METTL9 (methyltransferase 9, His-X-His N1(pi)-histidine)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 51108 |
| Gene name | Methyltransferase 9, His-X-His N1(pi)-histidine |
| Gene symbol | METTL9 |
| Synonyms (NCBI Gene) |
CGI-81DREVDREV1PAP1hMETTL9
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| Chromosome | 16 |
| Chromosome location | 16p12.2 |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9H1A3 | ||||||||||
| Protein name | Protein-L-histidine N-pros-methyltransferase (EC 2.1.1.-) (DORA reverse strand protein) (DREV) (DREV1) (Methyltransferase-like protein 9) (hMETTL9) | ||||||||||
| Protein function | Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins (PubMed:33563959, PubMed:34562450, PubMed:37015930, PubMed:37398635). Specifically methylates the second Hi | ||||||||||
| PDB | 7Y9C , 7YF2 , 7YF3 , 7YF4 , 8GZE , 8GZF | ||||||||||
| Family and domains |
Pfam
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| Sequence |
MRLLAGWLCLSLASVWLARRMWTLRSPLTRSLYVNMTSGPGGPAAAAGGRKENHQWYVCN |
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| Sequence length | 318 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with METTL9 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to METTL9 (see Related Genes above), that are NOT already directly curated for METTL9 itself -- a lead worth checking, not a confirmed association.
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