METTL4 (methyltransferase 4, N6-adenosine)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 64863
• Gene name: Methyltransferase 4, N6-adenosine
• Gene symbol: METTL4
• Synonyms (NCBI Gene): HsT661
• Chromosome: 18
• Chromosome location: 18p11.32

miRNA Show/Hide all (175)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048094	hsa-miR-197-3p	CLASH	23622248
MIRT1144659	hsa-miR-106a	CLIP-seq
MIRT1144660	hsa-miR-106b	CLIP-seq
MIRT1144661	hsa-miR-17	CLIP-seq
MIRT1144662	hsa-miR-1909	CLIP-seq
MIRT1144663	hsa-miR-208a	CLIP-seq
MIRT1144664	hsa-miR-208b	CLIP-seq
MIRT1144665	hsa-miR-20a	CLIP-seq
MIRT1144666	hsa-miR-20b	CLIP-seq
MIRT1144667	hsa-miR-302a	CLIP-seq
MIRT1144668	hsa-miR-302b	CLIP-seq
MIRT1144669	hsa-miR-302c	CLIP-seq
MIRT1144670	hsa-miR-302d	CLIP-seq
MIRT1144671	hsa-miR-302e	CLIP-seq
MIRT1144672	hsa-miR-3129-3p	CLIP-seq
MIRT1144673	hsa-miR-3136-5p	CLIP-seq
MIRT1144674	hsa-miR-3159	CLIP-seq
MIRT1144675	hsa-miR-3609	CLIP-seq
MIRT1144676	hsa-miR-3663-5p	CLIP-seq
MIRT1144677	hsa-miR-3667-5p	CLIP-seq
MIRT1144678	hsa-miR-371-5p	CLIP-seq
MIRT1144679	hsa-miR-371b-5p	CLIP-seq
MIRT1144680	hsa-miR-372	CLIP-seq
MIRT1144681	hsa-miR-373	CLIP-seq
MIRT1144682	hsa-miR-3915	CLIP-seq
MIRT1144683	hsa-miR-3925-3p	CLIP-seq
MIRT1144684	hsa-miR-3928	CLIP-seq
MIRT1144685	hsa-miR-3978	CLIP-seq
MIRT1144686	hsa-miR-4261	CLIP-seq
MIRT1144687	hsa-miR-4269	CLIP-seq
MIRT1144688	hsa-miR-4439	CLIP-seq
MIRT1144689	hsa-miR-4450	CLIP-seq
MIRT1144690	hsa-miR-4475	CLIP-seq
MIRT1144691	hsa-miR-4496	CLIP-seq
MIRT1144692	hsa-miR-4645-5p	CLIP-seq
MIRT1144693	hsa-miR-4668-5p	CLIP-seq
MIRT1144694	hsa-miR-4673	CLIP-seq
MIRT1144695	hsa-miR-4710	CLIP-seq
MIRT1144696	hsa-miR-4755-3p	CLIP-seq
MIRT1144697	hsa-miR-4786-3p	CLIP-seq
MIRT1144698	hsa-miR-4792	CLIP-seq
MIRT1144699	hsa-miR-4796-3p	CLIP-seq
MIRT1144700	hsa-miR-4803	CLIP-seq
MIRT1144701	hsa-miR-499-5p	CLIP-seq
MIRT1144702	hsa-miR-513c	CLIP-seq
MIRT1144703	hsa-miR-514b-5p	CLIP-seq
MIRT1144704	hsa-miR-515-5p	CLIP-seq
MIRT1144705	hsa-miR-519d	CLIP-seq
MIRT1144706	hsa-miR-520a-3p	CLIP-seq
MIRT1144707	hsa-miR-520b	CLIP-seq
MIRT1144708	hsa-miR-520c-3p	CLIP-seq
MIRT1144709	hsa-miR-520d-3p	CLIP-seq
MIRT1144710	hsa-miR-520e	CLIP-seq
MIRT1144711	hsa-miR-520f	CLIP-seq
MIRT1144712	hsa-miR-548aa	CLIP-seq
MIRT1144713	hsa-miR-548ah	CLIP-seq
MIRT1144714	hsa-miR-548t	CLIP-seq
MIRT1144715	hsa-miR-636	CLIP-seq
MIRT1144716	hsa-miR-766	CLIP-seq
MIRT1144717	hsa-miR-922	CLIP-seq
MIRT1144718	hsa-miR-93	CLIP-seq
MIRT1144719	hsa-miR-943	CLIP-seq
MIRT2041174	hsa-miR-3117-5p	CLIP-seq
MIRT1144672	hsa-miR-3129-3p	CLIP-seq
MIRT1144678	hsa-miR-371-5p	CLIP-seq
MIRT1144679	hsa-miR-371b-5p	CLIP-seq
MIRT2041175	hsa-miR-4698	CLIP-seq
MIRT1144702	hsa-miR-513c	CLIP-seq
MIRT1144703	hsa-miR-514b-5p	CLIP-seq
MIRT1144717	hsa-miR-922	CLIP-seq
MIRT2454024	hsa-miR-4659a-3p	CLIP-seq
MIRT2454025	hsa-miR-4659b-3p	CLIP-seq
MIRT2454026	hsa-miR-4777-5p	CLIP-seq
MIRT2454027	hsa-miR-518d-5p	CLIP-seq
MIRT2454028	hsa-miR-519b-5p	CLIP-seq
MIRT2454029	hsa-miR-519c-5p	CLIP-seq
MIRT2454030	hsa-miR-520c-5p	CLIP-seq
MIRT2454031	hsa-miR-526a	CLIP-seq
MIRT2454032	hsa-miR-579	CLIP-seq
MIRT2569845	hsa-miR-103a	CLIP-seq
MIRT2569846	hsa-miR-107	CLIP-seq
MIRT2569847	hsa-miR-1236	CLIP-seq
MIRT2569848	hsa-miR-133a	CLIP-seq
MIRT2569849	hsa-miR-133b	CLIP-seq
MIRT2569850	hsa-miR-15a	CLIP-seq
MIRT2569851	hsa-miR-15b	CLIP-seq
MIRT2569852	hsa-miR-16	CLIP-seq
MIRT2569853	hsa-miR-182	CLIP-seq
MIRT2569854	hsa-miR-185	CLIP-seq
MIRT2569855	hsa-miR-195	CLIP-seq
MIRT2569856	hsa-miR-2113	CLIP-seq
MIRT2569857	hsa-miR-31	CLIP-seq
MIRT2569858	hsa-miR-3133	CLIP-seq
MIRT2569859	hsa-miR-3144-3p	CLIP-seq
MIRT2569860	hsa-miR-3158-5p	CLIP-seq
MIRT2569861	hsa-miR-3166	CLIP-seq
MIRT2569862	hsa-miR-34a	CLIP-seq
MIRT2569863	hsa-miR-34c-5p	CLIP-seq
MIRT2569864	hsa-miR-3611	CLIP-seq
MIRT2569865	hsa-miR-3613-3p	CLIP-seq
MIRT2569866	hsa-miR-3647-3p	CLIP-seq
MIRT2569867	hsa-miR-3688-5p	CLIP-seq
MIRT2569868	hsa-miR-377	CLIP-seq
MIRT2569869	hsa-miR-424	CLIP-seq
MIRT2569870	hsa-miR-4306	CLIP-seq
MIRT2569871	hsa-miR-4318	CLIP-seq
MIRT2569872	hsa-miR-4434	CLIP-seq
MIRT2569873	hsa-miR-4457	CLIP-seq
MIRT2569874	hsa-miR-4468	CLIP-seq
MIRT2569875	hsa-miR-4470	CLIP-seq
MIRT2569876	hsa-miR-4494	CLIP-seq
MIRT2569877	hsa-miR-4499	CLIP-seq
MIRT2569878	hsa-miR-449a	CLIP-seq
MIRT2569879	hsa-miR-449b	CLIP-seq
MIRT2569880	hsa-miR-4502	CLIP-seq
MIRT2569881	hsa-miR-4516	CLIP-seq
MIRT2569882	hsa-miR-4531	CLIP-seq
MIRT2569883	hsa-miR-4644	CLIP-seq
MIRT2569884	hsa-miR-4676-5p	CLIP-seq
MIRT2569885	hsa-miR-4693-5p	CLIP-seq
MIRT1144696	hsa-miR-4755-3p	CLIP-seq
MIRT2569886	hsa-miR-4757-5p	CLIP-seq
MIRT2569887	hsa-miR-4771	CLIP-seq
MIRT2569888	hsa-miR-4777-3p	CLIP-seq
MIRT1144699	hsa-miR-4796-3p	CLIP-seq
MIRT1144700	hsa-miR-4803	CLIP-seq
MIRT2569889	hsa-miR-495	CLIP-seq
MIRT2569890	hsa-miR-497	CLIP-seq
MIRT2569891	hsa-miR-514	CLIP-seq
MIRT2569892	hsa-miR-514b-3p	CLIP-seq
MIRT2569893	hsa-miR-520g	CLIP-seq
MIRT2569894	hsa-miR-520h	CLIP-seq
MIRT2569895	hsa-miR-575	CLIP-seq
MIRT2569896	hsa-miR-603	CLIP-seq
MIRT2569897	hsa-miR-758	CLIP-seq
MIRT2569898	hsa-miR-875-5p	CLIP-seq
MIRT2569899	hsa-miR-888	CLIP-seq
MIRT2569900	hsa-miR-892a	CLIP-seq
MIRT2569845	hsa-miR-103a	CLIP-seq
MIRT2569846	hsa-miR-107	CLIP-seq
MIRT2569847	hsa-miR-1236	CLIP-seq
MIRT2569848	hsa-miR-133a	CLIP-seq
MIRT2569849	hsa-miR-133b	CLIP-seq
MIRT2569850	hsa-miR-15a	CLIP-seq
MIRT2569851	hsa-miR-15b	CLIP-seq
MIRT2569852	hsa-miR-16	CLIP-seq
MIRT2569854	hsa-miR-185	CLIP-seq
MIRT2569855	hsa-miR-195	CLIP-seq
MIRT2569858	hsa-miR-3133	CLIP-seq
MIRT2569860	hsa-miR-3158-5p	CLIP-seq
MIRT2569861	hsa-miR-3166	CLIP-seq
MIRT2569862	hsa-miR-34a	CLIP-seq
MIRT2569863	hsa-miR-34c-5p	CLIP-seq
MIRT2569867	hsa-miR-3688-5p	CLIP-seq
MIRT2569869	hsa-miR-424	CLIP-seq
MIRT2569870	hsa-miR-4306	CLIP-seq
MIRT2569871	hsa-miR-4318	CLIP-seq
MIRT2569873	hsa-miR-4457	CLIP-seq
MIRT2569874	hsa-miR-4468	CLIP-seq
MIRT2569875	hsa-miR-4470	CLIP-seq
MIRT2569876	hsa-miR-4494	CLIP-seq
MIRT2569877	hsa-miR-4499	CLIP-seq
MIRT2569878	hsa-miR-449a	CLIP-seq
MIRT2569879	hsa-miR-449b	CLIP-seq
MIRT2569883	hsa-miR-4644	CLIP-seq
MIRT2569884	hsa-miR-4676-5p	CLIP-seq
MIRT2569885	hsa-miR-4693-5p	CLIP-seq
MIRT1144696	hsa-miR-4755-3p	CLIP-seq
MIRT2569887	hsa-miR-4771	CLIP-seq
MIRT1144699	hsa-miR-4796-3p	CLIP-seq
MIRT2569890	hsa-miR-497	CLIP-seq
MIRT2569893	hsa-miR-520g	CLIP-seq
MIRT2569894	hsa-miR-520h	CLIP-seq
MIRT2569895	hsa-miR-575	CLIP-seq
MIRT2569900	hsa-miR-892a	CLIP-seq

Gene ontology (GO) Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0005634	Component	Nucleus	IDA	31913360, 32183942
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IDA	32183942
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	32183942
GO:0005829	Component	Cytosol	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008173	Function	RNA methyltransferase activity	IBA
GO:0008173	Function	RNA methyltransferase activity	IDA	31913360
GO:0008757	Function	S-adenosylmethionine-dependent methyltransferase activity	IEA
GO:0009007	Function	Site-specific DNA-methyltransferase (adenine-specific) activity	IBA
GO:0009007	Function	Site-specific DNA-methyltransferase (adenine-specific) activity	IDA	32183942
GO:0009007	Function	Site-specific DNA-methyltransferase (adenine-specific) activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032259	Process	Methylation	IEA
GO:0036396	Component	RNA N6-methyladenosine methyltransferase complex	IEA
GO:0036396	Component	RNA N6-methyladenosine methyltransferase complex	IMP	36354136
GO:0043484	Process	Regulation of RNA splicing	IMP	31913360
GO:0045814	Process	Negative regulation of gene expression, epigenetic	ISS
GO:0090296	Process	Regulation of mitochondrial DNA replication	IMP	32183942
GO:0106347	Function	U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity	IEA
GO:0120049	Process	SnRNA (adenine-N6)-methylation	IDA	31913360
GO:0140640	Function	Catalytic activity, acting on a nucleic acid	IEA
GO:1903108	Process	Regulation of mitochondrial transcription	IMP	32183942
GO:1990204	Component	Oxidoreductase complex	IMP	36354136

Other IDs

• MIM: 619626
• HGNC: 24726
• e!Ensembl: ENSG00000101574

Protein

• UniProt ID: Q8N3J2
• Protein name: N(6)-adenine-specific methyltransferase METTL4 (Methyltransferase-like protein 4) (N(6)-adenine-specific DNA methyltransferase METTL4) (EC 2.1.1.72) (snRNA (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4) (EC 2.1.1.-)
• Protein function: N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA (PubMed:31913360, PubMed:32183942). Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal posi
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05063	MT-A70	281 → 455	MT-A70	Family

• Sequence:

  MSVVHQLSAGWLLDHLSFINKINYQLHQHHEPCCRKKEFTTSVHFESLQMDSVSSSGVCA
  AFIASDSSTKPENDDGGNYEMFTRKFVFRPELFDVTKPYITPAVHKECQQSNEKEDLMNG
  VKKEISISIIGKKRKRCVVFNQGELDAMEYHTKIRELILDGSLQLIQEGLKSGFLYPLFE
  KQDKGSKPITLPLDACSLSELCEMAKHLPSLNEMEHQTLQLVEEDTSVTEQDLFLRVVEN
  NSSFTKVITLMGQKYLLPPKSSFLLSDISCMQPLLNYRKTFDVIVIDPPWQNKSVKRSNR
  YSYLSPLQIQQIPIPKLAAPNCLLVTWVTNRQKHLRFIKEELYPSWSVEVVAEWHWVKIT
  NSGEFVFPLDSPHKKPYEGLILGRVQEKTALPLRNADVNVLPIPDHKLIVSVPCTLHSHK
  PPLAEVLKDYIKPDGEYLELFARNLQPGWTSWGNEVLKFQHVDYFIAVESGS

• Sequence length: 472

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Clear cell carcinoma of kidney	Likely pathogenic	rs148311311	RCV005930401	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (15)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ASTHMA	—	GWAS catalog	36543808	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA	—	GWAS catalog	19684603	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	36543808	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	37359372	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	28604730	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	28604730	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	28604730	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	31969693	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	35069183	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	28604730	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	40341939	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	26888256	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (8)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Colonic Neoplasms	Colonic neoplasm	Pubtator	31823961	Inhibit	★☆☆☆☆ Found in Text Mining only
Congenital anomaly of face	Facial dysmorphism	BEFREE	30982744		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	37061119	Associate	★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Intellectual developmental disorder	Pubtator	34452636	Associate	★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	31217906		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31823961		★☆☆☆☆ Found in Text Mining only
Paresthesia	Paresthesia	Pubtator	23834954	Associate	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	35177638	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for METTL4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to METTL4.