MFAP1 (microfibril associated protein 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 4236
• Gene name: Microfibril associated protein 1
• Gene symbol: MFAP1
• Synonyms (NCBI Gene): AMP
• Chromosome: 15
• Chromosome location: 15q15.3

miRNA Show/Hide all (141)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1145677	hsa-miR-1180	CLIP-seq
MIRT1145678	hsa-miR-1285	CLIP-seq
MIRT1145679	hsa-miR-1912	CLIP-seq
MIRT1145680	hsa-miR-3130-5p	CLIP-seq
MIRT1145681	hsa-miR-3145-5p	CLIP-seq
MIRT1145682	hsa-miR-3153	CLIP-seq
MIRT1145683	hsa-miR-3187-5p	CLIP-seq
MIRT1145684	hsa-miR-323b-3p	CLIP-seq
MIRT1145685	hsa-miR-33a	CLIP-seq
MIRT1145686	hsa-miR-33b	CLIP-seq
MIRT1145687	hsa-miR-3692	CLIP-seq
MIRT1145688	hsa-miR-378g	CLIP-seq
MIRT1145689	hsa-miR-3927	CLIP-seq
MIRT1145690	hsa-miR-3973	CLIP-seq
MIRT1145691	hsa-miR-4274	CLIP-seq
MIRT1145692	hsa-miR-4330	CLIP-seq
MIRT1145693	hsa-miR-4457	CLIP-seq
MIRT1145694	hsa-miR-4482	CLIP-seq
MIRT1145695	hsa-miR-4486	CLIP-seq
MIRT1145696	hsa-miR-4497	CLIP-seq
MIRT1145697	hsa-miR-4519	CLIP-seq
MIRT1145698	hsa-miR-4650-3p	CLIP-seq
MIRT1145699	hsa-miR-4664-3p	CLIP-seq
MIRT1145700	hsa-miR-4666-5p	CLIP-seq
MIRT1145701	hsa-miR-4668-5p	CLIP-seq
MIRT1145702	hsa-miR-4747-5p	CLIP-seq
MIRT1145703	hsa-miR-513b	CLIP-seq
MIRT1145704	hsa-miR-520g	CLIP-seq
MIRT1145705	hsa-miR-520h	CLIP-seq
MIRT1145706	hsa-miR-548aa	CLIP-seq
MIRT1145707	hsa-miR-548ag	CLIP-seq
MIRT1145708	hsa-miR-548ai	CLIP-seq
MIRT1145709	hsa-miR-548p	CLIP-seq
MIRT1145710	hsa-miR-586	CLIP-seq
MIRT1145711	hsa-miR-612	CLIP-seq
MIRT1145712	hsa-miR-656	CLIP-seq
MIRT1145713	hsa-miR-671-5p	CLIP-seq
MIRT1145714	hsa-miR-7	CLIP-seq
MIRT2041424	hsa-miR-3126-3p	CLIP-seq
MIRT1145684	hsa-miR-323b-3p	CLIP-seq
MIRT1145690	hsa-miR-3973	CLIP-seq
MIRT1145691	hsa-miR-4274	CLIP-seq
MIRT1145697	hsa-miR-4519	CLIP-seq
MIRT2041425	hsa-miR-4782-5p	CLIP-seq
MIRT1145704	hsa-miR-520g	CLIP-seq
MIRT1145705	hsa-miR-520h	CLIP-seq
MIRT2271106	hsa-miR-145	CLIP-seq
MIRT2271107	hsa-miR-2681	CLIP-seq
MIRT2271108	hsa-miR-3180-5p	CLIP-seq
MIRT1145691	hsa-miR-4274	CLIP-seq
MIRT1145693	hsa-miR-4457	CLIP-seq
MIRT1145697	hsa-miR-4519	CLIP-seq
MIRT2271109	hsa-miR-4520a-3p	CLIP-seq
MIRT2271110	hsa-miR-4520b-3p	CLIP-seq
MIRT2271111	hsa-miR-4712-5p	CLIP-seq
MIRT1145703	hsa-miR-513b	CLIP-seq
MIRT2271112	hsa-miR-770-5p	CLIP-seq
MIRT1145677	hsa-miR-1180	CLIP-seq
MIRT2570062	hsa-miR-1273d	CLIP-seq
MIRT2570063	hsa-miR-132	CLIP-seq
MIRT2570064	hsa-miR-212	CLIP-seq
MIRT2570065	hsa-miR-3127-3p	CLIP-seq
MIRT1145681	hsa-miR-3145-5p	CLIP-seq
MIRT2570066	hsa-miR-3148	CLIP-seq
MIRT1145682	hsa-miR-3153	CLIP-seq
MIRT2570067	hsa-miR-3652	CLIP-seq
MIRT2570068	hsa-miR-3672	CLIP-seq
MIRT2570069	hsa-miR-3688-3p	CLIP-seq
MIRT1145687	hsa-miR-3692	CLIP-seq
MIRT1145689	hsa-miR-3927	CLIP-seq
MIRT2570070	hsa-miR-4263	CLIP-seq
MIRT1145691	hsa-miR-4274	CLIP-seq
MIRT1145692	hsa-miR-4330	CLIP-seq
MIRT2570071	hsa-miR-4430	CLIP-seq
MIRT2570072	hsa-miR-4436b-5p	CLIP-seq
MIRT2570073	hsa-miR-4446-3p	CLIP-seq
MIRT2570074	hsa-miR-4492	CLIP-seq
MIRT1145696	hsa-miR-4497	CLIP-seq
MIRT2570075	hsa-miR-4498	CLIP-seq
MIRT1145697	hsa-miR-4519	CLIP-seq
MIRT2570076	hsa-miR-4535	CLIP-seq
MIRT1145698	hsa-miR-4650-3p	CLIP-seq
MIRT1145699	hsa-miR-4664-3p	CLIP-seq
MIRT1145700	hsa-miR-4666-5p	CLIP-seq
MIRT1145701	hsa-miR-4668-5p	CLIP-seq
MIRT2570077	hsa-miR-4694-3p	CLIP-seq
MIRT2570078	hsa-miR-4760-5p	CLIP-seq
MIRT2570079	hsa-miR-4773	CLIP-seq
MIRT2570080	hsa-miR-4776-5p	CLIP-seq
MIRT1145706	hsa-miR-548aa	CLIP-seq
MIRT1145707	hsa-miR-548ag	CLIP-seq
MIRT1145708	hsa-miR-548ai	CLIP-seq
MIRT1145709	hsa-miR-548p	CLIP-seq
MIRT2570081	hsa-miR-556-5p	CLIP-seq
MIRT2570082	hsa-miR-570	CLIP-seq
MIRT2570083	hsa-miR-576-5p	CLIP-seq
MIRT2570084	hsa-miR-581	CLIP-seq
MIRT2570085	hsa-miR-587	CLIP-seq
MIRT1145712	hsa-miR-656	CLIP-seq
MIRT1145714	hsa-miR-7	CLIP-seq
MIRT2570086	hsa-miR-762	CLIP-seq
MIRT2570087	hsa-miR-875-3p	CLIP-seq
MIRT1145677	hsa-miR-1180	CLIP-seq
MIRT2570062	hsa-miR-1273d	CLIP-seq
MIRT2570063	hsa-miR-132	CLIP-seq
MIRT2570064	hsa-miR-212	CLIP-seq
MIRT2570065	hsa-miR-3127-3p	CLIP-seq
MIRT1145681	hsa-miR-3145-5p	CLIP-seq
MIRT2570066	hsa-miR-3148	CLIP-seq
MIRT1145682	hsa-miR-3153	CLIP-seq
MIRT2570067	hsa-miR-3652	CLIP-seq
MIRT2570068	hsa-miR-3672	CLIP-seq
MIRT2570069	hsa-miR-3688-3p	CLIP-seq
MIRT1145687	hsa-miR-3692	CLIP-seq
MIRT2570070	hsa-miR-4263	CLIP-seq
MIRT1145691	hsa-miR-4274	CLIP-seq
MIRT1145692	hsa-miR-4330	CLIP-seq
MIRT2570071	hsa-miR-4430	CLIP-seq
MIRT2570072	hsa-miR-4436b-5p	CLIP-seq
MIRT2570073	hsa-miR-4446-3p	CLIP-seq
MIRT2570074	hsa-miR-4492	CLIP-seq
MIRT1145696	hsa-miR-4497	CLIP-seq
MIRT2570075	hsa-miR-4498	CLIP-seq
MIRT1145697	hsa-miR-4519	CLIP-seq
MIRT1145699	hsa-miR-4664-3p	CLIP-seq
MIRT1145700	hsa-miR-4666-5p	CLIP-seq
MIRT1145701	hsa-miR-4668-5p	CLIP-seq
MIRT2570077	hsa-miR-4694-3p	CLIP-seq
MIRT1145702	hsa-miR-4747-5p	CLIP-seq
MIRT2570078	hsa-miR-4760-5p	CLIP-seq
MIRT2570079	hsa-miR-4773	CLIP-seq
MIRT1145706	hsa-miR-548aa	CLIP-seq
MIRT1145709	hsa-miR-548p	CLIP-seq
MIRT2570081	hsa-miR-556-5p	CLIP-seq
MIRT2570082	hsa-miR-570	CLIP-seq
MIRT2570083	hsa-miR-576-5p	CLIP-seq
MIRT2570084	hsa-miR-581	CLIP-seq
MIRT2570085	hsa-miR-587	CLIP-seq
MIRT1145714	hsa-miR-7	CLIP-seq
MIRT2570086	hsa-miR-762	CLIP-seq
MIRT2570087	hsa-miR-875-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IBA
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	28781166
GO:0001527	Component	Microfibril	IDA	1374398
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	22365833, 25416956, 28514442, 30886144, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	28781166
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005684	Component	U2-type spliceosomal complex	IBA
GO:0005813	Component	Centrosome	IDA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0071005	Component	U2-type precatalytic spliceosome	IDA	28781166

Other IDs

• MIM: 600215
• HGNC: 7032
• e!Ensembl: ENSG00000140259

Protein

• UniProt ID: P55081
• Protein name: Microfibrillar-associated protein 1 (Spliceosome B complex protein MFAP1)
• Protein function: Involved in pre-mRNA splicing as a component of the spliceosome.
• PDB: 5F5S , 5O9Z , 6AHD , 7AAV , 7ABF , 7ABG , 7ABI , 8H6K , 8Q7N , 8QO9 , 8QPE , 8QZS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06991	MFAP1	189 → 399	Microfibril-associated/Pre-mRNA processing	Family

• Sequence:

  MSVPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEF
  QFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEV
  EGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESE
  SESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYT
  LKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKE
  KAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDF
  SAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNTKFFKQK
  AAGVRDVFERPSAKKRKTT

• Sequence length: 439

Pathways

Reactome Pathway:

Molecules associated with elastic fibres

Related Genes

No strongly related genes found yet for MFAP1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to MFAP1.