570570	hsa-miR-4472	CLIP-seq
MIRT2570571	hsa-miR-4667-3p	CLIP-seq
MIRT2570572	hsa-miR-4708-5p	CLIP-seq
MIRT2570573	hsa-miR-4713-5p	CLIP-seq
MIRT2570574	hsa-miR-4723-5p	CLIP-seq
MIRT1146963	hsa-miR-4728-5p	CLIP-seq
MIRT2570575	hsa-miR-4756-3p	CLIP-seq
MIRT2570576	hsa-miR-4758-3p	CLIP-seq
MIRT2570577	hsa-miR-532-3p	CLIP-seq
MIRT2570564	hsa-miR-1470	CLIP-seq
MIRT1551302	hsa-miR-149	CLIP-seq
MIRT2570565	hsa-miR-150	CLIP-seq
MIRT1551303	hsa-miR-24	CLIP-seq
MIRT1551304	hsa-miR-3064-5p	CLIP-seq
MIRT2570566	hsa-miR-3689d	CLIP-seq
MIRT1551305	hsa-miR-4284	CLIP-seq
MIRT2570567	hsa-miR-4286	CLIP-seq
MIRT2570568	hsa-miR-4447	CLIP-seq
MIRT2570569	hsa-miR-4469	CLIP-seq
MIRT2570570	hsa-miR-4472	CLIP-seq
MIRT2570571	hsa-miR-4667-3p	CLIP-seq
MIRT2570572	hsa-miR-4708-5p	CLIP-seq
MIRT2570573	hsa-miR-4713-5p	CLIP-seq
MIRT2570574	hsa-miR-4723-5p	CLIP-seq
MIRT1146963	hsa-miR-4728-5p	CLIP-seq
MIRT2570575	hsa-miR-4756-3p	CLIP-seq
MIRT2570576	hsa-miR-4758-3p	CLIP-seq
MIRT2684973	hsa-miR-4766-3p	CLIP-seq
MIRT1551308	hsa-miR-4794	CLIP-seq
MIRT2570577	hsa-miR-532-3p	CLIP-seq
MIRT2684974	hsa-miR-532-5p	CLIP-seq
MIRT2684975	hsa-miR-548p	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0003830	Function	Beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	IEA
GO:0003830	Function	Beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	IMP	19403558
GO:0003830	Function	Beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	ISS
GO:0003830	Function	Beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	TAS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005794	Component	Golgi apparatus	IEA
GO:0006044	Process	N-acetylglucosamine metabolic process	IBA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006487	Process	Protein N-linked glycosylation	ISS
GO:0008104	Process	Intracellular protein localization	IMP	19403558
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	8370666
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IBA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0030334	Process	Regulation of cell migration	IDA	26801611
GO:0034599	Process	Cellular response to oxidative stress	ISS
GO:0050435	Process	Amyloid-beta metabolic process	ISS
GO:0050890	Process	Cognition	ISS
GO:1902966	Process	Positive regulation of protein localization to early endosome	ISS
GO:1905166	Process	Negative regulation of lysosomal protein catabolic process	ISS

Other IDs

• MIM: 604621
• HGNC: 7046
• e!Ensembl: ENSG00000128268

Protein

• UniProt ID: Q09327
• Protein name: Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC 2.4.1.144) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III) (GNT-III) (GlcNAc-T III) (N-acetylglucosaminyltransferase III)
• Protein function: It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04724	Glyco_transf_17	186 → 358	Glycosyltransferase family 17	Family

• Sequence:

  MKMRRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLVSSFFWNNAPVTPQA
  SPEPGGPDLLRTPLYSHSPLLQPLPPSKAAEELHRVDLVLPEDTTEYFVRTKAGGVCFKP
  GTKMLERPPPGRPEEKPEGANGSSARRPPRYLLSARERTGGRGARRKWVECVCLPGWHGP
  SCGVPTVVQYSNLPTKERLVPREVPRRVINAINVNHEFDLLDVRFHELGDVVDAFVVCES
  NFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPPGGRQDGWIADDYLRTFLTQDG
  VSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLE
  VVSGCTVDMLQAVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCS
  WCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRGLIRTGGWFDGTQQEYPPADPSEH
  MYAPKYLLKNYDRFHYLLDNPYQEPRSTAAGGWRHRGPEGRPPARGKLDEAEV

• Sequence length: 533

Pathways

KEGG Pathway	Reactome Pathway
N-Glycan biosynthesis	Reactions specific to the hybrid N-glycan synthesis pathway
Metabolic pathways

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	35764056	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	35764056	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	26198764, 35396580	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

No strongly related genes found yet for MGAT3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to MGAT3.